Journal
SYNLETT
Volume -, Issue 4, Pages 525-549Publisher
GEORG THIEME VERLAG KG
DOI: 10.1055/s-0028-1087806
Keywords
fluorine; nitrogen; asymmetric synthesis; diastereoselectivity; regioselectivity
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Funding
- Ministerio de Educacion y Ciencia of Spain [CTQ2007-61462, CTQ2006-011317]
- Generalitat Valenciana [GR03/193]
- IMPIVA and Industrias Afrasa [IMIDTD/2007/230]
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Fluorinated organic compounds, in particular those containing nitrogen atoms, are popular targets in medicinal chemistry. They are obtained through chemical synthesis, usually by employing small, fluorinated molecules as starting building blocks. This account focuses on the reactivity and synthetic applications of different types of fluorinated building blocks. It summarizes recent methodologies developed in our and other laboratories for the synthesis of a variety of nitrogen-containing organofluorine compounds.
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