4.4 Article

α-Arylation of Cyclic Amines by Aryl Transfer in Lithiated Ureas

Journal

SYNLETT
Volume -, Issue 3, Pages 421-424

Publisher

GEORG THIEME VERLAG KG
DOI: 10.1055/s-0028-1087543

Keywords

arylation; amines; heterocycles; lithiation; ureas

Funding

  1. Deutscher Akademischer Austauschadienst
  2. Leverhulme Trust
  3. EU

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Treatment with base of N'-aryl Urea derivatives of hetero- or carbocyclic amines with benzylic nitrogen atoms promotes rearrangement with transfer of the aryl ring from N to C, giving rise to alpha-arylated products.

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