Journal
SYNLETT
Volume -, Issue 6, Pages 941-944Publisher
GEORG THIEME VERLAG KG
DOI: 10.1055/s-0028-1088215
Keywords
biphenyl; asymmetric synthesis; desymmetrization; enzyme catalysis; hydrolysis
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Funding
- Ministry of Education. Culture. Sports. Science, and Technology, Japan [16073210]
- Global COE program (Tokyo Institute of Technology)
- Grants-in-Aid for Scientific Research [16073210] Funding Source: KAKEN
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Axially chiral, tetra-ortho-substituted biphenyl derivatives were efficiently synthesized through desymmetrization of sigma-symmetric precursors by enzyme-catalyzed hydrolysis. Both of the enantiomers were accessible in highly enantioselective manner and in high yield by suitable choice of enzyme.
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