4.4 Article

Synthesis of isoquinoline-3-carboxylates and benzocyclobutanes via reaction of 2-amidoacrylate esters with arynes

Journal

SYNLETT
Volume -, Issue 8, Pages 1159-1164

Publisher

GEORG THIEME VERLAG KG
DOI: 10.1055/s-2008-1072723

Keywords

arynes; isoquinoline heterocycles; benzocyclobutanes; annulations; 2-amidoacrylate esters

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A mild and general method for the synthesis of a variety of 2-substituted isoquinoline 3-carboxylates and benzocyclobutanes from the reaction of 2-amidoacrylate esters with arynes has been developed.

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