Article
Clinical Neurology
Tommy Kwan Hin Fong, Teris Cheung, Sze Ting Joanna Ngan, Kelvin Tong, Wai Yan Vivian Lui, Wai Chi Chan, Corine Sau Man Wong, Calvin Pak Wing Cheng
Summary: This study aimed to assess the effectiveness and tolerability of transcranial pulse stimulation (TPS) with neuro-navigation in older adults with mild neurocognitive disorder (NCD). The results showed a significant improvement in cognition of elderly with mild NCD after receiving TPS intervention. This study provides valuable information for the long-term effect of TPS in cognition in older adults.
ANNALS OF CLINICAL AND TRANSLATIONAL NEUROLOGY
(2023)
Review
Microbiology
Federico Brandalise, Elisa Roda, Daniela Ratto, Lorenzo Goppa, Maria Letizia Gargano, Fortunato Cirlincione, Erica Cecilia Priori, Maria Teresa Venuti, Emanuela Pastorelli, Elena Savino, Paola Rossi
Summary: An increasing number of studies are investigating the potential of bioactive compounds from medicinal mushrooms, particularly Hericium erinaceus, in treating neurological degenerative diseases. These compounds have shown promising results in recovering or improving various brain conditions, but further clinical trials are needed to confirm their safety and efficacy. This survey summarizes the current knowledge on dietary supplementation of H. erinaceus and its therapeutic potential in clinical settings, highlighting the urgent need for additional clinical trials to explore its neuroprotective applications.
Article
Neurosciences
Xiaohui Chen, Andi Chen, Jianjie Wei, Yongxin Huang, Jianhui Deng, Pinzhong Chen, Yanlin Yan, Mingxue Lin, Lifei Chen, Jiuyun Zhang, Zhibin Huang, Xiaoqian Zeng, Cansheng Gong, Xiaochun Zheng
Summary: The study aimed to investigate whether DEX improves cognitive impairment by promoting hippocampal neurogenesis via the BDNF/TrkB/CREB signaling pathway in neonatal rats with HIBD. The results demonstrated that DEX effectively increased the protein expression of BDNF and the phosphorylation of TrkB and CREB, promoting neurogenesis in the dentate gyrus of the hippocampus in neonatal rats with HIBD. Furthermore, inhibiting the BDNF/TrkB/CREB pathway significantly counteracted the advantageous outcomes of DEX on hippocampal neurogenesis, neuronal survival, and cognitive improvement.
CNS NEUROSCIENCE & THERAPEUTICS
(2023)
Article
Nutrition & Dietetics
Ying Zhang, Qian Zhou, Lu Lu, Yu Su, Wei Shi, Hu Zhang, Ran Liu, Yuepu Pu, Lihong Yin
Summary: It has been reported that disordered Cu metabolism is associated with neurodegenerative diseases. This study investigated the effects of Cu on cognitive functions in mice and the potential mechanisms. The results showed that Cu exacerbates learning and memory impairment, induces neuronal degeneration and oxidative damage, and affects synaptic regulation and the CREB/BDNF pathway.
Article
Biochemistry & Molecular Biology
Alice Bruscolini, Angela Iannitelli, Marco Segatto, Pamela Rosso, Elena Fico, Marzia Buonfiglio, Alessandro Lambiase, Paola Tirassa
Summary: This study investigated the correlation between the expression levels of NGF and BDNF in tears and serum and ophthalmic and psycho-cognitive symptoms in Graves' Orbitopathy (GO) patients. The results showed that NGF and BDNF expression correlated with ophthalmic symptoms, while mature/precursor NGF and BDNF correlated with psycho-cognitive variables. This study is the first to suggest that changes in NGF and BDNF processing in tears and serum may be associated with ocular and cognitive alterations in GO patients.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Medicine, General & Internal
Teodora Yaneva-Sirakova, Latchezar Traykov, Kiril Karamfiloff, Ivo Petrov, Julieta Hristova, Dobrin Vassilev
Summary: Carotid stenting can affect the levels of neurotrophins, which are important for the survival, development, and function of neurons.
ANNALS OF MEDICINE
(2023)
Review
Biochemistry & Molecular Biology
Pietro Cacialli
Summary: This study examines the role of neurotrophins in zebrafish and mammals after TBI, revealing that while the reparative mechanisms in the mammalian brain are limited, adult fish brains have high regenerative properties.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Biochemistry & Molecular Biology
Julia Doroszkiewicz, Jan Mroczko, Piotr Rutkowski, Barbara Mroczko
Summary: Alzheimer's disease is the most common cause of dementia worldwide. The lack of established pathology makes it challenging to find suitable approaches for treatment. In addition to the known hallmarks of the disease, such as amyloid β peptides and hyperphosphorylated tau, inflammation and diet also play important roles. Adhering to a beneficial diet high in neuroprotective foods and BDNF-boosting substances may improve memory, cognition, and biomarkers, and even reduce the risk of developing Alzheimer's disease.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Neurosciences
Maryam Abdollahzadeh, Hamdollah Panahpour, Safa Ghaheri, Hakimeh Saadati
Summary: Chemotherapy with cisplatin can cause cognitive impairment and behavioral deficits, while reducing hippocampal BDNF levels. However, supplementation with calcitriol can alleviate these effects and upregulate BDNF mRNA. Additionally, calcitriol alone can also modulate BDNF levels.
BRAIN RESEARCH BULLETIN
(2022)
Review
Nutrition & Dietetics
Tobias Ziegler, Melina Tsiountsioura, Lisa Meixner-Goetz, Gerhard Cvirn, Manfred Lamprecht
Summary: With the increasing elderly population, neurodegenerative diseases are on the rise, making it important to detect brain aging early and slow down its progression. Neurotrophins such as BDNF and NGF, as well as amyloid-beta and tau proteins, play significant roles in cognitive function and aging. Polyphenols, a class of plant-metabolites, have gained attention for their health benefits and anti-oxidative properties in relation to these biomarkers.
Article
Anesthesiology
Julia Sanchez-Sanchez, Cristina Vicente-Garcia, Daniel Canada-Garcia, Dionisio Martin-Zanca, Juan C. Arevalo
Summary: Pain serves as a protective mechanism against harmful stimuli, and the NGF/TrkA axis plays a crucial role as a pain mediator. However, the clinical approval of NGF antibodies is hindered due to side effects. This study reveals that ARMS/Kidins220, a scaffold protein for Trk receptors, modulates nociception. Reduction of ARMS/Kidins220 in TrkA-expressing cells results in hyperalgesia to certain stimuli, which can be reversed by simultaneous deletion of BDNF. Mechanistically, capsaicin-induced reduction of ARMS/Kidins220 leads to enhanced BDNF secretion. These findings highlight the role of ARMS/Kidins220 in the regulation of pain through the NGF/TrkA axis and BDNF secretion.
Article
Biochemistry & Molecular Biology
Rodrigo R. Nieto, Hernan Silva, Alejandra Armijo, Ruben Nachar, Alfonso Gonzalez, Carmen Paz Castaneda, Cristian Montes, Manuel Kukuljan
Summary: Despite the importance of cognitive symptoms in schizophrenia, not every patient experiences significant cognitive deficits. This study investigated the relationship between brain-derived neurotrophic factor (BDNF) and cognitive functioning in two subgroups of schizophrenic patients. The results showed a significant positive correlation between plasma BDNF levels and cognitive deficits in a subgroup of patients, suggesting a role for BDNF in cognitive functioning in schizophrenics with cognitive deficits, but not in those with normal cognitive status.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Neurosciences
Xiaosu Guo, Ye Tian, Yaping Yang, Shiping Li, Li Guo, Jiong Shi
Summary: The study demonstrates that PACAP regulates synaptic plasticity and exerts an anti-apoptotic role through Sirt3.
MOLECULAR NEUROBIOLOGY
(2021)
Article
Biotechnology & Applied Microbiology
Patrick Devlin, Xueyuan Cao, Ansley Grimes Stanfill
Summary: Genetic variations in the BDNF gene are associated with altered gene expression in key brain regions, potentially contributing to behavioral phenotypes related to compulsive, impulsive, and addictive disorders. These SNPs could be further investigated as therapeutic and diagnostic targets for managing psychiatric disorders.
Editorial Material
Biochemistry & Molecular Biology
Gerhard Gruender, Paul Cumming
Summary: Indirect agonism plays a role in the mechanism of antipsychotic action and in the pharmacological aspect of the serotonin drug pimavanserin. Treatments with pimavanserin and SSRIs have shown potential in reducing A beta deposition in transgenic Alzheimer's disease model mice, but further research is needed to understand the convergence of signaling pathways leading to A beta deposition.
JOURNAL OF NEUROCHEMISTRY
(2021)
Article
Biotechnology & Applied Microbiology
Monique Michels, Emily Corneo, Luana Cucker, Carla Sasso Simon, Gabriel Fernandes Alves de Jesus, Carolina Michels, Kristian Madeira, Ana Paula Voytena, Marina Rossetto, Fernanda Ramlov, Danusa de Castro Damasio, Felipe Dal-Pizzol
Summary: This study evaluated the efficacy of Bifidobacterium lactis CCT 7858 in preventing antibiotic-related diarrhea and improving gastrointestinal symptoms. The results showed that this strain can reduce diarrhea and gastrointestinal symptoms.
PROBIOTICS AND ANTIMICROBIAL PROTEINS
(2023)
News Item
Biochemistry & Molecular Biology
Giselli Scaini, Joao Quevedo
MOLECULAR PSYCHIATRY
(2023)
Letter
Biochemistry & Molecular Biology
Albert J. Fenoy, Joao Quevedo, Jair C. Soares
MOLECULAR PSYCHIATRY
(2023)
Article
Pharmacology & Pharmacy
Roberta Eduarda Grolli, Amanda Gollo Bertollo, Joao Paulo Behenck, Laura de Araujo Borba, Marcos Eduardo Plissari, Silvio Jose Batista Soares, Aline Manica, Larissa da Silva Joaquim, Fabricia Petronilho, Joao Quevedo, Margarete Dulce Bagatini, Gislaine Zilli Reus, Zuleide Maria Ignacio
Summary: This study evaluated the effects of chronic mild stress on depressive-like behaviors, oxidative stress, and inflammation in rats, as well as the possible antidepressant, antioxidant, and anti-inflammatory effects of quetiapine. The results showed that chronic stress increased depressive-like behaviors, while quetiapine significantly reduced these behaviors. Chronic stress also increased MPO activity and IL-6 levels in the serum of rats, which were both significantly reduced by quetiapine.
NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY
(2023)
Article
Microbiology
Monique Michels, Emily Corneo, Luana Bezerra Goncalves Rocha, Rodrigo Dias, Ana Paula Lorenzen Voytena, Marina Rossetto, Fernanda Ramlov, Felipe Dal-Pizzol, Gabriel Fernandes Alves Jesus
Summary: This study aimed to evaluate the potential and specificity of Microbe-Associated Molecular Patterns (MAMPs) in inflammatory and antioxidant response in NIH-3T3 fibroblast cells and wound healing process. The findings showed that MAMPs significantly promoted wound healing and exhibited specific effects in anti-inflammatory and antioxidant activities.
ARCHIVES OF MICROBIOLOGY
(2023)
Article
Neurosciences
Melina More Bertotti, Evandro Tostes Martins, Fernando Zanela Areas, Helena Dresch Vascouto, Norma Beatriz Rangel, Hiago Murilo Melo, Katia Lin, Emil Kupek, Felipe Dal Pizzol, Alexandra J. Golby, Roger Walz
Summary: The accuracy of the GCS-P score as a prognostic index for predicting hospital mortality in patients with severe traumatic brain injury was evaluated and compared with a model combining GCS, pupil response, and other prognostic factors. The results show that the GCS-P score can accurately predict the mortality of patients with severe traumatic brain injury.
ARQUIVOS DE NEURO-PSIQUIATRIA
(2023)
Review
Medicine, Research & Experimental
Tatiana Barichello, Vijayasree V. Giridharan, Carlos Henrique R. Catalao, Cristiane Ritter, Felipe Dal-Pizzol
Summary: Sepsis is a life-threatening disorder caused by an unregulated immune response to infection. This response triggers a complex process that promotes the production of inflammatory mediators, resulting in the disruption of blood-brain barrier function and the activation of glial cells. These changes lead to sepsis-associated encephalopathy, which can contribute to cognitive deterioration and increased susceptibility to cognitive decline later in life.
Article
Neurosciences
Samira S. Valvassori, Taise Possamai-Della, Jorge M. Aguiar-Geraldo, Romulo Goronci Sant'Ana, Gustavo C. Dal-Pont, Bruna Pescador, Alexandra I. Zugno, Joao Quevedo, Felipe Dal-Pizzol
Summary: The study aimed to investigate the effects of sepsis on behavioural and biochemical responses induced by m-amphetamine. Rats underwent cecal ligation and puncture surgery and were then injected with saline or m-amphetamine. The results showed that sepsis enhanced the behavioural responses to m-amphetamine, induced inflammatory response, and altered neurotrophic factors in the brain.
EUROPEAN JOURNAL OF NEUROSCIENCE
(2023)
Article
Endocrinology & Metabolism
Franciele Rabelo, Isabela da S. Lemos, Camila P. Dal Toe, Debora D. Casagrande, Maria Luisa S. Freitas, Micaela R. Quadra, Igor R. Lima, Jaqueline S. Generoso, Monique Michels, Paulo C. L. Silveira, Felipe Dal Pizzol, Emilio Luiz Streck
Summary: Maple Syrup Urine Disease (MSUD) is a genetic disorder that causes the accumulation of certain amino acids in the body. This can lead to oxidative stress and inflammation, which play a role in the disease's progression. In this study, the researchers investigated the acute effects of a specific amino acid on inflammatory markers in rats.
METABOLIC BRAIN DISEASE
(2023)
Article
Neurosciences
Taise Possamai-Della, Jose Henrique Cararo, Jorge M. Aguiar-Geraldo, Jefte Peper-Nascimento, Alexandra I. Zugno, Gabriel R. Fries, Joao Quevedo, Samira S. Valvassori
Summary: This study evaluated the effects of prenatal stress on behavior, HPA-axis, and epigenetic parameters in stressed dams and their offspring. It found that prenatal stress led to abnormal emotional behavior in female offspring, accompanied by hyperactivity of the HPA-axis and epigenetic adaptations in the activity of HDAC and DNMT, as well as acetylation in H3K9 and H3K14. In addition, prenatal stressed female offspring showed increased levels of ACTH compared to their male counterpart.
MOLECULAR NEUROBIOLOGY
(2023)
Article
Neurosciences
Camila N. C. Lima, Emese H. C. Kovacs, Salahudeen Mirza, Alexandra Del Favero-Campbell, Alexandre Paim Diaz, Joao Quevedo, Benney M. R. Argue, Jenny Gringer Richards, Aislinn Williams, John A. Wemmie, Vincent A. Magnotta, Jess G. Fiedorowicz, Jair C. Soares, Marie E. Gaine, Gabriel R. Fries
Summary: Bipolar disorder (BD) is associated with premature mortality and aging, including accelerated epigenetic aging. Suicide attempts (SA) are significantly higher in BD and are linked to decreased lifespan, biological aging, and poorer clinical outcomes. This study investigated the relationship between GrimAge, an epigenetic clock, and SA in BD individuals.
NEUROPSYCHOPHARMACOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Rafaela C. Cordeiro, Camila N. C. Lima, Gabriel R. Fries, Giovana Zunta-Soares, Jair C. Soares, Joao Quevedo, Giselli Scaini
Summary: This study investigates the impact of mitochondrial dysfunction on bipolar disorder (BD). The study finds that BD patients have a lower mitochondrial health index (MHI) compared to non-psychiatry controls, with a negative correlation between MHI and cell-free mtDNA levels. The study further reveals that MHI is related to the expression of mitochondria quality control (MQC) proteins, and a longer illness duration, worse functional status, and higher depressive symptoms are associated with lower MHI and higher cell-free mtDNA levels.
MOLECULAR PSYCHIATRY
(2023)
News Item
Biochemistry & Molecular Biology
Samira S. Valvassori, Joao Quevedo, Giselli Scaini
MOLECULAR PSYCHIATRY
(2023)
Article
Biotechnology & Applied Microbiology
Ana Paula Pesarico, Gabriel Fernandes Alves Jesus, Emily Corneo, Heloisa de Medeiros Borges, Karen de Vasconcelos Calixto, Michelle Lima Garcez, Tatiani Bellettini-Santos, Ana Paula Lorenzen Voytena, Marina Rossetto, Fernanda Ramlov, Felipe Dal-Pizzol, Monique Michels
Summary: This study investigates the protective effects of several Bacillus strains against LPS-induced intestinal inflammation. The results show that B. coagulans and B. amyloliquefaciens have significant protective effects against pathological changes and increased inflammatory cytokines.
JOURNAL OF APPLIED MICROBIOLOGY
(2023)
Article
Neurosciences
E. A. Kelly, T. M. Love, J. L. Fudge
Summary: Dopamine is involved in stress-related illnesses, and corticotropin-releasing factor plays a role in stress responses. This study examined the synaptic terminals between dopamine and non-dopamine cells and found that dopamine regulation may occur indirectly through contacts with non-dopamine neurons.