Article
Otorhinolaryngology
Diogo Raposo, Joao Orfao, Marco Menezes, Mafalda Trindade-Soares, Ana Guimaraes, Filipe Freire
Summary: This study analyzed the ABR findings of preterm and term infants in the NICU with perinatal problems. The results suggest that perinatal problems significantly impair the ABR threshold and the auditory pathway maturational process in preterm infants, but not in term infants.
OTOLARYNGOLOGY-HEAD AND NECK SURGERY
(2021)
Article
Medicine, General & Internal
Yun Cao, Siyuan Jiang, Jianhua Sun, Mingyan Hei, Laishuan Wang, Huayan Zhang, Xiaolu Ma, Hui Wu, Xiaoying Li, Huiqing Sun, Wei Zhou, Yuan Shi, Yanchen Wang, Xinyue Gu, Tongling Yang, Yulan Lu, Lizhong Du, Chao Chen, Shoo K. Lee, Wenhao Zhou
Summary: This cohort study evaluated care practices and outcomes for very preterm infants in Chinese neonatal intensive care units. The findings suggest that survival rates and survival without major morbidity for these infants in China are lower compared to high-income countries, highlighting the need for clinical quality improvement and health services reorganization to enhance outcomes.
Article
Multidisciplinary Sciences
Gabriel Beltrao, Regine Stutz, Franziska Hornberger, Wallace A. Martins, Dimitri Tatarinov, Mohammad Alaee-Kerahroodi, Ulrike Lindner, Lilly Stock, Elisabeth Kaiser, Sybelle Goedicke-Fritz, Udo Schroeder, Bhavani M. R. Shankar, Michael Zemlin
Summary: This study investigates the feasibility of using a contactless radar-based approach for breathing monitoring in the Neonatal intensive care unit (NICU). The authors address the challenges of monitoring in a real clinical setup and propose a novel random body movement mitigation technique and an accurate frequency estimator. The radar-based solution provides reliable breathing frequency estimation, laying the foundation for future studies on completely contactless vital signs monitoring.
SCIENTIFIC REPORTS
(2022)
Article
Neurosciences
Linlin Liu, Yi Hu, Yumei Lu, Liping Hu, Changqing Gao, Shengjie Nie
Summary: Epigenetic alterations of the SLC6A4 gene are related to the pathophysiology of schizophrenia, with higher methylation levels observed especially in male patients.
NEUROSCIENCE LETTERS
(2022)
Article
Immunology
Sarah A. Coggins, Erika M. Edwards, Dustin D. Flannery, Jeffrey S. Gerber, Jeffrey D. Horbar, Karen M. Puopolo
Summary: This study describes late-onset Serratia infection in very preterm infants. Serratia infection is associated with lower survival rate and significant morbidity, highlighting the need for recognition and targeted prevention strategies for this opportunistic nosocomial infection.
PEDIATRIC INFECTIOUS DISEASE JOURNAL
(2023)
Article
Pediatrics
Christine Manich Bech Baggesgaard, Anja Poulsen, Kia Hee Schultz Dungu, Lotte Jensen, Hanna Rahimi, Lise Aunsholt, Stine Lund
Summary: This study investigated the timeliness of childhood vaccinations in preterm infants in Denmark and identified factors influencing delayed vaccination. The results showed that most preterm infants received the first vaccination on time, but the timeliness decreased with subsequent vaccinations. Therefore, efforts should be made to educate healthcare personnel and parents to ensure timely vaccination.
Article
Obstetrics & Gynecology
Leslie M. Harris, Veronika Shabanova, Josefa L. Martinez-Brockman, Desiree Leverette, Brittney Dioneda, Margaret G. Parker, Sarah N. Taylor
Summary: This retrospective cohort study found that social disadvantage was associated with lower family visitation rates, which in turn affected infant feeding and follow-up.
JOURNAL OF PERINATOLOGY
(2023)
Article
Multidisciplinary Sciences
Alice Hoffsten, Laszlo Markasz, Katharina Ericson, Leif D. Nelin, Richard Sindelar
Summary: Autopsy determined the final cause of death in one-third of cases, and necrotizing enterocolitis as a cause of death increased significantly during the study period. The autopsy rate did not change significantly between the two study periods.
SCIENTIFIC REPORTS
(2021)
Article
Pediatrics
Anisha Singh, Howard W. Francis, P. Brian Smith, Reese H. Clark, Rachel G. Greenberg
Summary: In infants born at 22-32 weeks of gestation, there is an association between hyperbilirubinemia and a failed newborn hearing screen. Each 1 mg/dL increase in maximum total bilirubin is slightly associated with an increased odds of a failed hearing screen. Further prospective studies are needed to determine if this increased risk translates to hearing loss.
JOURNAL OF PEDIATRICS
(2021)
Article
Nutrition & Dietetics
Ching-Min Chang, Ming-Horng Tsai, Wei-Chao Liao, Peng-Hong Yang, Shiao-Wen Li, Shih-Ming Chu, Hsuan-Rong Huang, Ming-Chou Chiang, Jen-Fu Hsu
Summary: This study aimed to investigate the effects of probiotics on the gut microbiota of extremely preterm infants. The results showed that probiotics increased the abundance of Lactobacillus and reduced the duration of total parenteral nutrition. The probiotic group also had a lower rate of late-onset sepsis.
Article
Obstetrics & Gynecology
Chelsea Lockyear, Kristi Coe, Rachel G. Greenberg, Reese H. Clark, Samia Aleem
Summary: A cohort study showed that there was no significant improvement in the length of stay (LOS) of late preterm infants over a 20-year period, despite various practice changes. The study also found an increasing postmenstrual age (PMA) at discharge for all gestational ages, and a decrease in invasive ventilation, receipt of phototherapy, and reflux medications.
JOURNAL OF PERINATOLOGY
(2023)
Article
Pediatrics
Juan D. Rios, Prakesh S. Shah, Marc Beltempo, Deepak Louis, Amit Mukerji, Shahirose Premji, Vibhuti Shah, Shoo K. Lee, Petros Pechlivanoglou
Summary: The study developed and validated an itemized costing algorithm for in-patient neonatal intensive care unit (NICU) costs for prematurely born infants. Results showed that NICU costs for preterm infants increase as gestational age decreases and length of stay increases. The cost estimates provided are easily accessible, transparent, and consistent with previous estimates.
JOURNAL OF PEDIATRICS
(2021)
Article
Pediatrics
Nick Fulkoski, Zsuzsoka Kecskes, Tejasvi Chaudhari
Summary: This study aimed to characterize pain management practices in extremely preterm infants admitted to the neonatal intensive care unit (NICU). The study found that extremely preterm infants underwent an average of 11.24 minor painful procedures (MPP) per day during the first 14 days of NICU admission, with missed opportunities to bundle MPP occurring 75.98% of the time. The study also found that infants experiencing a higher number of MPP had lower motor composite scores. Therefore, there is a need for quality improvement initiatives in pain management for extremely preterm infants in the NICU.
JOURNAL OF PAEDIATRICS AND CHILD HEALTH
(2023)
Article
Pediatrics
Nienke H. van Dokkum, Marlou L. A. de Kroon, Peter H. Dijk, Karianne E. Kraft, Sijmen A. Reijneveld, Arend F. Bos
Summary: Studying the stress response in premature infants during the first 28 days after birth revealed significant variations within infants and over time, with the highest scores occurring in the first 7 days. Factors such as low Apgar scores, sepsis, intraventricular hemorrhages, and mechanical ventilation were significantly associated with higher cumulative stress scores.
Article
Oncology
Marie Camerota, Stefan Graw, Todd M. Everson, Elisabeth C. McGowan, Julie A. Hofheimer, T. Michael O'Shea, Brian S. Carter, Jennifer B. Helderman, Jennifer Check, Charles R. Neal, Steven L. Pastyrnak, Lynne M. Smith, Lynne M. Dansereau, Sheri A. DellaGrotta, Carmen J. Marsit, Barry M. Lester
Summary: The study found that mothers of premature infants can be divided into groups with few risk factors, elevated physical risk factors, and elevated psychological risk factors, with differential DNA methylation at 2 CpG sites in newborns from higher risk subgroups. Higher cumulative prenatal risk was associated with methylation at 15 CpG sites, 12 of which were located in genes previously linked to physical and mental health and neurodevelopment.
CLINICAL EPIGENETICS
(2021)
Article
Nursing
Domenica Mallardi, Pasqua Piemontese, Nadia Liotto, Rosaria M. Colombo, Antonella Dodaro, Antonella Schiavello, Chiara Tabasso, Laura Plevani, Elena Bezze, Camilla Menis, Paola Roggero, Fabio Mosca
JOURNAL OF HUMAN LACTATION
(2022)
Article
Family Studies
Martina Maria Mensi, Michela Criscuolo, Eleonora Vai, Chiara Rogantini, Marika Orlandi, Elena Ballante, Valeria Zanna, Silvia Mazzoni, Umberto Balottin, Renato Borgatti
Summary: This study used the FACES-IV questionnaire to identify typical family functioning in families with a daughter affected by restrictive eating disorders. While parents showed balanced functioning and good agreement on the questionnaire, results from the LTPc observation indicated differences in parents' perceptions compared to standardized evaluation.
Article
Psychiatry
Sarah Nazzari, Serena Grumi, Fabiana Mambretti, Marco Villa, Roberto Giorda, Livio Provenzi
Summary: This study observed the methylation status of NR3C1 and SLC6A4 genes in Italian mothers and infants exposed to COVID-19 lockdown during different stages of pregnancy. The findings revealed lower methylation of NR3C1 and SLC6A4 in mothers and infants exposed during the first trimester, which remained significant after controlling for confounders. Therefore, women and infants should be adequately monitored for psychological health during and after the pandemic.
TRANSLATIONAL PSYCHIATRY
(2022)
Article
Neurosciences
Livio Provenzi, Elisa Roberti, Elena Capelli
Summary: From the very beginning of their life, human beings are immersed in a social and interactive environment that shapes their social and cognitive development. To understand this bidirectional relationship with the social environment, a complexity-sensitive approach is needed in neuroscience. Recent advances in hyperscanning techniques have highlighted similar patterns of brain activity in adult-child dyads, providing valuable insights for developmental research. The application of hyperscanning to atypical and clinical populations can inform family-centered care for children and their parents.
SOCIAL COGNITIVE AND AFFECTIVE NEUROSCIENCE
(2023)
Article
Pediatrics
Giorgia Baradel, Livio Provenzi, Matteo Chiappedi, Marika Orlandi, Arianna Vecchio, Renato Borgatti, Martina Maria Mensi
Summary: The quality of family interactions is found to be a crucial factor in restrictive eating disorders. This study explores the association between adolescent patients' interactive behaviors observed in the family and the severity of their eating disorders and interpersonal problems. It suggests that better organization and affective contact during family interactions are correlated with lower severity of restrictive eating disorders and fewer interpersonal problems.
Article
Multidisciplinary Sciences
Sarah Nazzari, Serena Grumi, Giacomo Biasucci, Lidia Decembrino, Elisa Fazzi, Roberta Giacchero, Maria Luisa Magnani, Renata Nacinovich, Barbara Scelsa, Arsenio Spinillo, Elena Capelli, Elisa Roberti, Livio Provenzi, MOM-COPE Study Grp
Summary: This study suggests that prenatal maternal stress during the COVID-19 pandemic might have increased the risk of an altered socio-cognitive development in infants as assessed through an observational paradigm at 12 months. Special preventive attention should be devoted to infants born during the pandemic.
Article
Multidisciplinary Sciences
Greta Castellini, Marta Acampora, Livio Provenzi, Lucia Cagliero, Luigi Lucini, Serena Barello
Summary: Individual health-related behavior is a significant factor affecting both climate change and chronic disease and understanding the underlying factors of behavior change is important to promote sustainable and healthy lifestyles. This study examines the relationship between health consciousness and pro-environmental behavior. The results show that individuals with higher health consciousness are more likely to engage in pro-environmental behaviors.
SCIENTIFIC REPORTS
(2023)
Editorial Material
Psychology, Multidisciplinary
Livio Provenzi, Giorgia Bussu, Valentina Riva
FRONTIERS IN PSYCHOLOGY
(2023)
Article
Psychology, Developmental
Sarah Nazzari, Serena Grumi, Fabiana Mambretti, Marco Villa, Roberto Giorda, Matteo Bordoni, Orietta Pansarasa, Renato Borgatti, Livio Provenzi
Summary: Maternal antenatal anxiety is a risk factor for child emotional development, and both sex and DNA methylation may contribute to this association. This study found that higher maternal antenatal anxiety was associated with greater negative emotionality in 6-month-old infants. Additionally, the methylation of the BDNF gene was found to mediate this effect in males but not in females. These findings have implications for promoting emotional well-being in mothers and infants.
DEVELOPMENT AND PSYCHOPATHOLOGY
(2023)
Article
Psychology, Developmental
Elena Capelli, Giorgia Anceresi, Serena Grumi, Livio Provenzi
Summary: Maternal bonding is crucial for infant development and well-being. This study examines the impact of maternal mental health and infant temperament on postnatal bonding, as well as the stability and factors influencing changes in bonding from 3 to 6 months of age. The findings highlight the importance of both maternal mental health and infant temperament in maternal postnatal bonding and provide valuable information for early childhood prevention and care.
INFANT BEHAVIOR & DEVELOPMENT
(2023)
Article
Biochemistry & Molecular Biology
Sarah Nazzari, Lucia Cagliero, Serena Grumi, Enrico Pisoni, Giulia Mallucci, Roberto Bergamaschi, Julia Maccarini, Roberto Giorda, Livio Provenzi
Summary: Antenatal exposures to maternal stress and PM2.5 can affect the developmental outcomes of infants. This study investigated the independent and interactive influence of maternal stress and PM2.5 on DNA methylation levels in the SLC6A4 gene in newborns. Higher levels of SLC6A4 DNAm were found in newborns born to mothers with higher levels of PRS and greater PM2.5 exposure, especially during the second trimester of pregnancy.
MOLECULAR PSYCHIATRY
(2023)
Review
Behavioral Sciences
Arianna Vecchio, Elisa Roberti, Sayreth Giovannetti Pulido, Marika Orlandi, Livio Provenzi, Martina Mensi
Summary: The Rorschach inkblot test is widely used in clinical psychology and psychiatry to access psychological processes that are not easily captured by self-report measures. Research on the neural correlates of the test using fMRI, EEG, and fNIRS has provided valuable insights into the underlying perceptual-cognitive processes and potential neuroimaging markers of psychopathology risk. This paper systematizes the available literature on the topic and summarizes the findings on the visual, social, and emotional processes related to the Rorschach inkblot test.
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
(2023)
Article
Microbiology
Diego Forni, Uberto Pozzoli, Rachele Cagliani, Mario Clerici, Manuela Sironi
Summary: CpG and UpA dinucleotides are under-represented in vertebrate genomes compared to invertebrate genomes. Vertebrate-infecting viruses tend to have a stronger bias against CpG, especially single-stranded (ss) RNA(+) viruses, while ssRNA(-) viruses show no specific bias related to the host clade. CpG depletion is not likely driven by the zinc-finger antiviral protein (ZAP) and CpG dinucleotides tend to be preferentially depleted in A/U-rich contexts in both vertebrate- and invertebrate-infecting viruses. Analysis of SARS-CoV-2 reveals a depletion of CpG dinucleotides in specific viral open reading frames (ORFs). The study provides insights into viral evolution and the modulation of CpG for generating attenuated viruses.
MICROBIOLOGY SPECTRUM
(2023)
Correction
Neurosciences
Elisa Roberti, Elena Capelli, Livio Provenzi
SOCIAL COGNITIVE AND AFFECTIVE NEUROSCIENCE
(2023)
Article
Pediatrics
Giulia Cossu, Arianna Vecchio, Marika Orlandi, Erica Casini, Renato Borgatti, Martina Maria Mensi
Summary: Suicide is an important public health issue. A study found that adolescents with a history of suicidal attempts faced greater difficulties in social relations, risky behaviors, and had more intense suicidal ideation compared to those with suicidal ideation only. The use of MMPI-A to assess certain features may help identify young people at high risk of suicide.