Journal
SWISS MEDICAL WEEKLY
Volume 141, Issue -, Pages -Publisher
E M H SWISS MEDICAL PUBLISHERS LTD
DOI: 10.4414/smw.2011.13202
Keywords
high-sensitive cardiac troponin; diagnosis; acute myocardial infarction: sensitivity; specificity
Categories
Funding
- Swiss Heart Foundation
- Professor Max Cloetta Foundation
- University of Basel and the Department of Internal Medicine
- Swiss National Science Foundation [PP00B-102853]
- Abbott
- Biosite
- Brahms
- Nanosphere
- Roche
- Siemens
- Department of Internal Medicine
- University Hospital Basel
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Cardiac troponin I and T (cTn) are structural proteins unique to the heart. Detection of cTn in peripheral blood indicates cardiomyocyte necrosis. As acute myocardial infarction (AMI) is the most important cause of cardiomyocyte necrosis, cTns have become an integral part in the diagnosis of AMI. In this indication, cTns are superior to all other biomarkers indiacting cardiomyocyte necrosis such as CK-MB and myoglobin, and are therefore considered the preferred marker in the diagnosis of AMI. It is important to highlight that cTn indicates and quantifies cardiomyocyte necrossi irrespective of its cause? The major limitation of contemporary cTn assays is a sensitivity deficit in the first few hours of AMI due to a delayed increase of circulating levels. Recent advances in assay technology have lead to a refinement in cardiac troponin (cTn) assays that have had a profound impact on clinicalpractice. High-sensitive cTn assays have two differentiatin features from contemporary cTn assays: 1) detection of cTn in healthy person and 2) a precise definition of what is normal (=the 99th percentile). Recent multicentre studies have shown that high-sensitive cTn assays improve the early diagnosis of AMI. To achieve the best clinical use, cTn has to be interpreted as a quantiative variable. Rising and/or falling levels differentiate acute from chronic cardiomyocyte necrosis. The term troponin-positive should therefore be avoided. Detectable levels will become the norm and have to be clearly differentiated from elevated levels. The differential diagnosis of a small amount of cardiomyocyte necrosis and therefore mild elevation of cTn is broad and includes acute and chronic cardiac disorders. The differential diagnosis of a large amount of cardiomyocyte necrosis and therefore substantial elevation of cTn is much smaller and largely restricted to AMI, myocarditis and tako-tsubo cardiomyopathy.
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