Article
Neurosciences
Natalia Merkulyeva, Aleksandr Mikhalkin
Summary: The study revealed the presence of neurons similar to Cajal-Retzius cells in the primary visual cortex of cats, suggesting a potential shared developmental mechanism of corticogenesis between carnivores and primates.
NEUROSCIENCE LETTERS
(2021)
Article
Multidisciplinary Sciences
Ekin Bolukbasi, Nathaniel S. Woodling, Dobril K. Ivanov, Jennifer Adcott, Andrea Foley, Arjunan Rajasingam, Lauren M. Gittings, Benjamin Aleyakpo, Teresa Niccoli, Janet M. Thornton, Linda Partridge
Summary: Reduced activity of the insulin/insulin-like growth factor signaling pathway has been shown to increase healthy lifespan in various animal species. In the adult nervous system of Drosophila, specific transcription factors like neuronal FKH and glial FOXO play independent roles in extending healthy lifespan. The importance of cell type-specific mapping of transcription factor activity for preserving healthy function with age is highlighted in this study.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Neurosciences
Alvaro Duque, Alexander Joseph McDonald
Summary: This study investigates the susceptibility of pyramidal neurons expressing NPNF in the neocortex to degeneration in Alzheimer's disease. Analysis of NPNF expression patterns in different nuclei of the primate amygdala revealed the presence of NPNF+ NPNs in the BNC and CNC, with distinct staining patterns observed in different nuclei.
Review
Biochemistry & Molecular Biology
Karen L. Elliott, Gabriela Pavlinkova, Victor V. Chizhikov, Ebenezer N. Yamoah, Bernd Fritzsch
Summary: The article presents a molecular review of transcription factors involved in the development of spiral ganglia, cochlear nuclei, and cochlear hair cells, emphasizing the interactions between Neurog1, Neurod1, and Atoh1. It highlights the significant interplay between bHLH genes and their potential to partially replace one another. Additionally, other genes such as Eya1/Six1, Sox2, Pax2, Gata3, Fgfr2b, Foxg1, and Lmx1a/b play vital roles in the auditory system.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Neurosciences
Emily Castro-Fonseca, Viviane Morais, Camila G. da Silva, Juliana Wollner, Jaqueline Freitas, Arthur F. Mello-Neto, Luiz E. Oliveira, Vilson C. de Oliveira, Renata E. P. Leite, Ana T. Alho, Roberta D. Rodriguez, Renata E. L. Ferretti-Rebustini, Claudia K. Suemoto, Wilson Jacob-Filho, Ricardo Nitrini, Carlos A. Pasqualucci, Lea T. Grinberg, Fernanda Tovar-Moll, Roberto Lent
Summary: The human cerebral cortex is responsible for higher-order neural functions and has different cellular composition based on sex and age. Men have more neurons in the occipital lobe, while women have higher neuronal density in the frontal lobe. There are no sex differences in the number and density of cells in the other lobes and the whole neocortex. On average, the neocortex has approximately 10.2 billion neurons, with 34% in the frontal lobe and the remaining 66% evenly distributed among the other lobes. Aging affects the non-neuronal cell population in the frontal lobe but does not affect the number of neurons in the cortex. Our study provides insights into the modulation of cortical cellularity by sex and age.
Article
Optics
Xindong Song, Yueqi Guo, Chenggang Chen, Xiaoqin Wang
Summary: This study reports the development of a silent two-photon imaging system for imaging auditory neuronal functions in common marmosets. Full-frame raster scanning was achieved using acoustooptical deflectors, eliminating mechanical vibrations and acoustic artifacts.
LIGHT-SCIENCE & APPLICATIONS
(2022)
Article
Neurosciences
Huiying Tan, Xiaotao Li, Kang Huang, Moxuan Luo, Liping Wang
Summary: This study investigated the morphological and distributional properties of the entire population of SMI-32(+) RGCs in the rat retina using intracellular neurobiotin injections combined with SMI-32 antibody staining. The findings showed that SMI-32(+) RGCs are evenly distributed throughout the rat retina, with distinct characteristics in different regions, and the cells were classified into five clusters based on morphological features. The research provides a comprehensive description of the morphology and distribution of SMI-32 immunoreactive RGCs in the rat retina.
JOURNAL OF COMPARATIVE NEUROLOGY
(2022)
Review
Multidisciplinary Sciences
Benjamin Rich Zendel
Summary: Hearing abilities decline with age, and one of the most commonly reported hearing issues in older adults is difficulty understanding speech in noisy environments. Interestingly, individuals who receive music training, even for a short period of time, show improved speech understanding in noisy environments. These improvements are associated with enhanced working memory abilities and increased activity in motor and premotor cortical regions.
ANNALS OF THE NEW YORK ACADEMY OF SCIENCES
(2022)
Article
Biology
Liping Yu, Jiawei Hu, Chenlin Shi, Li Zhou, Maozhi Tian, Jiping Zhang, Jinghong Xu
Summary: The study demonstrates the essential role of auditory cortex in information encoding and maintenance during an auditory working memory task, particularly in the early delay period.
Review
Cell Biology
Julia Elmers, Lorenza S. Colzato, Katja Akguen, Tjalf Ziemssen, Christian Beste
Summary: This article proposes an interdisciplinary approach that neurofilaments (NFs) may serve as a mechanical hinge connecting inflammation, neurodegeneration, and cognitive functions. The authors suggest that NFs could not only be used as biomarkers for these processes but also have predictive power for future cognitive decline. They advocate for the use of NFs and MRI parameters to provide a comprehensive view of disease activity in neurological diseases and emphasize the potential of NFs as an early warning system for cognitive decline.
AGEING RESEARCH REVIEWS
(2023)
Article
Biochemistry & Molecular Biology
Rebecca E. Poulsen, Leandro A. Scholz, Lena Constantin, Itia Favre-Bulle, Gilles C. Vanwalleghem, Ethan K. Scott
Summary: Most animals have complex auditory systems to identify salient features of the acoustic landscape and respond appropriately. Despite having simpler brains, larval fish rely heavily on sophisticated sensory processing for survival.
Article
Biochemical Research Methods
Lan Tian, Ming Zeng, Geng Tian, Jingjing Xu
Summary: This paper proposes a universal and operable system and corresponding method to quantitatively measure and analyze photosensitivity of cells in vitro to weak pulse laser, which is of great significance for lights' medical applications.
BIOMEDICAL OPTICS EXPRESS
(2023)
Article
Neurosciences
Alexander Joseph McDonald, Franco Mascagni
Summary: The study found that neurons in the basolateral nucleus of the amygdala containing SMI-32+ NNFs are primarily nonpyramidal neurons, suggesting that the neuronal subpopulations in the BNC that degenerate in Alzheimer's disease may be parvalbumin-positive and mediodorsal nucleus-projecting nonpyramidal neurons.
JOURNAL OF COMPARATIVE NEUROLOGY
(2021)
Article
Geriatrics & Gerontology
C. Zhao, Z. Chen, W. Liang, Z. Yang, Z. Du, S. Gong
Summary: The study established a new model for accelerated aging of ACNs by treating them with D-gal in vitro, which resulted in senescence characteristics such as inhibited cell proliferation, increased oxidative stress, decreased mitochondrial function, and elevated neuronal apoptosis. This model provides a promising approach for exploring the underlying mechanisms of ARHL.
JOURNAL OF NUTRITION HEALTH & AGING
(2022)
Article
Neurosciences
Kelson Shilling-Scrivo, Jonah Mittelstadt, Patrick O. Kanold
Summary: Age-related hearing loss, or presbycusis, is a common condition affecting one-third of the global population. This study investigates the role of the aging brain in presbycusis and demonstrates that old animals with preserved peripheral hearing exhibit increased prestimulus activity, reduced attentional gain, and increased noise correlations in the primary auditory cortex. These changes contribute to a decrease in the representation of target sounds among distracting stimuli.
JOURNAL OF NEUROSCIENCE
(2022)
Review
Cell Biology
Ladislav Ouda, Oliver Profant, Josef Syka
CELL AND TISSUE RESEARCH
(2015)
Article
Behavioral Sciences
Ladislav Ouda, Milan Jilek, Josef Syka
BEHAVIOURAL BRAIN RESEARCH
(2016)
Article
Geriatrics & Gerontology
Zuzana Balogova, Jiri Popelar, Francesca Chiumenti, Tetyana Chumak, Jana Svobodova Burianova, Natalia Rybalko, Josef Syka
FRONTIERS IN AGING NEUROSCIENCE
(2018)
Article
Anatomy & Morphology
Ladislav Ouda, Jana Burianova, Zuzana Balogova, Hui Pin Lu, Josef Syka
BRAIN STRUCTURE & FUNCTION
(2016)
Article
Audiology & Speech-Language Pathology
Oliver Profant, Jana Burianova, Josef Syka
Article
Neurosciences
Jiri Popelar, Natalia Rybalko, Jana Burianova, Beat Schwaller, Josef Syka
NEUROSCIENCE LETTERS
(2013)
Article
Neurosciences
Bohdana Hruskova, Johana Trojanova, Michaela Kralikova, Adolf Melichar, Stepanka Suchankova, Jolana Bartosova, Jana Svobodova Burianova, Jiri Popelar, Josef Syka, Rostislav Turecek
NEUROSCIENCE LETTERS
(2019)
Article
Anatomy & Morphology
Jana Svobodova Burianova, Josef Syka
BRAIN STRUCTURE & FUNCTION
(2020)
Article
Geriatrics & Gerontology
Oliver Profant, Antonin Skoch, Jaroslav Tintera, Veronika Svobodova, Diana Kucharova, Jana Svobodova Burianova, Josef Syka
FRONTIERS IN AGING NEUROSCIENCE
(2020)
Article
Audiology & Speech-Language Pathology
Natalia Rybalko, Jiri Popelar, Daniel Suta, Jana Svobodova Burianova, Giuseppe S. Alvaro, Charles H. Large, Josef Syka
Summary: The novel pharmaceuticals AUT0 0 063 and AUT00202 may influence the intrinsic firing properties of neurons in the central auditory system of aged animals and have potential to treat age-related hearing disorders.
Article
Neurosciences
Jana Dubisova, Jana Svobodova Burianova, Lucie Svobodova, Pavol Makovicky, Noelia Martinez-Varea, Anda Cimpean, James W. Fawcett, Jessica C. F. Kwok, Sarka Kubinova
Summary: Memory retention was enhanced by attenuating perineuronal net formation using 4-MU treatment in mice, but the effect was not sustained.
BRAIN RESEARCH BULLETIN
(2022)
Article
Physiology
J. Popelar, M. Diaz Gomez, J. Lindovsky, N. Rybalko, J. Burianova, T. Oohashi, J. Syka
PHYSIOLOGICAL RESEARCH
(2017)