Article
Surgery
Karim Boudjema, Clara Locher, Charles Sabbagh, Pablo Ortega-Deballon, Bruno Heyd, Philippe Bachellier, Sylvie Metairie, Francois Paye, Pascal Bourlier, Rene Adam, Aude Merdrignac, Christelle Tual, Estelle Le Pabic, Laurent Sulpice, Bernard Meunier, Jean-Marc Regimbeau, Eric Bellissant
Summary: This study compared simultaneous resection and delayed resection of synchronous colorectal cancer liver metastases, finding no significant difference in the rate of major complications between the two groups. However, delayed resection tended to impair overall survival.
Article
Oncology
C. D. Griffiths, P. Karanicolas, S. Gallinger, A. D. Wei, V. Francescutti, P. E. Serrano
Summary: A feasibility trial was conducted to evaluate the health-related quality-of-life in patients undergoing simultaneous resection of synchronous colorectal liver metastases. The study found that fatigue and role functioning significantly worsened following the surgery, and this deterioration persisted at the 12-week follow-up.
ANNALS OF SURGICAL ONCOLOGY
(2023)
Article
Oncology
C. D. Griffiths, P. Karanicolas, S. Gallinger, A. D. Wei, V. Francescutti, P. E. Serrano
Summary: Simultaneous resection of colorectal liver metastases may lead to significant worsening fatigue and role functioning, which persist at 12 weeks post-surgery.
ANNALS OF SURGICAL ONCOLOGY
(2023)
Article
Surgery
Diamantis I. Tsilimigras, Kota Sahara, J. Madison Hyer, Adrian Diaz, Dimitrios Moris, Fabio Bagante, Alfredo Guglielmi, Andrea Ruzzenente, Sorin Alexandrescu, George Poultsides, Kazunari Sasaki, Federico Aucejo, Aslam Ejaz, Jordan M. Cloyd, Timothy M. Pawlik
Summary: The study found that the proportion of patients undergoing simultaneous resection for synchronous colorectal liver metastases increased over time, while the incidence of severe complications decreased over time. Survival rates were comparable between simultaneous and staged resection in the long term.
Article
Oncology
Pablo E. Serrano, Sameer Parpia, Paul Karanicolas, Steven Gallinger, Alice C. Wei, Marko Simunovic, Mohit Bhandari, Mark Levine
Summary: The study tested the feasibility of a simultaneous resection clinical trial in patients with synchronous colorectal cancer liver metastases, showing a high feasibility but higher than anticipated postoperative complication rate.
JOURNAL OF SURGICAL ONCOLOGY
(2022)
Article
Integrative & Complementary Medicine
Lijun Huang, Xiao Tang, Jiafeng Fang, Zongheng Zheng, Hongbo Wei
Summary: This study compared the differences between simultaneous and delayed surgery for synchronous colorectal liver metastases, and found that although there was no difference in survival rate, delayed surgery had fewer liver-related infections compared to simultaneous surgery.
EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Yun Xu, Yuqin Zhang, Charlie Zhilin Zheng, Cong Li, Tian'an Guo, Ye Xu
Summary: This study compared the therapeutic efficacy of thermal ablation (TA) and hepatic resection (HR) in patients with synchronous colorectal liver metastases (CRLM) without extrahepatic metastases. The results showed that TA and HR provide comparable five-year overall survival (OS) and disease-free survival (DFS) in these patients, but the TA group had a higher rate of local tumor progression.
EUROPEAN RADIOLOGY
(2022)
Article
Surgery
Arkaitz Perfecto, Mikel Gastaca, Mikel Prieto, Jorge Cervera, Patricia Ruiz, Alberto Ventoso, Ibone Palomares, Jose Maria Garcia, Andres Valdivieso
Summary: In selected patients, totally laparoscopic simultaneous resections of colorectal cancer and synchronous liver metastases are technically feasible, with acceptable morbidity rate and mid-term survival.
SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES
(2022)
Article
Medicine, General & Internal
Hiroaki Nozawa, Takeaki Ishizawa, Hideo Yasunaga, Hiroaki Ishii, Hirofumi Sonoda, Shigenobu Emoto, Koji Murono, Kazuhito Sasaki, Kazushige Kawai, Nobuhisa Akamatsu, Junichi Kaneko, Junichi Arita, Kiyoshi Hasegawa, Soichiro Ishihara
Summary: This study retrospectively analyzed patients with primary colorectal cancer and liver metastases who underwent one-stage resection with different approaches. The laparoscopic groups had smaller blood loss and shorter hospital stays compared to the open surgery group. However, postoperative complication rates and survival outcomes were similar among the groups.
Article
Medicine, General & Internal
Noemi Reboux, Valerie Jooste, Juste Goungounga, Michel Robaszkiewicz, Jean-Baptiste Nousbaum, Anne-Marie Bouvier
Summary: This study analyzed the temporal patterns and outcomes of synchronous and metachronous liver metastases from colorectal cancer using a population-based cohort study in France. The incidence of synchronous liver metastases remained relatively stable over time, while the probability of developing metachronous liver metastases decreased. Survival rates were significantly higher for patients with metachronous liver metastases compared to synchronous metastases. The differences in the epidemiological features of synchronous and metachronous liver metastases may have implications for future clinical trials.
Article
Oncology
Jiamin Zhou, Longhai Feng, Xinxiang Li, Miao Wang, Yiming Zhao, Ning Zhang, Longrong Wang, Ti Zhang, Anrong Mao, Ye Xu, Lu Wang
Summary: The study aimed to investigate the value of total laparoscopic simultaneous colorectal and hepatic resection in patients with synchronous colorectal cancer liver metastases. The results showed that laparoscopic surgery had longer operation time and less intraoperative blood loss compared to open surgery. There were no significant differences in postoperative morbidity and long-term survival among the different surgery groups.
FRONTIERS IN ONCOLOGY
(2022)
Article
Oncology
Shannon N. Radomski, Sophia Y. Chen, Miloslawa Stem, Joy Z. Done, Jonathan E. Efron, Bashar Safar, Chady Atallah
Summary: This study investigates the safety of simultaneous surgical approach for colorectal cancer patients with colorectal liver metastases. The results show that simultaneous resection of colorectal and synchronous liver metastases is associated with increased morbidity risk in most cases, although rates of readmission and reoperation were not increased. Minimally invasive surgical approaches may significantly mitigate this risk.
JOURNAL OF SURGICAL ONCOLOGY
(2023)
Article
Gastroenterology & Hepatology
Anna Lindhoff Larsson, Bergthor Bjornsson, Baerbel Jung, Olof Hallbook, Karolina Vernmark, Katarina Berg, Per Sandstrom
Summary: This study compared postoperative outcomes and survival rates of patients who underwent simultaneous or staged resection for synchronous colorectal cancer liver metastases. The simultaneous resection group had shorter hospital stay and lower recurrence rate compared to the staged resection group. There were no significant differences in disease-free survival and overall survival between the two groups. Age and Clavien-Dindo score had an impact on survival.
Article
Multidisciplinary Sciences
Han-Ki Lim, Minjung Kim, Ji Won Park, Seung-Bum Ryoo, Kyu Joo Park, Nam-Joon Yi, Kwang-Woong Lee, Kyung-Suk Suh, Heung-Kwon Oh, Duck-Woo Kim, Sung-Bum Kang, Jai Young Cho, Dong-Woon Lee, Sung Chan Park, Jae Hwan Oh, Aesun Shin, Seung-Yong Jeong
Summary: This study aimed to compare the short- and long-term outcomes of simultaneous laparoscopic, hybrid, and open resection for colorectal cancer and synchronous liver metastases. The results showed that simultaneous laparoscopic resection can be performed safely with enhanced postoperative recovery and comparable long-term outcomes compared to hybrid and open resection.
SCIENTIFIC REPORTS
(2022)
Article
Oncology
Anthony K. C. Chan, James M. Mason, Minas Baltatzis, Ajith K. Siriwardena
Summary: The study recruited 125 patients with colorectal cancer and synchronous liver metastases, showing equivalent perioperative complications and healthcare occupancy outcomes between patients completing staged and synchronous pathways. Future research should focus on optimizing pathway selection criteria, integrating cancer genomics data, and considering patient preferences.
ANNALS OF SURGICAL ONCOLOGY
(2022)
Article
Surgery
Sam E. Mason, Eftychios Manoli, James L. Alexander, Liam Poynter, Lauren Ford, Petra Paizs, Afeez Adebesin, James S. McKenzie, Francesca Rosini, Rob Goldin, Ara Darzi, Zoltan Takats, James M. Kinross
Summary: This study used REIMS to analyze the lipid composition of colorectal tissues and evaluate its accuracy for real-time tissue recognition and risk stratification. The results showed that REIMS can differentiate samples of carcinoma, adenoma, and normal mucosa with 93.1% accuracy and 96.1% negative predictive value for carcinoma. It can also predict the presence of neoplasia (carcinoma or adenoma) with 96.0% accuracy and 91.8% negative predictive value. In addition, the study identified unique lipidomic features associated with colorectal carcinogenesis, such as the progressive increase in relative abundance of phosphatidylglycerols, sphingomyelins, and monounsaturated fatty acid-containing phospholipids.
Review
Surgery
Theophilus T. K. Anyomih, Thomas Jennings, Alok Mehta, J. Robert O'Neill, Ioanna Panagiotopoulou, Stavros Gourgiotis, Elizabeth Tweedle, John Bennett, R. Justin Davies, Constantinos Simillis
Summary: A systematic literature review and meta-analysis comparing outcomes of appendectomy performed by trainees versus trained surgeons found no difference in patient safety and perioperative outcomes. Trainees had longer operating time, but shorter duration of hospital stay and decreased reoperation rate.
AMERICAN JOURNAL OF SURGERY
(2023)
Review
Gastroenterology & Hepatology
C. Simillis, M. Charalambides, A. Mavrou, T. Afxentiou, M. P. Powar, J. Wheeler, R. J. Davies, N. S. Fearnhead
Summary: Operative blood loss has a significant impact on short-term and long-term outcomes following colorectal cancer surgery. Increased blood loss is associated with higher morbidity, anastomotic leak, postoperative ileus, surgical site infections, and prolonged hospital stay. It is also associated with worse overall survival, recurrence-free survival, and small bowel obstruction caused by colorectal cancer recurrence. Measures should be taken to minimize operative blood loss during colorectal cancer surgery.
TECHNIQUES IN COLOPROCTOLOGY
(2023)
Article
Pathology
Clare McGenity, Rebecca Randell, Christopher Bellamy, Alastair Burt, Alyn Cratchley, Robert Goldin, Stefan G. Hubscher, Desley A. H. Neil, Alberto Quaglia, Dina Tiniakos, Judy Wyatt, Darren Treanor
Summary: This study surveyed members of the UK Liver Pathology Group to understand their attitudes and priorities towards digital pathology and artificial intelligence in liver disease. The majority of liver pathologists in the UK are in favor of using digital pathology and AI in clinical practice, research, and education.
JOURNAL OF CLINICAL PATHOLOGY
(2023)
Article
Cell Biology
Elliot H. H. Akama-Garren, Paul Miller, Thomas M. M. Carroll, Michael Tellier, Gopinath Sutendra, Ludovico Buti, Justyna Zaborowska, Robert D. D. Goldin, Elizabeth Slee, Francis G. G. Szele, Shona Murphy, Xin Lu
Summary: Maintaining a balance between tolerance and autoimmunity is crucial for preventing human diseases. The protein p53 and its regulator iASPP play important roles in immunological tolerance and tumorigenesis. Deficiency in iASPP promotes tumor development but reduces susceptibility to autoimmune diseases. Furthermore, iASPP-deficient tumors exhibit immunosuppression characteristics, suggesting potential therapeutic opportunities for targeting the iASPP/p53 axis in autoimmune diseases and cancer.
CELL DEATH & DISEASE
(2023)
Article
Gastroenterology & Hepatology
Karl King Yong, Yun He, Hoi Ching Annie Cheung, Ramya Sriskandarajah, William Jenkins, Robert Goldin, Sabina Beg
Summary: This study aimed to determine if combining multiple small colorectal polyps in a single specimen pot can reduce carbon footprint without negatively impacting clinical outcomes. Results showed that consolidating small polyps could decrease carbon footprint, but may also result in missing advanced lesions. Therefore, changing practice at a national level could amplify the reduction in carbon footprint from judicious use of specimen pots.
FRONTLINE GASTROENTEROLOGY
(2023)
Article
Biochemistry & Molecular Biology
Paul Miller, Elliot H. Akama-Garren, Richard P. Owen, Constantinos Demetriou, Thomas M. Carroll, Elizabeth Slee, Khatoun Al Moussawi, Michael Ellis, Robert Goldin, Eric O'Neill, Xin Lu
Summary: iASPP is an inhibitor of p53 that suppresses inflammation and oncogenic KRAS-driven pancreatic cancer tumorigenesis.
CELL DEATH AND DIFFERENTIATION
(2023)
Review
Oncology
Constantinos Simillis, Amulya Khatri, Nick Dai, Thalia Afxentiou, Catherine Jephcott, Sarah Smith, Rashmi Jadon, Demetris Papamichael, Jim Khan, Michael P. Powar, Nicola S. Fearnhead, James Wheeler, Justin Davies
Summary: This systematic literature review investigated and compared the neoadjuvant therapy strategies for stage II and III rectal cancer. The study found that conventional neoadjuvant therapies with short-course radiation or long-course chemoradiotherapy have oncological benefits without increasing perioperative complication rates. Prolonged wait to surgery may improve oncological outcomes. Total neoadjuvant therapies provide additional benefits in terms of complete response, positive resection margins, and disease-free survival. Monoclonal antibody therapy may further improve oncological outcomes but currently is only applicable to a small subgroup of patients and requires further validation.
CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Nila Jambulingam, Roberta Forlano, Benjamin Preston, Benjamin H. Mullish, Greta Portone, Yama Baheer, Michael Yee, Robert D. Goldin, Mark R. Thursz, Pinelopi Manousou
Summary: Nonalcoholic fatty liver disease (NAFLD) is a major cause of chronic liver disease worldwide, and fibrosis stage is an important predictor for clinical outcomes. This study investigates the metabolic profile of NAFLD patients in relation to fibrosis progression. The results show that a combination of metabolites and lipoproteins can accurately identify fast fibrosis progressors and perform better than noninvasive markers. These specific metabolic profiles can predict fibrosis progression in patients with NAFLD, and algorithms combining metabolites and lipids could be used for risk stratification of these patients.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Gastroenterology & Hepatology
Emma Rose McGlone, Matthieu Siebert, Marian Dore, David C. D. Hope, Iona Davies, Bryn Owen, Bernard Khoo, Rob Goldin, Dave Carling, Stephen Bloom, Maude Le Gall, Tricia M-M. Tan
Summary: The study investigated the effects of sleeve gastrectomy on weight-independent improvements in liver steatosis in mice with diet-induced obesity. It was found that VSG not only improves liver fat content but also enhances insulin and glucagon sensitivity.
LIVER INTERNATIONAL
(2023)
Article
Gastroenterology & Hepatology
Diego Calvisi, Luke Boulter, Javier Vaquero, Anna Saborowski, Luca M. Fabris, Pedro Rodrigues, Cedric E. Coulouarn, Rui Castro, Oreste Segatto, Chiara Raggi, Luc J. W. van der Laan, Guido Carpino, Benjamin Goeppert, Stephanie J. Roessler, Timothy Kendall, Matthias Evert, Ester W. Gonzalez-Sanchez, Juan Valle, Arndt Vogel, John J. Bridgewater, Mitesh J. Borad, Gregory R. Gores, Lewis Roberts, Jose J. G. B. Marin, Jesper Andersen, Domenico Alvaro, Alejandro M. Forner, Jesus Banales, Vincenzo Cardinale, Rocio I. R. Macias, Silve Vicent, Xin Chen, Chiara Braconi, Monique M. A. Verstegen, Laura Fouassier, Lewis Roberts, Alexander Scheiter, Florin M. Selaru, Katja Evert, Kirsten Utpatel, Laura Broutier, Massimiliano Cadamuro, Meritxell Huch, Robert Goldin, Sergio A. Gradilone, Yoshimasa Saito
Summary: In this Consensus Statement, experts provide recommendations on the criteria for preclinical models of cholangiocarcinoma (CCA) to increase disease understanding and develop novel therapeutic approaches.
NATURE REVIEWS GASTROENTEROLOGY & HEPATOLOGY
(2023)
Article
Multidisciplinary Sciences
Jonathan W. Lo, Domenico Cozzetto, James L. Alexander, Nathan P. Danckert, Matthew Madgwick, Naomi Knox, Jillian Yong Xin Sieh, Marton Olbei, Zhigang Liu, Hajir Ibraheim, Jesus Miguens Blanco, Hiromi Kudo, Rocio Castro Seoane, Lucia A. Possamai, Robert Goldin, Julian Marchesi, Tamas Korcsmaros, Graham M. Lord, Nick Powell
Summary: Immune checkpoint inhibitors (CPIs) are a new cancer treatment that can potentially cure previously untreatable diseases. However, they can also cause off-target immune-mediated tissue injury. Researchers found that CPI-colitis in mice depends on the composition of the intestinal microbiota and the expression of certain immune molecules. Targeting these factors may hold the key to reversing CPI-colitis.
NATURE COMMUNICATIONS
(2023)
Article
Gastroenterology & Hepatology
David J. Pinato, Takahiro Kaneko, Antonio D'Alessio, Alejandro Forner, Petros Fessas, Beatriz Minguez, Edoardo G. Giannini, Federica Grillo, Alba Diaz, Francesco A. Mauri, Claudia A. M. Fulgenzi, Alessia Dalla Pria, Robert D. Goldin, Giulia Pieri, Pierluigi Toniutto, Claudio Avellini, Maria Corina Plaz Torres, Ayse U. Akarca, Teresa Marafioti, Sherrie Bhoori, Jose Maria Miro, Mark Bower, Norbert Brau, Vincenzo Mazzaferro
Summary: The aim of this study was to evaluate the impact of HIV infection on the functional characteristics of T cell infiltrate in hepatocellular carcinoma (HCC). Results showed that HIV infection was associated with increased immune exhaustion and higher expression of PD-L1 in tumor tissue. Therefore, prospective testing of immunotherapy in HIV-associated HCC is warranted.
Meeting Abstract
Gastroenterology & Hepatology
Jonathan W. Lo, Domenico Cozzetto, Matthew Madgwick, Jillian Y. Sieh, Marton Olbei, James L. Alexander, Jesus Miguens Blanco, Hiromi Kudo, Hajir Ibraheim, Zhigang Liu, Rocio Castro Seoane, Robert Goldin, Julian Marchesi, Tamas Korcsmaros, Graham Lord, Nick Powell
Meeting Abstract
Gastroenterology & Hepatology
Nikhil Vergis, Vishal C. Patel, Karolina Bogdanowicz, Justyna Czyzewska-Khan, Rosemary Keshinro, Francesca Fiorentino, Emily Day, Paul Middleton, Stephen Atkinson, Mary Cross, Daphne Babalis, Neil Foster, Alberto Quaglia, Josephine Lloyd, Robert D. Goldin, William Rosenberg, Richard Parker, Paul Richardson, Steven Masson, Gavin Whitehouse, Cyril Sieberhagen, David Patch, Ashwin Dhanda, Emma Lord, Ewan Forrest, Nikolai Naoumov, Mark Thursz
JOURNAL OF HEPATOLOGY
(2022)