Article
Gastroenterology & Hepatology
Chih-Wen Lin, Tsung-Chin Wu, Hung-Yu Lin, Chao-Ming Hung, Pei-Min Hsieh, Jen-Hao Yeh, Pojen Hsiao, Ya-Ling Huang, Yu-Chan Li, Ya-Chin Wang, Chih-Wen Shu, Yaw-Sen Chen
Summary: The clinicopathological features of cHCC-CC group were more similar to those of HCC group than CC group. The overall survival rate was significantly lower in cHCC-CC group compared to HCC group. However, after propensity score matching, there were no significant differences in overall survival and disease-free survival between cHCC-CC group and HCC group or CC group.
BMC GASTROENTEROLOGY
(2021)
Article
Medicine, General & Internal
Youyin Tang, Lingyan Wang, Fei Teng, Tao Zhang, Yunuo Zhao, Zheyu Chen
Summary: cHCC-CC patients had intermediate prognosis between HCC and ICC, with lymph node infiltration and postoperative TACE being independent risk factors associated with prognosis.
INTERNATIONAL JOURNAL OF MEDICAL SCIENCES
(2021)
Review
Oncology
Marcus Bahra, Ali Yahyazadeh
Summary: Combined hepatocellular-cholangiocarcinoma (cHCC-CC) is a rare liver tumor with both hepatocellular and cholangiocellular differentiation. Accurate diagnosis is challenging, and radical oncological surgery is the only curative option. Factors such as clinicopathological characteristics and biological behavior are crucial in understanding this tumor.
Article
Oncology
Wen-qiang Wang, Jian Li, Bin-yong Liang, Xing Lv, Rong-hua Zhu, Jin-lin Wang, Zhi-yong Huang, Shu-hong Yang, Er-lei Zhang
Summary: This study compared the prognostic outcomes of anatomical resection (AR) and non-anatomical resection (NAR) for patients with combined hepatocellular-cholangiocarcinoma (cHCC-CCA). The results showed that AR had better 5-year overall survival and recurrence-free survival rates compared to NAR, especially for patients with tumors smaller or equal to 5 cm in diameter.
FRONTIERS IN ONCOLOGY
(2022)
Article
Multidisciplinary Sciences
Shizheng Mi, Ziqi Hou, Guoteng Qiu, Zhaoxing Jin, Qingyun Xie, Jiwei Huang
Summary: This study aims to investigate the impact of liver transplantation versus liver resection on the prognosis of combined hepatocellular cholangiocarcinoma (CHC) patients. The results show that liver transplantation is associated with better overall survival and cancer-specific survival compared to liver resection. However, this advantage does not appear in the subgroup analysis based on tumor size. Multivariate analysis confirms the protective effect of liver transplantation on overall survival.
Article
Oncology
Daw-Shyong Perng, Chao-Ming Hung, Hung-Yu Lin, Paul Morgan, Yao-Chun Hsu, Tsung-Chin Wu, Pei-Min Hsieh, Jen-Hao Yeh, Pojen Hsiao, Chih-Yuan Lee, Yu-Chan Li, Ya-Chin Wang, Yaw-Sen Chen, Chih-Wen Lin
Summary: The study found that high LC3 expression in tumors of cHCC-CC patients is significantly associated with favorable clinical prognosis, including prolonged overall survival and disease-free survival.
Article
Gastroenterology & Hepatology
Maria Reig, Giuseppe Cabibbo
Summary: The potential impact of DAAs in BCLC-B/C stage patients with HCC is understudied, as HCC patients have been excluded from DAA trials. The decision on using DAAs should be made based on individual patient profiles.
JOURNAL OF HEPATOLOGY
(2021)
Review
Gastroenterology & Hepatology
Aurelie Beaufrere, Julien Calderaro, Valerie Paradis
Summary: Combined hepatocellular-cholangiocarcinoma (cHCC-CCA) is a tumor with both hepatocytic and biliary differentiation, whose diagnosis is primarily based on morphology and immunostaining, with a prognosis worse than hepatocellular carcinoma and treatment limited to surgery.
JOURNAL OF HEPATOLOGY
(2021)
Article
Oncology
Yijun Wu, Hongzhi Liu, Yifan Chen, Jianxing Zeng, Qizhen Huang, Jinyu Zhang, Yongyi Zeng, Jingfeng Liu
Summary: The MiVI-TTG scheme is a better prognostic predictor than the two-tiered MiVI grading scheme in cHCC patients. M2 and MiVI-positive are independent risk factors for overall survival and early recurrence.
Article
Surgery
Jinmok Bae, Dong Woo Shin, Kwang Bum Cho, Keun Soo Ahn, Tae-Seok Kim, Yong Hoon Kim, Koo Jeong Kang
Summary: This study retrospectively analyzed the data of 117 patients diagnosed with Bismuth type IV perihilar cholangiocarcinoma at Keimyung University Dongsan Hospital from 2005 to 2020. The results showed that surgical resection was associated with better survival rates for these patients.
LANGENBECKS ARCHIVES OF SURGERY
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Changwu Zhou, Yi Wang, Li Ma, Xianling Qian, Chun Yang, Mengsu Zeng
Summary: The study aimed to investigate the correlation between MRI features and biomarkers, as well as prognostic factors for RFS and OS in cHCC-CCA patients. Results showed that cHCC-CCA imaging features were not correlated with AFP or CA19-9 levels. Age, CA19-9 > 37 U/ml, arterial phase peritumoral enhancement, and delayed enhancement were identified as independent predictors of poor RFS. Arterial phase peripheral enhancement was found to be an independent predictor of poor OS.
EUROPEAN RADIOLOGY
(2022)
Article
Cell Biology
Diane Dayoung Park, Gege Xu, Simon S. Park, Nathan E. Haigh, Chatchai Phoomak, Sopit Wongkham, Emanual Maverakis, Carlito B. Lebrilla
Summary: Research has found that secreted proteins in cholangiocarcinoma (CCA) cells are mainly fucosylated and fucosialylated glycoforms. By analyzing the glycan and protein profiles, it was discovered that combining the genes encoding fucosyltransferases and sialyltransferases with secretory protein-coding gene expression, particularly thrombospondin-1, had favorable prognostic effects and could provide improved risk assessment and indicate stages of disease progression in CCA patients.
JOURNAL OF CELLULAR PHYSIOLOGY
(2023)
Article
Oncology
Xiao-hui Li, En-liang Zhou, Chong-yu Zhao, Bo-kang Cui, Xiao-yuan Dong, Hang Du, Xiao-jun Lin
Summary: Combining postoperative adjuvant chemotherapy with immunotherapy extends the relapse-free survival (RFS) and overall survival (OS) of patients with cholangiocarcinoma following radical resection.
Article
Radiology, Nuclear Medicine & Medical Imaging
Changwu Zhou, Xin Lu, Yi Wang, Xianling Qian, Chun Yang, Mengsu Zeng
Summary: The study aimed to distinguish MR features based on different proportions of the HCC component and investigate whether the proportion of HCC component could predict the prognosis of cHCC-CCA patients. The results showed that cHCC-CCAs with an HCC component >70% had a better overall survival prognosis compared to those with an HCC component <=70%.
EUROPEAN RADIOLOGY
(2022)
Review
Oncology
Matteo Renzulli, Daryl Ramai, Jameel Singh, Samridhi Sinha, Nicolo Brandi, Anna Maria Ierardi, Elisa Albertini, Rodolfo Sacco, Antonio Facciorusso, Rita Golfieri
Summary: Cholangiocarcinoma and combined hepatocellular cholangiocarcinoma are aggressive primary malignancies with liver resection as the main treatment modality. Locoregional therapies can provide local tumor control and increase chances of survival.