Review
Oncology
Tian-Run Lv, Fei Liu, Hai-Jie Hu, Parbatraj Regmi, Wen-Jie Ma, Qing Yang, Yan-Wen Jin, Fu-Yu Li
Summary: EHBDR does not provide a survival advantage for patients with gallbladder carcinoma, especially for non-jaundiced patients. The resected group has higher rates of disease recurrence, postoperative complications, and positive margins. Routine EHBDR is not recommended for non-jaundiced patients.
Review
Surgery
Jisheng Zhu, Guoyong Li, Peng Du, Xin Zhou, Weidong Xiao, Yong Li
Summary: The study compared the efficacy and safety of LCBDE + LC with IO-ERCP + LC for the treatment of gallbladder and CBD stones, finding no significant difference in technical success, morbidity, major morbidity, and conversion rate. However, LCBDE + LC had a higher biliary leak rate, lower postoperative pancreatitis rate, and higher rate of retained stones compared to IO-ERCP + LC.
SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES
(2021)
Article
Surgery
Seung Jae Lee, In Seok Choi, Ju Ik Moon, Yong Woo Choi
Summary: Single-stage laparoscopic CBD exploration (LCBDE) combined with laparoscopic cholecystectomy (LC) is a safe and effective treatment option for patients with concomitant gallbladder stones and common bile duct stones compared to endoscopic stone extraction (ESE) combined with LC. LCBDE should be considered for patients at high risk of ESE failure, and careful follow-up is recommended for patients at high risk of recurrence of CBD stones, especially within 24 months after surgical or endoscopic treatment.
SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES
(2022)
Article
Pharmacology & Pharmacy
W. -F. Lan, J. -H. LI, Q. -B. Wang, X. -P. Zhan, W. -L. Yang, L. -T. Wang, K. -Z. Tang
Summary: This study compared the effectiveness and safety of laparoscopic common bile duct exploration (LCBDE) and endoscopic retrograde cholangiopancreatography (ERCP) combined with laparoscopic cholecystectomy (LC) for treating gallbladder and common bile duct stones. The results showed no significant difference in treatment outcomes between LCBDE and ERCP. However, LCBDE had a higher rate of bile leakage and a lower rate of postoperative pancreatitis, cholangitis, and hemorrhage.
EUROPEAN REVIEW FOR MEDICAL AND PHARMACOLOGICAL SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Taifeng Zhu, Haoming Lin, Jian Sun, Chao Liu, Rui Zhang
Summary: This study compared the safety and effectiveness of primary duct closure (PDC) and T-tube drainage (TTD) after laparoscopic common bile duct exploration (LCBDE), showing that PDC was superior in terms of operation time, postoperative complications, hospital stay, and expenses. Both RCTs and cohort studies supported PDC as a safe and effective choice for patients with choledocholithiasis after transductal LCBDE.
JOURNAL OF ZHEJIANG UNIVERSITY-SCIENCE B
(2021)
Article
Oncology
Kari Hemminki, Kristina Sundquist, Jan Sundquist, Asta Foersti, Vaclav Liska, Akseli Hemminki, Xinjun Li
Summary: Liver cancer, including hepatocellular carcinoma, gallbladder cancer, and bile duct cancer, is influenced by various risk factors such as alcohol, viral hepatitis, gallstones, infections, autoimmune diseases, and diabetes. This study demonstrates that the combination of these risk factors can account for at least 50% of the causes of these cancers, highlighting the significance of chronic inflammation as an underlying mechanism. The use of national hospital records in Sweden provides valuable insights into the potential comorbidities associated with hepatobiliary cancers.
Article
Health Care Sciences & Services
Pablo Perez-Moreno, Ismael Riquelme, Patricia Garcia, Priscilla Brebi, Juan Carlos Roa
Summary: Gallbladder cancer is an aggressive neoplasm that is often asymptomatic in early stages and is typically diagnosed at an advanced stage. The presence of gallstones is the main risk factor, while other factors such as inflammation can also contribute to the development of gallbladder cancer. Understanding the early carcinogenic mechanisms is crucial for prevention.
JOURNAL OF PERSONALIZED MEDICINE
(2022)
Review
Medicine, General & Internal
Chang-Cheng Dong, Xue-Jun Jiang, Xue-Ying Shi, Bing Li, Liang Chen
Summary: This study conducted a meta-analysis on the risk factors related to bile duct injury after laparoscopic cholecystectomy, aiming to provide reference basis for preventing and reducing this complication.
Article
Surgery
Takashi Muraki, Burcin Pehlivanoglu, Bahar Memis, Michelle D. Reid, Takeshi Uehara, Olca Basturk, Jennifer Golia Pernicka, David S. Klimstra, William R. Jarnagin, Tetsuya Ito, Osamu Hasebe, Shinji Okaniwa, Naoto Horigome, Takeshi Hisa, Pardeep Mittal, Juan M. Sarmiento, Shishir K. Maithel, Jill Koshiol, Susan Tsai, Douglas Evans, Mert Erkan, Volkan Adsay
Summary: Pancreatobiliary maljunction (PBM) accounts for 8% of gallbladder cancer (GBC) cases in the West and is often undiagnosed. PBM-GBCs tend to occur at a younger age and often through the adenoma-carcinoma sequence, resulting in unusual carcinoma types. Cholecystectomy and surveillance of bile ducts are warranted if PBM is encountered.
Article
Radiology, Nuclear Medicine & Medical Imaging
Seung Bae Yoon, Tae Yeon Jeon, Sung-Hoon Moon, Dong Woo Shin, Ji Won Park, Sung Eun Kim, Min-Jeong Kim
Summary: This study conducted a systematic review and meta-analysis to evaluate the success rate and complication rate of percutaneous transhepatic fluoroscopy-guided management (PTFM) for the removal of common bile duct stones (CBDS). The results showed a high overall stone clearance rate (97.1%) and a low complication rate (13.8%) for PTFM. PTFM can be considered as an alternative treatment option for patients who cannot undergo endoscopic management.
EUROPEAN RADIOLOGY
(2023)
Review
Surgery
Caining Lei, Tingting Lu, Wenwen Yang, Man Yang, Hongwei Tian, Shaoming Song, Shiyi Gong, Jia Yang, Wenjie Jiang, Kehu Yang, Tiankang Guo
Summary: In comparing LC-IntraERCP and LC-LCBDE, there were no significant differences in terms of surgical success rate, overall postoperative complications, conversion to laparotomy, and operative time. However, LC-IntraERCP may be more effective in reducing the rate of retained stones.
SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES
(2021)
Review
Medicine, General & Internal
Shaohua Yang, Sheng Hu, Xiaohui Gu, Xiaowen Zhang
Summary: Age, abnormal preoperative liver function, gallbladder wall thickening, acute and subacute inflammation of the gallbladder, cholecystolithiasis complicated with effusion, and anatomic variations of the gallbladder triangle are closely associated with bile duct injury in laparoscopic cholecystectomy in China.
Article
Microbiology
Mari Kirishima, Seiya Yokoyama, Kei Matsuo, Taiji Hamada, Michiko Shimokawa, Toshiaki Akahane, Tomoyuki Sugimoto, Hirohito Tsurumaru, Matsujiro Ishibashi, Yuko Mataki, Takao Ootsuka, Mitsuharu Nomoto, Chihiro Hayashi, Akihiko Horiguchi, Michiyo Higashi, Akihide Tanimoto
Summary: This study investigated the microbiota composition in patients with pancreaticobiliary cancers and benign diseases using 16S rRNA gene amplicon sequencing and found a significant association between certain microbes and overall survival prognosis. These findings suggest that microbiota composition may be a potential biomarker for distinguishing the malignancy of pancreaticobiliary tract cancers.
Review
Critical Care Medicine
Shahin Mohseni, Gary Alan Bass, Maximilian Peter Forssten, Isidro Martinez Casas, Matthew Martin, Kimberly A. Davis, Elliott R. Haut, Michael Sugrue, Hayato Kurihara, Babak Sarani, Yang Cao, Raul Coimbra
Summary: This network meta-analysis indicates that laparoscopic CBD exploration and intraoperative ERCP have similar outcomes and provide a preferable single-anesthesia patient pathway with a shorter overall length of hospital stay compared to the two-stage approaches.
JOURNAL OF TRAUMA AND ACUTE CARE SURGERY
(2022)
Article
Gastroenterology & Hepatology
Seo Hee Choi, Chai Hong Rim, In-Soo Shin, Won Sup Yoon, Woong Sub Koom, Jinsil Seong
Summary: The benefits of adjuvant radiotherapy (ART) in gallbladder cancer (GBC) treatment remain inconclusive. In this study, a systematic review of 21 studies involving GBC patients was conducted. The results showed that ART can significantly reduce locoregional recurrence in GBC patients, but has no significant effect on distant metastasis. Furthermore, ART showed similar survival outcomes in patients with similar or slightly inferior clinical profiles.
HEPATOLOGY INTERNATIONAL
(2022)
Article
Dentistry, Oral Surgery & Medicine
T. K. Batra, M. R. Tilak, E. Pai, N. Verma, B. K. Gupta, G. Yadav, R. K. Dubey, N. J. Francis, M. Pandey
Summary: The study conducted on 21 patients undergoing head and neck cancer surgery during the COVID-19 pandemic showed an increase in pre-induction tracheostomies, prolonged hospital stays, and higher rate of surgery postponements. However, there was no significant difference in postoperative morbidity and mortality. Despite the increased rescheduling of surgeries, definitive cancer care surgery was not deferred to ensure maximum safety for patients and healthcare workers.
INTERNATIONAL JOURNAL OF ORAL AND MAXILLOFACIAL SURGERY
(2021)
Review
Oncology
Satya Vijay Chigurupati, Mridula Shukla, Manoj Pandey
Summary: Primary sacral diffuse large B cell non-Hodgkin's lymphoma is a rare entity with only 11 reported cases. Diagnosis requires histopathological examination and immunohistochemistry. In this case, the patient underwent chemotherapy and radiotherapy, with a 3-year follow-up showing no evidence of disease recurrence.
WORLD JOURNAL OF SURGICAL ONCOLOGY
(2021)
Review
Oncology
Jasmine A. McDonald, Roshni Rao, Marley Gibbons, Rajiv Janardhanan, Surinder Jaswal, Ravi Mehrotra, Manoj Pandey, Venkatraman Radhakrishnan, Pooja Ramakant, Nandini Verma, Mary Beth Terry
Summary: The incidence of breast cancer in India, particularly among young women, is rising without population-based mammography screening. Experts convened to discuss this trend, environmental exposures, and clinical implications associated with breast cancer in India, and outlined recommendations for its management. Consensus was reached on the association of late-stage breast cancer prevalence and high mortality rates with detection practices primarily through clinical and self-breast exams rather than mammography. Sessions included discussions on Triple-Negative BC (TNBC) etiology, potential risk factors, limited treatment options, and the need for more rigorous scientific evidence to support reported TNBC rates. The Think Tank session resulted in long-term and short-term goals aimed at reducing breast cancer incidence in India, including regional etiological studies on environmental exposures, standardization for molecular subtyping of breast cancer cases, and enhancing public awareness of breast health.
CANCER CAUSES & CONTROL
(2021)
Article
Biochemistry & Molecular Biology
Ruhi Dixit, Manoj Pandey, Monika Rajput, Vijay Kumar Shukla
Summary: This study investigated the whole transcriptome profile of gallbladder cancer patients using RNA sequencing and identified key genes and pathways associated with the disease. Results showed that CCKAR, CDKN2A, and LRRK2 were the most involved genes in the progression and development of gallbladder cancer through pathways such as PI3K-Akt, Wnt, and hedgehog signaling.
MOLECULAR BIOLOGY REPORTS
(2022)
Review
Oncology
Roli Purwar, Kishan Soni, Mridula Shukla, Ashish Verma, Tarun Kumar, Manoj Pandey
Summary: PEComas are a rare type of tumor characterized by expression of muscle and melanocytic markers. TFE3-associated PEComas are a new variant that lack response to targeted mTOR inhibitor therapy. The patient in the case showed excellent response to Everolimus therapy.
WORLD JOURNAL OF SURGICAL ONCOLOGY
(2022)
Article
Oncology
Roli Purwar, Kishan Soni, Ragini Tilak, Ashish Verma, Manoj Pandey
Summary: Peritonitis associated with Curvularia lunata is rare, with only five cases reported in the literature, all in middle-aged patients with comorbidities undergoing dialysis. This case report presents a 21-year-old female patient who was diagnosed with ovarian malignancy based on raised CA 125 and suspected tubo-ovarian mass on MRI, but was later found to have a pelvic collection with Curvularia lunata infection.
WORLD JOURNAL OF SURGICAL ONCOLOGY
(2022)
Article
Immunology
Upinder Kaur, Sapna Bala, Aditi Joshi, Noti Taruni Srija Reddy, Chetan Japur, Mayank Chauhan, Nikitha Pedapanga, Shubham Kumar, Anurup Mukherjee, Vaibhav Mishra, Dolly Talda, Rohit Singh, Rohit Kumar Gupta, Ashish Kumar Yadav, Poonam Jyoti Rana, Jyoti Srivastava, Shobha K. Bhat, Anup Singh, Naveen P. G. Kumar, Manoj Pandey, Kishor Patwardhan, Sangeeta Kansal, Sankha Shubhra Chakrabarti
Summary: This study examined the real-world effectiveness of COVID-19 vaccines in India and the health issues associated with vaccination. The results showed that the vaccines can reduce the severity of COVID-19 but offer only marginal protection against occurrence. Additionally, individuals receiving the vaccine after recovery from COVID-19 have a higher risk of persistent health issues.
Article
Biochemistry & Molecular Biology
Monika Rajput, Satyavjiay Chigurupati, Roli Purwar, Mridula Shukla, Manoj Pandey
Summary: This study analyzed the pathogenesis of gallbladder cancer using NGS technology and identified multiple interacting signaling pathways. The results suggest that mTOR-MAPK targeted treatment may be an effective therapeutic option.
MOLECULAR BIOLOGY REPORTS
(2022)
Article
Oncology
Kishan Soni, J. F. Neville, Roli Purwar, Tarun Kumar, Ghanshyam Yadav, Nimisha Verma, Manoj Pandey
Summary: This study reveals a higher mortality rate in cancer patients undergoing surgery during the COVID-19 pandemic, with no significant change in morbidity rates. Additionally, a proportion of healthcare workers also contracted COVID-19, but there were no deaths in this group.
WORLD JOURNAL OF SURGICAL ONCOLOGY
(2022)
Review
Oncology
Roli Purwar, Rakesh Ranjan, Kishan Soni, Manoj Pandey, Satyanshu K. Upadhyay, Esha Pai, Tarun Kumar
Summary: The debate on systematic lymphadenectomy in epithelial ovarian cancers was ignited by the LION trial but remains inconclusive. Meta-analysis of randomized controlled trials showed a trend towards improved progression-free survival with lymphadenectomy, but no significant benefit on overall survival. More well-conducted trials are needed for a definitive answer.
WORLD JOURNAL OF SURGICAL ONCOLOGY
(2022)
Review
Oncology
Roli Purwar, Rakesh Ranjan, Manjusha Pal, Satyanshu K. Upadhyay, Tarun Kumar, Manoj Pandey
Summary: A meta-analysis of randomized control trials was conducted to study the role of PARP inhibitors in different populations of ovarian cancer. The results suggest that PARPi have a meaningful clinical benefit in PSOC, HRD, BRACm, and also in HRP and PROC, but further studies are needed to recommend their routine use in the HRP and PROC groups.
WORLD JOURNAL OF SURGICAL ONCOLOGY
(2023)
Review
Oncology
Roli Purwar, Madhumita Tripathi, Monika Rajput, Manjusha Pal, Manoj Pandey
Summary: A 60-year-old man with a history of colon cancer presented with abdominal pain and melena. Further investigations revealed a second primary adenocarcinoma in the stomach, which was treated with total gastrectomy. Next-generation sequencing identified novel mutations in KMT2A, LTK, and MST1R genes, and further studies are needed to understand their role in gastric carcinogenesis.
WORLD JOURNAL OF SURGICAL ONCOLOGY
(2023)
Review
Pharmacology & Pharmacy
Priya Dev, Kamalesh Chakravarty, Manoj Pandey, Rakesh Ranjan, Mareena Cyriac, Vijaya Nath Mishra, Abhishek Pathak
Summary: The role of environmental contaminants in stroke is still being investigated, with inconsistent results in studies on the association of air pollution, noise, and water pollution with stroke. A systematic review and meta-analysis were conducted to examine the effect of persistent organic pollutants (POPs) on ischemic stroke patients. Five eligible studies were included, with polychlorinated biphenyls (PCBs) being the most studied POP associated with ischemic stroke. Living near a source of POP contamination was found to increase the risk of exposure and ischemic stroke. Further extensive studies are needed to confirm the association between POPs and ischemic stroke.
Article
Oncology
Nisha Rateria, Ritu Ojha, Mridula Shukla, Manoj Pandey
Summary: This article presents a unique case of rectal adenocarcinoma in a woman with germline MSH6 and PMS1 mutations, and simultaneous somatic APC and TP53 mutations. The case highlights a possible interaction between the two pathways and emphasizes the importance of evaluating both germline and somatic mutations in colorectal cancer patients for tailored therapy.
WORLD JOURNAL OF SURGICAL ONCOLOGY
(2023)
Letter
Surgery
D. Biswas, S. V. Chigurupati, M. Pandey
BRITISH JOURNAL OF SURGERY
(2021)