Journal
SURGICAL ONCOLOGY CLINICS OF NORTH AMERICA
Volume 18, Issue 3, Pages 453-+Publisher
W B SAUNDERS CO-ELSEVIER INC
DOI: 10.1016/j.soc.2009.03.002
Keywords
Barrett's esophagus; Biomarkers; Esophageal adenocarcinoma; Stem cell; Aneuploidy
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This article focuses on the conceptual basis underlying the acquisition of each of the physiologic cancer hallmarks by metaplastic Barrett's cells. The acquired genetic alterations that have shown the most promise as potential molecular biomarkers to predict neoplastic progression in patients with Barrett's esophagus are reviewed. Moreover, the role of stem cells and stem cell markers in Barrett's carcinogenesis is addressed.
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