Article
Clinical Neurology
Philipp Dammann, Adib A. Abla, Rustam Al-Shahi Salman, Hugo Andrade-Barazarte, Vladimir Benes, Marco Cenzato, E. Sander Connolly, Jan F. Cornelius, William T. Couldwell, Rafael G. Sola, Santiago Gomez-Paz, Erik Hauck, Juha Hernesniemi, Juri Kivelev, Giuseppe Lanzino, R. Loch Macdonald, Jacques J. Morcos, Christopher S. Ogilvy, Hans-Jakob Steiger, Gary K. Steinberg, Alejandro N. Santos, Laurel Rauschenbach, Marvin Darkwah Oppong, Boerge Schmidt, Robert F. Spetzler, Karl Schaller, Michael T. Lawton, Ulrich Sure
Summary: This study sought consensus on the surgical management aspects of brainstem cavernous malformations (BSCMs) and provided a summary of factors influencing surgical treatment decisions.
JOURNAL OF NEUROSURGERY
(2022)
Article
Clinical Neurology
Scheherazade Le, Viet Nguyen, Leslie Lee, S. Charles Cho, Carmen Malvestio, Eric Jones, Robert Dodd, Gary Steinberg, Jaime Lopez
Summary: This study introduced a novel intraoperative neuromonitoring technique using direct brainstem somatosensory evoked potentials for functional mapping to assist in surgery. Successful recording of brainstem SSEPs at low stimulation intensities may help reduce postoperative neurological deficits and aid in safe lesion resection. Further refinement of this technique could potentially benefit the mapping of other brainstem lesions.
JOURNAL OF NEUROSURGERY
(2021)
Article
Clinical Neurology
Philipp Dammann, Annika Herten, Alejandro N. Santos, Laurel Rauschenbach, Bixia Chen, Marvin Darkwah Oppong, Boerge Schmidt, Michael Forsting, Christoph Kleinschnitz, Ulrich Sure
Summary: This study assessed outcomes after surgery for brainstem cavernous malformations (BSCMs) and found that patients' health-related quality of life (HRQOL) was impaired post-surgery, especially in those with unfavorable functional outcomes. Psychological impairment was more significant in unfavorable outcome patients, while minimal in those with favorable outcomes. Symptoms related to brainstem and cranial nerves had a notable impact on HRQOL.
JOURNAL OF NEUROSURGERY
(2021)
Article
Clinical Neurology
Joshua S. Catapano, Kavelin Rumalla, Visish M. Srinivasan, Peter M. Lawrence, Kristen Larson Keil, Michael T. Lawton
Summary: This article proposes a novel taxonomy for medullary cavernous malformations based on clinical presentation and anatomical location. A large 2-surgeon experience over a 30-year period was used to apply the taxonomy system to 551 patients who underwent microsurgical resection of brainstem cavernous malformations. Five distinct subtypes were defined for the medullary lesions, and surgical approaches were selected based on the subtype. The study confirms that the proposed taxonomy can improve clinical communication and patient outcomes.
JOURNAL OF NEUROSURGERY
(2023)
Article
Clinical Neurology
Joshua S. Catapano, Kavelin Rumalla, Visish M. Srinivasan, Peter M. Lawrence, Kristen Larson Keil, Michael T. Lawton
Summary: This study proposes a novel taxonomy for midbrain cavernous malformations based on clinical presentation and anatomical location. Different subtypes of midbrain BSCMs were identified and associated with distinct neurological symptoms and surgical approaches. The proposed taxonomy can enhance diagnostic acumen, improve surgical planning, and optimize patient outcomes.
JOURNAL OF NEUROSURGERY
(2022)
Article
Clinical Neurology
Annika Herten, Dino Saban, Alejandro N. Santos, Bixia Chen, Marvin Darkwah Oppong, Laurel Rauschenbach, Ramazan Jabbarli, Karsten Wrede, Ulrike Bingel, Daniel Mueller, Dagny Holle-Lee, Boerge Schmidt, Yan Li, Ulrich Sure, Philipp Dammann
Summary: This study assessed the occurrence and significance of postoperative neuropathic pain in patients with surgically treated brainstem cavernous malformations. It was found that 8% of patients suffered from NP after surgery, impacting their health-related quality of life and life satisfaction.
EUROPEAN JOURNAL OF NEUROLOGY
(2022)
Article
Clinical Neurology
Joachim Oertel, Gerrit Fischer, Stefan Linsler, Matthias Huelser, Christoph Sippl, Fritz Teping
Summary: This study provides detailed information on the role of endoscopy in surgical resection of brainstem cavernous malformations. By retrospectively analyzing medical documentation, radiologic studies, and intraoperative video documentation, the study found that endoscopic techniques can be safely implemented and enable a smaller surgical corridor for brainstem cavernous malformations.
NEUROSURGICAL REVIEW
(2022)
Article
Clinical Neurology
Sungel Xie, Xin-Ru Xiao, Shun-Wu Xiao, Ming-Xiang Xie, Jun-Ting Zhang, Zhen Wu, Li-Wei Zhang
Summary: Surgical timing is a crucial factor in determining long-term outcomes for patients who undergo surgery after severe hemorrhagic events from brainstem CMs. Patients undergoing surgery during the acute or chronic period may have poorer neurological outcomes compared to those in the subacute period. Successful neurological outcomes can be achieved through surgical treatment, particularly during the subacute hemorrhage period.
NEUROSURGICAL REVIEW
(2021)
Article
Clinical Neurology
Yang Yang, Julia Velz, Marian C. Neidert, Wei Lang, Luca Regli, Oliver Bozinov
Summary: The study introduced a score system to aid clinicians in treatment decision-making for patients with BSCMs, based on factors such as patient age, lesion size, hemorrhagic events, mRS, and axial location. The score scale classified patients into different grades to determine whether surgery or non-surgery was the optimal treatment option. The proposed BSCM operating score was found to be a useful tool for neurosurgeons in determining the most suitable treatment approach for patients with BSCMs.
NEUROSURGICAL REVIEW
(2022)
Article
Clinical Neurology
Alejandro N. Santos, Laurel Rauschenbach, Marvin Darkwah Oppong, Bixia Chen, Annika Herten, Michael Forsting, Ulrich Sure, Philipp Dammann
Summary: Treatment indications for patients with brainstem cavernous malformations (BSCMs) are difficult and controversial. Authors aimed to validate the performance of two proposed BSCM grading systems. The study found that multiple bleedings, lesion diameter, and patient age were predictors of unfavorable postoperative outcomes, and that both the LG and the DS scores were robust tools for estimating patient outcome.
JOURNAL OF NEUROSURGERY
(2021)
Article
Clinical Neurology
Julia Velz, Marian Christoph Neidert, Yang Yang, Kevin Akeret, Peter Nakaji, Luca Regli, Oliver Bozinov
Summary: According to the study results, the mortality rate associated with brainstem cavernous malformations (BSCM) in patients managed conservatively is nearly as low as in patients treated surgically, likely due to good surgical selection currently.
CEREBROVASCULAR DISEASES
(2021)
Article
Clinical Neurology
Adela Bubenikova, Petr Skalicky, Vladimir Benes, Vladimir Sr Benes Sr, Ondrej Bradac
Summary: This study compares the treatment efficacy for cerebral cavernous malformations (CCMs). The results show that surgical treatment is effective in preventing hemorrhage with acceptable morbidity and mortality. Conservative treatment and radiosurgical management are also justified treatment alternatives. Brainstem and deep-seated CCMs are predominantly associated with higher hemorrhage rates.
JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY
(2022)
Review
Surgery
George Fotakopoulos, Hugo Andrade-Barazarte, Juri Kivelev, Mardjono Tjahjadi, Felix Goehre, Juha Hernesniemi
Summary: This study conducted a systematic review and meta-analysis on the therapeutic strategies for brainstem cavernous malformations. The findings suggest that there is no superiority between microsurgical resection and stereotactic radiosurgery in terms of mortality, rebleeding rate, and permanent neurological deficits.
FRONTIERS IN SURGERY
(2022)
Review
Clinical Neurology
Xiangyu Gao, Kangyi Yue, Jidong Sun, Yuan Cao, Boyan Zhao, Haofuzi Zhang, Shuhui Dai, Lei Zhang, Peng Luo, Xiaofan Jiang
Summary: Treating brainstem cavernous malformations with microsurgery or radiosurgery has shown to be effective in reducing the rehemorrhage rate. The neurosurgery cohort had lower incidence of symptomatic intracranial hemorrhage, while the radiosurgery cohort had lower incidence of persistent focal neurological deficit.
FRONTIERS IN NEUROLOGY
(2021)
Article
Clinical Neurology
Xiao-Ying Xu, Da Li, Lai-Rong Song, Pan-Pan Liu, Ze-Yu Wu, Liang Wang, Li -Wei Zhang, Jun-Ting Zhang, Zhen Wu
Summary: The objective of this study was to create a nomogram for accurately predicting the 5-year prospective hemorrhage risk in brainstem cavernous malformations (BSCMs). Using a retrospective observational series, patients with confirmed BSCMs were divided into training, validation, and external validation cohorts, and a nomogram was constructed using a multivariable Cox model and other evaluation indices. The nomogram demonstrated good predictive accuracy and clinical utility. It can assist clinicians in risk stratification for patients.
JOURNAL OF NEUROSURGERY
(2023)
