Article
Multidisciplinary Sciences
Yasaman-Sadat Borghei, Saman Hosseinkhani, Mohammad Reza Ganjali
Summary: This review focuses on the basic physicochemical properties of plasmonic nanoparticles and their applications in biomedical and tissue engineering. It aims to provide a comprehensive and authoritative overview to the scientific community. The review introduces the fundamental characteristics of nanomaterials and illustrates their applications in the field through selected case studies.
JOURNAL OF ADVANCED RESEARCH
(2022)
Review
Engineering, Biomedical
Suhun Chae, Dong-Woo Cho
Summary: The development of three-dimensional (3D) bioprinting has facilitated the creation of tissue constructs that resemble natural tissues in structure and function. This review focuses on the rational design and biofabrication strategies of 3D bioprinted tissue constructs for orthopedic tissue engineering applications. The review summarizes the fundamentals of 3D bioprinting techniques and biomaterial inks, the recent advances in 3D bioprinting technology for orthopedic tissue engineering, and the challenges and future directions of 3D bioprinting in orthopedic tissue engineering and regenerative medicine.
ACTA BIOMATERIALIA
(2023)
Review
Polymer Science
Shuo Chen, Yihan Wang, Lei Yang, Chengzhen Chu, Shichun Cao, Zhao Wang, Jiajia Xue, Zhengwei You
Summary: In this review, the recent progress in synthesis, process technologies, and biomedical applications of biodegradable elastomers is summarized. The emphasis is on the molecular design and processing strategies of biodegradable polyesters and polyurethanes, as well as the newly developed functionalities in biomedical applications. Future research directions, challenges, and potential solutions are discussed.
PROGRESS IN POLYMER SCIENCE
(2023)
Review
Chemistry, Multidisciplinary
Oystein Arlov, Dominic Rutsche, Maryam Asadi Korayem, Ece Ozturk, Marcy Zenobi-Wong
Summary: Sulfated polysaccharides play central roles in biological functions, and engineered sulfated polysaccharides exhibit novel and augmented biological properties through facilitating interactions with other macromolecules.
ADVANCED FUNCTIONAL MATERIALS
(2021)
Review
Engineering, Biomedical
Sophie Wendels, Luc Averous
Summary: Polyurethanes (PUs) have a wide range of applications in the biomedical field, showing advanced properties such as controlled biotic and abiotic degradation. They possess precise tissue biomimicking structures and shape-recovery properties, making them suitable for cell adhesion, proliferation, and differentiation. While substitution of fossil-based materials for biomedical implants is slowly improving, achieving higher renewable contents is still necessary for biobased certifications.
BIOACTIVE MATERIALS
(2021)
Review
Crystallography
Klaudia Malisz, Beata Swieczko-Zurek
Summary: Graphene is a two-dimensional nanomaterial composed of carbon atoms with sp2 hybrid orbitals. It has outstanding physiochemical, mechanical, and biological properties. Chemical vapor deposition is the most popular method for graphene production. Graphene and its composite have various biomedical applications, including sensors, implantology, and gene/drug delivery.
Review
Polymer Science
Wenqing Liang, Yongqiang Dong, Hailiang Shen, Ruyi Shao, Xudong Wu, Xiaogang Huang, Bin Sun, Bin Zeng, Songou Zhang, Fangming Xu
Summary: Successful materials design for bone tissue engineering involves understanding the structure and composition of host bone tissue, and selecting appropriate biomimetic natural or synthetic materials. Challenges in biomaterial design drive the development of bio-inspired materials to enhance biofunctionality. Researchers must understand the goals, mechanisms, and requirements of bone tissue regeneration in order to design future research strategies effectively.
POLYMERS FOR ADVANCED TECHNOLOGIES
(2021)
Article
Biochemistry & Molecular Biology
Carlo Diaferia, Elisabetta Rosa, Enrico Gallo, Giovanni Smaldone, Mariano Stornaiuolo, Giancarlo Morelli, Antonella Accardo
Summary: Peptide-based hydrogels, specifically the Fmoc derivatives of series K, are capable of self-assembly and gelation in aqueous solutions, with Fmoc-K3 hydrogel showing potential for tissue engineering applications by supporting cell adhesion, survival, and duplication. The gelification process is dependent on the balance of aggregation forces within the peptide sequences, such as van der Waals, hydrogen bonding, and pi-pi stacking.
Review
Chemistry, Applied
Masoud Hamidi, Oseweuba Valentine Okoro, Peiman Brouki Milan, Mohammad Reza Khalili, Hadi Samadian, Lei Nie, Amin Shavandi
Summary: Fungal exopolysaccharides have diverse potential applications in various industries. However, there are only a few commercialized products based on fungal EPSs in the biomedical field. This review critically discusses the potential biomedical applications of fungal EPSs in tissue engineering, drug and gene delivery.
CARBOHYDRATE POLYMERS
(2022)
Review
Chemistry, Multidisciplinary
Hai-Qing Song, Yaqian Fan, Yang Hu, Gang Cheng, Fu-Jian Xu
Summary: This review summarizes the potential and advantages of polysaccharide-peptide conjugates in biomedical applications, as well as provides an overview of the design, conjugation chemistry, and applications. In addition, the challenges and demands of polysaccharide-peptide conjugates are also discussed for future prospects.
ADVANCED FUNCTIONAL MATERIALS
(2021)
Review
Chemistry, Applied
Sumit Murab, Aastha Gupta, Malgorzata Katarzyna Wlodarczyk-Biegun, Anuj Kumar, Patrick van Rijn, Patrick Whitlock, Sung Soo Han, Garima Agrawal
Summary: This review highlights the importance of alginate-based hydrogel inks for fabricating 3D printed scaffolds for bone and cartilage regeneration. The fundamentals of direct extrusion 3D bioprinting method are discussed, and a comprehensive overview of various alginate-based hydrogel ink formulations that have been used so far is provided. The requirements of hydrogel inks and 3D printed scaffolds to achieve similarity to the native tissue environment are summarized.
CARBOHYDRATE POLYMERS
(2022)
Review
Biochemistry & Molecular Biology
Girolamo Casella, Silvia Carlotto, Francesco Lanero, Mirto Mozzon, Paolo Sgarbossa, Roberta Bertani
Summary: Cyclic and polyphosphazenes are substrates characterized by -P=N- repeating units, which can be easily substituted with organic groups to create new materials for industrial applications. They have promising biomedical applications, such as antimicrobial agents in drug delivery and immunoadjuvants in tissue engineering. Their properties can be tailored by the number of repetitive units and the nature of the substituent groups.
Article
Chemistry, Physical
Lijuan Wang, Yushuang Shang, Jie Zhang, Jiang Yuan, Jian Shen
Summary: The development of keratin-based biomaterials provides a valuable approach for addressing environmental pollutants and transforming waste into wealth. The properties and biomedical applications of keratin biomaterials, such as drug delivery, wound healing, and tissue engineering, are extensively discussed in this review, offering valuable insights for further research and development.
ADVANCES IN COLLOID AND INTERFACE SCIENCE
(2023)
Review
Biochemistry & Molecular Biology
Sabbir Ansari, Neha Sami, Durdana Yasin, Nazia Ahmad, Tasneem Fatma
Summary: Polyhydroxyalkanoates (PHA) are biological polyesters of hydroxyacids, considered as environmentally friendly alternatives to petroleum-based plastics, with biodegradability and biocompatibility. Research on different PHA in cell culture systems or animal hosts in recent years has shown their potential for applications in medical devices.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Review
Pharmacology & Pharmacy
Hossein Omidian, Sumana Dey Chowdhury, Niloofar Babanejad
Summary: Cryogels, versatile biomaterials composed of synthetic and natural materials, have wide applications in tissue engineering, drug delivery, regenerative medicine, and therapeutics. However, optimizing cryogel properties remains challenging, and researchers are exploring advanced manufacturing techniques and addressing long-term stability. Combination therapies and drug delivery systems using cryogels show promise, but in vivo evaluation and clinical trials are crucial for determining safety and efficacy. Overcoming practical challenges such as scalability, structural integrity, mass transfer constraints, biocompatibility, seamless integration, and cost-effectiveness is essential for the successful application of cryogels in biomedical fields.