Article
Oncology
Nikhil Lal, Dedrick Kok Hong Chan, Minn E. Ng, Louis Vermeulen, Simon James Alexander Buczacki
Summary: High lymph node (LN) yield is predictive of overall and disease-free survival in non-metastatic colon cancer. There is no association between higher LN yield and increasing nodal positivity, but it is strongly linked with gene expression changes associated with the adaptive and dendritic cell immune response, especially in node-negative cancers. These findings were validated in an independent dataset.
BRITISH JOURNAL OF CANCER
(2022)
Article
Oncology
Madeleine Hetterich, Michael Gerken, Olaf Ortmann, Elisabeth C. Inwald, Monika Klinkhammer-Schalke, Holm Eggemann, Atanas Ignatov
Summary: The study found that axillary lymph node micrometastases have an impact on the survival and recurrence rates of breast cancer patients, but this effect disappears after adjusting for age, tumor size, and grading. For patients with micrometastases, adjuvant chemotherapy did not significantly improve overall survival or recurrence-free survival compared to those without adjuvant chemotherapy.
BREAST CANCER RESEARCH AND TREATMENT
(2021)
Article
Oncology
Huolun Feng, Zejian Lyu, Weijun Liang, Guanfu Cai, Zhenru Deng, Meiyu Jiang, Deqing Wu, Yong Li
Summary: Through rigorous statistical methods and a large sample size, the study suggests that the optimal number of ELNs for prognostic stratification in node-negative colon cancer is 15. This finding highlights the importance of ELNs as a prognostic factor in cancer patients.
Article
Oncology
Yansong Xu, Yi Chen, Chenyan Long, Huage Zhong, Fangfang Liang, Ling-xu Huang, Chuanyi Wei, Shaolong Lu, Weizhong Tang
Summary: Preoperative CEA level, grading, and PNI were identified as independent risk factors for LNM in colon cancer. The nomogram constructed in this study demonstrated good consistency and calibration capabilities for predicting LNM risk in both the training and validation sets.
FRONTIERS IN ONCOLOGY
(2021)
Article
Oncology
Wangxin Yan, Huizhen Zhou, Si Shi, Jixu Lin, Qiangkang Lin
Summary: Younger age, female gender, more lymph nodes harvested, Black race, and higher tumor grade were more prone to be diagnosed with lymph node involvement. The receipt of adjuvant chemotherapy following radical surgery significantly decreased the risk of colon cancer-specific mortality by 33.9% in T1 colon cancer with lymph node involvement.
FRONTIERS IN ONCOLOGY
(2021)
Article
Oncology
Inge van den Berg, Marcel Smid, Robert R. J. Coebergh van den Braak, Carolien H. M. van Deurzen, Vanja de Weerd, John A. Foekens, Jan N. M. IJzermans, John W. M. Martens, Saskia M. Wilting
Summary: Circular RNAs (circRNAs) play an important role in tumor progression of colon cancer (CC) and have potential clinical value as biomarkers for diagnosis, prognosis, and treatment. A large cohort study identified a diverse catalog of circRNAs in stage I/II colon tumors and found that high circRNA diversity was associated with favorable disease-free survival (DFS). Specific circRNAs were also associated with MSI and CMS, highlighting their potential utility for prognostic stratification in patients with early-stage colon cancer.
Article
Surgery
Kiyoaki Sugiura, Yuki Seo, Yuki Tajima, Hiroto Kikuchi, Akira Hirata, Jumpei Nakadai, Hideo Baba, Takayuki Kondo, Akitsugu Makino, Yujin Kato, Shimpei Matsui, Ryo Seishima, Kohei Shigeta, Koji Okabayashi, Yuko Kitagawa
Summary: This study investigates the necessity of lymph node dissection during colon cancer surgery and finds that main lymph node metastasis (MLNM) has a significant impact on the prognosis of colon cancer patients. Adding the MLNM status to the TNM staging system can enhance prognostic evaluation and the clinical efficacy of adjuvant therapy.
WORLD JOURNAL OF SURGERY
(2023)
Article
Multidisciplinary Sciences
Kenichi Ishii, Jun Watanabe, Kouki Goto, Yusuke Suwa, Kazuya Nakagawa, Hirokazu Suwa, Mayumi Ozawa, Atsushi Ishibe, Chikara Kunisaki, Itaru Endo
Summary: The study investigated the impact of APN metastasis on the prognosis of patients with high-risk stage III colon cancer, revealing that APN metastasis is an independent risk factor for 5-year overall survival and relapse-free survival.
SCIENTIFIC REPORTS
(2022)
Article
Surgery
Vignesh Raman, Oliver K. Jawitz, Norma E. Farrow, Soraya L. Voigt, Kristen E. Rhodin, Chi-Fu J. Yang, Megan C. Turner, Thomas A. D'Amico, David H. Harpole, Betty C. Tong
Summary: In this study of patients with upfront, complete resection of node-positive esophageal adenocarcinoma, adjuvant chemotherapy was associated with improved survival for LNR >=12%. LNR may be used as an adjunct in decision-making about adjuvant therapies in this patient population.
Article
Oncology
John M. Masterson, Michael Luu, Aurash Naser-Tavakolian, Stephen J. Freedland, Howard Sandler, Zachary S. Zumsteg, Timothy J. Daskivich
Summary: The number and density of metastatic lymph nodes on lymphadenectomy predict mortality in prostate cancer. The study found that the impact of lymph node density on overall mortality is negligible in patients with 3 or fewer metastatic lymph nodes, who make up the majority of patients with metastatic lymph nodes. Pathological nodal staging should primarily focus on the count of lymph nodes rather than density.
PROSTATE CANCER AND PROSTATIC DISEASES
(2023)
Article
Multidisciplinary Sciences
Kyu Hye Choi, Jin Ho Song, Ji Hyun Hong, Youn Soo Lee, Jin Hyoung Kang, Dong-Il Sun, Min-Sik Kim, Yeon-Sil Kim
Summary: This study analyzed the predictive value of lymph node ratio (LNR) for survival and distant metastasis in HPV(+) OPC patients. The results showed that LNR may be a more useful tool than lymph node number in predicting survival and distant metastasis in these patients.
Review
Oncology
Mathieu Struys, Wim Ceelen
Summary: The incidence of locoregional, potentially preventable lymph node recurrence after surgery for colon cancer is low and is not affected by the extent of lymphadenectomy.
Article
Medicine, General & Internal
Jeanne Tie, Joshua D. Cohen, Kamel Lahouel, Serigne N. Lo, Yuxuan Wang, Suzanne Kosmider, Rachel Wong, Jeremy Shapiro, Margaret Lee, Sam Harris, Adnan Khattak, Matthew Burge, Marion Harris, James Lynam, Louise Nott, Fiona Day, Theresa Hayes, Sue-Anne McLachlan, Belinda Lee, Janine Ptak, Natalie Silliman, Lisa Dobbyn, Maria Popoli, Ralph Hruban, Anne Marie Lennon, Nicholas Papadopoulos, Kenneth W. Kinzler, Bert Vogelstein, Cristian Tomasetti, Peter Gibbs
Summary: This study found that using ctDNA results to guide treatment decisions for stage II colon cancer reduced the use of adjuvant chemotherapy without compromising recurrence-free survival.
NEW ENGLAND JOURNAL OF MEDICINE
(2022)
Article
Oncology
Pan Gao, Tianle Zhu, Jingjing Gao, Hu Li, Xi Liu, Xiansheng Zhang
Summary: This study aimed to explore the prognostic value of examined lymph node count and lymph node density in penile cancer patients. The results showed that examined lymph node count and lymph node density were independent prognostic factors for the overall survival of penile cancer patients, with recommended cutoff values of 13 examined lymph nodes and lymph node density >9.3%.
FRONTIERS IN ONCOLOGY
(2021)
Article
Gastroenterology & Hepatology
Hironori Fukuoka, Yosuke Fukunaga, Toshiya Nagasaki, Takashi Akiyoshi, Tsuyoshi Konishi, Satoshi Nagayama, Masashi Ueno
Summary: This study analyzed the patterns of lymph node metastasis in transverse colon cancer and reported the short- and long-term outcomes of different treatment procedures. The results showed differences in lymph node metastasis frequency and pathological vascular invasion rate among different surgical approaches. 5-year overall survival rates and relapse-free survival rates also varied for right hemicolectomy, transverse colectomy, and left hemicolectomy. The only independent prognostic factor for relapse-free survival was lymph node metastasis.
DISEASES OF THE COLON & RECTUM
(2022)