Article
Oncology
Victor Lago, Beatriz Montero, Susana Lopez, Pablo Padilla-Iserte, Luis Matute, Tiermes Marina, Marta Gurrea, Guillermina Montoliu, Pilar Bello, Santiago Domingo
Summary: The objective of this study is to determine the role of sentinel lymph node ultrastaging in apparent early-stage ovarian cancer. The study shows that a uniform protocol for ultrastaging is essential for lower-volume metastasis detection and to provide reproducible information for future studies.
GYNECOLOGIC ONCOLOGY
(2021)
Article
Surgery
Rosemary Nustas, Ahmed A. Messallam, Theresa Gillespie, Steven Keilin, Saurabh Chawla, Vaishali Patel, Qiang Cai, Field F. Willingham
Summary: In a large national cohort in the US, factors such as lymphovascular invasion, high-grade histology, T stage, and tumor size were independently associated with lymph node metastasis in early gastric adenocarcinoma. Patients with low-grade tumors, smaller than 3 cm, and without lymphovascular invasion had a very low risk of nodal involvement, suggesting they may be considered for endoscopic resection.
SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES
(2022)
Article
Medicine, General & Internal
Shimin Yang, Chunli Liu, Chunbo Li, Keqin Hua
Summary: The study aimed to construct a new nomogram based on F-18-FDG PET/CT and clinical characteristics to assess the risk of lymph node metastasis in early-stage cervical cancer patients. The nomogram was validated and showed good accuracy and clinical utility in predicting lymph node metastasis.
FRONTIERS IN MEDICINE
(2022)
Article
Oncology
Feng Li, Suokai Zhai, Li Fu, Lin Yang, Yousheng Mao
Summary: This study aimed to develop nomograms for intraoperative prediction of lymph node metastasis in early-stage lung adenocarcinoma. The nomograms showed good discriminatory performance in predicting lymph node metastasis and N2 lymph node metastasis. Additionally, it was found that there were survival outcome differences between systematic mediastinal lymphadenectomy and limited mediastinal lymphadenectomy for high-risk patients.
Article
Cardiac & Cardiovascular Systems
Keiju Aokage, Kenji Suzuki, Masashi Wakabayashi, Tomonori Mizutani, Aritoshi Hattori, Haruhiko Fukuda, Shun-Ichi Watanabe
Summary: The study aimed to develop a prediction model of pathological lymph node status (PLNS) in peripheral adenocarcinoma with a dominant solid component, based on clinical and radiological factors. The model showed high diagnostic performance in predicting PLNS, successfully identifying patients who could benefit from wedge resection or other local therapies.
EUROPEAN JOURNAL OF CARDIO-THORACIC SURGERY
(2021)
Article
Cell Biology
Bo Dong, Chunli Wu, Lan Huang, Yu Qi
Summary: This study identified the potential role of macrophages in lymph node metastasis, and the macrophage-related gene SPP1 as a potential biomarker for early lymph node metastasis in LUAD. The study also revealed the involvement of a long non-coding RNA (lncRNA, AC037441) in regulating early lymph node metastasis.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Oncology
Xiangyu Zhao, Yuxing Chen, Xiaoqin Sun, Zaoke He, Tao Wu, Chenxu Wu, Jing Chen, Jinyu Wang, Kaixuan Diao, Xue-Song Liu
Summary: This study found that EFNA4, a member of the EPH family, is amplified and up-regulated in lung tumor patients, especially in those with lymph node metastases. Overexpression of EFNA4 promotes lung tumor cell proliferation and migration, while knockdown or knockout of EFNA4 inhibits cell proliferation and migration. These findings suggest that the amplification of the EFNA4 gene may play an oncogenic role in promoting lung cancer lymph node metastasis.
Article
Oncology
Silvia Cabrera, Natalia R. Gomez-Hidalgo, Virginia Garcia-Pineda, Vicente Bebia, Sergi Fernandez-Gonzalez, Paula Alonso, Tomas Rodriguez-Gomez, Pere Fuste, Myriam Gracia-Segovia, Cristina Lorenzo, Enrique Chacon, Fernando Roldan Rivas, Octavio Arencibia, Marina Marti Edo, Soledad Fidalgo, Josep Sanchis, Pablo Padilla-Iserte, Manuel Pantoja-Garrido, Sergio Martinez, Ricard Peiro, Cecilia Escayola, M. Reyes Oliver-Perez, Cristina Aghababyan, Carmen Tauste, Sara Morales, Anna Torrent, Jesus Utrilla-Layna, Francesc Fargas, Ana Calvo, Laura Aller de Pace, Antonio Gil-Moreno
Summary: Our study evaluated the implementation of SLN biopsy in early-stage endometrial cancer patients and its oncologic outcomes. We found that SLN biopsy has a high sensitivity in detecting nodal disease. Patients with negative nodes and low-volume disease had similar oncologic outcomes after tailored adjuvant treatments.
ANNALS OF SURGICAL ONCOLOGY
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Xujie Gao, Tingting Ma, Jingli Cui, Yuwei Zhang, Lingwei Wang, Hui Li, Zhaoxiang Ye
Summary: This study developed and validated a CT-based radiomics model for predicting lymph node metastasis in early stage gastric cancer, showing good performance and clinical utility.
ACADEMIC RADIOLOGY
(2021)
Article
Oncology
Ziyu Zhang, Li Li, Yang Gao, Xiaoxiong Xiao, Liyan Ji, Zhipeng Zhou, Juan Jiang, Shiqing Liu, Jian An, Pengbo Deng, Nannan Du, Pansong Li, Xuefeng Xia, Chengping Hu, Min Li
Summary: We investigated the immune environment in tumor-draining lymph nodes (TDLNs) of non-small cell lung cancer (NSCLC) patients with or without lymph node (LN) metastasis. Our findings suggest that LN metastasis facilitates tumor-specific antigen presentation in TDLNs and induces T cell priming, while existing tumor cells generate an immune-suppressive environment in metastasis-positive LNs.
Article
Medicine, General & Internal
Lei Chen, Funing Yang, Zhaoyan Qi, Jiandong Tai
Summary: Tumor budding (TB), a powerful predictor of colorectal cancer (CRC), was studied to develop a prediction model for lymph node metastasis (LNM) and local recurrence in pT1 CRC patients. Independent predictors for LNM and recurrence were identified and used to construct predictive nomograms for treatment decision-making. The models showed potential clinical application value and postoperative chemotherapy was associated with better outcomes in high-risk patients.
FRONTIERS IN MEDICINE
(2022)
Article
Obstetrics & Gynecology
Ester P. Olthof, Constantijne H. Mom, Malou L. H. Snijders, Hans H. B. Wenzel, Jacobus Velden, Maaike A. Aa
Summary: The number of lymph node metastases and the lymph node ratio have an impact on survival in patients with early-stage cervical cancer. Categorizing patients based on lymph node status can help determine their risk of survival.
ACTA OBSTETRICIA ET GYNECOLOGICA SCANDINAVICA
(2022)
Article
Gastroenterology & Hepatology
Anna Dupree, Hanno Ehlken, Thomas Roesch, Marina Lueken, Matthias Reeh, Yuki B. Werner, Jocelyn de Heer, Guido Schachschal, Till S. Clauditz, Oliver Mann, Jakob R. Izbicki, Stefan Groth
Summary: The study retrospectively reviewed T1 cancer patients undergoing laparoscopic LN sampling after endoscopic resection and found that using the extended LLS technique increased the detection rate of LN. Adverse events were rare, but some patients had LN metastases requiring surgery.
GASTROINTESTINAL ENDOSCOPY
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Meng Jiang, Chang-Li Li, Xiao-Mao Luo, Zhi-Rui Chuan, Rui-Xue Chen, Shi-Chu Tang, Wen-Zhi Lv, Xin-Wu Cui, Christoph F. Dietrich
Summary: A radiomics nomogram based on ultrasound elastography was developed and validated for preoperative assessment of axillary lymph node status in early-stage breast cancer patients. The model showed favorable predictive ability and could provide incremental information for clinical decision-making.
EUROPEAN RADIOLOGY
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Chengzhou Zhang, Liping Wang, Xiaoting Cai, Mengfei Li, Dandan Sun, Ping Wang
Summary: The relationship between tumor and pleura is a risk factor for occult lymph node metastasis (OLNM) in peripheral clinical stage IA solid adenocarcinoma. Patients with type 3 or 4 tumor-pleura relationship are more likely to have visceral pleural invasion and predict OLNM.
EUROPEAN RADIOLOGY
(2023)