Article
Surgery
Hyo-Joon Yang, Moon Kyung Joo, Jae Myung Park, Ji Yong Ahn, Jae-Young Jang, Joo Hyun Lim, Su Youn Nam, Jie-Hyun Kim, Byung-Hoon Min, Wan-Sik Lee, Bong Eun Lee, Woon Geon Shin, Hang Lak Lee, Tae-Geun Gweon, Moo In Park, Jeongmin Choi, Chung Hyun Tae, Young-Il Kim, Keun Won Ryu, Il Ju Choi
Summary: The study developed a six-score prediction model to help predict the likelihood of curative ESD for undifferentiated-type EGC, based on factors such as tumor size and location. This model showed good performance in both the development and validation cohorts, providing valuable information for treatment decision-making.
SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES
(2022)
Article
Gastroenterology & Hepatology
Jiyoung Yoon, Seung-Yeon Yoo, Young Soo Park, Kee Don Choi, Beom Su Kim, Moon-Won Yoo, In Seob Lee, Jeong Hwan Yook, Ga Hee Kim, Hee Kyong Na, Ji Yong Ahn, Jeong Hoon Lee, Kee Wook Jung, Do Hoon Kim, Ho June Song, Gin Hyug Lee, Hwoon-Yong Jung
Summary: This study investigated the prevalence and risk factors of lymph node metastasis (LNM) in undifferentiated early gastric cancer (UD-EGC) cases meeting the expanded indication for endoscopic submucosal dissection (ESD). The results showed that the risk of LNM is higher than expected when using the current expanded indication for UD-EGC. Histological evaluation could provide useful clues for reducing the risk of LNM.
WORLD JOURNAL OF GASTROENTEROLOGY
(2022)
Article
Gastroenterology & Hepatology
Mitsuaki Ishioka, Toshiyuki Yoshio, Yuji Miyamoto, Ken Namikawa, Yoshitaka Tokai, Shoichi Yoshimizu, Yusuke Horiuchi, Akiyoshi Ishiyama, Toshiaki Hirasawa, Tomohiro Tsuchida, Junko Fujisaki
Summary: This study investigated the incidence and characteristics of metachronous cancer after endoscopic submucosal dissection for undifferentiated-type gastric cancer, finding a correlation between Helicobacter pylori infection and metachronous cancer development. The curative resection rate after ESD for undifferentiated-type cancer was significantly lower. Surveillance should be conducted more carefully after ESD for undifferentiated-type cancer, especially in H. pylori-infected patients.
GASTROINTESTINAL ENDOSCOPY
(2021)
Article
Medicine, General & Internal
Dae-Gon Ryu, Su-Jin Kim, Cheol-Woong Choi, Su-Bum Park, Hyeong-Seok Nam, Si-Hak Lee, Sun-Hwi Hwang
Summary: Endoscopic submucosal dissection (ESD) is the preferred treatment for early gastric cancer (EGC) with low risk of lymph node metastasis. Predicting the risk of local recurrence after ESD is crucial for management and prevention. Factors associated with a higher risk of local recurrence include lesion size >= 15 mm, incomplete histologic resection, undifferentiated adenocarcinoma, scar, and the absence of erythema of the surface. Regular endoscopic surveillance is important to predict local recurrence, especially in patients with larger lesions, incomplete histologic resection, surface changes of scars, and no surface erythema.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Surgery
Jeong Ho Song, Sejin Lee, Sung Hyun Park, Anastasios Kottikias, Aleisa Abdulmohsen, Nasser Alrashidi, Minah Cho, Yoo Min Kim, Hyoung-Il Kim, Woo Jin Hyung
Summary: This study suggests that patients with early gastric cancer who meet the surgical indications can be treated with endoscopic submucosal dissection. The location of the tumor, as well as its size and histological features, are key factors in determining whether curative resection can be achieved with ESD.
SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES
(2022)
Article
Medicine, General & Internal
Yu-Lan Gao, Yue-han Zhang, Meng Cao
Summary: This study retrospectively analyzed the preoperative endoscopic evaluation in endoscopic submucosal dissection (ESD) for early gastric cancer and precancerous lesions. Accurate preoperative assessment of lesion type, extent, and depth of invasion is helpful in improving the complete resection rate and reducing the risk of additional surgery in ESD.
Article
Gastroenterology & Hepatology
Waku Hatta, Yosuke Tsuji, Toshiyuki Yoshio, Naomi Kakushima, Shu Hoteya, Hisashi Doyama, Yasuaki Nagami, Takuto Hikichi, Masakuni Kobayashi, Yoshinori Morita, Tetsuya Sumiyoshi, Mikitaka Iguchi, Hideomi Tomida, Takuya Inoue, Tomoyuki Koike, Tatsuya Mikami, Kenkei Hasatani, Jun Nishikawa, Tomoaki Matsumura, Hiroko Nebiki, Dai Nakamatsu, Ken Ohnita, Haruhisa Suzuki, Hiroya Ueyama, Yoshito Hayashi, Mitsushige Sugimoto, Shinjiro Yamaguchi, Tomoki Michida, Tomoyuki Yada, Yoshiro Asahina, Toshiaki Narasaka, Shiko Kuribasyashi, Shu Kiyotoki, Katsuhiro Mabe, Tomohiro Nakamura, Naoki Nakaya, Mitsuhiro Fujishiro, Atsushi Masamune
Summary: A prediction model for bleeding after endoscopic submucosal dissection (ESD) for early gastric cancer (EGC) was developed and externally validated, showing moderately good discrimination and good calibration.
Article
Oncology
Meng Qian, Yuan Sheng, Min Wu, Song Wang, Kaiguang Zhang
Summary: This retrospective case-control study compared the clinical outcomes of endoscopic submucosal dissection (ESD) and surgical resection for early gastric cancer (EGC). After propensity score-matching, the ESD group showed comparable overall survival, disease-specific survival, and recurrence-free survival with the surgery group. The ESD group also had less blood loss, fewer adverse events, lower hospital cost, and a shorter operative time and hospital duration. Therefore, ESD can be considered as a first-line treatment for EGC.
Article
Medicine, General & Internal
Yinuo Zhao, Huogen Wang, Yanyan Fan, Chaohui Jin, Qinwei Xu, Jiyong Jing, Tianqiao Zhang, Xuedong Zhang, Wanyuan Chen
Summary: In this study, we developed a software pipeline named "Pathology Helper" to assist in the construction of high-quality mucosal recovery maps, reducing the workload of endoscopists and pathologists, while accelerating their ability to diagnose EGC.
FRONTIERS IN MEDICINE
(2022)
Review
Oncology
Zhi Zheng, Jie Yin, Xiao-Ye Liu, Xiao-Sheng Yan, Rui Xu, Meng-Yi Li, Jun Cai, Guang-Yong Chen, Jun Zhang, Zhong-Tao Zhang
Summary: The advancement of endoscopic treatment technology has facilitated minimally invasive treatment for EGC, but challenges remain in managing non-curative resection patients, improving clinical staging accuracy, and selecting appropriate treatment methods.
WORLD JOURNAL OF GASTROINTESTINAL ONCOLOGY
(2021)
Article
Gastroenterology & Hepatology
Gil Ho Lee, Eunyoung Lee, Bumhee Park, Jin Roh, Sun Gyo Lim, Sung Jae Shin, Kee Myung Lee, Choong-Kyun Noh
Summary: By comparing the clinical outcomes of ESD and surgery in patients with UD intramucosal EGC, it was found that the ESD group had a shorter hospital stay, but inferior RFS and local recurrence were observed.
WORLD JOURNAL OF GASTROENTEROLOGY
(2022)
Article
Medicine, General & Internal
Mai Murakami, Takuto Hikichi, Jun Nakamura, Minami Hashimoto, Tsunetaka Kato, Ryoichiro Kobashi, Takumi Yanagita, Rei Suzuki, Mitsuru Sugimoto, Yuki Sato, Hiroki Irie, Mika Takasumi, Tadayuki Takagi, Yuko Hashimoto, Masao Kobayakawa, Hiromasa Ohira
Summary: ESD is an effective and safe treatment for patients with early gastric cancers in the remnant stomach, even when suture line involvement is present.
Article
Oncology
Ji Eun Na, Hyuk Lee, Yang Won Min, Byung-Hoon Min, Jun Haeng Lee, Poong-Lyul Rhee, Kyoung-Mee Kim, Jae J. Kim
Summary: Primary endoscopic submucosal dissection is clinically feasible and oncologically safe for cT1bN0M0 gastric cancer, with a high curative resection rate. It can potentially eliminate unnecessary surgery and further management can be based on post-procedure pathology results.
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
(2021)
Article
Gastroenterology & Hepatology
Linda S. Yang, Andrew C. F. Taylor, Alexander J. Thompson, Paul Desmond, Bronte A. Holt
Summary: This study analyzed 1217 gastric cancer cases reported to the Victorian Cancer Registry between 2011 and 2016, finding that 20% of cases met histological criteria for early gastric cancer suitable for ESD. The majority of EGC cases met criteria for ESD, yet 86% of actual treatments involved surgery. Systems should be implemented to improve training, accreditation, and access to ESD in order to increase its utilization.
JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY
(2021)
Review
Gastroenterology & Hepatology
Mitsuru Esaki, Eikichi Ihara, Takuji Gotoda
Summary: ESD is a less invasive local treatment for early gastric cancer, but technically difficult, especially for larger and more invasive lesions. Complete resection and accurate histological assessment of EGC lesions are essential for evaluating endoscopic curability. Understanding the features of each endoscopic instrument and technique is crucial for successful and safe ESD procedures.
EXPERT REVIEW OF GASTROENTEROLOGY & HEPATOLOGY
(2021)
Article
Gastroenterology & Hepatology
Joon Seop Lee, Hyun Seok Lee, Byung Ik Jang, Eun Soo Kim, Sung Kook Kim, Kyeong Ok Kim, Yoo Jin Lee, Hyun Jik Lee, Eun Young Kim, Yun Jin Lung, Chang Heon Yang
Summary: The study found that approximately one-third of newly diagnosed IBD Asian patients had low BMD. Clinical factors associated with low BMD included a high level of alkaline phosphatase in UC patients and being underweight in CD patients.
DIGESTIVE DISEASES AND SCIENCES
(2021)
Article
Gastroenterology & Hepatology
Jung Won Jeon, Soo Jin Kim, Jae Young Jang, Sun-Moon Kim, Chul-Hyun Lim, Jae Myung Park, Su Jin Hong, Chan Gyoo Kim, Seong Woo Jeon, Si Hyung Lee, Jae Kyu Sung, Gwang Ho Baik
Summary: This study evaluates the clinical outcomes of endoscopic resection for gastric low-grade dysplasia and high-grade dysplasia diagnosed on forceps biopsy, and identifies factors predicting pathologic upstaging to gastric cancer. Factors such as Helicobacter pylori infection, smoking history, tumor characteristics, and location in the stomach are significantly associated with the development of gastric cancer in patients with dysplasia. Increasing number of risk factors predicting GC on pretreatment biopsy correlates with higher rates of upstaging to GC after endoscopic resection.
Review
Gastroenterology & Hepatology
Kyeong Ok Kim, Eun Young Kim
Summary: The use of artificial intelligence in colonoscopy has shown improved detection of colorectal polyps and shorter analysis time. By combining AI technology, higher diagnostic accuracy in predicting pathology and cellular diagnosis in real-time can be achieved, leading to enhanced colonoscopy efficiency. More prospective studies with minimized selection bias, standardized utilization consensus, and regulatory approval are needed for AI application in daily clinical practice.
Article
Gastroenterology & Hepatology
Joon Seop Lee, Seong Woo Jeon, Hyun Seok Lee, Yong Hwan Kwon, Su Youn Nam, Han Ik Bae, An Na Seo
Summary: The study demonstrated that administration of rebamipide improved atrophic gastritis and intestinal metaplasia in the antrum, especially in patients with Helicobacter pylori non-infection.
DIGESTIVE DISEASES AND SCIENCES
(2022)
Article
Gastroenterology & Hepatology
Eun Soo Kim, Kyeong Ok Kim, Byung Ik Jang, Eun Young Kim, Yoo Jin Lee, Hyun Seok Lee, Joon Seop Lee, Sung Kook Kim, Yun Jin Jung, Sang-Bum Kang, Manasi Agrawal, Ryan Ungaro, Jean-Frederic Colombel
Summary: After propensity score matching, the colectomy rate within 1 year after ASUC was lower in Korea compared to the USA, with no significant differences in other outcomes between the two groups.
DIGESTIVE DISEASES AND SCIENCES
(2022)
Article
Gastroenterology & Hepatology
Su Youn Nam, Sang Won Lee, Seong Woo Jeon, Yong Hwan Kwon
Summary: The study found that sodium alginate can relieve epigastric pain/soreness after EGD with biopsy. The treatment group showed decreased scores for acid regurgitation and epigastric soreness, while there were no significant improvements in the control group.
Article
Gastroenterology & Hepatology
Eun Young Kim
CLINICAL ENDOSCOPY
(2021)
Review
Gastroenterology & Hepatology
Dong Wook Lee, Eun Young Kim
Summary: The scope of endoscopic management for pancreatobiliary malignancies is expanding, including early detection, characterization, staging, and palliative therapy. Endoscopic management provides similar efficacy to surgical management with less morbidity.
DIGESTIVE DISEASES AND SCIENCES
(2022)
Article
Gastroenterology & Hepatology
Hyeong Ho Jo, Eun Young Kim, Jin Tae Jung, Joong Goo Kwon, Eun Soo Kim, Hyun Seok Lee, Yoo Jin Lee, Kyeong Ok Kim, Byung Ik Jang
Summary: Fecal calprotectin levels in patients with intestinal tuberculosis decreased significantly after one month of therapeutic anti-tubercular trial, and all patients achieved FC levels below 100 μg/g after one month of TATT.
CLINICAL ENDOSCOPY
(2022)
Article
Gastroenterology & Hepatology
Joon Seop Lee, Seong Woo Jeon, Yong Hwan Kwon
Summary: The study compared the diagnostic accuracy of NBI and i-scan for predicting histology of intermediate-to-large colorectal polyps, finding similar results between the two modalities. When using the JNET classification, both NBI and i-scan showed acceptable inter-/intra-observer agreement.
CLINICAL ENDOSCOPY
(2021)
Article
Gastroenterology & Hepatology
Sun Moon Kim, Eun Young Kim, Jin Woong Cho, Seong Woo Jeon, Ji Hyun Kim, Tae Hyeon Kim, Jeong Seop Moon, Jin-Oh Kim
Summary: By utilizing EUS, it is possible to effectively differentiate between gastric GISTs and leiomyomas. The study findings suggest that by considering patient age, sex, and four EUS factors, a predictive model and nomogram can be developed to assist in the accurate differentiation between the two conditions. The ROC curve analysis demonstrated the discriminative performance of the predictive model.
CLINICAL ENDOSCOPY
(2021)
Article
Gastroenterology & Hepatology
Kyeong Ok Kim, Eun Young Kim, Yoo Jin Lee, Hyun Seok Lee, Eun Soo Kim, Yun Jin Chung, Byung Ik Jang, Sung Kook Kim, Chang Heon Yang
Summary: The study evaluated the effectiveness, safety, and tolerability of a novel oral sulphate tablet compared to polyethylene glycol and ascorbate in patients with inflammatory bowel disease. The novel tablet showed higher cleansing effectiveness and satisfaction, indicating its potential as an effective and safe option for patients with inactive IBD.
JOURNAL OF CROHNS & COLITIS
(2022)
Article
Gastroenterology & Hepatology
Myeongseok Koh, Jong Yoon Lee, Song-Hee Han, Seong Woo Jeon, Su Jin Kim, Joo Young Cho, Seong Hwan Kim, Jae Young Jang, Gwang Ho Baik, Jin Seok Jang
Summary: This study aimed to compare the efficacy of I-SCAN-optical enhancement (I-SCAN-OE) versus chromoendoscopy in evaluating the horizontal margins of gastric epithelial neoplasms, and the results showed no significant difference in delineation scores between the two methods.
Article
Gastroenterology & Hepatology
Hyo-Joon Yang, Young-Il Kim, Ji Yong Ahn, Kee Don Choi, Sang Gyun Kim, Seong Woo Jeon, Jie-Hyun Kim, Sung Kwan Shin, Hyuk Lee, Wan Sik Lee, Gwang Ha Kim, Jae Myung Park, Woon Geon Shin, Il Ju Choi
Summary: This study validated the effectiveness of the eCura system in undifferentiated-type early gastric cancer, and found that close follow-up without additional treatment can be considered for low-risk patients, while additional surgery is recommended for intermediate- and high-risk patients.
Article
Infectious Diseases
Su Youn Nam, Seong Woo Jeon, Deuk Kju Jung, Sung-Jae Heo
Summary: This study aimed to determine factors affecting serum levels of anti-SARS-CoV-2 antibodies in young and middle aged healthy adults 2 months after COVID-19 vaccination. The study found an inverse correlation between antibody levels and weight and BMI.
INFECTION AND CHEMOTHERAPY
(2022)