Review
Radiology, Nuclear Medicine & Medical Imaging
Guang-Peng Zhou, Yi-Zhou Jiang, Li-Ying Sun, Zhi-Jun Zhu
Summary: Early transjugular intrahepatic portosystemic shunt (TIPS) placement in cirrhotic patients with acute variceal bleeding (AVB) has shown to significantly reduce mortality, control bleeding, and prevent rebleeding without increasing the risk of hepatic encephalopathy. The survival benefit of early TIPS was observed in high-risk patients, supporting its wider utilization in clinical practice.
EUROPEAN RADIOLOGY
(2021)
Article
Gastroenterology & Hepatology
Li Ma, Jingqin Ma, Wen Zhang, Qingxin Liu, Zihan Zhang, Minjie Yang, Jiaze Yu, Xin Zhou, Shiyao Chen, Jian Wang, Jianjun Luo, Zhiping Yan
Summary: In cirrhotic patients with variceal bleeding, delayed PPG has a higher predictive power for variceal rebleeding than immediate PPG.
HEPATOLOGY INTERNATIONAL
(2023)
Article
Multidisciplinary Sciences
Yang Chen, Chongtu Yang, Songjiang Huang, Jiacheng Liu, Yingliang Wang, Chen Zhou, Tongqiang Li, Chaoyang Wang, Shuguang Ju, Yaowei Bai, Wei Yao, Bin Xiong
Summary: Thrombocytopenia, the most frequent hematologic disorder in cirrhosis patients, is perceived as a contributing factor for bleeding events. However, this study found no statistically significant difference in bleeding rates after TIPS between the normal platelet count group and the thrombocytopenia group. Platelet count was not associated with bleeding events after TIPS, suggesting that thrombocytopenia should not be considered an absolute contraindication for TIPS in cirrhosis patients.
SCIENTIFIC REPORTS
(2023)
Review
Gastroenterology & Hepatology
Yong Lv, Daiming Fan, Guohong Han
Summary: Liver diseases, especially viral hepatitis, have a major impact in China and globally. Portal hypertension is the most severe complication of chronic liver diseases, and TIPS is an effective treatment for these complications. This review focuses on the history, current application, and management of TIPS complications in China.
LIVER INTERNATIONAL
(2023)
Article
Medicine, General & Internal
Yonghua Bi, Jianzhuang Ren, Xinwei Han, Kefeng Guo, Xueliang Tu
Summary: This study compared the safety and efficacy of cTIPS and TIPS in cirrhotic patients with CTPV after conventional TIPS failure. Retrospective analysis of cirrhotic patients diagnosed with CTPV and treated with cTIPS or TIPS was conducted. The clinical outcomes, long-term survival rates, and patency rates were compared between the two groups. cTIPS was found to be safe and effective in these patients.
Article
Gastroenterology & Hepatology
Yong Lu, Hui Chen, Bohan Luo, Wei Bai, Kai Li, Zhengyu Wang, Dongdong Xia, Wengang Guo, Qiuhe Wang, Xiaomei Li, Jie Yuan, Hongwei Cai, Jielai Xia, Zhanxin Yin, Daiming Fan, Guohong Han
Summary: This study compared the efficacy and safety of interventional treatment and medication treatment for hepatic encephalopathy and found that both treatments were equally effective with no significant difference in adverse events.
LANCET GASTROENTEROLOGY & HEPATOLOGY
(2022)
Article
Gastroenterology & Hepatology
Wei-Li Qi, Jun Wen, Tian-Fu Wen, Wei Peng, Xiao-Yun Zhang, Jun-Yi Shen, Xiao Li, Chuan Li
Summary: Portal hypertension combined with esophagogastric variceal bleeding is a serious complication in patients with hepatitis B virus-related cirrhosis in China. Splenectomy plus pericardial devascularization and transjugular intrahepatic portosystemic shunt are effective treatments for this complication. This study compared the effectiveness and safety of these two treatment methods.
WORLD JOURNAL OF GASTROINTESTINAL SURGERY
(2023)
Review
Medicine, General & Internal
Sasidharan Rajesh, Shobhit Singh, Cyriac Abby Philips
Summary: This article provides a concise yet comprehensive overview of the role and placement scenarios of TIPS in patients with chronic non-malignant PVT, with or without underlying liver disease, supported by exemplary instances from the authors' experience.
Review
Gastroenterology & Hepatology
Hae Lim Lee, Sung Won Lee
Summary: Transjugular intrahepatic portosystemic shunt (TIPS) is an effective intervention to relieve portal hypertension and its complications. Careful patient selection and assessment can lead to excellent outcomes despite potential adverse events after TIPS implementation.
CLINICAL AND MOLECULAR HEPATOLOGY
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Huzheng Yan, Zhanwang Xiang, Chenghao Zhao, Shuyang Luo, Huan Liu, Mingan Li, Mingsheng Huang
Summary: This study proposed a strategy for creating a 6-mm TIPS and assessed its effectiveness compared to a conventional 8-mm shunt for TIPS-induced hepatic encephalopathy. The results showed that the 6-mm shunt significantly reduced the incidence of overt HE, protected perioperative liver function, and did not affect stent patency or rebleeding rate.
EUROPEAN RADIOLOGY
(2023)
Article
Medicine, General & Internal
Hong-Liang Wang, Wei-Jie Lu, Yue-Lin Zhang, Chun-Hui Nie, Tan-Yang Zhou, Guan-Hui Zhou, Tong-Yin Zhu, Bao-Quan Wang, Sheng-Qun Chen, Zi-Niu Yu, Li Jing, Jun-Hui Sun
Summary: This study found that the presence or absence of portal vein thrombosis did not affect the survival rate or incidence of shunt dysfunction in cirrhosis patients undergoing TIPS treatment. Risk factors for mortality included age, MELD score, and refractory ascites.
FRONTIERS IN MEDICINE
(2021)
Review
Gastroenterology & Hepatology
Sern Wei Yeoh, Hong Kuan Kok
Summary: The use of TIPSS in patients with PVT is becoming more common and has shown positive outcomes. While technically challenging, TIPSS can effectively reduce portal hypertensive complications in PVT patients and should no longer be considered a contraindication. High-volume specialist centers are recommended for performing TIPSS in PVT patients to minimize procedural risks.
JOURNAL OF DIGESTIVE DISEASES
(2021)
Article
Urology & Nephrology
Ayah Megahed, Todd Schlachter, Joshua Cornman-Homonoff
Summary: This article discusses a rare case of varicocele related to portal hypertension, emphasizing the complexity of imaging workup and intervention in such cases.
Article
Gastroenterology & Hepatology
Junyang Luo, Mingan Li, Chun Wu, Duo Zhu, Haofan Wang, Mingsheng Huang, Zaibo Jiang
Summary: For patients with hepatocellular carcinoma, transjugular intrahepatic portosystemic shunt (TIPS) has been shown to reduce the risk of variceal rebleeding compared to endoscopic therapy (ET). However, TIPS did not significantly improve long-term survival. The study found that locoregional therapies for HCC were safe after effective prevention of variceal rebleeding in TIPS group.
EUROPEAN JOURNAL OF GASTROENTEROLOGY & HEPATOLOGY
(2021)
Article
Surgery
Wenyue Wu, Fuming Zhang, Xuecan Mei, Qianqian Zhang, Jing Jin, Derun Kong
Summary: This study compared the effectiveness of balloon-compression endoscopic injection sclerotherapy (bc-EIS) with transjugular intrahepatic portosystemic shunt (TIPS) in preventing rebleeding after esophageal variceal bleeding. The results showed that bc-EIS is not inferior to TIPS in terms of survival and rebleeding control, but it is associated with a lower risk of hepatic encephalopathy and liver dysfunction.
SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES
(2023)
Article
Immunology
Y. Lin, L. Cheng, Y. Liu, Y. Wang, Q. Wang, H. L. Wang, G. Shi, J. S. Li, Q. N. Wang, Q. M. Yang, S. Chen, X. L. Su, Y. Yang, M. Jiang, X. Hu, P. Fan, C. Fang, Z. G. Zhou, L. Dai, H. X. Deng
Summary: The study showed that BATF3 plays a role in colitis and colitis-associated colon cancer, promoting the occurrence and development of CAC through induction of inflammatory stimulation, and playing a key role in recruiting neutrophils.
MUCOSAL IMMUNOLOGY
(2021)
Article
Oncology
Linping Lei, Xuqin Xie, Long He, Keling Chen, Zhaoying Lv, Bin Zhou, Yuan Li, Wenjun Hu, Zongguang Zhou
Summary: Camptothecin and its derivatives are potent anticancer drugs, but have associated side effects. Combining BET inhibitor JQ1 with Camptothecin can effectively reduce side effects and exhibit antitumor effects.
INVESTIGATIONAL NEW DRUGS
(2021)
Article
Surgery
Kai Liu, Xin-Zu Chen, Yu-Chen Zhang, Wei-Han Zhang, Xiao-Long Chen, Li-Fei Sun, Kun Yang, Bo Zhang, Zong-Guang Zhou, Jian-Kun Hu
Summary: The study suggests that spleen-preserving splenic hilar lymph node dissection should be considered as an essential procedure in patients undergoing total gastrectomy for gastric cancer to improve survival outcomes.
Article
Surgery
Hua Yang, Wei-Han Zhang, Kai Liu, Yu-Qing Dan, Xin-Zu Chen, Kun Yang, Zhi-Xin Chen, Jia-Ping Chen, Zong-Guang Zhou, Jian-Kun Hu
Summary: This study aimed to compare the effectiveness of clockwise modularized laparoscopic lymphadenectomy with traditional open surgery in gastric cancer patients. The results showed that the CML group had more examined lymph nodes, less intraoperative blood loss, and a longer surgical duration compared to the OG group, but similar rates of postoperative complications and postoperative hospital stay.
SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES
(2021)
Review
Oncology
Kun Yang, Zhi-Yun Zang, Kai-Fan Niu, Li-Fei Sun, Wei-Han Zhang, Yue-Xin Zhang, Xiao-Long Chen, Zong-Guang Zhou, Jian-Kun Hu
Summary: This meta-analysis found that splenectomy does not increase overall survival rate or postoperative mortality for gastric cancer patients, but it significantly raises the incidence of postoperative complications.
FRONTIERS IN ONCOLOGY
(2021)
Article
Gastroenterology & Hepatology
Hai-Ning Chen, Yang Shu, Fei Liao, Xue Liao, Hongying Zhang, Yun Qin, Zhu Wang, Maochao Luo, Qiuluo Liu, Zhinan Xue, Minyuan Cao, Shouyue Zhang, Wei-Han Zhang, Qianqian Hou, Xuyang Xia, Han Luo, Yan Zhang, Lie Yang, Jian-Kun Hu, Xianghui Fu, Bo Liu, Hongbo Hu, Canhua Huang, Yong Peng, Wei Cheng, Lunzhi Dai, Li Yang, Wei Zhang, Biao Dong, Yuan Li, Yuquan Wei, Heng Xu, Zong-Guang Zhou
Summary: The study provides insights into the genomic evolution and metastatic patterns of colorectal cancer, suggesting that biopsy/sequencing of metastases should be considered for patients with multiorgan or late postoperative metastasis.
Article
Gastroenterology & Hepatology
Xuyang Yang, Chaoyang Gu, Tao Hu, Mingtian Wei, Wenjian Meng, Ziqiang Wang, Xiangbing Deng, Zongguang Zhou
Summary: Selective lateral lymph node dissection (sLLND) is important for rectal cancer patients, with the pretreatment maximum short-axis diameter of lateral lymph node (>= 8 mm) being a crucial indication for the procedure. Patients with lateral lymph node metastasis (LLNM) have worse prognosis compared to those without LLNM.
TECHNIQUES IN COLOPROCTOLOGY
(2021)
Article
Medicine, General & Internal
Wenhan Wu, Zongguang Zhou
Summary: This study developed and validated prediction models for predicting hospital death in patients with AMI using traditional statistics and machine learning. The machine learning model showed better clinical utility and accuracy compared to the traditional statistics prediction model, suggesting that a combined nomogram-machine learning predictive model may improve care for AMI patients.
INTERNATIONAL JOURNAL OF GENERAL MEDICINE
(2021)
Article
Cell Biology
Jiyan Yuan, Zeliang Wei, Guang Xin, Xubao Liu, Zongguang Zhou, Yi Zhang, Xiuxian Yu, Chengyu Wan, Qingqiu Chen, Weiyu Zhao, Xueling Wang, Yuman Dong, Zhen Chen, Xiaoting Chen, Hai Niu, Wen Huang
Summary: The study showed that VB12 protects against acute pancreatitis through the CBS/SIRT1 pathway, highlighting the potential for improving pancreatic damage.
OXIDATIVE MEDICINE AND CELLULAR LONGEVITY
(2021)
Review
Oncology
Haoyan Wu, Chuanwen Fan, Chao Fang, Libin Huang, Yuan Li, Zongguang Zhou
Summary: The addition of consolidation chemotherapy to preoperative short-course radiotherapy can enhance pathologic response in locally advanced rectal cancer, without increasing toxicity. Short-course radiotherapy followed by consolidation chemotherapy is recommended as a neoadjuvant treatment option for locally advanced rectal cancer.
RADIATION ONCOLOGY
(2022)
Article
Oncology
Rui Ge, Kai Liu, Weihan Zhang, Kun Yang, Xiaolong Chen, Linyong Zhao, Zongguang Zhou, Jiankun Hu
Summary: This study evaluated the safety and feasibility of laparoscopic gastrectomy for locally advanced gastric cancer after neoadjuvant chemotherapy. The results showed that laparoscopic assisted gastrectomy resulted in less intraoperative blood loss and shorter postoperative hospital stays compared to traditional open gastrectomy. There were no significant differences in operative duration, number of harvested lymph nodes, and postoperative complication rates between the two groups.
JOURNAL OF ONCOLOGY
(2022)
Article
Medicine, Research & Experimental
Chunqi Liu, Liang Wang, Xiaocong Liu, Yuping Tan, Lei Tao, Yuzhou Xiao, Pengchi Deng, Huijuan Wang, Qianyi Deng, Yiyun Lin, Hui Jie, Huaqin Zhang, Jing Zhang, Yong Peng, Hu Zhang, Zongguang Zhou, Qingxiang Sun, Xiaobo Cen, Yinglan Zhao
Summary: The study revealed a novel nonmetabolic function of SHMT2 in stabilizing beta-catenin to prevent its ubiquitylation-mediated degradation, providing a potential therapeutic strategy for colorectal cancer therapy.
Article
Surgery
Shiwei Yang, Bing Wu, Yong Wang, Lie Yang, Wenqin Luo, Wenzhang Lei, Zongguang Zhou
Summary: The study demonstrates a simple and safe UHS mesh technique for repairing medium ventral hernia defects, showing high surgical success rate and few postoperative complications.
Article
Surgery
Tao Pan, Hui Wang, Kai Liu, Xin-zu Chen, Wei-han Zhang, Xiao-long Chen, Kun Yang, Bo Zhang, Zong-guang Zhou, Jian-kun Hu
Summary: The study found that closure of Petersen's defect significantly decreased the rates of Petersen's hernia and suspected Petersen's hernia after gastrectomy for gastric cancer, suggesting that PD closure is recommended for reducing the risk of these complications.
LANGENBECKS ARCHIVES OF SURGERY
(2021)
Article
Nanoscience & Nanotechnology
Wen Kai Liu, Yuan Qing Song, Yan Ma, Xin Li, Peng Chen, Feng Luo, Jie Hua Li, Zhen Li, Lie Yang, Hong Tan, Zong Guang Zhou
Summary: A series of PEGylated active carbon nanoparticles with improved dispersity in water were prepared for potential application in lymphatic targeted tracing and chemotherapy of colorectal cancer. These nanoparticles were able to achieve improved stability, solubility, and drug loading properties, showing promising efficacy in killing cancer cells and serving as drug carriers for targeted therapy without the need for suspending agents.
JOURNAL OF NANO RESEARCH
(2021)