Article
Surgery
L. J. X. Giesen, J. W. T. Dekker, M. Verseveld, R. M. P. H. Crolla, G. P. van der Schelling, C. Verhoef, P. B. Olthof
Summary: A study conducted in the Netherlands shows that the use of robot-assisted surgery for rectal cancer resections is increasing. While the conversion rate is lower in the robot-assisted surgery group, the proportion of defunctioning ileostomies is higher, and overall outcomes are comparable to laparoscopic surgery.
SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES
(2023)
Article
Gastroenterology & Hepatology
Ziwei Zeng, Zhihang Liu, Liang Huang, Huashan Liu, Haiqing Jie, Shuangling Luo, Xingwei Zhang, Liang Kang
Summary: The study compared the learning curves and outcomes of transanal total mesorectal excision with laparoscopic total mesorectal excision, finding that in different phases of the learning curve, operative time, intraoperative blood loss, and postoperative stay were significantly lower in the transanal group, with similar short-term and histopathologic outcomes between the two groups.
DISEASES OF THE COLON & RECTUM
(2021)
Review
Health Care Sciences & Services
Simona Giuratrabocchetta, Giampaolo Formisano, Adelona Salaj, Enrico Opocher, Luca Ferraro, Francesco Toti, Paolo Pietro Bianchi
Summary: Minimally invasive treatment of rectal cancer with Total Mesorectal Excision is complex and challenging, with robotic surgery offering advantages in dexterity but cost and benefits still need further evaluation.
JOURNAL OF PERSONALIZED MEDICINE
(2021)
Article
Surgery
Jung Kyong Shin, Hee Cheol Kim, Seong Hyeon Yun, Yoon Ah Park, Yong Beom Cho, Jung Wook Huh, Woo Yong Lee
Summary: Both transanal total mesorectal excision (taTME) and robotic total mesorectal excision (R-TME) have similar short-term outcomes for patients with rectal cancer after undergoing neoadjuvant chemoradiation. High quality total mesorectal excision can be equally achieved with both transanal and robotic approaches.
SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES
(2021)
Article
Surgery
Jingqing Ren, Shaojie Liu, Huixing Luo, Bailin Wang, Fan Wu
Summary: There was no significant difference in short-term efficacy between TaTME and LaTME for low rectal cancer, but TaTME had a longer operation time and a greater circumferential resection margin distance.
ASIAN JOURNAL OF SURGERY
(2021)
Article
Surgery
Ziwei Zeng, Zhihang Liu, Shuangling Luo, Zhenxing Liang, Liang Huang, Lei Ruan, Junji Chen, Haiqing Jie, Wenfeng Liang, Huashan Liu, Liang Kang
Summary: There were no significant differences in the 3-year local recurrence rate between the taTME and laTME groups. Additionally, the disease-free survival and overall survival rates within 3 years after surgery were also similar between the two groups.
SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES
(2022)
Article
Oncology
Fengming Xu, Yiqiao Zhang, Jiafu Yan, Bowen Xu, Guocong Wu, Zhengyang Yang, Liting Sun, Xiao Zhang, Hongwei Yao, Zhongtao Zhang
Summary: This study evaluated the learning curve of transanal total mesorectal excision (taTME) in patients with mid-low rectal cancer. The results showed that surgeons require approximately 42, 75, and 68 cases to achieve proficiency and mastery in total operative time, postoperative complications, and anastomotic leakage, respectively.
WORLD JOURNAL OF SURGICAL ONCOLOGY
(2022)
Review
Medicine, General & Internal
Giampaolo Formisano, Luca Ferraro, Adelona Salaj, Simona Giuratrabocchetta, Gaetano Piccolo, Giulia Di Raimondo, Paolo Pietro Bianchi
Summary: Robotic surgery offers significant advantages for treating extraperitoneal rectal cancer compared to conventional laparoscopy. Robotic anterior resection (RAR) can overcome the technical challenges of laparoscopic total mesorectal excision (TME) and provide high-quality surgery with favorable oncological outcomes. Recent data show that RAR offers clinical and oncological benefits for difficult TMEs, such as low and advanced rectal tumors, in terms of complication rate, specimen quality, recurrence rate, and survival.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Surgery
Roberto Persiani, Annamaria Agnes, Francesco Belia, Domenico D'Ugo, Alberto Biondi
Summary: TaTME surgery requires 71 cases to master mOT, 55-69 cases for MCs and reoperation, and 27 cases for AL. Attention should be paid during the first part of the learning curve to avoid an increased rate of MCs and AL.
SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES
(2021)
Article
Medicine, General & Internal
Antonio Caycedo-Marulanda, Lawrence Lee, Sami A. Chadi, Chris P. Verschoor, Jordan Crosina, Shady Ashamalla, Carl J. Brown
Summary: The study found that transanal TME performed by experienced surgeons had a low incidence of local recurrence and systemic recurrence, suggesting it may be an acceptable approach for rectal cancer management.
Article
Oncology
Bo Tang, Tao Li, Gengmei Gao, Jun Shi, Taiyuan Li
Summary: This study assessed the learning curve of robotic-assisted total mesorectal excision for rectal cancer and its impact on long-term oncologic outcomes. The results showed that surgical outcomes improved after 36 cases, and the learning curve seemingly did not have an obvious impact on long-term oncologic outcomes.
FRONTIERS IN ONCOLOGY
(2022)
Review
Multidisciplinary Sciences
Yinyin Guo, Yichen Guo, Yanxin Luo, Xia Song, Hui Zhao, Laiyuan Li
Summary: A meta-analysis comparing pathologic outcomes of robotic rectal surgery (RRS) and open rectal surgery (ORS) for rectal cancer found no significant difference in terms of CRM positivity, number of harvested lymph nodes, complete TME rates, and DRM length, indicating equivalent outcomes between the two surgical approaches.
Article
Surgery
Po-Jung Chen, Wei-Chih Su, Tsung-Kun Chang, Yen-Cheng Chen, Ching-Chun Li, Tzu-Chieh Yin, Hsiang-Lin Tsai, Cheng-Jen Ma, Ching-Wen Huang, Jaw-Yuan Wang
Summary: This study examined the oncological outcomes of patients with rectal cancer undergoing robotic-assisted total mesorectal excision (TME) after neoadjuvant concurrent chemoradiotherapy (CCRT). Results showed that robotic-assisted TME is safe and effective for treating stage II-III rectal cancer patients, with acceptable short-term oncological outcomes. It may be considered as a therapeutic alternative for salvage surgery in T4 tumors invading adjacent organs.
ASIAN JOURNAL OF SURGERY
(2021)
Review
Health Care Sciences & Services
Fabio Rondelli, Alessandro Sanguinetti, Andrea Polistena, Stefano Avenia, Claudio Marcacci, Graziano Ceccarelli, Walter Bugiantella, Michele De Rosa
Summary: Total mesorectal excision is the gold standard technique for rectal cancer surgery, while the transanal approach to the mesorectum was introduced to overcome technical difficulties related to distal rectal dissection. Research shows that this approach is most beneficial for patients with mid-low rectal cancer and is safe and feasible, with oncological and functional outcomes comparable to traditional approaches.
JOURNAL OF PERSONALIZED MEDICINE
(2021)
Article
Surgery
Vicente Simo, Patricia Tejedor, Luis Miguel Jimenez, Cristina Hernan, Jaime Zorilla, Jorge Arrredondo, Fernando Lapuente, Carlos Pastor
Summary: This study evaluated the mid-term oncological impact of TaTME for treating rectal cancer and showed positive outcomes at 2 years of follow-up. However, there is a lack of evidence in the literature regarding TaTME and oncological outcomes.
SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES
(2021)
Article
Surgery
Youngbae Jeon, Kyoung-Won Han, Won-Suk Lee, Jeong-Heum Baek
Summary: This study evaluated the clinical outcomes of surgical treatment for nonagenarian patients with colorectal cancer, showing that surgery can be considered in carefully selected patients due to better overall survival compared to nonsurgical treatment.
Article
Biochemistry & Molecular Biology
Jaekyung Jung, Yeon-Hwa Lee, Xizhu Fang, Su-Jung Kim, Seong Hoon Kim, Do-Hee Kim, Na-Young Song, Hye-Kyung Na, Jeong-Heum Baek, Young-Joon Surh
Summary: IL-1β-induced upregulation of SIRT1 stimulates the production of proinflammatory cytokines via nuclear accumulation of c-Jun, leading to the growth and progression of colon cancer.
ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS
(2021)
Article
Biochemistry & Molecular Biology
Ha-Na Lee, Yeon-Seo Choi, Seong Hoon Kim, Xiancai Zhong, Wonki Kim, Joon Sung Park, Soma Saeidi, Byung Woo Han, Nayoung Kim, Hye Seung Lee, Yoon Jin Choi, Jeong-Heum Baek, Hye-Kyung Na, Young-Joon Surh
Summary: The research reveals a decreased level of RvD1 in blood from colorectal cancer patients and mice with inflammation-induced colon cancer, and demonstrates that RvD1 can protect against colorectal carcinogenesis by suppressing IL-6-mediated chromosomal instability. Additionally, RvD1 inhibits the STAT3 signaling pathway by blocking the IL-6 receptor, suggesting a potential novel function of RvD1 as an IL-6R antagonist that may contribute to inhibiting tumorigenesis.
Article
Optics
Jin Woo Baik, Hyojin Kim, Myeongjoo Son, Junwon Choi, Kwang Gi Kim, Jeong Heum Baek, Yeon Ho Park, Jungsuk An, Hae Young Choi, Seon Young Ryu, Jin Young Kim, Kyunghee Byun, Chulhong Kim
Summary: This study demonstrates a novel label-free high-speed reflection-mode ultraviolet photoacoustic microscopy (UV-PAM) system for intraoperative histopathology, showcasing its potential as an alternative method with minimal tissue preparation processes. The system shows promise for quick and accurate tumor margin identification in cancer resection surgeries.
LASER & PHOTONICS REVIEWS
(2021)
Article
Oncology
Jeong-Heum Baek, Youngbae Jeon, Kyoung-Won Han, Dong Hae Jung, Kyung-Ok Kim
Summary: The study evaluated the effect of mistletoe extract on tumor responses in rectal cancer patients undergoing neoadjuvant chemoradiotherapy. Patients treated with mistletoe extract showed better outcomes in terms of tumor responses, indicating potential efficacy in improving oncologic outcomes. Further prospective and randomized studies are needed to confirm and extend these results.
WORLD JOURNAL OF SURGICAL ONCOLOGY
(2021)
Article
Oncology
Yeon-Hwa Lee, Su-Jung Kim, Xizhu Fang, Na-Young Song, Do-Hee Kim, Jinyoung Suh, Hye-Kyung Na, Kyung-Ok Kim, Jeong-Heum Baek, Young-Joon Surh
Summary: SIRT1 and its phosphorylated form at serine 27 are upregulated in colon cancer patients' tissues and cells. The phosphorylated form of SIRT1 regulates the activity of Snail and transcription of interleukin by deacetylation, promoting the proliferation and tumor formation of colon cancer cells.
MOLECULAR ONCOLOGY
(2022)
Article
Oncology
So-Yeon Park, Jee-Heun Kim, Jang-Hyun Choi, Choong-Jae Lee, Won-Jae Lee, Sehoon Park, Zee-Yong Park, Jeong-Heum Baek, Jeong-Seok Nam
Summary: This study highlights the important role of lipid rafts (LRs) in colorectal cancer, where an LR-disrupting alkylphospholipid drug can suppress CSC populations and their self-renewal activities. By inhibiting the LR/CHEK1 axis, the drug forces CSCs to enter inappropriate mitosis, leading to catastrophic cell death.
CLINICAL AND TRANSLATIONAL MEDICINE
(2021)
Article
Environmental Sciences
Jaya Bagaria, Kyung-Ok Kim, Eva Bagyinszky, Seong Soo A. An, Jeong-Heum Baek
Summary: This study aimed to investigate genes responsible for locally advanced rectal cancer patients not reacting to radiotherapy, identifying specific genes more commonly mutated in non-complete response patients and potentially serving as genetic biomarkers for early detection of radiation-resistant rectal cancer patients.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2022)
Article
Oncology
Youngbae Jeon, Kug Hyun Nam, Seok Won Choi, Tae Sik Hwang, Jeong-Heum Baek
Summary: This study compared the oncologic outcomes between surgical T4 and T3 in pathologic stage IIA right colon cancer patients. It found significant differences in the 5-year overall survival rate and 5-year disease-free survival rate between the two groups, with surgical T4 being an independent predictive factor for recurrence.
FRONTIERS IN ONCOLOGY
(2022)
Article
Medicine, Research & Experimental
Xizhu Fang, Yeon-Hwa Lee, Jeong-Hoon Jang, Su-Jung Kim, Seong Hoon Kim, Do-Hee Kim, Hye-Kyung Na, Kyung-Ok Kim, Jeong-Heum Baek, Young-Joon Surh
Summary: This study found that ARD1 stabilizes NRF2 by increasing its acetylation levels, thereby enhancing the oncogenic function of NRF2 in human colon cancer.
Article
Oncology
Youngbae Jeon, Sun Jin Sym, Bong Kyu Yoo, Jeong-Heum Baek
Summary: This study evaluated the safety and tolerability of a dietary supplement of G-NLC in patients with colorectal cancer, showing comparable long-term survival outcomes with acceptable toxicity. Further research is needed to establish the efficacy of this treatment regimen.
INTEGRATIVE CANCER THERAPIES
(2022)
Article
Spectroscopy
Kyung-Ok Kim, Van-An Duong, Na-Young Han, Jong-Moon Park, Jung Ho Kim, Hookeun Lee, Jeong-Heum Baek
Summary: This study aimed to identify possible biomarkers for predicting the response of rectal cancer patients to neoadjuvant chemoradiotherapy (nCRT). Comparative proteomic analysis was performed on rectal tissue samples before and after nCRT, and several potential biomarkers were identified, including lyso-phosphatidylcholine acyltransferase 2, annexin A13, aldo-ketose reductase family 1 member B1, and cathelicidin antimicrobial peptide.
MASS SPECTROMETRY LETTERS
(2022)
Article
Surgery
Sun-Ho Kwon, Yea-Il Joo, Seon Hahn Kim, Dae Ho Lee, Jeong-Heum Baek, Soon Sup Chung, Ji-Yeon Shin, Chang Soo Eun, Nam Kyu Kim
Summary: This meta-analysis aimed to assess the safety and efficacy of TaTME for rectal cancer in South Korea. Results showed comparable outcomes between TaTME and LaTME, with the benefit of low conversion rate for TaTME.
ANNALS OF SURGICAL TREATMENT AND RESEARCH
(2021)
Article
Medicine, Research & Experimental
So-Yeon Park, Ji-Young Kim, Gyu-Beom Jang, Jang-Hyun Choi, Jee-Heun Kim, Choong-Jae Lee, Sunjae Lee, Jeong-Heum Baek, Kwan-Kyu Park, Jin-Man Kim, Hee Jin Chang, Nam-Chul Cho, Jeong-Seok Nam
Summary: This study identified an increased expression of CD45 in CRC (EpCAM+) epithelial cells after CRT treatment. High CD45 expression promoted CRC cell survival upon 5-fluorouracil or radiation treatment, while CD45 depletion sensitized CRC cells to CRT. CD45 was found to be preferentially expressed in cancer stem-like cells (CSCs) and played a crucial role in CSC functions such as cancer initiation, repopulation, and metastasis.
Meeting Abstract
Oncology
Joon-Hyop Lee, Jeong-Heum Baek, Young Jae Kim, Kwang-Gi Kim
ANNALS OF SURGICAL ONCOLOGY
(2021)