Article
Surgery
Stefan Wallen, Gustaf Bruze, Johan Ottosson, Claude Marcus, Johan Sundstrom, Eva Szabo, Torsten Olbers, Maria Palmetun-Ekback, Ingmar Naslund, Martin Neovius
Summary: This study aimed to compare the use of opioids in patients with obesity who underwent bariatric surgery versus those who underwent intensive lifestyle modification. The results showed that patients who underwent bariatric surgery had a higher proportion of opioid users and a larger total opioid dose, especially in those who received additional surgery during follow-up.
Article
Endocrinology & Metabolism
D. Moriconi, M. L. Manca, M. Anselmino, E. Rebelos, R. Bellini, S. Taddei, E. Ferrannini, M. Nannipieri
Summary: This study assessed the impact of bariatric surgery on remission and relapse of type 2 diabetes mellitus (T2DM) and analyzed predictive factors. The results showed that bariatric surgery significantly improved BMI, fasting glucose, and haemoglobin A1c (HbA1c). The remission rates at 1 and 10 years post-surgery were 74% and 53% respectively. T2DM duration, baseline HbA1c, and ensuing insulin therapy were identified as the strongest predictors of remission. Short T2DM duration and good glycemic control before surgery were essential for long-lasting remission, while weight loss did not impact the long-term relapse of T2DM.
DIABETES & METABOLISM
(2022)
Article
Medicine, General & Internal
Jean-Eric Tarride, Aristithes G. Doumouras, Dennis Hong, J. Michael Paterson, Semra Tibebu, Francis Nguyen, Richard Perez, Valerie H. Taylor, Feng Xie, Vanessa Boudreau, Eleanor Pullenayegum, David R. Urbach, Mehran Anvari
Summary: This study compared 4-year health care expenditures after RYGB and sleeve gastrectomy, finding no significant differences in all-cause mortality and number of hospital admissions between the two procedures, but more frequent nonelective hospitalizations with RYGB. Patients who underwent RYGB had a lower rate of subsequent bariatric procedures.
Article
Endocrinology & Metabolism
Nawfal W. Istfan, Marine Lipartia, Wendy A. Anderson, Donald T. Hess, Caroline M. Apovian
Summary: This study presents a practical approach for early recognition of weight regain after bariatric surgery, including classification and treatment options. Emphasizing the importance of regular long-term follow-up for all bariatric surgery patients.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2021)
Article
Medicine, General & Internal
Brianna N. Lauren, Francesca Lim, Abraham Krikhely, Elsie M. Taveras, Jennifer A. Woo Baidal, Brandon K. Bellows, Chin Hur
Summary: This study evaluated the cost-effectiveness of medical therapy, sleeve gastrectomy (SG), and Roux-en-Y gastric bypass (RYGB) in patients with severe obesity and type 2 diabetes (T2D). The results showed that RYGB is the most cost-effective treatment strategy, resulting in the highest number of quality-adjusted life-years (QALYs) gained.
Article
Surgery
Saniea F. Majid, Farah A. Husain, Yong Choi, Sujata Gill, Bruce Schirmer, Matthew Kroh, Marina Kurian
Summary: This article presents the top 10 seminal articles regarding Roux-en-Y gastric bypass (RYGB), focusing on operative safety, outcomes, surgical technique, and physiologic changes after the procedure. These articles aim to enhance surgeons' understanding and mastery of RYGB surgery, supporting its widespread acceptance and use.
SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES
(2022)
Article
Cardiac & Cardiovascular Systems
Tara Perunovic, Jens P. Goetze
Summary: Multiple mechanisms contribute to essential hypertension, and antihypertensive drugs primarily target increased sympathetic nervous system activity, altered production of vasoactive mediators, vascular inflammation, fibrosis, and increased peripheral resistance. C-type natriuretic peptide (CNP) is an endothelium-derived peptide that influences vascular signaling through two receptors, NPR-B and NPR-C. This article summarizes the effects of CNP on the vasculature in relation to essential hypertension and proposes targeting the CNP system as a potential tool for managing long-term essential hypertension.
JACC-BASIC TO TRANSLATIONAL SCIENCE
(2023)
Article
Endocrinology & Metabolism
Rinki Murphy, Lindsay D. Plank, Michael G. Clarke, Nicholas J. Evennett, James Tan, David D. W. Kim, Richard Cutfield, Michael W. C. Booth
Summary: SR-LRYGB provided superior diabetes remission and weight loss compared with LSG at 5 years, with similar low risks of complications.
Article
Veterinary Sciences
Mingzhen Fan, Yuyang Miao, Yutong Yan, Kunyuan Zhu, Xiaoe Zhao, Menghao Pan, Baohua Ma, Qiang Wei
Summary: The study found that C-type natriuretic peptide regulates the expression and secretion of S100A7 in goat mammary epithelial cells through the NPR-B/JNK/c-Jun signaling pathway, playing an important role in mammary gland innate immunity.
FRONTIERS IN VETERINARY SCIENCE
(2022)
Article
Cardiac & Cardiovascular Systems
Scott A. Hubers, John A. Schirger, S. Jeson Sangaralingham, Yang Chen, John C. Burnett, David Hodge, Horng H. Chen
Summary: Infusion of B-type natriuretic peptide (BNP) in patients with acute anterior myocardial infarction did not have significant effects on parameters of left ventricular remodeling. However, there was a trend towards reduced left ventricular infarction size in patients with a baseline left ventricular ejection fraction of <40% who were treated with BNP. These results do not support the use of intravenous BNP in patients after recent myocardial infarction.
Article
Peripheral Vascular Disease
Liyue Xu, Brendan T. Keenan, David Maislin, Thorarinn Gislason, Bryndis Benediktsdottir, Sigrun Gudmundsdottir, Marianna Gardarsdottir, Bethany Staley, Frances M. Pack, Xiaofeng Guo, Yuan Feng, Jugal Chahwala, Pritika Manaktala, Anila Hussein, Maheshwara Reddy-Koppula, Zeba Hashmath, Jonathan Lee, Raymond R. Townsend, Richard J. Schwab, Allan Pack, Samuel T. Kuna, Julio A. Chirinos
Summary: This study investigated the impact of obesity on the effectiveness of PAP therapy and the levels of NT-proBNP in adults with and without OSA. The results indicated that obesity modified the effects of PAP treatment on NT-proBNP and left atrial volume index, suggesting potential differences in cardiac remodeling in obese individuals with OSA.
Review
Biochemical Research Methods
Meysam Gachpazan, Arash Mohammadinejad, Amin Saeidinia, Hamid Reza Rahimi, Majid Ghayour-Mobarhan, Farveh Vakilian, Majid Rezayi
Summary: Heart disease poses a serious threat to human health globally, leading to rising mortality rates. B-type natriuretic peptide is a crucial biomarker for diagnosis of heart failure, but faces challenges such as low concentration and short half-life in blood.
ANALYTICAL AND BIOANALYTICAL CHEMISTRY
(2021)
Review
Biochemistry & Molecular Biology
Vittoriano Della Corte, Gaetano Pacinella, Federica Todaro, Rosaria Pecoraro, Antonino Tuttolomondo
Summary: Natriuretic peptides are a complex molecular network with pleiotropic effects on various organs and tissues, primarily maintaining cardiovascular homeostasis and regulating water-salt balance. Increasing knowledge of their receptors, molecular mechanisms, and discovery of new peptides has led to a better understanding of their physiological and pathophysiological roles, with potential therapeutic applications.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Medicine, General & Internal
Heejin Hong, Jihyun Kim, Hana Min, Yong Won Kim, Tae-Youn Kim
Summary: This study aimed to investigate the prognostic value of B-type natriuretic peptide (BNP) in sudden cardiac arrest (SCA) regardless of the etiology. It was found that patients with lower BNP concentration had a higher survival rate to discharge, but BNP was not an independent factor in predicting clinical outcomes.
Article
Surgery
David E. Arterburn, Eric Johnson, Karen J. Coleman, Lisa J. Herrinton, Anita P. Courcoulas, David Fisher, Robert A. Li, Mary Kay Theis, Liyan Liu, James R. Fraser, Sebastien Haneuse
Summary: Among patients with severe obesity undergoing SG and RYGB, significantly more weight loss was observed at 5 years compared to nonsurgical patients. Weight regain was common after surgery, but regain to within 5% of baseline was rare.
Meeting Abstract
Surgery
Justin Eisenberg, Kate Kiely, Syed Ali Rizvi, Anil Hingorani, Natalie Marks, Enrico Ascher
JOURNAL OF VASCULAR SURGERY
(2016)
Meeting Abstract
Cardiac & Cardiovascular Systems
W. Stein, S. Schrepfer, K. Van Der Bogt, K. Kiely, M. Pelletier, H. Li, B. Chang, V. Taylor, R. Robbins
JOURNAL OF HEART AND LUNG TRANSPLANTATION
(2008)
Meeting Abstract
Cardiac & Cardiovascular Systems
W. Stein, S. Schrepfer, J. Velotta, J. Bartos, K. Kiely, M. Fischbein, R. C. Robbins
JOURNAL OF HEART AND LUNG TRANSPLANTATION
(2008)
Meeting Abstract
Cardiac & Cardiovascular Systems
W. Stein, S. Schrepfer, K. Van Der Bogt, K. Kiely, G. Hoyt, E. Masuda, V. Taylor, R. C. Robbins
JOURNAL OF HEART AND LUNG TRANSPLANTATION
(2008)
Meeting Abstract
Biochemistry & Molecular Biology
Nayna A. Lodhia, Leanne V. Almario, Adam Eltorai, Jaffer Kattan, Margaret M. Nkansah, Matthew Kerolus, Kate Kiely, John Morton
Meeting Abstract
Gastroenterology & Hepatology
Nayna A. Lodhia, Jaffer M. Kattan, Dylan Gwaltney, Kate E. Kiely, Shushmita Ahmed, Homero Rivas, John M. Morton
Meeting Abstract
Gastroenterology & Hepatology
Shushmita Ahmed, Alex Taylor, Chhavi Bajaj, Dylan Gwaltney, Kate Kiely, John M. Morton