Article
Oncology
Joana Vidal, David Casadevall, Beatriz Bellosillo, Carles Pericay, Rocio Garcia-Carbonero, Ferran Losa, Laia Layos, Vicente Alonso, Jaume Capdevila, Javier Gallego, Ruth Vera, Antonieta Salud, Marta Martin-Richard, Miguel Nogue, Elena Cillan, Joan Maurel, Iris Faull, Victoria Raymond, Carlos Fernandez-Martos, Clara Montagut
Summary: The study showed that in patients with LARC undergoing TNT, the detection of presurgery ctDNA identified individuals at high risk of systemic recurrence, with shorter disease-free survival and overall survival. This sets the foundation for future clinical trials using liquid biopsy to personalize treatment post TNT.
CLINICAL CANCER RESEARCH
(2021)
Article
Oncology
Julio Garcia-Aguilar, Sujata Patil, Marc J. Gollub, Jin K. Kim, Jonathan B. Yuval, Hannah M. Thompson, Floris S. Verheij, Dana M. Omer, Meghan Lee, Richard F. Dunne, Jorge Marcet, Peter Cataldo, Blase Polite, Daniel O. Herzig, David Liska, Samuel Oommen, Charles M. Friel, Charles Ternent, Andrew L. Coveler, Steven Hunt, Anita Gregory, Madhulika G. Varma, Brian L. Bello, Joseph C. Carmichael, John Krauss, Ana Gleisner, Philip B. Paty, Martin R. Weiser, Garrett M. Nash, Emmanouil Pappou, Jose G. Guillem, Larissa Temple, Iris H. Wei, Maria Widmar, Sabrina Lin, Neil H. Segal, Andrea Cercek, Rona Yaeger, J. Joshua Smith, Karyn A. Goodman, Abraham J. Wu, Leonard B. Saltz
Summary: This study demonstrates that organ preservation is achievable in patients with locally advanced rectal cancer treated with total neoadjuvant therapy, without a decrease in survival.
JOURNAL OF CLINICAL ONCOLOGY
(2022)
Article
Oncology
Reinhard Ruppert, Theodor Junginger, Rainer Kube, Joachim Strassburg, Andreas Lewin, Joerg Baral, Christoph A. Maurer, Joerg Sauer, Johannes Lauscher, Guenther Winde, Rena Thomasmeyer, Sigmar Stelzner, Cornelius Bambauer, Soenke Scheunemann, Axel Faedrich, Daniel Wollschlaeger, Susanne Merkel
Summary: This study aimed to investigate whether neoadjuvant chemoradiotherapy can be restricted to high-risk patients with rectal cancer without compromising oncological outcomes. It was found that low-risk patients do not require neoadjuvant therapy, while high-risk patients should intensify their neoadjuvant therapy to improve prognosis.
JOURNAL OF CLINICAL ONCOLOGY
(2023)
Article
Medicine, General & Internal
Stefano Scabini, Emanuele Romairone, Davide Pertile, Andrea Massobrio, Alessandra Aprile, Luca Tagliafico, Domenico Soriero, Luca Mastracci, Federica Grillo, Almalina Bacigalupo, Ciro Marrone, Maria Caterina Parodi, Marina Sartini, Maria Luisa Cristina, Roberto Murialdo, Gabriele Zoppoli, Alberto Ballestrero
Summary: This study evaluated the results of laparotomic, laparoscopic, and robotic surgery in treating rectal cancer. The study found that laparoscopic TME is a better choice in a multidisciplinary context, while robotic TME has a significant difference in terms of hospital stay.
Article
Surgery
Jung Kyong Shin, Hee Cheol Kim, Seong Hyeon Yun, Yoon Ah Park, Yong Beom Cho, Jung Wook Huh, Woo Yong Lee
Summary: Both transanal total mesorectal excision (taTME) and robotic total mesorectal excision (R-TME) have similar short-term outcomes for patients with rectal cancer after undergoing neoadjuvant chemoradiation. High quality total mesorectal excision can be equally achieved with both transanal and robotic approaches.
SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES
(2021)
Article
Surgery
Jingqing Ren, Shaojie Liu, Huixing Luo, Bailin Wang, Fan Wu
Summary: There was no significant difference in short-term efficacy between TaTME and LaTME for low rectal cancer, but TaTME had a longer operation time and a greater circumferential resection margin distance.
ASIAN JOURNAL OF SURGERY
(2021)
Article
Surgery
Ziwei Zeng, Zhihang Liu, Shuangling Luo, Zhenxing Liang, Liang Huang, Lei Ruan, Junji Chen, Haiqing Jie, Wenfeng Liang, Huashan Liu, Liang Kang
Summary: There were no significant differences in the 3-year local recurrence rate between the taTME and laTME groups. Additionally, the disease-free survival and overall survival rates within 3 years after surgery were also similar between the two groups.
SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES
(2022)
Article
Medicine, General & Internal
Antonio Caycedo-Marulanda, Lawrence Lee, Sami A. Chadi, Chris P. Verschoor, Jordan Crosina, Shady Ashamalla, Carl J. Brown
Summary: The study found that transanal TME performed by experienced surgeons had a low incidence of local recurrence and systemic recurrence, suggesting it may be an acceptable approach for rectal cancer management.
Article
Gastroenterology & Hepatology
Brandon C. Chapman, Samuel H. Lai, Tyler Friedrich, Christopher H. Lieu, Marina Moskalenko, Jeffrey R. Olsen, Whitney Herter, Elisa H. Birnbaum, Martin D. McCarter, Jon D. Vogel
Summary: The objective of this study was to identify patient and tumor characteristics that predict a complete response following total neoadjuvant therapy. The results showed that over one-third of rectal cancer patients treated with total neoadjuvant therapy can achieve a pathological complete response or sustained clinical complete response with nonoperative management, making oncological resection unnecessary in these patients.
DISEASES OF THE COLON & RECTUM
(2023)
Article
Multidisciplinary Sciences
Jung Kyong Shin, Jung Wook Huh, Woo Yong Lee, Seong Hyeon Yun, Hee Cheol Kim, Yong Beom Cho, Yoon Ah Park
Summary: This study analyzed the predictive factors, recurrence patterns, oncologic outcomes, and prognostic factors of patients with pathologic complete response (pCR) in rectal cancer who underwent radical surgery after neoadjuvant chemoradiotherapy (nCRT). The study found that clinical node negativity, tumor size < 4 cm, and well differentiation were significant independent clinical predictors for achieving pCR. Patients with pCR had better long-term outcomes compared to those without pCR.
SCIENTIFIC REPORTS
(2022)
Article
Surgery
Po-Jung Chen, Wei-Chih Su, Tsung-Kun Chang, Yen-Cheng Chen, Ching-Chun Li, Tzu-Chieh Yin, Hsiang-Lin Tsai, Cheng-Jen Ma, Ching-Wen Huang, Jaw-Yuan Wang
Summary: This study examined the oncological outcomes of patients with rectal cancer undergoing robotic-assisted total mesorectal excision (TME) after neoadjuvant concurrent chemoradiotherapy (CCRT). Results showed that robotic-assisted TME is safe and effective for treating stage II-III rectal cancer patients, with acceptable short-term oncological outcomes. It may be considered as a therapeutic alternative for salvage surgery in T4 tumors invading adjacent organs.
ASIAN JOURNAL OF SURGERY
(2021)
Article
Multidisciplinary Sciences
Jung Kyong Shin, Hee Cheol Kim, Woo Yong Lee, Seong Hyeon Yun, Yong Beom Cho, Jung Wook Huh, Yoon Ah Park
Summary: Intersphincteric resection (ISR) for low-lying rectal cancer aims to avoid abdominoperineal resection (APR). This study compared open and minimally invasive ISR, finding similar 5-year disease-free survival rates. Minimally invasive ISR showed advantages in postoperative outcomes like reduced surgical site infection and shorter hospital stay.
SCIENTIFIC REPORTS
(2021)
Article
Oncology
Francesco Marchegiani, Valeria Palatucci, Giulia Capelli, Mario Guerrieri, Claudio Belluco, Daniela Rega, Emilio Morpurgo, Claudio Coco, Angelo Restivo, Silvia De Franciscis, Carlo Aschele, Alessandro Perin, Michele Bonomo, Andrea Muratore, Antonino Spinelli, Salvatore Ramuscello, Francesca Bergamo, Giampaolo Montesi, Gaya Spolverato, Paola Del Bianco, Maria Antonietta Gambacorta, Paolo Delrio, Salvatore Pucciarelli
Summary: The short-term outcomes of rectum-preservation for locally advanced rectal cancer patients achieving major clinical response or complete clinical response after neoadjuvant therapy were reported in the study. Transanal local excision for patients achieving cCR or mCR is safe, with an increased cCR rate seen when there is a 12-week interval from chemoradiotherapy completion to LE. Performing LE after achieving cCR reduces the risk of ypT >.
ANNALS OF SURGICAL ONCOLOGY
(2022)
Article
Surgery
Vicente Simo, Patricia Tejedor, Luis Miguel Jimenez, Cristina Hernan, Jaime Zorilla, Jorge Arrredondo, Fernando Lapuente, Carlos Pastor
Summary: This study evaluated the mid-term oncological impact of TaTME for treating rectal cancer and showed positive outcomes at 2 years of follow-up. However, there is a lack of evidence in the literature regarding TaTME and oncological outcomes.
SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES
(2021)
Review
Health Care Sciences & Services
Simona Giuratrabocchetta, Giampaolo Formisano, Adelona Salaj, Enrico Opocher, Luca Ferraro, Francesco Toti, Paolo Pietro Bianchi
Summary: Minimally invasive treatment of rectal cancer with Total Mesorectal Excision is complex and challenging, with robotic surgery offering advantages in dexterity but cost and benefits still need further evaluation.
JOURNAL OF PERSONALIZED MEDICINE
(2021)