Article
Cardiac & Cardiovascular Systems
Deepika Razia, Sumeet K. Mittal, Sarah Fournier, Rajat Walia, Michael A. Smith, Ross M. Bremner, Jasmine L. Huang
Summary: Gastro-oesophageal reflux disease after lung transplantation may contribute to chronic lung allograft dysfunction. Antireflux surgery can improve long-term allograft function and show a survival benefit. This study compares outcomes between medical and surgical management of reflux in lung recipients.
EUROPEAN JOURNAL OF CARDIO-THORACIC SURGERY
(2023)
Review
Surgery
Sophia K. McKinley, Rebecca C. Dirks, Danielle Walsh, Celeste Hollands, Lauren E. Arthur, Noe Rodriguez, Joyce Jhang, Ahmed Abou-Setta, Aurora Pryor, Dimitrios Stefanidis, Bethany J. Slater
Summary: The review found that surgical treatment of GERD can improve short-term quality of life, but does not show significant superiority in short-term symptom control. Compared to total fundoplication, partial fundoplication leads to higher rates of prolonged PPI usage.
SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES
(2021)
Review
Surgery
Mohamed AbdAlla Salman, Ahmed Salman, Hossam El-Din Shaaban, Mohamed Alasmar, Mohamed Tourky, Mujahid Gasemelseed Fadlallah Elhaj, Sadaf Khalid, Mahmoud Gebril, Mahmoud Alrahawy, Mohammed Elsherbiney, Mohamed Moustafa Assal, Mohamed Hosny Abdo Osman, Aboalgasim Alamin Mohammed, Ahmed Elewa
Summary: This study compared the short-term and long-term outcomes of laparoscopic Nissen fundoplication and laparoscopic Toupet fundoplication (LTF) for the treatment of GERD. The LTF group had longer operation time, less postoperative dysphagia and gas bloating, less pressure on the lower esophageal sphincter, and higher Demeester scores. However, there were no statistically significant differences in perioperative complications, GERD recurrence, reoperation rate, quality of life, or reoperation rate between the two groups.
SURGICAL LAPAROSCOPY ENDOSCOPY & PERCUTANEOUS TECHNIQUES
(2023)
Article
Surgery
Bethany J. Slater, Rebecca C. Dirks, Sophia K. McKinley, Mohammed T. Ansari, Geoffrey P. Kohn, Nirav Thosani, Bashar Qumseya, Sarah Billmeier, Shaun Daly, Catherine Crawford, Anne P. Ehlers, Celeste Hollands, Francesco Palazzo, Noe Rodriguez, Arianne Train, Eelco Wassenaar, Danielle Walsh, Aurora D. Pryor, Dimitrios Stefanidis
Summary: The expert panel developed 7 conditional recommendations for the treatment of GERD in both adults and children, highlighting the superiority of surgical treatment over medical management in adults. However, there was insufficient evidence to make a recommendation for children. Surgical approaches, including robotic or laparoscopic, and partial or complete fundoplication, were suggested based on shared decision-making and patient values.
SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES
(2021)
Article
Gastroenterology & Hepatology
Tahmina Lata, Jodie Trautman, Philip Townend, Robert B. Wilson
Summary: This study aimed to review the current management of gastro-oesophageal reflux disease (GORD), including treatment costs, safety profile, and effectiveness. It found widespread overprescribing of proton pump inhibitors (PPIs) in Western and Eastern nations, with observational associations of adverse effects with long-term PPI use. Laparoscopic fundoplication is supported as a long-term management option for PPI-responsive GORD and PPI-refractory GORD. The importance of establishing a definitive diagnosis before invasive management, especially in PPI-refractory heartburn, is emphasized.
GASTROENTEROLOGY REPORT
(2023)
Article
Medicine, General & Internal
Ronnie Fass, Guy E. Boeckxstaens, Hashem El-Serag, Rachel Rosen, Daniel Sifrim, Michael F. Vaezi
Summary: Gastro-oesophageal reflux disease is common in adults and children, with diagnosis primarily based on history, physical examination, and treatment varying with age. Treatment options include medications, endoscopic interventions, or surgery.
NATURE REVIEWS DISEASE PRIMERS
(2021)
Article
Surgery
Bethany J. Slater, Amelia Collings, Rebecca Dirks, Jon C. Gould, Alia P. Qureshi, Ryan Juza, Maria Rita Rodriguez-Luna, Claire Wunker, Geoffrey P. Kohn, Shanu Kothari, Elizabeth Carslon, Stephanie Worrell, Ahmed M. Abou-Setta, Mohammed T. Ansari, Dimitrios Athanasiadis, Shaun Daly, Francesca Dimou, Ivy N. Haskins, Julie Hong, Kumar Krishnan, Anne Lidor, Virginia Litle, Donald Low, Anthony Petrick, Ian S. Soriano, Nirav Thosani, Amy Tyberg, Vic Velanovich, Ramon Vilallonga, Jeffrey M. Marks
Summary: This guideline provides evidence-based recommendations for the treatment of gastroesophageal reflux disease (GERD) using endoscopic and surgical methods. Thirteen recommendations were formulated, including a treatment algorithm and suggestions for future research.
SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES
(2023)
Article
Gastroenterology & Hepatology
Adam Frankel, Hock Soo Ong, B. Mark Smithers, Les K. Nathanson, David C. Gotley
Summary: This study evaluated the efficacy of laparoscopic fundoplication in patients with chronic cough without asthma and pathologic gastro-oesophageal reflux. It found that 61% of the patients experienced relief in cough after the surgery, while predictors of cough response to fundoplication were not accurately predicted by typical GORD symptoms or pH study variables.
Review
Medicine, General & Internal
Sumit Midya, Debasish Ghosh, Mohamed Wajih Mahmalat
Summary: The addition of fundoplication to Heller's cardiomyotomy for achalasia can help prevent postoperative reflux symptoms, but there is uncertainty on the best type of fundoplication to use. Different fundoplications showed varying effects on postoperative reflux and dysphagia in combination with LHC, with Nissen fundoplication causing increased risk of severe dysphagia. Additional research is needed to determine the most effective fundoplication approach for achalasia treatment.
COCHRANE DATABASE OF SYSTEMATIC REVIEWS
(2022)
Article
Surgery
Francisco Schlottmann, Francisco Laxague, Cristian A. Angeramo, Emmanuel E. Sadava, Fernando A. M. Herbella, Marco G. Patti
Summary: Laparoscopic redo fundoplication (LRF) is a feasible and safe procedure that provides symptom relief and improved quality of life for the majority of patients, with low recurrence rates.
Article
Gastroenterology & Hepatology
K. H. Fuchs, W. Breithaupt, G. Varga, B. Babic, T. Schulz, A. Meining
Summary: Our study on 1131 patients undergoing primary LF revealed that careful patient selection and the use of mechanical sphincter augmentation can result in satisfying outcomes for the majority of severe GERD patients.
DISEASES OF THE ESOPHAGUS
(2022)
Review
Agriculture, Dairy & Animal Science
Ioannis Savvas, Kiriaki Pavlidou, Tilemachos Anagnostou, Eugenia Flouraki, George Kazakos, Dimitrios Raptopoulos
Summary: This systematic review investigates the effect of preoperative fasting duration and drugs on gastro-oesophageal reflux (GOR) in dogs and cats during anaesthesia. The study found that many factors seem to affect the development of GOR, but due to the limited number of studies and low level of evidence, no reliable conclusions can be drawn.
Article
Gastroenterology & Hepatology
K. H. Fuchs, W. Breithaupt, G. Varga, B. Babic, J. Eckhoff, A. Meining
Summary: This study aims to understand the reasons for failure and the management of failure after antireflux surgery. The major reasons for failure were migration and insufficient mobilization during the primary operation. The complexity of the redo-procedure increased with each increasing number of required redo-operations, leading to decreased quality-of-life and increased complication rates. Resections were frequently necessary after three redo-operations.
DISEASES OF THE ESOPHAGUS
(2022)
Article
Surgery
Zhi-tong Li, Xiang-lin Kong, Rui Zhang, Jian-ning Yao, Chun-xia Li, Xin-wei Han, Zhong-gao Wang, Kang-dong Liu, Feng Ji
Summary: This study evaluated the effects of balloon catheter dilation combined with laparoscopic fundoplication surgery and proton pump inhibitors (PPIs) in patients with reflux-induced esophageal strictures. The results showed that the clinical success rate was higher in the balloon dilatation combined with LF group, with fewer dilation sessions required and better outcomes. The incidence of reflux esophagitis was also lower in this group. Therefore, balloon dilatation with concomitant LF is effective and safe for esophageal stricture secondary to GERD.
SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES
(2023)
Article
Surgery
Orcun Yalav, Serdar Gumus, Osman Erdogan, Zafer Teke, Ahmet Rencuzogullari
Summary: Revisional surgeries for failed anti-reflux surgeries are technically challenging and require experienced surgeons. Different procedures may be necessary, including takedown of the previous fundoplication, reconstruction of fundoplication, removal of the mesh, or wedge resection. Successful outcomes can be achieved laparoscopically in well-equipped centers by experienced surgeons.
ANNALI ITALIANI DI CHIRURGIA
(2021)
Article
Gastroenterology & Hepatology
M. Konradsson, M. I. van Berge Henegouwen, C. Bruns, M. A. Chaudry, E. Cheong, M. A. Cuesta, G. E. Darling, S. S. Gisbertz, S. M. Griffin, C. A. Gutschow, R. van Hillegersberg, W. Hofstetter, A. H. Hoelscher, Y. Kitagawa, J. J. B. van Lanschot, M. Lindblad, L. E. Ferri, D. E. Low, M. D. P. Luyer, N. Ndegwa, S. Mercer, K. Moorthy, C. R. Morse, P. Nafteux, G. A. P. Nieuwehuijzen, P. Pattyn, C. Rosman, J. P. Ruurda, J. Rasanen, P. M. Schneider, W. Schroeder, B. Sgromo, H. Van Veer, B. P. L. Wijnhoven, M. Nilsson
DISEASES OF THE ESOPHAGUS
(2020)
Article
Gastroenterology & Hepatology
L. J. Halliday, S. L. F. Doran, B. Sgromo, Y. K. S. Viswanath, O. Tucker, B. Patel, P. S. Jambulingam, K. Dawas, S. Mercer, C. Baker, M. Mughal, G. B. Hanna, K. Moorthy
DISEASES OF THE ESOPHAGUS
(2020)
Review
Gastroenterology & Hepatology
K. Patel, A. Askari, K. Moorthy
DISEASES OF THE ESOPHAGUS
(2020)
Article
Gastroenterology & Hepatology
Laura J. Halliday, Emre Doganay, Venetia Wynter-Blyth, Hayley Osborn, John Buckley, Krishna Moorthy
Summary: Prehabilitation can help maintain cardiorespiratory fitness in oesophageal cancer patients during neoadjuvant chemotherapy and lead to an increase in fitness before surgery. Adherence to the exercise program and weekly physical activity levels play roles in the effectiveness of prehabilitation, with higher exercise volumes associated with a reduced risk of post-operative pneumonia.
JOURNAL OF GASTROINTESTINAL SURGERY
(2021)
Article
Oncology
William R. C. Knight, Ricardo McEwen, Ben E. Byrne, Wais Habib, Rebecca Bott, Janine Zylstra, Ula Mahadeva, James A. Gossage
Article
Gastroenterology & Hepatology
P. C. Mueller, J. R. Kapp, D. Vetter, L. Bonavina, W. Brown, S. Castro, E. Cheong, G. E. Darling, J. Egberts, L. Ferri, S. S. Gisbertz, I Gockel, P. P. Grimminger, W. L. Hofstetter, A. H. Hoelscher, D. E. Low, M. Luyer, S. R. Markar, S. P. Moenig, K. Moorthy, C. R. Morse, B. P. Mueller-Stich, P. Nafteux, A. Nieponice, G. A. P. Nieuwenhuijzen, M. Nilsson, C. Palanivelu, P. Pattyn, M. Pera, J. Rasanen, U. Ribeiro, C. Rosman, W. Schroeder, B. Sgromo, M. van Berge Henegouwen, R. van Hillegersberg, H. van Veer, F. van Workum, D. Watson, B. P. L. Wijnhoven, C. A. Gutschow
Summary: This study achieved international consensus on criteria for hospital discharge after esophagectomy through a 3-round Delphi process involving 40 esophageal surgeons from 16 countries and 4 continents. The consensus included criteria related to nutrition, gas passage, removal of central venous catheters, and use of adequate analgesia. These standardized endpoints can serve as objective measures for short-term recovery and assist in making decisions about patient discharge to reduce the risk of premature discharge or prolonged admission.
DISEASES OF THE ESOPHAGUS
(2021)
Article
Gastroenterology & Hepatology
Laura J. Halliday, Emre Doganay, Venetia A. Wynter-Blyth, George B. Hanna, Krishna Moorthy
Summary: This study demonstrates that a personalized, home-based multimodal prehabilitation program can reduce the incidence of post-operative pneumonia and shorten hospital stay for patients undergoing oesophageal cancer surgery. This model of prehabilitation is effective and relevant to centralized cancer services.
JOURNAL OF GASTROINTESTINAL SURGERY
(2021)
Letter
Surgery
Osama Moussa, Patricia Ortega, Sami Mansour, Sara Flod, Jonathan Cousins, Saira Hameed, Trisha Tan, Alex Miras, Harvinder Chahal, Sherif Hakky, Krishna Moorthy, Christos Tsironis, Ahmed Ahmed, Sanjay Purkayastha
Article
Surgery
Kyle Lam, Scarlet Nazarian, Nishita Gadi, Sherif Hakky, Krishna Moorthy, Christos Tsironis, Ahmed Ahmed, James M. Kinross, Sanjay Purkayastha
Summary: The study found that most bariatric surgery patients have limited awareness of surgeon specific outcome reports (SSOR), but they are willing to access the reports once informed. While some patients have accessed SSOR before, the majority indicated that it does not influence their choice of surgeon. Participants expressed a preference for public release of outcome reports at the surgeon level and hospital level, with a focus on complication rates, patient reported outcome measures, and reoperation rate.
SURGERY FOR OBESITY AND RELATED DISEASES
(2022)
Article
Biology
Alvin Wei Tian Ng, Gianmarco Contino, Sarah Killcoyne, Ginny Devonshire, Ray Hsu, Sujath Abbas, Jing Su, Aisling M. Redmond, Jamie M. J. Weaver, Matthew D. Eldridge, Simon Tavare, Paul A. W. Edwards, Rebecca C. Fitzgerald
Summary: This study categorizes genomic structural variants (SVs) in 383 cases of oesophageal cancer, uncovering mutational patterns and new disease drivers. Identification of SV events in OAC is crucial for targeted therapies.
COMMUNICATIONS BIOLOGY
(2022)
Article
Gastroenterology & Hepatology
Isabel Bartella, Laura F. C. Fransen, Christian A. Gutschow, Christiane J. Bruns, Mark L. van Berge Henegouwen, M. Asif Chaudry, Edward Cheong, Miguel A. Cuesta, Elke Van Daele, Suzanne S. Gisbertz, Richard van Hillegersberg, Arnulf Hoelscher, Stuart Mercer, Krishna Moorthy, Philippe Nafteux, Magnus Nilsson, Piet Pattyn, Guillaume Piessen, Jari Rasanen, Camiel Rosman, Jelle P. Ruurda, Paul M. Schneider, Bruno Sgromo, Grard A. Nieuwenhuijzen, Misha D. P. Luyer, Wolfgang Schroeder
Summary: This study achieved international consensus on the surgical steps of minimally invasive Ivor Lewis esophagectomy with high intrathoracic anastomosis through a two-round Delphi process. Three essential technical areas of intrathoracic gastric tube reconstruction and three main techniques for minimally invasive intrathoracic anastomosis were identified. The results may serve as a clinical guideline and aid in harmonizing the technical evolution of this complex surgical procedure.
DISEASES OF THE ESOPHAGUS
(2021)
Letter
Surgery
S. Samarasinghe, A. Sudlow, G. K. Dimitriadis, A. R. Ahmed, S. Purkayastha, C. Tsironis, S. Hakky, K. Moorthy, S. J. B. Aylwin, S. Panagiotopoulos, S. El-Hassani, A. G. Patel, H. Chahal, S. Hameed, C. W. le Roux, D. J. Pournaras, A. D. Miras
BRITISH JOURNAL OF SURGERY
(2021)
Article
Endocrinology & Metabolism
Alexander Dimitri Miras, Anna Kamocka, Belen Perez-Pevida, Sanjay Purkayastha, Krishna Moorthy, Ameet Patel, Harvinder Chahal, Gary Frost, Paul Bassett, Lidia Castagnetto-Gissey, Lucy Coppin, Nicola Jackson, Anne Margot Umpleby, Stephen Robert Bloom, Tricia Tan, Ahmed Rashid Ahmed, Francesco Rubino
Summary: The study demonstrates that lengthening the intestinal bypass during RYGB does not affect GLP-1 secretion, suggesting that the characteristic enhancement of GLP-1 response after RYGB may not depend on delivering nutrients to more distal intestinal segments.
Article
Oncology
Emre Doganay, Venetia Wynter-Blyth, Laura Halliday, Tom MacKinnon, Hayley Osborn, Krishna Moorthy
REHABILITATION ONCOLOGY
(2020)
Article
Gastroenterology & Hepatology
SriGanesh Jammula, Annalise C. Katz-Summercorn, Xiaodun Li, Constanza Linossi, Elizabeth Smyth, Sarah Killcoyne, Daniele Biasci, Vinod V. Subash, Sujath Abbas, Adrienn Blasko, Ginny Devonshire, Amber Grantham, Filip Wronowski, Maria O'Donovan, Nicola Grehan, Matthew D. Eldridge, Simon Tavare, Rebecca C. Fitzgerald