Article
Medicine, Research & Experimental
Alberto Daniele Arosio, Marco Valentini, Frank Rikki Canevari, Luca Volpi, Apostolos Karligkiotis, Dimitris Terzakis, Paolo Battaglia, Christos Georgalas, Maurizio Bignami, Paolo Castelnuovo, Mario Turri-Zanoni
Summary: This retrospective case-series study investigated the use of prelacrimal approach (PLA) in three European referral centers, focusing on preoperative radiological parameters and their association with postoperative morbidity. The results showed a correlation between the width of prelacrimal recess and the internal angle of pyriform notch with postoperative morbidity. The most common sequela was paresthesia of the ipsilateral anterior superior alveolar process, with the internal angle of pyriform notch being predictive of postoperative morbidity.
Article
Multidisciplinary Sciences
Guowen Zhan, Shanshan Guo, Honglei Hu, Jianchun Liao, Ruishan Dang, Youxiong Yang
Summary: The study investigated the morphological characteristics and interconnected regularities of the cavernous sinus venous spaces using an expanded endoscopic approach. The findings provide valuable information for surgeons to accurately locate neurovascular structures and predict tumor invasion and extension during endoscopic CS surgery.
SCIENTIFIC REPORTS
(2022)
Article
Clinical Neurology
Alexander S. Zhang, Benjamin P. Jonker, Cara L. Morris, Raewyn G. Campbell, Raquel Alvarado, Mark Winder, Raymond Sacks, Kachorn Seresirikachorn, Richard J. Harvey
Summary: This study retrospectively reviewed a case series of endoscopic endonasal biopsies of isolated cavernous sinus lesions at two tertiary institutions. The results showed that endoscopic endonasal biopsy was safe and effective in obtaining histologic diagnosis for these lesions, and had a significant impact on therapeutic decision making.
WORLD NEUROSURGERY
(2023)
Review
Clinical Neurology
Mendel Castle-Kirszbaum, Brent Uren, Tony Goldschlager
Summary: Understanding anatomical variations and utilizing the endoscopic endonasal route to access the sella are essential for safe and efficient surgery. Anatomic variations in skeletal, vascular, and neural structures should be considered during the operative exposure, with a preoperative checklist provided for guidance.
WORLD NEUROSURGERY
(2021)
Review
Oncology
Yinzi Wu, Zhimin Li, Jun Gao, Yong Yao, Renzhi Wang, Xinjie Bao
Summary: This case report presents the first complete resection of a cavernous sinus epidermoid cyst using a simple endoscopic endonasal transcavernous approach. The patient showed no signs of recurrence during the 1-year follow up. This new surgical method provides more options for neurosurgeons in the treatment of epidermoid cysts.
FRONTIERS IN ONCOLOGY
(2022)
Article
Surgery
Haibo Zhu, Chuzhong Li, Songbai Gui, Xinsheng Wang, Xuyi Zong, Peng Zhao, Jiwei Bai, Chunhui Liu, Lei Cao, Zhenye Li, Yazhuo Zhang
Summary: This study investigated the effectiveness, safety, complications, and prognosis of endoscopic endonasal surgery for pituitary adenomas with cavernous sinus invasion (CSI). The results showed a significant correlation between CSI and female, older age, operation history, and non-gross total resection (NGTR). Among the pituitary adenomas with CSI, bone invasion, NGTR, and Grade 4 of Knosp classification were identified as independent risk factors for regrowth. Endoscopic endonasal surgery was found to be an excellent choice for treating pituitary adenomas with CSI.
JOURNAL OF CRANIOFACIAL SURGERY
(2022)
Article
Surgery
Xiao Dong, Xiaoyu Wang, Anwen Shao, Jianmin Zhang, Yuan Hong
Summary: Dealing with ventral medial pontine cavernous malformations can be challenging due to their location and potential risks, but the endoscopic endonasal approach provides a safer and more efficient option for resection.
FRONTIERS IN SURGERY
(2021)
Article
Clinical Neurology
Lijun Heng, Hang Wang, Shuo Zhang, Xue Jiang, Yan Qu
Summary: The cavernous sinus molding technique with hemostatic agent injection during endoscopic endonasal pituitary surgery is a practical, effective, and safe method for controlling intracavernous bleeding. It involves making a small incision in the cavernous sinus wall, injecting the hemostatic agent along the venous channels to establish partial molding, and using tailored instruments for injection. Multi-spot injections are preferred for better bleeding control and reducing complications. Postoperative complications were not observed in the patients treated with this technique.
ACTA NEUROCHIRURGICA
(2022)
Article
Clinical Neurology
Rafael Martinez-Perez, Douglas A. Hardesty, Giuliano Silveira-Bertazzo, Ricardo L. Carrau, Daniel M. Prevedello
Summary: The aim of this study was to find reliable landmarks to identify the oculomotor triangle (OCMT) during the endoscopic endonasal transoculomotor approach (EETA) and protect the internal carotid artery (ICA) from injury. The study found that the clinoid-to-vidian line (CVL) and the sagittal paraclival line (SPL) are reliable anatomical landmarks that can help surgeons avoid inadvertent injury to the ICA.
NEUROSURGICAL REVIEW
(2021)
Article
Endocrinology & Metabolism
Ge Chen, Mingchu Li, Wenlong Xu, Xu Wang, Ming Feng, Renzhi Wang, Xiaohai Liu
Summary: In this study, we retrospectively analyzed 17 patients with clival chordoma who underwent endoscopic endonasal surgery. The results showed a high resection rate and low morbidity rate, with no perioperative deaths or new focal neurological deficits. Radiation therapy had a positive impact on reducing recurrence in patients with subtotal resection.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Clinical Neurology
Viola Bartoletti, Nicolo Norri, Ivan El-Sayed, Adib A. Abla, Roberto Rodriguez Rubio
Summary: The multilayer topology at the intersection of the regional compartments in the medial orbital apex was comprehensively described through an endoscopic approach. Various landmarks and structures were identified, including the sphenoethmoidal suture, optic risk zone, and orbital fusion line. Understanding these structures can help tailor an endoscopic approach to the medial orbital space.
WORLD NEUROSURGERY
(2023)
Article
Clinical Neurology
Masato Nakaya, Ryota Tamura, Kento Takahara, Takumi Senuma, Keisuke Yoshida, Yohei Kitamura, Ryo Ueda, Masahiro Toda
Summary: This study aimed to establish a simple volume reconstruction algorithm of the nasal cavity and paranasal sinus for the operability analysis of invasive pituitary neuroendocrine tumors (PitNETs). The semiautomatic segmentation method produced accurate and time-saving results for volumetric analyses of the nasal cavity and paranasal sinuses. The volume of the sphenoid sinus was significantly correlated with the extent of tumor removal in patients with nonfunctioning Knosp grade 3 and 4 PitNETs.
FRONTIERS IN NEUROLOGY
(2023)
Article
Oncology
Simona Serioli, Mariagrazia Nizzola, Pedro Plou, Alessandro De Bonis, Jenna Meyer, Luciano C. P. C. Leonel, Andrea A. Tooley, Lilly H. Wagner, Elizabeth A. Bradley, Jamie J. Van Gompel, Maria Elena Benini, Iacopo Dallan, Maria Peris-Celda
Summary: This study aims to provide a detailed description of the anatomy to understand the potential and limitations of transorbital approaches (TOAs). Measurements of the orbit region and surrounding areas were performed on CT scans and dry skulls, and dissection was done on specimens to illustrate the TOA. Three clinical cases were presented to highlight the surgical applications.
Article
Oncology
In-Ho Jung, Jihwan Yoo, Seonah Choi, Seung Hoon Lim, JaeSang Ko, Tae Hoon Roh, Je Beom Hong, Eui Hyun Kim
Summary: The study demonstrates the feasibility and efficacy of endoscopic transorbital approach (ETOA) in accessing and exploring the cavernous sinus (CS) in skull base tumors. The ETOA provides a unique and valuable surgical route to the CS, especially for the lateral and posterior compartments, and can be used in synergy with other surgical approaches.
FRONTIERS IN ONCOLOGY
(2022)
Review
Surgery
Yingxi Wu, Li Gong, Yunze Zhang, Min Zheng, Junting Li, Yafei Xue, Yan Qu, Tianzhi Zhao
Summary: Hemangiopericytomas (HPCs) invading the cavernous sinus are rare tumors with a high risk of local recurrence. Surgical resection is challenging due to the abundant blood supply and important structures in the cavernous sinus. This report presents two cases of HPCs invading the cavernous sinus, detailing their clinical manifestations, imaging findings, surgical approaches, and histopathological features.
FRONTIERS IN SURGERY
(2022)
Article
Endocrinology & Metabolism
Derya Metin-Armagan, Nil Comunoglu, Gulay Bulut, Pinar Kadioglu, Hiraku Kameda, Nurperi Gazioglu, Necmettin Tanriover, Melek Ozturk
ENDOCRINE PATHOLOGY
(2020)
Article
Clinical Neurology
Ali Karadag, Mehmet Senoglu, Erik H. Middlebrooks, Burak Kinali, Mustafa Guvencer, Cigdem Icke, Salih Sayhan, Nuri Karabay, Mahmut Camlar, Osarenoma U. Olomu, Necmettin Tanriover
JOURNAL OF CLINICAL NEUROSCIENCE
(2020)
Article
Clinical Neurology
Serhat Baydin, Oguz Baran, Abuzer Gungor, Enis Kuruoglu, Necmettin Tanriover
WORLD NEUROSURGERY
(2020)
Article
Endocrinology & Metabolism
Derya Metin Armagan, Ayse Seda Akdemir, Hande Mefkure Ozkaya, Ozge Polat Korkmaz, Nurperi Gazioglu, Pinar Kadioglu, Necmettin Tanriover, Fatma-Kaya Dagistanli, Ahmet Dirican, Melek Ozturk
Summary: In this study, we investigated the genotype distributions of SNPs in miR-107 and miR-23b genes related to acromegaly, finding a significant association of the T-allele with certain clinical features in patients. Additionally, patients who responded to SSA treatment showed higher Ki-67 index. No polymorphisms were observed in the miR-23b and miR-107 genes in the Turkish population.
EXPERIMENTAL AND CLINICAL ENDOCRINOLOGY & DIABETES
(2021)
Article
Endocrinology & Metabolism
Hande Mefkure Ozkaya, Muge Sayitoglu, Nil Comunoglu, Eda Sun, Fatma Ela Keskin, Duygu Ozata, Rabia Hacer Hocaoglu, Khusan Khodzaev, Sinem Firtina, Necmettin Tanriover, Nurperi Gazioglu, Buge Oz, Pinar Kadioglu
Summary: In GH-secreting adenomas and non-functioning adenomas, there was no significant difference in gene expression of aromatase and non-functioning protein. However, ERR gene expression was higher in GH-secreting adenomas.
EXPERIMENTAL AND CLINICAL ENDOCRINOLOGY & DIABETES
(2021)
Review
Clinical Neurology
Mary Murphy, Silvia Hernandez-Duran, Eliana Kim, Noora Al-Shehhi, Marike Broekman, Mania de Praeter, Annie Dubuisson, Evelyne Emery, Nurperi Gazioglu, Rachel Grossman, Insa Katrin Janssen, Maria Karampouga, Lika Khorbaladze, Xanthoula Lambrianou, Laura Lippa, Hulda Magnadottir, Stiliana Mihaylova, Ermira Pajaj, Katrin Rabiei, Ana Rodriguez-Hernandez, Anastasia Tasiou, Pia Vayssiere, Gail Rosseau
Summary: This paper chronicles the history of European women in neurosurgery, highlighting the remarkable achievements of female neurosurgeons throughout the decades. The women honored in this paper have overcome adversity, made significant contributions to society and institutional neurosurgery, and excelled in various fields. Through comprehensive research, it is evident that the future of European neurosurgery is increasingly female.
JOURNAL OF CLINICAL NEUROSCIENCE
(2021)
Review
Clinical Neurology
Silvia Hernandez-Duran, Mary Murphy, Eliana Kim, Noora Al-Shehhi, Marike Broekman, Mania de Praeter, Annie Dubuisson, Evelyne Emery, Nurperi Gazioglu, Rachel Grossman, Insa Katrin Janssen, Maria Karampouga, Lika Khorbaladze, Xanthoula Lambrianou, Laura Lippa, Hulda Magnadottir, Stiliana Mihaylova, Ermira Pajaj, Katrin Rabiei, Ana Rodriguez-Hernandez, Anastasia Tasiou, Pia Vayssiere, Gail Rosseau
Summary: Over the past century, women in neurosurgery in Europe have made significant advancements and breakthroughs. With resilience and camaraderie, these female neurosurgeons have triumphed over great obstacles and challenges to achieve success.
JOURNAL OF CLINICAL NEUROSCIENCE
(2021)
Article
Clinical Neurology
Mehmet Serhat Mangan, Erdem Gelegen, Tahire Baserer, Nurperi Gazioglu, Cengiz Aras
Summary: This study suggests that lower mean preoperative RNFL thickness was associated with poorer long-term visual prognosis. Preoperative RNFL thickness measurements may be helpful in predicting the recovery of visual field and visual acuity after decompression surgery in patients with chiasmal lesion presenting with visual impairment.
CLINICAL NEUROLOGY AND NEUROSURGERY
(2021)
Article
Endocrinology & Metabolism
Emre Durcan, Fatma Ela Keskin, Hande Mefkure Ozkaya, Sabri Sirolu, Serdar Sahin, Ozge Polat Korkmaz, Nurperi Gazioglu, Necmettin Tanriover, Nil Comunoglu, Buge Oz, Osman Kizilkilic, Pinar Kadioglu
Summary: The expression levels of FGFR-4 in pituitary adenomas may serve as a marker for more aggressive tumor behavior. Patients without remission, with residual lesion, and T2-hyperintense adenoma had higher median H-scores for FGFR-4.
EXPERIMENTAL AND CLINICAL ENDOCRINOLOGY & DIABETES
(2022)
Article
Clinical Neurology
Enes Akkaya, Mehmet Yigit Akgun, Emine Sebnem Durmaz, Seckin Aydin, Hande Mefkure Ozkaya, Nil Comunoglu, Osman Kizilkilic, Nurperi Gazioglu, Pinar Kadioglu, Necmettin Tanriover
Summary: The signal intensity in T2-weighted Magnetic Resonance Imaging can predict postoperative results in acromegaly patients with macroadenoma. The surgical remission rates were significantly lower in the T2-hyperintense group compared to the T2-hypointense and T2-isointense groups in newly diagnosed acromegaly patients. Preoperative T2-intensity images may predict the probability of post-surgical remission in patients with newly diagnosed acromegaly.
JOURNAL OF CLINICAL NEUROSCIENCE
(2021)
Review
Pathology
Sylvia L. Asa, Ozgur Mete, Michael D. Cusimano, Ian E. McCutcheon, Arie Perry, Shozo Yamada, Hiroshi Nishioka, Olivera Casar-Borota, Silvia Uccella, Stefano La Rosa, Ashley B. Grossman, Shereen Ezzat
Summary: The classification of adenohypophysial neoplasms as pituitary neuroendocrine tumors (PitNETs) reflects their characteristics as epithelial neuroendocrine neoplasms with a spectrum of clinical behaviors. Tumor growth and hormone hypersecretion can cause significant morbidity and mortality in patients. The intense study of PitNETs has provided important information about the importance of cellular differentiation in tumor prognosis.
Article
Multidisciplinary Sciences
Hilal Eren Gozel, Kivanc Kok, Fatma Ozlen, Cihan Isler, Sadrettin Pence
Summary: This study classified CCM patients into epilepsy and hemorrhage groups, identifying different gene expressions but no deregulation in CCM1-3 genes. The results suggest that new candidate genes should be explored to further elucidate CCM pathology.
SCIENTIFIC REPORTS
(2021)
Article
Clinical Neurology
Dilan Demir, Ahmet Numan Demir, Cem Sulu, Guldana Zulfaliyeva, Semih Can Cetintas, Hande Mefkure Ozkaya, Pinar Kadioglu, Nurperi Gazioglu, Necmettin Tanriover
Summary: This study investigated the remission rates, factors related to remission, secondary treatments, and outcomes of prolactinoma patients undergoing endoscopic transsphenoidal surgery (ETSS). The initial surgical remission rate was 60%, and recurrence was detected in 25.9% of patients. After secondary treatments, the long-term biochemical remission rate was 91.1%. Factors associated with failure in surgical remission included male gender, older age, larger tumor size, advanced stage, and elevated prolactin level at diagnosis. Patients who received preoperative dopamine agonist treatment and had a prolactin level of <19 ng/mL in the first postoperative week had a higher likelihood of surgical remission. For difficult cases of prolactinoma, a multidisciplinary approach involving neurosurgery and endocrinology is recommended.
WORLD NEUROSURGERY
(2023)
Article
Clinical Neurology
Xanthoula Lambrianou, Christos Tzerefos, Insa K. Janssen, Stiliana Mihaylova, Aysegul Esen Aydin, Selma Al-Ahmad, Marike LD. Broekman, Nurperi Gazioglu, Silvia Hernandez Duran, Daniela Luminita Ivan, Maria Karampouga, Hulda B. Magnadottir, Ermira Pajaj, Ana Rodriguez-Hernandez, Gail Rosseau, Niina Salokorpi, Eleni Tsianaka, Pia Vayssiere, Mary Murphy, Anastasia Tasiou
Summary: This study examines gender differences in the household and childrearing contributions of neurosurgeons and their impact on personal and professional life. The findings show that female neurosurgeons take on more responsibilities at home, especially during child-rearing years, and are more likely to be living alone or without children compared to their male colleagues. Supportive facilities, flexible programs, universal life policies, and efforts to reduce social stereotypes are important in overcoming gender inequalities faced by women in neurosurgery.
Article
Clinical Neurology
Seckin Aydin, Baris Ozoner, Serdar Sahin, Orkhan Alizada, Nil Comunoglu, Buge Oz, Nurperi Gazioglu, Pinar Kadioglu, Necmettin Tanriover
CLINICAL NEUROLOGY AND NEUROSURGERY
(2020)