Article
Cell Biology
Anabel Martinez Lyons, Luke Boulter
Summary: The Notch signaling pathway is crucial for cell-cell communication, cellular proliferation, and fate specification. In the vertebrate liver, a lack of Notch signaling leads to failure in bile duct formation, resulting in cholestasis and requiring liver transplantation.
DISEASE MODELS & MECHANISMS
(2021)
Article
Cell Biology
Motoko Sasaki, Yasunori Sato, Yasuni Nakanuma
Summary: The prevalence of bile duct adenomas in the background liver was significantly higher in small duct iCCA compared to other primary liver carcinomas, suggesting they may be precursor lesions. Alterations in ARID1A, p53, and PBRM1 genes may be involved in the carcinogenesis of small duct iCCA.
Article
Surgery
Aaron Scott, Paul Wong, Laleh G. Melstrom
Summary: Intrahepatic cholangiocarcinoma is an aggressive tumor that often requires multimodal treatment. Surgical resection is the only curative option, but only a small percentage of patients have resectable disease. Diagnostic evaluation includes cross-sectional imaging and percutaneous biopsy. Surgical treatment aims for complete resection while preserving future liver remnant. Predictors of survival after surgery include margin status, vascular invasion, nodal disease, and tumor characteristics. Systemic chemotherapy and hepatic artery infusion are potential treatment options for unresectable cases. This review focuses on surgical intervention for resectable disease and the use of hepatic artery infusion for unresectable cases.
Article
Surgery
Jaume Tur-Martinez, Dolores C. Garcia-Olmo, Sara Puy, Pablo Muriel, Gian Pier Protti, Alba Boldo, Mario A. Gallardo, Sergio Bazaga, Manuel Perez-Miranda, Jorge Juan Olsina-Kissler
Summary: A new minimally invasive animal model of bile duct dilatation in pigs was developed through laparoscopic surgery. Postoperative analyses showed an increase in total bilirubin and gamma glutamyl transferase levels, with a majority of pigs showing dilation of the intrahepatic bile ducts. This animal model could be useful for training in EUS techniques and evaluating new therapeutic approaches.
SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES
(2021)
Article
Gastroenterology & Hepatology
Duc-Hung Pham, Ramesh Kudira, Lingfen Xu, C. Alexander Valencia, Jillian L. Ellis, Tiffany Shi, Kimberley J. Evason, Immaculeta Osuji, Nelson Matuschek, Liva Pfuhler, Mary Mullen, Sujit K. Mohanty, Ammar Husami, Laura N. Bull, Kejian Zhang, Sami Wali, Chunyue Yin, Alexander Miethke
Summary: In this study, variants in the ABCC12 gene were discovered in children with chronic cholestasis, shedding light on a potential link between MRP9 and bile duct homeostasis and cholestatic liver disease. Utilizing zebrafish and murine models, it was demonstrated that MRP9 deficiency can lead to cholangiocyte injury and progressive bile duct loss, indicating a possible therapeutic target for bile acid-induced cholangiocyte injury.
Article
Medicine, General & Internal
Jaram Lee, Ook Song, Hyeong-Min Park, Soo Young Lee, Chang Hyun Kim, Hyeong Rok Kim
Summary: Bile leakage as a postoperative complication of right hemicolectomy occurred in two colon cancer patients with a history of cholecystectomy. Both cases required surgical intervention to repair the intrahepatic bile duct injury, leading to successful recovery and discharge after reoperation.
Review
Oncology
Tian-Run Lv, Fei Liu, Hai-Jie Hu, Parbatraj Regmi, Wen-Jie Ma, Qing Yang, Yan-Wen Jin, Fu-Yu Li
Summary: EHBDR does not provide a survival advantage for patients with gallbladder carcinoma, especially for non-jaundiced patients. The resected group has higher rates of disease recurrence, postoperative complications, and positive margins. Routine EHBDR is not recommended for non-jaundiced patients.
Article
Medicine, General & Internal
Sung Yong Han, Dong Uk Kim, Hyeong Seok Nam, Dae Hwan Kang, Sung Ill Jang, Dong Ki Lee, Dong Woo Shin, Kwang Bum Cho, Min Jae Yang, Jae Chul Hwang, Jin Hong Kim, Hoonsub So, Sung Jo Bang, Min Je Sung, Chang-Il Kwon, Dong Wook Lee, Chang-Min Cho, Jae Hee Cho
Summary: This study evaluated the predictors of malignancy in intraductal papillary neoplasm of the bile duct (IPNB) according to anatomical location and investigated the prognosis without surgery. The results showed that extrahepatic IPNB (E-IPNB) had a higher rate of malignancy than intrahepatic IPNB (I-IPNB), with mural nodule > 12 mm in I-IPNB and mural nodule enhancement in E-IPNB being predictive factors for malignancy.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Gastroenterology & Hepatology
Sung Hyun Cho, Tae Jun Song, Dongwook Oh, Do Hyun Park, Dong-Wan Seo, Sung Koo Lee
Summary: In patients with unresectable MHO, EUS-HDS showed comparable efficacy and safety to PTBD for right biliary system drainage, with longer stent patency and lower frequency of reinterventions. The study did not find significant differences in technical success, clinical success, or adverse events between the two procedures.
JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY
(2023)
Article
Oncology
Kevin C. Soares, Joshua S. Jolissaint, Sarah M. McIntyre, Kenneth P. Seier, Mithat Gonen, Carlie Sigel, Naaz Nasar, Andrea Cercek, James J. Harding, Nancy E. Kemeny, Louise C. Connell, Bas Groot Koerkamp, Vinod P. Balachandran, Michael I. D'Angelica, Jeffrey A. Drebin, T. Peter Kingham, Alice C. Wei, William R. Jarnagin
Summary: The role of locoregional therapy versus systemic chemotherapy for unresectable intrahepatic cholangiocarcinoma remains controversial. This study compared overall survival in patients treated with resection, hepatic arterial infusion pump chemotherapy, or systemic chemotherapy, and evaluated the efficacy of locoregional salvage therapy. The findings highlight the importance of hepatic disease control and the potential benefits of liver-directed therapy.
Article
Oncology
Hideya Yamazaki, Takuya Kimoto, Motohisa Suzuki, Masao Murakami, Osamu Suzuki, Masaru Takagi, Norio Katoh, Takeshi Arimura, Takashi Ogino, Hiroyuki Ogino
Summary: This study examined the outcomes of patients with biliary duct carcinoma treated with particle beam therapy. The results showed that particle beam therapy has good efficacy for biliary duct carcinoma, with higher radiation doses improving overall survival. In particular, higher radiation doses were associated with better outcomes for patients with extrahepatic biliary duct carcinoma.
Article
Gastroenterology & Hepatology
Shunya Takada, Hiroo Uchida, Akinari Hinoki, Chiyoe Shirota, Wataru Sumida, Takahisa Tainaka, Satoshi Makita, Aitaro Takimoto, Youichi Nakagawa, Takuya Maeda
Summary: Preoperative comprehension of the anatomical variations of the hepatic artery and bile duct is crucial for safe laparoscopic surgery for pancreaticobiliary maljunction. This study found that anatomical variations of the hepatic artery and bile duct have an important impact on surgical technique and postoperative complications, including aberrant right hepatic artery and aberrant posterior hepatic duct. In particular, the presence of aberrant posterior hepatic duct is associated with postoperative bile leak occurrence.
JOURNAL OF HEPATO-BILIARY-PANCREATIC SCIENCES
(2023)
Article
Gastroenterology & Hepatology
Jun Li, Jiongjiong Lu, Shaodong Lv, Shujun Sun, Caifeng Liu, Feng Xu, Haiying Sun, Jiamei Yang, Xinjun Wang, Xingyang Zhong, Junhua Lu
Summary: Studying the metabolic phenotypic differences between IBDS and ICC can provide potential mechanisms and therapeutic targets. Long-term monitoring of metabolites and liver function indicators in IBDS patients is important for monitoring IBDS carcinogenesis.
BMC GASTROENTEROLOGY
(2022)
Article
Surgery
Seong Ji Choi, Yoon Jai Hoon, Dong Hee Koh, Hang Lak Lee, Dae Won Jun, Ho Soon Choi
Summary: This study retrospectively analyzed 362 patients who underwent ERCP for CBD stones and found that risk factors such as low cystic duct insertion, distal CBD angulation, larger CBD diameter, more ERCP sessions, and longer cannulation time were associated with symptomatic recurrence of CBD stones. Patients with these risk factors, particularly low cystic duct insertion, should be followed more closely to prevent recurrence.
SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES
(2022)
Article
Cell Biology
Laura M. Molina, Junjie Zhu, Qin Li, Tirthadipa Pradhan-Sundd, Yekaterina Krutsenko, Khaled Sayed, Nathaniel Jenkins, Ravi Vats, Bharat Bhushan, Sungjin Ko, Shikai Hu, Minakshi Poddar, Sucha Singh, Junyan Tao, Prithu Sundd, Aatur Singhi, Simon Watkins, Xiaochao Ma, Panayiotis Benos, Andrew Feranchak, George Michalopoulos, Kari Nejak-Bowen, Alan Watson, Aaron Bell, Satdarshan P. Monga
Summary: YAP1 plays a key role in bile duct development, while hepatocytes achieve adaptation through reduced metabolic and synthetic function to survive for 8 months, blocking the formation of the biliary tree.
