Article
Gastroenterology & Hepatology
Michael R. Driedger, Thomas S. Yamashita, Patrick Starlinger, Kellie L. Mathis, Rory L. Smoot, Sean P. Cleary, David M. Nagorney
Summary: The concurrent resection of primary cancer and synchronous colorectal cancer liver metastases (CRCLM) may lead to increased morbidity and mortality, especially in patients undergoing major liver/major colorectal resections. Postoperative complications may result in the inability to receive adjuvant chemotherapy, which could impact survival outcomes.
Article
Health Care Sciences & Services
Sorin Tiberiu Alexandrescu, Narcis Octavian Zarnescu, Andrei Sebastian Diaconescu, Dana Tomescu, Gabriela Droc, Doina Hrehoret, Vladislav Brasoveanu, Irinel Popescu
Summary: The impact of postoperative complications on the long-term outcomes of patients undergoing simultaneous resection of colorectal cancer and synchronous liver metastases was investigated in this study. The presence, type, or grade of postoperative complications did not significantly affect overall survival or disease-free survival, while N2 stage and four or more synchronous liver metastases were identified as independent predictors for poor prognosis.
Article
Oncology
Florian E. Buisman, Wills F. Filipe, Nancy E. Kemeny, Raja R. Narayan, Rami M. Srouji, Vinod P. Balachandran, Thomas Boerner, Jeffrey A. Drebin, William R. Jarnagin, T. Peter Kingham, Alice C. Wei, Dirk J. Grunhagen, Cornelis Verhoef, Bas Groot Koerkamp, Michael I. D'Angelica
Summary: This study investigated the effectiveness of adjuvant hepatic arterial infusion pump (HAIP) chemotherapy after complete resection or ablation of recurrent colorectal liver metastases and found that adjuvant HAIP is associated with superior hepatic disease-free survival and overall survival.
ANNALS OF SURGICAL ONCOLOGY
(2021)
Article
Oncology
Andrew A. Gumbs, Roland Croner, Eric Lorenz, Andrea Benedetti Cacciaguerra, Tzu-Jung Tsai, Lee Starker, Joe Flanagan, Ng Jing Yu, Elie Chouillard, Mohammad Abu Hilal
Summary: This study evaluates the long-term outcomes of minimally invasive liver resection for colorectal liver metastases. The results show that laparoscopic and robotic approaches have similar survival rates and recurrence-free survival rates compared to open hepatectomy.
Review
Oncology
Alexandra Nassar, Stylianos Tzedakis, Alix Dhote, Marie Strigalev, Romain Coriat, Mehdi Karoui, Anthony Dohan, Martin Gaillard, Ugo Marchese, David Fuks
Summary: This literature review aimed to assess the feasibility of laparoscopic liver resection for multiple colorectal liver metastases. The minimally invasive approach for liver cancer has become a new standard of oncological care, and laparoscopic liver resection is a significant indication for multiple colorectal liver metastases. The purpose of this paper was to highlight the novelty and updates in the field of multiple minimally invasive liver resections and discuss the feasibility and outcomes of laparoscopic concomitant multiple liver resections for colorectal liver metastases.
Article
Oncology
Astrid Bauschke, Annelore Altendorf-Hofmann, Merten Homman, Thomas Manger, Joerg Pertschy, Herry Helfritzsch, Hubert Goebel, Utz Settmacher
Summary: The study retrospectively analyzed data from 637 patients between 1995 and 2018, finding that different factors affect the survival rates of patients with different tumor entities, and the Adam score can identify risk factors for most but not all tumor entities.
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
(2022)
Article
Oncology
Lily V. Saadat, Thomas Boerner, Debra A. Goldman, Mithat Gonen, Timothy L. Frankel, Efsevia Vakiani, T. Peter Kingham, William R. Jarnagin, Alice C. Wei, Kevin C. Soares, David B. Solit, Michael I. D'Angelica
Summary: RAS mutations are prognostic for mCRC patients. KRAS exon 3/4 mutations are rare and may be associated with a more favorable prognosis, but the difference in oncologic outcomes based on the mutated exon appears to be smaller than previously reported.
ANNALS OF SURGICAL ONCOLOGY
(2021)
Article
Surgery
Satoshi Matsukuma, Yukio Tokumitsu, Yuki Nakagami, Yoshitaro Shindo, Hiroto Matsui, Masao Nakajima, Michihisa Iida, Nobuaki Suzuki, Shigeru Takeda, Hiroaki Nagano
Summary: The study indicates that using a laparoscopic approach for partial liver resections and left lateral sectionectomies for liver tumors can reduce the rate of superficial incisional surgical site infections.
SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES
(2021)
Article
Gastroenterology & Hepatology
Maud Neuberg, loannis Triantafyllidis, Marine Lefevre, Mostefa Bennamoun, Anthony Sarran, Marc Beaussier, Christophe Louvet, Brice Gayet, David Fuks
Summary: The study found that NRH is a severe form of CALI that may worsen the short-term outcomes of patients undergoing LLR for CRLM. However, the remaining forms of CALI do not have a significant impact on perioperative outcomes after LLR.
JOURNAL OF GASTROINTESTINAL SURGERY
(2021)
Article
Surgery
Qichen Chen, Rui Zhang, Baocai Xing, Cong Li, Dianrong Xiu, Jinghua Chen, Yiqiao Deng, Xiao Chen, Rui Guo, Fenglin Chen, Jianhong Peng, Tao Sun, Hangyan Wang, Muxing Li, Qiwen Zheng, Xinyu Bi, Jianjun Zhao, Jianguo Zhou, Zhiyu Li, Zhen Huang, Yefan Zhang, Yizhou Zhang, Jianqiang Cai, Hong Zhao
Summary: There is no significant difference in postoperative infection rate between patients who undergo colorectal resection first and those who undergo liver resection first. Patients who undergo colorectal resection first have some better short-term outcomes and comparable progression-free survival (PFS) compared to those who undergo liver resection first.
INTERNATIONAL JOURNAL OF SURGERY
(2022)
Review
Oncology
D. Wagner, V. Wienerroither, M. Scherrer, M. Thalhammer, F. Faschinger, A. Lederer, H. M. Hau, R. Sucher, P. Kornprat
Summary: This review examines the evidence for sarcopenia as a prognostic parameter in colorectal liver metastases. The results suggest that sarcopenia does not significantly affect overall survival and disease-free survival, but it does have an influence on postoperative complication rates.
FRONTIERS IN ONCOLOGY
(2023)
Article
Oncology
Thomas Reinert, Lena Marie Skindhoj Petersen, Tenna Vesterman Henriksen, Marie Obo Larsen, Mads Heilskov Rasmussen, Amanda Frydendahl Boll Johansen, Nadia Ogaard, Michael Knudsen, Iver Nordentoft, Soren Vang, Soren Rasmus Palmelund Krag, Anders Riegels Knudsen, Frank Viborg Mortensen, Claus Lindbjerg Andersen
Summary: This study found that monitoring ctDNA status in plasma can detect the risk of recurrence in colorectal liver metastases patients earlier and can potentially assist in clinical decision-making in cases of indeterminate CT findings, reducing time-to-intervention.
INTERNATIONAL JOURNAL OF CANCER
(2022)
Article
Medicine, General & Internal
Sven H. Loosen, Christoph Roderburg, Patrick H. Alizai, Anjali A. Roeth, Sophia M. Schmitz, Mihael Vucur, Mark Luedde, David Schoeler, Pia Paffenholz, Frank Tacke, Christian Trautwein, Tom Luedde, Ulf P. Neumann, Tom F. Ulmer
Summary: Surgical tumor resection is potentially curative for patients with resectable colorectal liver metastases, but disease recurrence is common. Elevated levels of CEA, CA19-9, and CRP are associated with unfavorable prognosis after CRLM resection, with CEA being an independent prognostic marker.
Article
Gastroenterology & Hepatology
Lydia Newton, Ffion Dewi, Angus McNair, Dawn Gane, Jodie Rogers, Harry Dean, Anne Pullyblank
Summary: This study examined patient-reported surgical site infections (SSI) at 30 days following elective colorectal operations over 8 years. The majority of SSIs were reported after discharge, indicating the need for a standardized 30-day surveillance to monitor SSIs accurately.
COLORECTAL DISEASE
(2021)
Article
Oncology
Konstantinos Grapatsas, Fabian Doerr, Hruy Menghesha, Martin Schuler, Viktor Gruenwald, Sebastian Bauer, Hartmut H. -J. Schmidt, Stephan Lang, Rainer Kimmig, Stefan Kasper, Natalie Baldes, Servet Boeluekbas
Summary: This study investigates the morbidity and mortality after pulmonary metastasectomy (PM) and develops a score to predict high-risk patients. Preoperative cardiovascular comorbidities, major lung resections, repeated pulmonary metastasectomy, and open thoracotomy are identified as independent factors for postoperative complications. The developed Essen score can accurately predict the occurrence of postoperative complications.