Article
Orthopedics
Christopher E. Gross, Daniel Scott, Julie B. Samora, Moin Khan, Daniel G. Kang, Rachel M. Frank
Summary: This article discusses the complex relationship between orthopaedic surgeons and social media, where surgeons can educate patients and market themselves, while patients can anonymously rate their service and expertise.
JOURNAL OF BONE AND JOINT SURGERY-AMERICAN VOLUME
(2022)
Article
Computer Science, Information Systems
Amin Khaksar Pour, Woo Chaw Seng, Shivakumara Palaiahnakote, Hamid Tahaei, Nor Badrul Anuar
Summary: This study discusses the importance of using computer vision technology for automatic video content rating and introduces existing rating systems for classifying video content. It also discusses the challenges and trends in the field of video content analysis.
MULTIMEDIA TOOLS AND APPLICATIONS
(2021)
Article
Orthopedics
John C. Bonano, James I. Huddleston
Summary: The article discusses how to safely resume elective surgeries during the COVID-19 pandemic, including testing protocols and education measures. While testing protocols can help minimize the transmission of the virus, there are still some potential risks that need to be addressed, including the need for education on clinical manifestations and exposure control.
JOURNAL OF ARTHROPLASTY
(2021)
Article
Medicine, General & Internal
Akio Horiguchi, Masayuki Shinchi, Kenichiro Ojima, Yusuke Hirano, Keiichi Ito, Ryuichi Azuma
Summary: This study aimed to assess the surgical and patient-reported outcomes of delayed anastomotic urethroplasty (DAU) for pelvic fracture urethral injury (PFUI). The study found that DAU had a high success rate, and significantly improved the quality of life related to lower urinary tract symptoms and overall health-related quality of life.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Surgery
Brittany Fraser, Therese Rey-Conde, Jennifer Allen, John B. North
Summary: The study found that the majority of Queensland surgeons found the peer-review assessments fair and informative, with nearly half of respondents believing that the assessments improved the surgical care they provided. However, some surgeons disagreed with the opinions or recommendations of their assessors. A portion of surgeons remained neutral towards the ability of the assessments to improve surgical care at the hospital level.
JOURNAL OF SURGICAL RESEARCH
(2021)
Article
Education, Scientific Disciplines
Luke Selby, Julia R. Coleman, Teresa S. Jones, Mark Nehler, Paul Montero
Summary: Surgeons consistently underestimate the importance non-surgeons place on surgical topics in their practice. These results highlight the importance of a broad exposure to surgery in the surgical clerkship for all medical students, with potential variations depending on acute or non-acute non-surgical care career plans.
JOURNAL OF SURGICAL EDUCATION
(2021)
Article
Surgery
Sebastian Luense, Eric Wisotzky, Sophie Beckmann, Christoph Paasch, Richard Hunger, Rene Mantke
Summary: This survey aims to investigate the attitudes and desires of surgeons in Germany towards new AI-based laparoscopic systems. The results show that surgeons have high expectations for simple and intuitive maneuverability, image-stabilized camera guidance, and AI-based features such as visualization of anatomical landmarks and tissue damage protection.
LANGENBECKS ARCHIVES OF SURGERY
(2023)
Article
Gastroenterology & Hepatology
Jesse V. Groen, Martijn W. J. Stommel, Arantza F. Sarasqueta, Marc G. Besselink, Lodewijk A. A. Brosens, Casper H. J. van Eijck, Isaac Q. Molenaar, Joanne Verheij, Judith de Vos-Geelen, Martin N. Wasser, Bert A. Bonsing, J. Sven D. Mieog
Summary: This international survey revealed variations in surgical management and pathological assessment in pancreatoduodenectomy with venous involvement. The study emphasizes the lack of evidence and highlights the need for research to improve patient selection for VR, surgical techniques, postoperative management, and standardization of pathological assessment.
Article
Ethics
Michael H. Bernstein, Maayan N. Rosenfield, Charlotte Blease, Molly Magill, Richard M. Terek, Julian Savulescu, Francesca L. Beaudoin, Josiah D. Rich, Karolina Wartolowska
Summary: This study examines the attitudes of orthopaedic surgeons in the USA towards randomised placebo-controlled trials (RPCTs) for orthopaedic surgery. The findings suggest that a significant proportion of surgeons consider RPCTs unethical, while opinions on the value of RPCTs are polarised.
JOURNAL OF MEDICAL ETHICS
(2022)
Article
Surgery
Simon MacDonald, Paul M. Johnson
Summary: The study aimed to investigate Canadian general surgeons' practice patterns regarding elective repair of incisional hernias. The results showed that the majority of surgeons have over 10 years of experience and regularly perform incisional hernia repair, primarily using open surgery with mesh placement. However, there was significant variation in surgical approach, mesh location, fascial closure, and the use of component separation techniques among surgeons.
Article
Ophthalmology
Mulusew Asferaw, Kumale Tolesa, Sadik Taju Sherief, Bezawit Tadegagne, Mandefro Sintayehu, Addisu Worku, Teshager Wondale, Emebet Girma, Zelalem Gizachew, Clare Gilbert, Geoffrey Woodruff
Summary: The study found that although some ophthalmologists in Ethiopia had received training in pediatric ophthalmology, there are still insufficient resources and output for pediatric cataract surgery. Additionally, the distribution of surgeons is uneven and more well-equipped pediatric ophthalmology teams are urgently needed.
Article
Clinical Neurology
Dimitri Tkatschenko, Sonja Hansen, Julia Koch, Christopher Ames, Michael G. Fehlings, Sigurd Berven, Lali Sekhon, Christopher Shaffrey, Justin S. Smith, Robert Hart, Han Jo Kim, Jeffrey Wang, Yoon Ha, Kenny Kwan, Yong Hai, Marcelo Valacco, Asdrubal Falavigna, Nestor Taboada, Alfredo Guiroy, Juan Emmerich, Bernhard Meyer, Frank Kandziora, Claudius Thome, Markus Loibl, Wilco Peul, Alessandro Gasbarrini, Ibrahim Obeid, Martin Gehrchen, Andrej Trampuz, Peter Vajkoczy, Julia Onken
Summary: This study provides an international overview of the heterogeneity of surgical site infection prevention strategies in spine surgery. The results demonstrate a significant variation in pre-, peri-, and postoperative measures to prevent surgical site infection. There is a need for developing universal guidelines and testing areas of controversy in prospective clinical trials.
GLOBAL SPINE JOURNAL
(2023)
Article
Gastroenterology & Hepatology
E. Garofalo, F. Selvaggi, A. Spinelli, G. Pellino, K. Flashman, M. Frasson, M. Carvello, N. de'Angelis, A. Garcia-Granero, M. Harper, J. Warusavitarne, M. Coleman, E. Espin, V Celentano
Summary: In the surgical management of ileocolonic Crohn's disease, there was high agreement among colorectal surgeons on the main procedure to be performed, but there was controversy and low agreement on the treatment of multifocal disease, including the need for associated procedures such as strictureplasties. Additionally, there was significant heterogeneity in decisions on when to anastomose and when to fashion an ileostomy.
INTERNATIONAL JOURNAL OF COLORECTAL DISEASE
(2021)
Article
Urology & Nephrology
Charan Mohan, Elizabeth Sonntag, Mark Ehlers, Jason Akerman, Solomon Hayon, Brad Figler, R. Matthew Coward
Summary: The study investigated how surgeons approach ethically challenging scenarios in penile prosthesis surgery and identified patient-related factors impacting their decision-making process. The results showed that while the likelihood of offering penile prosthesis surgery decreased with most ethical dilemmas, specific clinical factors often augmented decision-making among urological prosthetic surgeons.
Article
Medicine, General & Internal
Jihyeon Choi, Jeong-Eun Lee, Bora Choi, Jungook Kim, Seung Eun Lee
Summary: The study found that female surgeons are more likely to experience gender discrimination in all forms and are more likely to acknowledge the presence of gender discrimination.
JOURNAL OF KOREAN MEDICAL SCIENCE
(2021)
Article
Gastroenterology & Hepatology
Tetsuro Toriumi, Koichi Yagi, Motonari Ri, Shoh Yajima, Yasuhiro Okumura, Susumu Aikou, Hiroharu Yamashita, Sachiyo Nomura, Yasuyuki Seto
Summary: This study aimed to identify prognostic factors for long-term outcomes of patients with node-negative ESCC, finding that lymphatic invasion (Ly+) was the only independent prognostic factor associated with worse overall survival and recurrence-free survival. Patients with node-negative ESCC and lymphatic invasion may benefit from adjuvant treatment.
DISEASES OF THE ESOPHAGUS
(2022)
Article
Oncology
Yusuke Nakamura, Jun Kinoshita, Takahisa Yamaguchi, Tatsuya Aoki, Hiroto Saito, Toshihide Hamabe-Horiike, Shinichi Harada, Sachiyo Nomura, Noriyuki Inaki, Sachio Fushida
Summary: By suppressing cancer-associated fibroblasts (CAFs), Tranilast improved the immunosuppressive microenvironment in a mouse PM model and showed potential as a candidate drug for PM treatment.
Article
Biochemistry & Molecular Biology
Souvick Roy, Mitsuro Kanda, Sachiyo Nomura, Zhongxu Zhu, Yuji Toiyama, Akinobu Taketomi, James Goldenring, Hideo Baba, Yasuhiro Kodera, Ajay Goel
Summary: This study developed a non-invasive liquid biopsy method for early detection of gastric cancer by using circular RNAs (circRNAs) as biomarkers. The researchers identified a panel of 8 circRNAs that could reliably distinguish gastric cancer patients from non-disease controls, even in early-stage patients. The decreased expression of circRNAs in serum samples suggested their tumor specificity.
Article
Surgery
Kota Itamoto, Hiraku Kumamaru, Susumu Aikou, Koichi Yagi, Hiroharu Yamashita, Sachiyo Nomura, Hiroaki Miyata, Shinji Kuroda, Toshiyoshi Fujiwara, Shunsuke Endo, Yuko Kitagawa, Yoshihiro Kakeji, Yasuyuki Seto
Summary: This study analyzed data from a Japanese nationwide database to explore the association between hospital volume and short-term outcomes of appendectomy, cholecystectomy, and pneumothorax surgery. The results showed that hospital volume had no impact on the short-term outcomes of these common surgeries.
Article
Surgery
Shinichiro Shiomi, Shoh Yajima, Shuntaro Yoshimura, Masayuki Urabe, Motonari Ri, Yasuhiro Okumura, Koichi Yagi, Susumu Aikou, Sachiyo Nomura, Yasuyuki Seto
Summary: This study aimed to explore the diagnostic accuracy and optimal criteria for predicting lymph node metastasis in esophageal squamous cell carcinoma, and found variations in diagnostic ability and cutoff values among different locations.
Article
Biochemistry & Molecular Biology
Rejina Shrestha, Naoko Murata-Kamiya, Satoshi Imai, Masami Yamamoto, Tetsuya Tsukamoto, Sachiyo Nomura, Masanori Hatakeyama
Summary: The initial step in bacterial infection is the adherence of the bacterium to the target cell surface. This study found that the mouse stomach has a much lower expression level of Ceacam1 compared to the human stomach, which leads to the inability of the bacteria to deliver the CagA protein due to the lack of interaction between HopQ and Ceacam1 in mouse gastric epithelial cells.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Multidisciplinary Sciences
Tomohiko Yasuda, Hyun Seok Lee, Su Youn Nam, Hiroto Katoh, Yuko Ishibashi, Somay Yamagata Murayama, Hidenori Matsui, Hiroki Masuda, Emiko Rimbara, Nobuyuki Sakurazawa, Hideyuki Suzuki, Hiroshi Yoshida, Yasuyuki Seto, Shumpei Ishikawa, Seong Woo Jeon, Masahiko Nakamura, Sachiyo Nomura
Summary: Genetic analysis and culturing techniques for gastric non-Helicobacter pylori Helicobacter (NHPH) are advancing, with NHPH reported to accompany certain gastric conditions. A study on Korean gastric cancer patients found a low percentage positive for NHPH, suggesting it may play a role in gastric cancer development, albeit with lower pathogenicity compared to H. pylori.
SCIENTIFIC REPORTS
(2022)
Article
Surgery
Emiko Kono, Urara Isozumi, Sachiyo Nomura, Kae Okoshi, Hiroyuki Yamamoto, Hiroaki Miyata, Itaru Yasufuku, Hiromichi Maeda, Junichi Sakamoto, Kazuhisa Uchiyama, Yoshihiro Kakeji, Kazuhiro Yoshida, Yuko Kitagawa
Summary: This study found that female surgeons in Japan have less surgical experience than male surgeons, and this gap tends to widen with an increase in years of experience, especially for medium- and high-difficulty operations. The gender disparity in surgical experience needs to be eliminated, so that female surgeons can advance to leadership positions.
Article
Medicine, General & Internal
Kae Okoshi, Hideki Endo, Sachiyo Nomura, Emiko Kono, Yusuke Fujita, Itaru Yasufuku, Koya Hida, Hiroyuki Yamamoto, Hiroaki Miyata, Kazuhiro Yoshida, Yoshihiro Kakeji, Yuko Kitagawa
Summary: This study compared the short-term surgical outcomes between male and female gastrointestinal surgeons in Japan. The results showed no significant difference in surgical mortality and surgical complications between the two genders. It was also observed that female surgeons took on patients at higher risk.
BMJ-BRITISH MEDICAL JOURNAL
(2022)
Article
Pathology
Hideaki Mita, Hiroto Katoh, Daisuke Komura, Miwako Kakiuchi, Hiroyuki Abe, Hirofumi Rokutan, Koichi Yagi, Sachiyo Nomura, Tetsuo Ushiku, Yasuyuki Seto, Shumpei Ishikawa
Summary: In this study, immunohistochemical analysis of 342 gastric cancer cases revealed that approximately half of the samples showed aberrant expression of CDH11 in gastric cancer cells. The aberrant expression of CDH11 was statistically associated with bone metastasis, as well as liver and distant lymph node metastasis. Therefore, aberrant CDH11 expression in gastric cancer cells can serve as a predictive biomarker for distant metastasis.
PATHOLOGY RESEARCH AND PRACTICE
(2023)
Article
Genetics & Heredity
Yasushi Totoki, Mihoko Saito-Adachi, Yuichi Shiraishi, Daisuke Komura, Hiromi Nakamura, Akihiro Suzuki, Kenji Tatsuno, Hirofumi Rokutan, Natsuko Hama, Shogo Yamamoto, Hanako Ono, Yasuhito Arai, Fumie Hosoda, Hiroto Katoh, Kenichi Chiba, Naoko Iida, Genta Nagae, Hiroki Ueda, Chen Shihang, Shigeki Sekine, Hiroyuki Abe, Sachiyo Nomura, Tetsuya Matsuura, Eiji Sakai, Takashi Ohshima, Yasushi Rino, Khay Guan Yeoh, Jimmy So, Kaushal Sanghvi, Richie Soong, Akihiko Fukagawa, Shinichi Yachida, Mamoru Kato, Yasuyuki Seto, Tetsuo Ushiku, Atsushi Nakajima, Hitoshi Katai, Patrick Tan, Shumpei Ishikawa, Hiroyuki Aburatani, Tatsuhiro Shibata
Summary: A study on a cross-ancestry genomic and transcriptomic cohort of gastric cancer reveals significantly mutated genes and mutational signatures, some of which are specific to certain ancestries. The research involves the analysis of 1,335 cases and identifies 77 significantly mutated genes, including ARHGAP5 and TRIM49C. Subtype-specific drivers, such as PIGR and SOX9, are also identified, particularly enriched in the diffuse subtype of the disease. The findings also highlight the association of non-protein-truncating CDH1 mutations with sporadic diffuse-type cases and the link between alcohol consumption or metabolism and RHOA mutations in patients with East Asian ancestry. The study provides comprehensive insights into the molecular landscape of gastric cancer across various subtypes and ancestries.
Article
Oncology
Kentaro Minegishi, Yoh Dobashi, Teruhide Koyama, Yuko Ishibashi, Miki Furuya, Hiroyoshi Tsubochi, Yasukazu Ohmoto, Tomohiko Yasuda, Sachiyo Nomura
Summary: Trefoil factors (TFFs) have been found to be upregulated in various types of cancer, indicating their potential as biomarkers for screening. This study evaluated the clinical relevance of serum and urinary TFFs as biomarkers for lung cancer and their correlation with TFF expression levels in lung cancer tissue. The results showed that serum TFF levels were significantly higher in lung cancer patients, while urinary TFF levels were lower. Serum TFF1, TFF2, TFF3, and urinary TFF1, TFF3 showed the highest potential to discriminate between cancer and non-cancer samples. The findings suggest that serum and urinary TFF levels could serve as predictive biomarkers for lung cancer.
Article
Gastroenterology & Hepatology
Long Long Cao, Heng Lu, Mohammed Soutto, Nadeem Bhat, Zheng Chen, Dunfa Peng, Ahmed Gomaa, Jia Bin Wang, Jian Wei Xie, Ping Li, Chao Hui Zheng, Sachiyo Nomura, Jashodeep Datta, Nipun Merchant, Zhi Bin Chen, Alejandro Villarino, Alexander Zaika, Chang Ming Huang, Wael El-Rifai
Summary: This study developed a classification method based on immune cell infiltration to classify GC and found that immune desert-type and excluded-type tumors are resistant to ICB therapy compared to immune-inflamed tumors. The study also identified the enrichment of epithelial-mesenchymal transition (EMT) signaling in immune desert-type GC, and showed that mesenchymal-like tumors in syngeneic mice exhibited T cell-exclusion and resistance to CTLA4 blockade.
Article
Surgery
Shinichiro Shiomi, Koichi Yagi, Ryohei Iwata, Shoh Yajima, Yasuhiro Okumura, Susumu Aikou, Hiroharu Yamashita, Sachiyo Nomura, Yasuyuki Seto
Summary: The study investigated the diagnostic utility of a newly established lymphatic flow mapping protocol for predicting lymph node metastasis in patients with esophageal or esophagogastric junction cancer. The results showed that this protocol potentially helps to predict lymph node metastasis intraoperatively in patients who did not undergo neoadjuvant chemotherapy.
SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES
(2023)
Article
Biochemistry & Molecular Biology
Yasuyoshi Sato, Hiroharu Yamashita, Yukari Kobayashi, Koji Nagaoka, Tetsuro Hisayoshi, Takuya Kawahara, Akihiro Kuroda, Noriyuki Saito, Ryohei Iwata, Yasuhiro Okumura, Koichi Yagi, Susumu Aiko, Sachiyo Nomura, Kazuhiro Kakimi, Yasuyuki Seto
Summary: We investigated the tumor immune response in gastric cancer patients receiving third-line nivolumab monotherapy to identify immune-related biomarkers for better patient selection. High T cell/Treg ratios and specific gene expression signatures show promise as potential biomarkers for treatment response, while the tumor-infiltrating immune response is compromised by prior treatments.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)