Article
Cardiac & Cardiovascular Systems
Dominic Emerson, Joanna Chikwe, Pedro Catarino, Mohamed Hassanein, Luqin Deng, Ryan S. Cantor, Amy Roach, Robert Cole, Fardad Esmailian, Jon Kobashigawa, Jaime Moriguchi, James K. Kirklin
Summary: In contemporary practice, elderly patients receiving LVADs showed improved survival, increased functional capacity, enhanced quality of life, and fewer complications compared with younger patients.
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2021)
Article
Cardiac & Cardiovascular Systems
Jared J. Herr, Ashwin Ravichandran, Farooq H. Sheikh, Anuradha Lala, Christopher V. Chien, Stephanie Hsiao, Ajay Srivastava, Dawn Pedrotty, Jennifer Nowaczyk, Shannon Tompkins, Sara Ahmed, Fei Xiang, Stephen Forest, Michael Z. Tong, Benjamin D'souza
Summary: The majority of referrals for advanced heart failure therapies came from heart failure cardiologists, with a prevalence of late referrals in high-risk patients. Patients referred by heart failure cardiologists were more likely to be offered AHF therapies. Late referrals correlated with worsened outcomes, highlighting the need for education among clinicians regarding the benefits and appropriate timing of referrals to AHF centers.
JOURNAL OF CARDIAC FAILURE
(2021)
Article
Cardiac & Cardiovascular Systems
Hongtao Tie, Jing Zhu, Sakir Akin, Larry A. Allen, Bi Huang, Sabrina Martens, Henryk Welp, Andrew Simpkin, Rui Shi, Qingchen Wu, Osama Soliman, Kadir Caliskan, Dan Chen
Summary: This study investigates the characteristics and outcomes of patients with cancer undergoing durable LVAD, and finds that cancer patients have lower survival rates, lower heart transplantation rates, and increased risk of bleeding after LVAD.
CIRCULATION-HEART FAILURE
(2023)
Article
Biotechnology & Applied Microbiology
Xin Shi, Li Zhang, Yi Li, Jieyuan Xue, Feng Liang, Han-wen Ni, Xia Wang, Zhaohua Cai, Ling-hong Shen, Tao Huang, Ben He
Summary: This study identified candidate genes significantly altered in heart failure (HF) through transcriptome analysis and related methods, and discovered specific biomarkers of endothelial cells and cardiac fibrosis. The results also revealed both commonality and specificity in the pathogenesis of HF between ischemic cardiomyopathy (ICM) and dilated cardiomyopathy (DCM), and found higher inflammation in ICM, which may be related to the activation of a chemokine signaling pathway.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Article
Cell Biology
Yuanxiu Song, Hongxia Li, Shuhong Ma, Min Zhu, Wen-Jing Lu, Feng Lan, Ming Cui
Summary: Alcoholic cardiomyopathy (ACM) is a myocardial injury caused by long-term heavy drinking. This study used human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs) to establish an in vitro model of ACM and found that AngII and AT1R play a role in alcohol-induced myocardial damage through oxidative stress. The mechanism may involve the regulation of NOX.
CELL DEATH DISCOVERY
(2022)
Review
Cell Biology
Ganyi Chen, Hongwei Jiang, Yiwei Yao, Zhonghao Tao, Wen Chen, Fuhua Huang, Xin Chen
Summary: Macrophages play a crucial role in cardiomyopathy and understanding their molecular mechanisms helps in understanding the development of the disease. Targeted therapy on macrophages has shown promise in experimental studies, but there are challenges and considerations for clinical translation.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Maciej Stapor, Adam Pilat, Andrzej Gackowski, Agnieszka Misiuda, Izabela Gorkiewicz-Kot, Michal Kaleta, Pawel Kleczynski, Krzysztof Zmudka, Jacek Legutko, Boguslaw Kapelak, Karol Wierzbicki
Summary: This study evaluates the feasibility of physiological pump speed optimization based on aortic valve opening (AVO) imaging during a cardiopulmonary exercise test (CPET) in LVAD patients. The results show that dynamic echo-guided pump speed adjustment based on AVO improves exercise tolerance and augments peak oxygen consumption and maximum workload.
Article
Engineering, Biomedical
Mariano Francisco Del Maria Javier, Eva Maria Javier Delmo, Roland Hetzer
Summary: This case report demonstrates the successful use of a ventricular assist device in a tumor patient with anthracycline-induced cardiomyopathy. The device supported the patient for 419 days until she was tumor-free and able to undergo heart transplantation. The patient has now been followed up for 18 years without any malignancy.
Review
Cardiac & Cardiovascular Systems
Seth J. Rotz, Thomas D. Ryan, Salim S. Hayek
Summary: Hematopoietic stem cell transplantation is a potentially curative treatment for various diseases, but it can also lead to significant cardiovascular complications that require pre-transplant evaluation.
JOURNAL OF THROMBOSIS AND THROMBOLYSIS
(2021)
Article
Pediatrics
Estela Azeka, Adam Arshad, Cristiane Martins, Anna Claudia Dominguez, Adailson Siqueira, Andre Silveira Loss, Marcelo Jatene, Nana Miura
Summary: The study described the clinical course of a newborn who developed dilated cardiomyopathy after COVID-19 infection, highlighting the importance of monitoring and intervention in such rare cases.
FRONTIERS IN PEDIATRICS
(2021)
Article
Cardiac & Cardiovascular Systems
Minoru Ono
Summary: ARVC is an inherited cardiomyocyte disease characterized by intractable ventricular arrhythmia. Fatal ventricular arrhythmia has been the primary cause of death in ARVC patients. However, improved early recognition and treatment have increased survival. For a small proportion of patients with biventricular failure, heart transplantation is the only option. There is no consensus on effectively supporting these patients with a mechanical circulatory device.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Cardiac & Cardiovascular Systems
Lily Rosenthal, Sarah Marie Ulrich, Linda Zimmerling, Paolo Brenner, Christoph Mueller, Sebastian Michel, Juergen Horer, Heinrich Netz, Nikolaus A. Haas, Christian Hagl
Summary: In this study, we analyzed the early and long-term survival of ABO-compatible heart transplantation in children under 3 years old. The results showed that pediatric heart transplantation has acceptable long-term results, but patients under 3 months old and those with single ventricle physiology had a higher early mortality rate.
INTERNATIONAL JOURNAL OF CARDIOLOGY
(2022)
Review
Cardiac & Cardiovascular Systems
Sofia Lakhdar, Chandan Buttar, Mahmood Nassar, Camelia Ciobanu, Rima Patel, Most Sirajum Munira
Summary: The study evaluated the outcomes of heart transplantation in cardiac amyloidosis. Previous studies have shown poor outcomes for amyloidosis patients after heart transplantation, but recent advancements in treatments have significantly improved the prognosis. The results of multiple studies were pooled and showed that with current treatments and a multidisciplinary approach, heart transplantation in amyloidosis patients may lead to encouraging outcomes in the current era.
HEART FAILURE REVIEWS
(2022)
Article
Cardiac & Cardiovascular Systems
Jingdong Li, Wanyue Zhu, Guanhua Su, Feng Zhu, Xinxin Shuai, Yidi Meng, Jiaming Zhang, Hao Chen
Summary: This case report describes two Chinese siblings with Becker muscular dystrophy (BMD) and left ventricular noncompaction (LVNC). A deletion mutation in exons 10 to 12 of the DMD gene was identified through genetic sequencing and quantitative testing. Muscle biopsies showed typical features of dystrophinopathies. Cardiac examinations revealed enlarged left ventricles, LVNC, and reduced left ventricular ejection fraction in both siblings. The proband underwent a heart transplantation with a complication-free follow-up of 4 years.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2023)
Article
Cardiac & Cardiovascular Systems
Laura Murphy, Gerard T. Giblin, Neasa Starr, Norma Caples, Regina Black, Carmel Halley, Kenneth McDonald, Emer Joyce
Summary: This study aimed to identify the accurate prevalence data for ambulatory advanced heart failure (HF) in European countries. The survey results showed that approximately 5% of the all-comer routine HF clinic population could be eligible for referral to an advanced HF center for assessment for advanced surgical therapies. The study also found that almost one-quarter of patients in this chronic outpatient population had NYHA III-IV symptoms. These findings are important for resource and service planning.
Article
Cardiac & Cardiovascular Systems
Noriyuki Kashiyama, Robert L. Kormos, Yasumoto Matsumura, Antonio D'Amore, Shigeru Miyagawa, Yoshiki Sawa, William R. Wagner
Summary: Combining ADSCs with a cardiac patch shows improved engraftment, cardiac function, and neovascularization in a rat ischemic cardiomyopathy model.
JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY
(2022)
Editorial Material
Cardiac & Cardiovascular Systems
Masaro Nakae, Koichi Toda, Daisuke Yoshioka, Shigeru Miyagawa, Satoshi Kainuma, Takuji Kawamura, Ai Kawamura, Noriyuki Kashiyama, Yoshiki Sawa
Summary: This study describes a new repair technique for ventricular septal rupture after acute myocardial infarction, using two patches to exclude the infarcted myocardium and close the rupture site without the need for sutures. The technique showed promising clinical outcomes in preventing recurrent interventricular shunt after ventricular septal rupture.
ANNALS OF THORACIC SURGERY
(2022)
Article
Cardiac & Cardiovascular Systems
Mikiko Senzai, Satoshi Kainuma, Koichi Toda, Shigeru Miyagawa, Daisuke Yoshioka, Takuji Kawamura, Ai Kawamura, Noriyuki Kashiyama, Yusuke Misumi, Takayoshi Ueno, Toru Kuratani, Tetsuhisa Kitamura, Sho Komukai, Kazuhiro Taniguchi, Yoshiki Sawa
Summary: This study aimed to investigate the incidence and determinants of postoperative adverse events in patients with ischemic cardiomyopathy who underwent long-term durable mitral valve repair. The results showed that approximately 50% of the patients died or were hospitalized for heart failure during the 5-year follow-up, even in the absence of recurrent mitral regurgitation. This finding suggests that durable mitral repair does not always lead to favorable clinical outcomes, and adverse events may be associated with volume overload due to impaired renal function and less favorable pulmonary hemodynamics.
ANNALS OF THORACIC SURGERY
(2022)
Article
Engineering, Biomedical
Hiroko Iseoka, Masao Sasai, Shigeru Miyagawa, Kazuhiro Takekita, Satoshi Date, Hirohito Ayame, Azusa Nishida, Sho Sanami, Takao Hayakawa, Yoshiki Sawa
Summary: Quality control is crucial in the manufacturing cost of cell products, with mycoplasma testing being an important biological test. A mycoplasma identification program using a convolutional neural network can reduce test time and improve sensitivity, leading to a low-cost and streamlined manufacturing process for cellular products.
JOURNAL OF ARTIFICIAL ORGANS
(2022)
Article
Cardiac & Cardiovascular Systems
Junki Yokota, Toru Kuratani, Kazuo Shimamura, Takayuki Shijo, Kizuku Yamashita, Toru Ide, Ryota Matsumoto, Shigeru Miyagawa
Summary: The study found that the use of protection sheet can significantly reduce the risk of radiation exposure to the eye of surgeons during endocardiovascular surgery in the hybrid operating room.
GENERAL THORACIC AND CARDIOVASCULAR SURGERY
(2022)
Article
Surgery
Masaaki Ryomoto, Taichi Sakaguchi, Hiroe Tanaka, Mitsuhiro Yamamura, Naosumi Sekiya, Shin Yajima, Hisashi Uemura, Ayaka Sato
Summary: This study evaluated the outcomes of open repair and endovascular repair for chronic type B dissecting aortic aneurysm. The results showed that open repair was still a better option for DeBakey IIIb dissection, but the distal un-resected aortic portion over 41 mm was associated with late aortic events.
ANNALS OF VASCULAR SURGERY
(2022)
Review
Cardiac & Cardiovascular Systems
Masato Nakamura, Hitoshi Yaku, Junya Ako, Hirokuni Arai, Tohru Asai, Taishiro Chikamori, Hiroyuki Daida, Kiyoshi Doi, Toshihiro Fukui, Toshiaki Ito, Kazushige Kadota, Junjiro Kobayashi, Tatsuhiko Komiya, Ken Kozuma, Yoshihisa Nakagawa, Koichi Nakao, Hiroshi Niinami, Takayuki Ohno, Yukio Ozaki, Masataka Sata, Shuichiro Takanashi, Hirofumi Takemura, Takafumi Ueno, Satoshi Yasuda, Hitoshi Yokoyama, Tomoyuki Fujita, Tokuo Kasai, Shun Kohsaka, Takashi Kubo, Susumu Manabe, Naoya Matsumoto, Shigeru Miyagawa, Tomohiro Mizuno, Noboru Motomura, Satoshi Numata, Hiroyuki Nakajima, Hirotaka Oda, Hiromasa Otake, Fumiyuki Otsuka, Ken-Ichiro Sasaki, Kazunori Shimada, Tomoki Shimokawa, Toshiro Shinke, Tomoaki Suzuki, Masao Takahashi, Nobuhiro Tanaka, Hiroshi Tsuneyoshi, Taiki Tojo, Dai Une, Satoru Wakasa, Koji Yamaguchi, Takashi Akasaka, Atsushi Hirayama, Kazuo Kimura, Takeshi Kimura, Yoshiro Matsui, Shunichi Miyazaki, Yoshitaka Okamura, Minoru Ono, Hiroki Shiomi, Kazuo Tanemoto
CIRCULATION JOURNAL
(2022)
Article
Engineering, Biomedical
Yuji Tominaga, Daisuke Yoshioka, Koichi Toda, Tetsuya Saito, Takuji Kawamura, Noriyuki Kashiyama, Ai Kawamura, Ryohei Matsuura, Takuji Watanabe, Masaki Taira, Shigeru Miyagawa
Summary: This study aimed to identify risk factors for adverse GYN-bleeding in women with implantable LVADs. The history of GYN-bleeding before implantation was found to be a significant risk factor for developing GYN-bleeding after LVAD implantation.
JOURNAL OF ARTIFICIAL ORGANS
(2022)
Article
Engineering, Biomedical
Tsubasa Mikami, Takuji Kawamura, Keita Inoguchi, Ai Kawamura, Kei Nakamoto, Daisuke Yoshioka, Koichi Toda, Yasushi Sakata, Shigeru Miyagawa
Summary: A pump infection is a fatal complication specific to left ventricular assist devices, and infection recurrence is a major concern during device exchange. In this case, we used the Impella 5.0 to maintain proper hemodynamics and treat the infection, effectively controlling the infection and minimizing organ dysfunction. This demonstrates that the Impella 5.0 can serve as an effective bridge for device exchange.
JOURNAL OF ARTIFICIAL ORGANS
(2022)
Article
Engineering, Biomedical
Tsutomu Doita, Takuji Kawamura, Koichi Inoue, Ai Kawamura, Noriyuki Kashiyama, Ryohei Matsuura, Tetsuya Saito, Daisuke Yoshioka, Koichi Toda, Shigeru Miyagawa
Summary: Thrombus formation is a common and often life-threatening complication in patients with severe heart failure and LVAD support. Choosing the appropriate treatment for pump thrombosis, particularly in emergency cases with severe pump failure, is challenging.
JOURNAL OF ARTIFICIAL ORGANS
(2022)
Article
Cell Biology
Yusuke Kametani, Shota Tanaka, Yuriko Wada, Shota Suzuki, Ayaka Umeda, Kosuke Nishinaka, Yoshiaki Okada, Makiko Maeda, Shigeru Miyagawa, Yoshiki Sawa, Masanori Obana, Yasushi Fujio
Summary: Mammalian cardiomyocytes largely cease to proliferate immediately after birth, limiting the regenerative activity of the heart. Inhibition of GSK-3 promotes cardiomyocyte proliferation, and YAP is endogenously activated. This study addresses the importance of YAP activity in GSK-3 inhibitor-induced cardiomyocyte proliferation.
JOURNAL OF CELLULAR PHYSIOLOGY
(2022)
Article
Multidisciplinary Sciences
Shohei Yoshida, Shigeru Miyagawa, Takashi Matsuzaki, Yasuyuki Ishii, Emi Fukuda-Kawaguchi, Takuji Kawamura, Ai Kawamura, Yuki Nakamura, Koichi Toda, Yoshiki Sawa
Summary: Mixed-chimera mice established using RGI-2001 showed prolonged graft survival after allogeneic iPSC-CM transplantation and reduced infiltration of immune cells.
Article
Cardiac & Cardiovascular Systems
Ai Kawamura, Koichi Maeda, Kizuku Yamashita, Kazuo Shimamura, Shigeru Miyagawa
Summary: This article reports the first experience of transfemoral (TF)-TAVR with the insertion of a filter device for two patients with severe aortic stenosis who were incidentally detected a grade 4 atheroma in the ascending aorta preoperatively. The patients had a favorable postoperative course without any cerebrovascular events or procedure-related complications.
GENERAL THORACIC AND CARDIOVASCULAR SURGERY
(2022)
Article
Medicine, General & Internal
Yuji Tominaga, Takayoshi Ueno, Masaki Taira, Shigeru Miyagawa, Yoshiki Sawa
Summary: The case study presented a 28-year-old male with multiple heart conditions and infective endocarditis, making surgical planning difficult due to the inability to accurately assess the cardiac condition. A staged approach was chosen, with pulmonary valve replacement performed first for source control, followed by a more definitive operation after recovery.
SAGE OPEN MEDICAL CASE REPORTS
(2022)
Article
Immunology
Satoko Motegi, Atsunori Tsuchiya, Takahiro Iwasawa, Takeki Sato, Masaru Kumagai, Kazuki Natsui, Shunsuke Nojiri, Masahiro Ogawa, Suguru Takeuchi, Yosiki Sakai, Shigeru Miyagawa, Yoshiki Sawa, Shuji Terai
Summary: ONO-1301 demonstrated therapeutic effects in ameliorating liver damage and fibrosis progression in a mouse model of NASH. It also suppressed liver tumor occurrence and showed anti-inflammatory properties in in vitro studies. Additionally, ONO-1301 can potentially be a new drug candidate against NASH due to its multidirectional effects on various pathways.
INFLAMMATION AND REGENERATION
(2022)
