Article
Medicine, General & Internal
Goh Eun Chung, Hyo Eun Park, Heesun Lee, Min Joo Kim, Su-Yeon Choi, Jeong Yoon Yim, Ji Won Yoon
Summary: The study found that sarcopenic obesity (SO) was significantly associated with a higher prevalence of high coronary calcium scoring (CAC) in a health check-up population. After adjusting for known risk factors, individuals with SO exhibited a significantly higher odds of a high CAC score. These findings suggest a synergistic effect of sarcopenia and obesity in increasing atherosclerotic burden in coronary arteries, potentially leading to adverse cardiovascular events.
FRONTIERS IN MEDICINE
(2021)
Article
Ophthalmology
Jin Hyung Kim, Seong Eun Kim, Seo Hee Kim, Byoung Wook Choi, Tyler Hyungtaek Rim, Suk Ho Byeon, Sung Soo Kim
Summary: The study found a significant negative association between coronary artery calcification and subfoveal choroidal thickness in subjects with subclinical atherosclerosis. This suggests that subfoveal choroidal thinning could potentially be a useful biomarker for predicting cardiovascular risk in older patients with subclinical atherosclerosis.
Article
Cardiac & Cardiovascular Systems
Qing-Yun Hao, Jing-Wei Gao, Zhi-Min Yuan, Ming Gao, Jing-Feng Wang, Francois Schiele, Shao-Ling Zhang, Pin-Ming Liu
Summary: The study found that elevated levels of remnant cholesterol (RC) were associated with an increased risk of coronary artery calcium (CAC) progression, independent of traditional cardiovascular risk factors, even in individuals with optimal LDL-C levels.
CIRCULATION-CARDIOVASCULAR IMAGING
(2022)
Article
Cardiac & Cardiovascular Systems
Nestor S. Martins, Joaquim Barreto, Sheila Tatsumi Kimura-Medorima, Sofia Helena Vitte, Thiago Quinaglia, Barbara Assato, Otavio Rizzi Coelho-Filho, Jose Roberto Matos-Souza, Wilson Nadruz, Andrei C. Sposito
Summary: This study found that in individuals with type 2 diabetes, carotid intimal thickness (cIT) is a better predictor of coronary artery calcification (CAC) than carotid intima-media thickness (cIMT), and carotid media thickness (cM) is not associated with CAC.
NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES
(2023)
Article
Endocrinology & Metabolism
Bart S. Ferket, M. G. Myriam Hunink, Umesh Masharani, Wendy Max, Joseph Yeboah, Kirsten E. Fleischmann
Summary: The study found that individuals with type 2 diabetes are more likely to develop coronary artery calcium at a younger age than those without diabetes, and the risk of CAC increases with longer duration of diabetes treatment. Factors such as male sex, White ethnicity/race, hypertension, hypercholesterolemia, obesity, and low serum creatinine are also associated with increased risk of CAC.
Article
Medicine, General & Internal
Sadiya S. Khan, Wendy S. Post, Xiuqing Guo, Jingyi Tan, Fang Zhu, Daniel Bos, Bahar Sedaghati-Khayat, Jeroen van Rooij, Aaron Aday, Norrina B. Allen, Maxime M. Bos, Andre G. Uitterlinden, Matthew J. Budoff, Donald M. Lloyd-Jones, Jonathan D. Mosley, Jerome I. Rotter, Philip Greenland, Maryam Kavousi
Summary: Coronary artery calcium score and polygenic risk score were evaluated for their ability to predict risk of coronary heart disease (CHD) in two population-based studies. The results showed that coronary artery calcium score had better discrimination and improved risk prediction when added to traditional risk factors compared to the polygenic risk score.
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
(2023)
Article
Transplantation
Ida M. H. Sorensen, Sasha S. Bjergfelt, Henrik O. Hjortkjaer, Klaus F. Kofoed, Theis Lange, Bo Feldt-Rasmussen, Christina Christoffersen, Susanne Bro
Summary: This study found that calcium scores in the coronary, carotid, and thoracic arteries are independent predictors of major adverse cardiovascular events and all-cause mortality in patients with chronic kidney disease. The potential of calcification in these three arterial sites for predicting cardiovascular events and mortality was most pronounced.
NEPHROLOGY DIALYSIS TRANSPLANTATION
(2023)
Article
Medicine, General & Internal
C. Rotondo, S. Sciacca, V Rella, G. Busto, R. Colia, F. P. Cantatore, A. Corrado
Summary: This study found varying degrees of cardiovascular impairment, particularly subclinical coronary artery disease, in SSc patients. Metabolic syndrome, carotid plaques, and peripheral artery disease were the major factors associated with subclinical coronary atherosclerosis (SCA). Furthermore, the presence of pulmonary arterial hypertension (PAH) was the sole predictor of major cardiovascular events (MCVE) during the follow-up period. These findings highlight the need for cardiovascular assessment and more aggressive treatment strategies to reduce MCVE in SSc patients.
EUROPEAN JOURNAL OF INTERNAL MEDICINE
(2023)
Article
Nutrition & Dietetics
Kirsty M. Mckenzie, Reeja Nasir, Yang Kong, Hasthi U. Dissanayake, Rowena McMullan, Adrienne Gordon, Alice Meroni, Melinda Phang, Michael R. Skilton
Summary: Evidence from animal models suggests that maternal diet during pregnancy may affect offspring cardiometabolic health. However, in healthy pregnancies, neither the quantity nor quality of maternal carbohydrate intake appears to have a significant impact on newborn aortic intima-medial thickness, except for fiber intake in overweight or obese women. The effect of carbohydrate quality may be more pronounced in high-risk pregnancies.
Article
Clinical Neurology
Ana Luiza Vieira de Araujo, Raul D. Santos, Marcio Sommer Bittencourt, Roberto Nery Dantas, Carlos Andre Oshiro, Cesar Higa Nomura, Edson Bor-Seng-Shu, Marcelo de Lima Oliveira, Claudia da Costa Leite, Maria da Graca Morais Martin, Maramelia Miranda Alves, Gisele Sampaio Silva, Victor Marinho Silva, Adriana Bastos Conforto
Summary: The frequency of coronary calcification is higher in patients with stroke or transient ischemic attack caused by large-artery atherosclerosis than in controls. CAC scores are even higher in patients with stenosis in both cervical and intracranial arteries.
FRONTIERS IN NEUROLOGY
(2023)
Article
Endocrinology & Metabolism
Claes Ohlsson, Maria Nethander, Anna-Karin Norlen, Matti Poutanen, Elias Freyr Gudmundsson, Thor Aspelund, Sigurdur Sigurdsson, Henrik Ryberg, Vilmundur Gudnason, Asa Tivesten
Summary: This study found an inverse association between serum levels of DHEA and testosterone and coronary artery calcification in elderly men, partially independently from each other. These results raise the question whether androgens produced by both the adrenals and the testes may contribute to male cardiovascular health.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2023)
Review
Hematology
Jean-Baptiste Michel, Jeremy Lagrange, Veronique Regnault, Patrick Lacolley
Summary: The arterial wall is organized into layers, with each layer playing a specific role in clearing substances from the blood. The endothelium acts as a barrier, while the media layer is involved in taking up molecules and particles. The outer layers, including the adventitia and perivascular tissue, also contribute to the clearance functions. These clearance functions are essential for maintaining arterial health but can also contribute to pathologies.
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
(2022)
Article
Medicine, General & Internal
Rafal Galaska, Dorota Kulawiak-Galaska, Karolina Dorniak, Aneta Strozyk, Agnieszka Sabisz, Magdalena Chmara, Bartosz Wasag, Agnieszka Mickiewicz, Andrzej Rynkiewicz, Marcin Fijalkowski, Marcin Gruchala
Summary: This study aimed to compare subclinical atherosclerosis in the ascending and descending aortas in patients with asymptomatic familial hypercholesterolemia (FH) and nonfamilial hypercholesterolemia (NFH) using 3D cardiovascular magnetic resonance imaging. The results showed that FH patients had significantly increased wall area and thickness in the aorta compared to NFH patients. The study also found that the etiology of hypercholesterolemia plays a significant role in determining the degree of subclinical atherosclerosis.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Cardiac & Cardiovascular Systems
Camilla Nordheim Solli, Sandra Chamat-Hedemand, Hanne Elming, Anh Ngo, Lasse Kjaer, Vibe Skov, Anders Lindholm Sorensen, Christina Ellervik, Andreas Fuchs, Per Ejlstrup Sigvardsen, Jorgen Tobias Kuhl, Klaus Fuglsang Kofoed, Borge G. Nordestgaard, Hans Hasselbalch, Niels Eske Bruun
Summary: This study investigated whether patients with Philadelphia-negative Myeloproliferative Neoplasms (MPNs) have an increased burden of cardiac calcification and found that MPNs patients have a higher prevalence of coronary artery calcium score (CACS) and aortic valve calcification (AVC) compared to the general population. This association remains significant after adjusting for cardiovascular risk factors.
INTERNATIONAL JOURNAL OF CARDIOLOGY
(2022)
Review
Public, Environmental & Occupational Health
Olatokunbo Osibogun, Oluseye Ogunmoroti, Olamide B. Kolade, Allison G. Hays, Victor Okunrintemi, Anum S. Minhas, Martha Gulati, Erin D. Michos
Summary: In pooled analyses, women with PCOS had approximately twofold greater odds of having CAC compared with women without PCOS. However, additional prospective studies will be needed to further understand the relationship between PCOS and CAC.
JOURNAL OF WOMENS HEALTH
(2022)