Article
Biochemistry & Molecular Biology
Ri-Na Yoo, Hyeon-Min Cho, Bong-Hyeon Kye, Yoon-Suk Lee, Yi-Suk Kim
Summary: Understanding the source and route of pelvic metastasis is crucial for developing effective strategies against rectal cancer. This study used cadaver specimens and intraoperative imaging to explore the lymphatic channels and flow from the distal rectum. The results showed direct drainage of lymphatic flow from the distal rectum into the presacral space, suggesting a possible route of metastasis in distal rectal cancer.
Review
Physiology
Lothar C. Dieterich, Carlotta Tacconi, Luca Ducoli, Michael Detmar
Summary: The lymphatic system is an important transport system in the human body, playing a crucial role in normal physiology and disease pathogenesis. The role of tumor-associated lymphatic vessels and lymphangiogenesis in lymph node metastasis has been well studied, but the mechanisms and relationship between lymphatic vessels and the dissemination of cancer cells to peripheral organs are still not fully understood. Lymphatic vessels also serve as a communication channel between tumors and the host immune system. Lymphatic endothelial cells have recently been recognized as regulators of tumor immunity and immunotherapy responsiveness.
PHYSIOLOGICAL REVIEWS
(2022)
Article
Biochemistry & Molecular Biology
Adam R. Markowski, Agnieszka U. Blachnio-Zabielska, Karolina Pogodzinska, Anna J. Markowska, Piotr Zabielski
Summary: Colorectal cancer is a heterogeneous group of tumors with varied clinical and pathological features based on anatomical location. Sphingolipids play a role in cancer formation and progression, and their changes are important in carcinogenesis. This study analyzed the sphingolipid profile in colorectal cancer and found differences in cellular sphingolipid amounts between rectal and colonic cancer. The study also revealed qualitative and quantitative disturbances in sphingolipid metabolism in colorectal cancer, indicating the complexity of changes during cancer development depending on the tumor's location.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Oncology
Xuexin Luo, Zhenxing Tu, Hongquan Chen, Jie Ding
Summary: Recent Mendelian randomization studies showed no significant association between blood lipids and colon/rectal cancer, except for a potential increased risk of colon cancer with higher total cholesterol levels.
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
(2021)
Article
Multidisciplinary Sciences
Yuki Ohta, Masayuki Fujii, Sirirat Takahashi, Ai Takano, Kosaku Nanki, Mami Matano, Hikaru Hanyu, Megumu Saito, Mariko Shimokawa, Shingo Nishikori, Yoshiko Hatano, Ryota Ishii, Kazuaki Sawada, Akihito Machinaga, Wataru Ikeda, Takeshi Imamura, Toshiro Sato
Summary: This study develops an experimental platform for tracking cancer stem cells in colorectal cancer and identifies dormant LGR5(+) cancer stem cells. Transcriptome analysis reveals an upregulation of cell-adhesion molecule COL17A1 in dormant cancer stem cells, and chemotherapy disrupts this dormancy through FAK-YAP activation. Inhibition of YAP signaling prevents chemoresistant cells from exiting dormancy and delays tumor regrowth.
Article
Immunology
Milena Petkova, Marle Kraft, Simon Stritt, Ines Martinez-Corral, Henrik Ortsaeter, Michael Vanlandewijck, Bojana Jakic, Eulalia Baselga, Sandra D. Castillo, Mariona Graupera, Christer Betsholtz, Taija Maekinen
Summary: Researchers have identified a new subtype of lymphatic endothelial cells called iLECs, which are positive for Ptx3 and are involved in PI3K-driven lymphatic malformations. These cells recruit pro-lymphangiogenic macrophages and promote pathological lymphatic vessel growth. Understanding the specific disease pathogenesis of different vessel types could lead to the development of more efficient therapies.
JOURNAL OF EXPERIMENTAL MEDICINE
(2023)
Article
Chemistry, Multidisciplinary
Zhonghua Wu, Bicheng Qu, Minxian Yuan, Jingjing Liu, Cen Zhou, Mingwei Sun, Zhexu Guo, Yaqing Zhang, Yongxi Song, Zhenning Wang
Summary: The overexpression of cysteine-rich intestinal protein-1 (CRIP1) in gastric cancer promotes lymphangiogenesis and lymphatic vessel permeability, leading to lymphatic metastasis. This study uncovers the role and mechanism of CRIP1 in mediating gastric cancer lymphatic metastasis, providing potential targets for future therapeutics.
Article
Biochemical Research Methods
Qing Jin, Binhua Liang, Xiujie Chen, Huiwen Liu
Summary: This study identified two molecular subtypes of colon cancer with lymphovascular invasion and 11 miRNA biomarkers for predicting high metastasis risk in stage II patients, providing a detailed classification and risk biomarkers for determining adjuvant chemotherapy post-surgery.
CURRENT BIOINFORMATICS
(2021)
Article
Oncology
Kyungmin Ji, Zhiguo Zhao, Mansoureh Sameni, Kamiar Moin, Yong Xu, Robert J. Gillies, Bonnie F. Sloane, Raymond R. Mattingly
Summary: Lymphatic metastasis is a crucial prognostic factor for breast cancer aggressiveness and patient survival. Current therapeutic approaches have limitations, prompting the need for new strategies to identify effective therapeutic targets. Studying spatial interactions between breast cancer cells and lymphatic cells can provide valuable insights into the complex mechanisms of lymphatic metastasis in breast cancer.
Review
Oncology
Katsunori Sakamoto, Kohei Ogawa, Kei Tamura, Masahiko Honjo, Naotake Funamizu, Yasutsugu Takada
Summary: This study aimed to clarify the prognostic impact of intrahepatic lymphatic vessel invasion (LVI) in liver cancer. The review of retrospective studies showed that LVI correlated with poor prognosis in intrahepatic cholangiocarcinoma (ICC) and colorectal liver metastases. Tumor-associated lymphangiogenesis was also found to be a prognostic factor in hepatocellular carcinoma (HCC) and ICC.
Article
Oncology
Shengbo Han, Decai Wang, Yan Huang, Zhu Zeng, Peng Xu, Hewei Xiong, Zunxiang Ke, Ya Zhang, Yuhang Hu, Fan Wang, Jie Wang, Yong Zhao, Wenfeng Zhuo, Gang Zhao
Summary: Research has shown that the emergence of Schwann cells around premalignant lesions of colon cancer may be an early indicator promoting tumorigenesis. This study explored the communication between colon cancer cells and Schwann cells, and identified NGF and exosomal miR-21-5p as potential therapeutic targets for colon cancer treatment.
JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
(2022)
Article
Multidisciplinary Sciences
Meng Wang, Yue Li, Yunyun Xiao, Muwen Yang, Jinxin Chen, Yunting Jian, Xin Chen, Dongni Shi, Xiangfu Chen, Ying Ouyang, Lingzhi Kong, Xinjian Huang, Jiewen Bai, Chuyong Lin, Libing Song
Summary: This study demonstrates that nicotine promotes lymphatic metastasis by preventing mRNA decay of VEGF-C mRNA through downregulating OTUD3 and ZFP36. The interaction between OTUD3 and ZFP36 stabilizes ZFP36 and inhibits VEGF-C mRNA decay, highlighting their crucial role in nicotine addiction-induced lymphatic metastasis in esophageal cancer.
NATURE COMMUNICATIONS
(2021)
Review
Chemistry, Medicinal
Sara Rezzola, Elena C. Sigmund, Cornelia Halin, Roberto Ronca
Summary: The lymphatic vasculature not only transports immune cells, but also plays important roles in tumor growth and dissemination. Recent studies have uncovered various mechanisms by which the lymphatic system affects cancer progression, from inducing lymphangiogenesis to preparing metastatic niches and modulating the immune response. The interactions between tumor cells and lymphatic endothelial cells, as well as between immune cells and lymphatic endothelial cells, are crucial in both the tumor microenvironment and tumor-draining lymph nodes.
MEDICINAL RESEARCH REVIEWS
(2022)
Article
Medicine, Research & Experimental
Jiawei Gao, Linjun Zhuang, Chenxin He, Xiangrong Xu, Zhaobi Zhu, Wei Chen
Summary: This study aims to identify the risk factors and prognosis of liver metastasis in patients with colon cancer.
JOURNAL OF INTERNATIONAL MEDICAL RESEARCH
(2023)
Review
Gastroenterology & Hepatology
Morten F. Hartwig, Lasse Slumstrup, Anne-Marie Kanstrup Fiehn, Ismail Gogenur
Summary: The aim of this study was to determine the risk of lymph node metastasis in pT2 colon cancer and identify the associated clinical and pathological risk factors. A total of 10 studies with 91,460 patients were included in the review. The overall risk of lymph node metastasis in pT2 colon cancer was found to be 19.3%.
COLORECTAL DISEASE
(2023)