Journal
SURGERY FOR OBESITY AND RELATED DISEASES
Volume 14, Issue 11, Pages 1748-1754Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/j.soard.2018.07.021
Keywords
Type 2 diabetes; Duodenal-jejunal bypass surgery; Intestinal microbiota; Metabolic surgery
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Funding
- CNPq (Conselho Nacional de Desenvolvimento Cientifico e Tecnologico) [479842/2013-2]
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Background: In recent years, studies indicate gut microbiota as an important modulator in the pathophysiology of type 2 diabetes. Environmental and genetic factors interact to control the host's intestinal microbiota, triggering metabolic disorders such as obesity and insulin resistance. Objectives: The objective of this study was to identify the fecal microbiota in adult type 2 diabetes patients and to assess changes in composition after metabolic surgery. Setting: University Hospital of the University of Sao Paulo. Methods: Twenty-one patients were enrolled in a randomized controlled study divided into 2 arms. One group underwent duodenal-jejunal bypass surgery with minimal gastric resection, and fecal samples were collected before the operation and after 6 and 12 months. The other group received medical care (standard care group) and was followed for 12 months. Fecal samples were collected at baseline and after 6 and 12 months. Fecal microbiota was analyzed using high -throughput sequencing with V4 16 S rRNA primers. Results: The fecal microbiota in duodenal-jejunal bypass surgery with minimal gastric resection group (Bacteroides, Akkermansia, and Dialister) exhibited increased abundance and diversity compared with that in the standard care group; however, the increase in A. muciniphila was only statistically significant in the surgical group, probably due to the study's small sample size. Conclusions: The data presented suggest that duodenal-jejunal bypass surgery with minimal gastric resection increases microbial richness and abundancy, mainly for those bacteria related to weight loss and metabolic control (Akkermansia), providing a better understanding of the role of microbiota in type 2 diabetes regulation and its changes after metabolic surgery. (C) 2018 American Society for Bariatric Surgery. Published by Elsevier Inc. All rights reserved.
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