Article
Surgery
Purun Lei, Guiru Jia, Xiaofeng Yang, Ying Ruan, Bo Wei, Tufeng Chen
Summary: The study found that preoperative use of OA+MBP significantly reduces the incidence of SSIs in colorectal surgery, particularly in left-sided resections.
INTERNATIONAL JOURNAL OF SURGERY
(2023)
Review
Medicine, General & Internal
Maria A. Willis, Ingrid Toews, Sophia L. Soltau, Joerg C. Kalff, Joerg J. Meerpohl, Tim O. Vilz
Summary: This article analyzed data from 21 RCTs and found that combined mechanical and oral antibiotic bowel preparation can reduce the risk of infection and leakage in elective colorectal surgery, with moderate-certainty evidence for preventing complications. However, the efficacy of mechanical or antibiotic bowel preparation alone remains uncertain.
COCHRANE DATABASE OF SYSTEMATIC REVIEWS
(2023)
Review
Gastroenterology & Hepatology
John C. Woodfield, Kari Clifford, Barry Schmidt, Mark Thompson-Fawcett
Summary: There are discrepancies in guidelines for colorectal surgery preparation, with the addition of oral antibiotics being shown to significantly reduce incisional surgical site infections. Methodological issues were identified in the included studies, highlighting the need for further well-designed pragmatic RCTs.
COLORECTAL DISEASE
(2022)
Article
Gastroenterology & Hepatology
Martin Rutegard, Alethea Tang, Darren James Gregoire, Christopher Stewart, Libor Hurt, Susan Chandler, Matthew David Hitchings, Brendan Healy, Dean Harris
Summary: The study aims to evaluate the impact of oral antibiotics on the incidence of surgical site infections in colorectal surgery. The results show that the use of oral antibiotics in colorectal surgery may reduce the risk of infection and alter the structure of the intestinal microbiome. However, further research is needed on the application methods of different oral antibiotics and the mechanism of the gut microbiome.
INTERNATIONAL JOURNAL OF COLORECTAL DISEASE
(2023)
Article
Surgery
John C. Woodfield, Kari Clifford, Barry Schmidt, Gregory A. Turner, Mohammad A. Amer, John L. McCall
Summary: The addition of oral antibiotics to intravenous antibiotics was found to be highly effective in reducing incisional surgical site infections among patients undergoing elective colorectal surgery. There were minimal differences in anastomotic leak and other clinical outcomes between different bowel preparation methods.
Article
Obstetrics & Gynecology
Akila Subramaniam, Yuanfan Ye, Rahel Mbah, Doreen M. Mbunwe, Seraphine Pekwarake, Edwan Yui Bunwi, Anthony Fondzeyuf, Mary G. Ngong, Jodie Dionne-Odom, Lorie M. Harper, Victoria C. Jauk, Waldemar A. Carlo, Gregory Halle-Ekane, Jeff M. Szychowski, Pius Tih, Alan T. Tita
Summary: The study compared the effectiveness of single-dose azithromycin, with or without amoxicillin, with placebo to prevent peripartum infection in laboring women. The results showed that a single dose of oral azithromycin with or without amoxicillin did not reduce maternal peripartum or neonatal infection in women with prolonged labor or rupture of membranes at term.
OBSTETRICS AND GYNECOLOGY
(2021)
Article
Surgery
L. Koskenvuo, T. Lehtonen, S. Koskensalo, S. Rasilainen, K. Klintrup, A. Ehrlich, T. Pinta, T. Scheinin, V. Sallinen
Summary: The study results showed that mechanical and oral antibiotic bowel preparation did not reduce the rate of surgical-site infections or complications in patients undergoing either right or left colectomy compared with no bowel preparation.
Article
Gastroenterology & Hepatology
Yumin Yue, Xi Chen, Hui Wang, Min Cheng, Bobo Zheng
Summary: A pooled analysis combined with trial sequential analysis demonstrated that mechanical bowel preparation (MBP) combined with oral antibiotic bowel decontamination (OAB) significantly reduces the incidence of anastomotic leak (AL) and surgical site infection (SSI) in patients after colorectal resection compared with MBP alone.
INTERNATIONAL JOURNAL OF COLORECTAL DISEASE
(2023)
Review
Microbiology
Tarek Mazzawi
Summary: Research suggests that manipulating gut microbiota can improve symptoms of irritable bowel syndrome (IBS), with dietary management and other approaches showing promise in changing gut composition and alleviating IBS symptoms. However, more research is needed to identify the exact mixture of beneficial bacteria.
Article
Nutrition & Dietetics
Dooheon Son, Youn Jung Choi, Min Young Son, Won Moon, Seun Ja Park, Sanghyun Lim, Jae Hyun Kim
Summary: The study aimed to evaluate the effects of probiotic pretreatment on gut microbiota alteration and recovery after bowel preparation and its correlation with minor complications. In a randomized, double-blind, placebo-controlled pilot trial with participants aged 40-65, probiotics or placebo were given for 1 month before colonoscopy. The results showed that probiotic pretreatment had beneficial effects on gut microbiota alteration and recovery, as well as a significant reduction in the duration of minor complications.
Article
Nutrition & Dietetics
Barbara Skrzydlo-Radomanska, Beata Prozorow-Krol, Halina Cichoz-Lach, Emilia Majsiak, Joanna Beata Bierla, Ewelina Kanarek, Agnieszka Sowniska, Bozena Cukrowska
Summary: The study found that multi-strain probiotic intervention significantly improved symptoms and quality of life in patients with IBS-D, with good tolerance and safety.
Review
Immunology
Shubhi Singh, Manisha Singh, Smriti Gaur
Summary: Probiotics, as live microorganisms, have immunomodulatory and anti-tumor properties. Research shows that oral probiotic vaccines can induce mucosal immunity and prevent enteric infections. The production of anti-inflammatory cytokines by probiotic bacteria plays a crucial role in colon cancer therapy. However, further studies are needed to explore the potential of probiotic strains as adjuvants in cancer treatment.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Gastroenterology & Hepatology
Chee Hoe Koo, Aik Yong Chok, Ian Jun Yan Wee, Isaac Seow-En, Yun Zhao, Emile John Kwong Wei Tan
Summary: This study investigates the efficacy of oral antibiotics and mechanical bowel preparation in preventing surgical site infection after elective colorectal surgery. The findings suggest that the combination of oral antibiotics and mechanical bowel preparation reduces the risk of surgical site infection. Certain oral antibiotic regimens show greater effectiveness than others.
INTERNATIONAL JOURNAL OF COLORECTAL DISEASE
(2023)
Article
Immunology
Chaofei Xia, Chunling Jiang, Wenyu Li, Jing Wei, Hu Hong, Jingao Li, Liu Feng, Hong Wei, Hongbo Xin, Tingtao Chen
Summary: Probiotic cocktail supplementation can reduce oral mucositis induced by chemoradiotherapy in patients with nasopharyngeal cancer by enhancing immune response and modifying gut microbiota structure.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Gastroenterology & Hepatology
Aleksandra Olkina, Aleksei Karachun, Sergey Bagnenko, Alexey Belyaev, Aleksei Petrov
Summary: This study aims to assess the clinical value of mechanical bowel preparation and oral antibiotics before rectal surgery and their impact on postoperative complications. The results of this study could potentially influence current preoperative practices and improve postoperative outcomes.
TECHNIQUES IN COLOPROCTOLOGY
(2023)