Article
Biochemistry & Molecular Biology
Chia-Yu Chang, Jui-Tai Chen, Tso-Hsiao Chen, Ruei-Ming Chen
Summary: This study found that the androgen receptor (AR) is upregulated in glioblastoma multiforme (GBM), and the AR inhibitor enzalutamide can kill drug-resistant and -sensitive GBM cells through an apoptotic mechanism.
Article
Multidisciplinary Sciences
Clement Adam, Lea Paolini, Naig Gueguen, Guillaume Mabilleau, Laurence Preisser, Simon Blanchard, Pascale Pignon, Florence Manero, Morgane Le Mao, Alain Morel, Pascal Reynier, Celine Beauvillain, Yves Delneste, Vincent Procaccio, Pascale Jeannin
Summary: Lactic acidosis is a metabolic state that occurs in injured tissues. Macrophages reduce their mitochondrial mass by mitophagy and rely on autophagy for survival in acidosis, utilizing acetoacetate as an alternative fuel. Mitochondrial integrity is retained, and these cells are dependent on autophagy due to the low extracellular pH in lactic acidosis, while acetoacetate can increase tissue tolerance to sustained lactic acidosis.
NATURE COMMUNICATIONS
(2021)
Article
Chemistry, Multidisciplinary
Hao Zhang, Ziting Zhang, Siwan Wang, Tianzhu Qiu, Tongpeng Xu, Yongqian Shu
Summary: Gastric cancer, with the third highest mortality rate globally, is primarily treated with chemotherapy. Aggregation-induced emission luminogens (AIEgens) have shown promising results as non-toxic and efficient chemotherapy agents for cancer treatment. This research confirmed that a specific AIEgen, TPE-Py, can induce apoptotic cell death in gastric cancer cells by targeting mitochondria and altering the mitochondrial apoptotic pathway.
Article
Food Science & Technology
Hee-Seop Lee, Darshika Amarakoon, Gillian Tamia, Yeonhwa Park, Dmitriy Smolensky, Seong-Ho Lee
Summary: This study discovered previously unrecognized adverse effects of pendimethalin on vascular endothelial cells. Pendimethalin significantly repressed the viability of human endothelial cells, induced cell cycle arrest and cell death, and impaired the tube forming and migratory abilities of endothelial cells. These effects were mediated by ER stress-induced mitochondrial dysfunction.
FOOD AND CHEMICAL TOXICOLOGY
(2022)
Article
Endocrinology & Metabolism
Bo Wang, Yang Li, Chao You
Summary: Our study demonstrated the neuroprotective effects of miR-129-3p targeting MCU in glucose fluctuation-mediated neuronal damage, mainly through regulating the apoptotic cell death and oxidative stress pathways.
DIABETES METABOLIC SYNDROME AND OBESITY-TARGETS AND THERAPY
(2021)
Article
Multidisciplinary Sciences
Elena F. Shevtsova, Plamena R. Angelova, Olga A. Stelmashchuk, Noemi Esteras, Nataliia A. Vasil'eva, Andrey Maltsev, Pavel N. Shevtsov, Alexander Shaposhnikov, Vladimir P. Fisenko, Sergey O. Bachurin, Andrey Y. Abramov
Summary: This study found that compounds Tg-2112x and Tg-2113x have protective effects on cells by reducing mitochondrial calcium uptake and preventing cell death and mitochondrial depolarization induced by beta-amyloid. Additionally, Tg-2113x restored fear extinction in aged mice. This research provides a basis for the development of a novel generation of disease-modifying neuroprotective agents.
SCIENTIFIC REPORTS
(2022)
Review
Biology
Yu-Chen Cheng, I-Ling Hung, Yen-Nung Liao, Wen-Long Hu, Yu-Chiang Hung
Summary: Salvia miltiorrhiza (SM) is a traditional Chinese medicine commonly used for cardiovascular and cerebrovascular diseases. Endothelial dysfunction, which can lead to inflammation and changes in vascular tone and permeability, plays a significant role in the pathology of cardiovascular diseases. Studies have shown that SM extracts have antioxidative, anti-inflammatory, and antithrombotic properties, suggesting a potential role in mitigating oxidative stress and endothelial dysfunction.
Article
Medicine, Research & Experimental
Andris Elksnis, Tomas A. Schiffer, Fredrik Palm, Yun Wang, Jing Cen, Kyril Turpaev, Anongnad Ngamjariyawat, Shady Younis, Suling Huang, Yu Shen, Ying Leng, Peter Bergsten, Tony Karlsborn, Nils Welsh, Xuan Wang
Summary: Imatinib protects insulin-producing cells by activating AMPK and down-regulating TXNIP, leading to reduced beta-cell death. Furthermore, Imatinib affects glucose metabolism and mitochondrial respiration chain.
Article
Biochemistry & Molecular Biology
Zong-Sheng Wu, Hou-Lun Luo, Yao-Chi Chuang, Wei-Chia Lee, Hung-Jen Wang, Michael B. Chancellor
Summary: Platelet-rich plasma (PRP) has been shown to alleviate symptoms of interstitial cystitis/bladder pain syndrome (IC/BPS) by regulating inflammatory processes and promoting tissue repair. This study found that PRP could protect the urothelium during ischemia/hypoxia by decreasing apoptosis through modulating the expression of HIF1 alpha, the mitochondria-mediated intrinsic apoptotic pathway, and reducing ROS.
Article
Polymer Science
Chien-Ying Lee, Yung-Chuan Ho, Shiuan-Shinn Lee, Yi-Ching Li, Mei-Yu Lai, Yu-Hsiang Kuan
Summary: This study aims to clarify the mechanisms underlying HEMA-induced cytotoxicity and apoptosis in macrophages. The results showed that HEMA induced concentration-dependent cell toxicity and mediated genotoxicity and apoptosis through mitochondrial dysfunction, intrinsic caspase pathway activation, and intracellular reactive oxygen species accumulation.
Article
Polymer Science
Krithiga Balakrishnan, Sangeetha C. Casimeer, Alaa Yousef Ghidan, Fatima Yousef Ghethan, Karthikkumar Venkatachalam, Anbu Singaravelu
Summary: In this study, polymer-based nanoparticles loaded with hesperidin were developed and characterized for their potential biomedical application in cancer treatment. The prepared nanoparticles showed promising characteristics for effectively repressing the growth of cancer cells in acidic conditions, suggesting their potential as potent anti-cancer candidates. Further research is needed to explore the toxicity and molecular mechanisms involved in the anti-cancer activity of the synthesized nanoparticles.
JOURNAL OF INORGANIC AND ORGANOMETALLIC POLYMERS AND MATERIALS
(2021)
Article
Medicine, Research & Experimental
Mansurah A. Abdulazeez, Hiba A. Jasim, Musa Bashir, Kehinde Ross, Amos A. Fatokun
Summary: This study investigated the effects of Peristrophe bicalyculata leaf extracts on cancer cells and their mechanisms of action. The extracts showed potential anti-tumor activity by inhibiting cancer cell growth and inducing oxidative stress, mitochondrial damage, and caspase activation. The study identified several constituents of the extracts, suggesting that they could be used as leads for developing novel anti-cancer agents.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Article
Neurosciences
Maurizio Ragni, Francesca Fenaroli, Chiara Ruocco, Agnese Segala, Giuseppe D'Antona, Enzo Nisoli, Alessandra Valerio
Summary: Mitochondrial dysfunction is involved in aging and neurodegenerative diseases, including ischemic stroke. Non-pharmacological interventions like exercise can prevent stroke, but they are challenging for older individuals. This study suggests that dietary supplementation with a balanced essential amino acid mixture (BCAAem) can mimic the effects of exercise on brain mitochondria and prevent neurodegeneration. BCAAem treatment directly promotes mitochondrial biogenesis and protects cortical neurons from ischemic damage. The mTOR and eNOS signaling pathways are involved in the effects of BCAAem. It is proposed that BCAAem supplementation can be an alternative to exercise in preventing brain mitochondrial dysfunction and aiding recovery after cerebral ischemia.
FRONTIERS IN NEUROSCIENCE
(2023)
Correction
Polymer Science
Krithiga Balakrishnan, Sangeetha C. Casimeer, Alaa Yousef Ghidan, Fatima Yousef Ghethan, Karthikkumar Venkatachalam, Anbu Singaravelu
Summary: The authors identified an inadvertent error in their article.
JOURNAL OF INORGANIC AND ORGANOMETALLIC POLYMERS AND MATERIALS
(2021)
Article
Oncology
Dong Gun Lee, Mindong Lee, Eun Byeol Go, Namhyun Chung
Summary: Pancreatic ductal adenocarcinoma (PDAC) is a deadly malignancy with low survival rates. A study found that bio-conjugating resveratrol with gold nanoparticles improves delivery performance and anti-tumor efficacy, potentially making it a candidate for treating pancreatic cancer.
CANCER NANOTECHNOLOGY
(2022)