Article
Biochemistry & Molecular Biology
Eszter Becskehazi, Marietta Margareta Korsos, Eleonora Gal, Laszlo Tiszlavicz, Zsofia Hoyk, Maria A. Deli, Zoltan Marton Kohler, Aniko Keller-Pinter, Attila Horvath, Kata Cseko, Zsuzsanna Helyes, Peter Hegyi, Viktoria Venglovecz
Summary: The study suggests that smoking affects the function of ion transporters, playing a role in the development of smoking-induced esophageal diseases. In metaplastic cells, CSE treatment increased the activity and protein expression of NHE-1, reducing proliferation in a NHE-1-dependent manner. Contrarily, in normal cells, the expression and activity of NHE-1 decreased due to smoke exposure.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Immunology
Ikenna C. Okereke, Aaron L. Miller, Daniel C. Jupiter, Catherine F. Hamilton, Gabriel L. Reep, Timothy Krill, Clark R. Andersen, Richard B. Pyles
Summary: The microbial community structures differ between patients with and without Barrett's esophagus, with certain organisms less likely to be detected as the severity of Barrett's esophagus worsens.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2021)
Article
Gastroenterology & Hepatology
Tarek Sawas, Shawn A. Zamani, Sarah Killcoyne, Andrew Dullea, Kenneth K. Wang, Prasad G. Iyer, Rebecca C. Fitzgerald, David A. Katzka
Summary: Existing Barrett's esophagus screening guidelines have limitations in detecting prevalent esophageal adenocarcinoma. An optimized approach is needed to identify individuals most suitable for esophageal adenocarcinoma screening, particularly one that does not rely on chronic reflux symptoms.
CLINICAL GASTROENTEROLOGY AND HEPATOLOGY
(2022)
Review
Oncology
Franz Ludwig Dumoulin, Fabian Dario Rodriguez-Monaco, Alanna Ebigbo, Ingo Steinbruck
Summary: Esophageal adenocarcinoma is the most common subtype of esophageal cancer in Western societies and its incidence is increasing. The development and validation of artificial intelligence systems in the field of gastroenterology may help address unresolved issues in the prevention and surveillance of this cancer.
Article
Gastroenterology & Hepatology
Benjamin D. Liu, Sharon C. Udemba, Sherif Saleh, Hannah Hill, Gengqing Song, Ronnie Fass
Summary: The study indicates that raloxifene increases the risk of GERD, esophageal stricture, and Barrett's esophagus in postmenopausal women with osteoporosis. It was also found that raloxifene was identified as a risk factor for these complications in multivariate analysis.
NEUROGASTROENTEROLOGY AND MOTILITY
(2023)
Review
Biochemistry & Molecular Biology
Pelin Ergun, Sezgi Kipcak, Serhat Bor
Summary: Barrett's esophagus (BE) is a condition resulting from chronic gastroesophageal reflux disease, which may progress to esophageal adenocarcinoma (EAC). The histological dysplasia grade is commonly used as a biomarker, but its effectiveness is limited due to cost and lack of progression in many BE patients. Clinicians require multiple or more quantitative biomarkers for early diagnosis of EAC, which has high mortality. Epigenetic factors in the early stages of neoplastic transformation show promise as predictive biomarkers. This review summarizes current research on DNA methylations, histone modifications, and noncoding RNAs (miRNAs) during the progression from BE dysplasia to EAC.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Biochemistry & Molecular Biology
Ahmed Sam Beydoun, Kaleigh A. Stabenau, Kenneth W. Altman, Nikki Johnston
Summary: Esophageal adenocarcinoma (EAC) is increasing rapidly and has a poor prognosis, often preceded by Barrett's esophagus (BE). This review provides an overview of BE, EAC, and the progression from BE to EAC. The definition, diagnosis, epidemiology, and risk factors for both conditions are discussed, with special attention given to areas of debate. The progression from BE to EAC is likely driven by inflammatory pathways, pepsin exposure, upregulation of growth factor pathways, and mitochondrial changes. Surveillance is conducted through serial endoscopic evaluation, with shorter intervals recommended for high-risk features.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Biochemistry & Molecular Biology
Jan Bilski, Monika Pinkas, Dagmara Wojcik-Grzybek, Marcin Magierowski, Edyta Korbut, Agnieszka Mazur-Bialy, Gracjana Krzysiek-Maczka, Slawomir Kwiecien, Katarzyna Magierowska, Tomasz Brzozowski
Summary: Both obesity and esophageal adenocarcinoma (EAC) rates have seen a significant increase in recent years in the United States and Western Europe. Obesity plays a key role in the development of EAC, with increased body mass index correlating with higher risk. Pathologically altered visceral fat in obesity is believed to contribute to this process. Visceral obesity may promote EAC through direct effects on gastroesophageal reflux disease and Barrett's esophagus (BE), as well as through the release of pro-inflammatory adipokines and insulin resistance. Disrupted adipokine production, such as the imbalance of leptin and adiponectin, is implicated in the pathogenesis of BE and EAC. This review discusses the epidemiology, pathophysiology, and molecular alterations associated with obesity in BE and EAC, with a focus on the potential role of adipokines and myokines. The review also highlights the possible crosstalk of adipokines and myokines during exercise and suggests lifestyle interventions, specifically regular physical activity, as a promising strategy for preventing the development of BE and EAC.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Gastroenterology & Hepatology
Tarek Sawas, Saam Dilmaghani, Lovekirat Dhaliwal, Kenneth K. Wang, Prasad G. Iyer, David A. Katzka
Summary: The study found that compared to BE patients, EAC patients had significantly lower rates of heartburn, diabetes, hyperlipidemia, hypertension, nonalcoholic steatohepatitis, and metabolic syndrome. Therefore, optimal strategies for screening for prevalent EAC may need to be adjusted.
AMERICAN JOURNAL OF GASTROENTEROLOGY
(2021)
Review
Gastroenterology & Hepatology
Leonardo H. Eusebi, Andrea Telese, Giovanna G. Cirota, Rehan Haidry, R. Maurizio Zagari, Franco Bazzoli, Alexander C. Ford
Summary: Gastro-esophageal reflux (GER) symptoms are associated with an increased odds of Barrett's esophagus (BE), especially when the symptoms occur weekly. However, GER symptoms have low sensitivity and specificity for predicting BE, except for a strong association with long segment BE. Screening individuals with weekly GER symptoms may be beneficial to rule out long segment BE.
JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY
(2022)
Article
Multidisciplinary Sciences
Nan Yi, Hailiang Zhao, Juan He, Xike Xie, Liexin Liang, Guowen Zuo, Mingyue Xiong, Yunxiao Liang, Tingzhuang Yi
Summary: Almost 50% of esophageal adenocarcinoma (EAC) patients are progressed from Barrett's esophagus (BE). However, effective stratification and therapy methods for BE and EAC are still lacking. Differentially expressed genes (DEGs) between BE and EAC were identified through the analysis of two public datasets (GSE26886 and GSE37200), followed by bioinformatics analyses to explore potential biomarkers associated with BE-EAC. The results revealed a number of up- and down-regulated genes, which were highly involved in tumorigenesis according to the GO and KEGG enrichment analysis. In addition, the study identified several potential diagnostic and prognostic biomarkers in BE-EAC.
SCIENTIFIC REPORTS
(2023)
Review
Biochemistry & Molecular Biology
Ksenia Maslenkina, Liudmila Mikhaleva, Maxim Naumenko, Rositsa Vandysheva, Michail Gushchin, Dmitri Atiakshin, Igor Buchwalow, Markus Tiemann
Summary: Barrett's esophagus (BE) is a premalignant lesion that can develop into esophageal adenocarcinoma (EAC). The development of BE is caused by biliary reflux and involves various stem cell origins. The concept of healing has been replaced by the cytokine storm and inflammatory microenvironment, leading to intestinal metaplasia. This review discusses the roles of molecular pathways in the pathogenesis of BE and EAC, including NOTCH, hedgehog, NF-?B, and IL6/STAT3.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Gastroenterology & Hepatology
Rishabh Khatri, Jay Patel, Jun Song, Zubair Malik, Michael S. S. Smith, Henry P. P. Parkman
Summary: This study compared the prevalence, symptoms, demographic factors, and esophageal testing in patients with esophageal inlet patch (IP) and Barrett's esophagus (BE). The study found that 1.3% of patients had IP, with 17.1% having concomitant BE; 4.9% had BE, with 4.6% also having IP. Both IP and BE patients primarily presented with heartburn and/or regurgitation symptoms. Patients with IP and/or BE were older, had higher BMI, lower lower esophageal sphincter pressures, and higher acid exposure time.
DIGESTIVE DISEASES AND SCIENCES
(2023)
Article
Surgery
Colin P. Dunn, Justin C. Henning, Jason A. Sterris, Paul Won, Caitlin Houghton, Nikolai A. Bildzukewicz, John C. Lipham
Summary: This retrospective study evaluated the effectiveness of MSA for Barrett's esophagus patients, showing significant reduction in Barrett's length and prevention of progression to dysplasia or neoplasia. The results remained consistent after 2 years of follow-up.
SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES
(2021)
Review
Gastroenterology & Hepatology
Bashar J. Qumseya, Yazan Qumsiyeh, Sandeep A. Ponniah, David Estores, Dennis Yang, Crystal N. Johnson-Mann, Jeffrey Friedman, Alexander Ayzengart, Peter V. Draganov
Summary: After analyzing 10 studies, it was found that the prevalence of BE is high in patients undergoing EGD after SG, with no significant correlation with postoperative GERD symptoms. Most cases of BE were observed after 3 years.
GASTROINTESTINAL ENDOSCOPY
(2021)
Editorial Material
Gastroenterology & Hepatology
H. Furlong, A. Nasr, T. N. Walsh
Article
Medicine, General & Internal
A. Bhargava, M. O'Callaghan, T. Abdelhafiz, P. Downey, A. Nasr, S. Nibhraonain, C. Davenport, M. G. Donovan, P. Keeling
IRISH JOURNAL OF MEDICAL SCIENCE
(2012)
Article
Medicine, General & Internal
S. N. S. Gilani, H. Furlong, K. Reichardt, A. O. Nasr, G. Theophilou, T. N. Walsh
IRISH JOURNAL OF MEDICAL SCIENCE
(2011)
Article
Gastroenterology & Hepatology
Ayman O. Nassr, Syeda Nadia Shah Gilani, Mohammed Atie, Tariq Abdelhafiz, Val Connolly, Neil Hickey, Thomas Noel Walsh
JOURNAL OF GASTROINTESTINAL SURGERY
(2011)
Article
Surgery
Moneer A. Abdelgadir, Seif Eldin I. Mahadi, Ayman O. Nasr, Mohamed ElMakki Ahmed
INTERNATIONAL JOURNAL OF SURGERY
(2010)
Article
Surgery
Ayman O. Nasr, Turki Muslih Al-Harbi, Fatimah Sami AlRamadan
Summary: In this case, a victim of a motor vehicle collision suffered from BCI and multiple organ injuries. Through multidisciplinary treatment, the patient recovered, highlighting the importance of a specialized medical team.
INTERNATIONAL JOURNAL OF SURGERY CASE REPORTS
(2021)
Letter
Emergency Medicine
Ayman O. Nasr, Ileana Lulic, Mahmoud T. Mustafa, Jonathan Tilsed, Dinka Lulic, Karl Thies
EUROPEAN JOURNAL OF TRAUMA AND EMERGENCY SURGERY
(2023)
Review
Medicine, General & Internal
Mamoun Nabri, Norah J. Alromaih, Sharifah A. Othman, Elham S. Alghusnah, Hossain Abu Al Ola, Adel Elbagir, Ayman O. Nasr
Summary: The article reported a case of asymptomatic inferior vena cava duplication discovered incidentally in a patient involved in an accident. Advancements in diagnostic imaging have greatly contributed to the incidental discoveries of inferior vena cava duplication.
AMERICAN JOURNAL OF CASE REPORTS
(2021)
Review
Obstetrics & Gynecology
AO Nasr, S Tormey, MA Aziz, B Lane
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
(2005)
Article
Medicine, General & Internal
A Nasr, K Reichardt, K Fitzgerald, M Arumugusamy, P Keeling, TN Walsh
IRISH JOURNAL OF MEDICAL SCIENCE
(2004)
Article
Medicine, General & Internal
S Tormey, A Nasyr, DA McNamara, PJ Byrne, TN Walsh
IRISH JOURNAL OF MEDICAL SCIENCE
(2003)