Article
Oncology
Maohui Chen, Hongjin Wang, Yizhou Huang, Feilong Guo, Wei Zheng, Chun Chen, Bin Zheng
Summary: The characteristics of IPNs after radical esophagectomy for metastatic esophageal cancer can be used to predict the risk of pulmonary metastases. By constructing a risk score model, physicians can make accurate decisions during follow-up or treatment.
WORLD JOURNAL OF SURGICAL ONCOLOGY
(2023)
Article
Oncology
Jie Li, Yixue Wen, Zhongzheng Xiang, Huan Du, Lidan Geng, Xiyue Yang, Yu Zhang, Jie Bai, Tangzhi Dai, Gang Feng, Lei Liu, Xiaobo Du
Summary: This study found that radiotherapy is an effective treatment for MOEC patients after initial treatment with curative-intent surgery and/or chemoradiotherapy. A radical radiation dose with BED10 >= 60 Gy has benefits in extending survival.
RADIOTHERAPY AND ONCOLOGY
(2021)
Article
Oncology
Xue-Fang Zhang, Yan Zhang, Xu-Wei Liang, Jia-Luo Chen, Sheng-Fang Zhi, Wen-Jing Yin, Meng-Yao Wang, En-Lai Dong, Dong-Ping Chen
Summary: This study retrospectively analyzed the distribution of distant lymph node metastasis in patients with metastatic NPC and its impact on prognosis. The results showed that subphrenic lymph node metastasis is associated with poor prognosis.
FRONTIERS IN ONCOLOGY
(2021)
Review
Oncology
Jie Du, Zhixian Bao, Tianhu Liang, Hongmei Zhao, Junxian Zhao, Ruipu Xu, Xiaohui Wang
Summary: Smoking, age, history of multiple other cancers, and Lugol-voiding lesions (LVLs) were identified as risk factors for MESCC. The overall pooled incidence of MESCC was 20.3%, with a 0.20% increase for each additional year of follow-up time. The head and neck were the most common locations for SPC, followed by the esophagus.
FRONTIERS IN ONCOLOGY
(2023)
Article
Pathology
Gianluca Businello, Matteo Fassan, Silvia Degasperi, Giulia Traverso, Melania Scarpa, Imerio Angriman, Andromachi Kotsafti, Ignazio Castagliuolo, Marta Sbaraglia, Romeo Bardini, Marco Scarpa
Summary: The study suggests that HPV infection is not a factor associated with esophageal squamous cell carcinoma (ESCC) after head and neck squamous cell carcinoma (HNSCC). Instead, p53 overexpression is common in HNSCC-associated ESCCs. The altered immune microenvironment, characterized by dysregulated lymphomonocytic infiltration, may play a crucial role in the development of metachronous ESCC.
PATHOLOGY RESEARCH AND PRACTICE
(2021)
Article
Oncology
Zhaodong Fei, Huiling Hong, Ting Xu, Yiying Xu, Jiawei Chen, Xiufang Qiu, Jianming Ding, Ye Feng, Chaoxiong Huang, Li Li, Mengying Li, Chuanben Chen
Summary: This retrospective study identified the main risk factors for metachronous metastatic nasopharyngeal carcinoma (NPC) and estimated their weight in different time periods. It was found that most metastasis occurred within the first 2 years after treatment, with early metastasis mainly influenced by tumor-related factors and late metastasis affected by patient-related factors.
Article
Oncology
Yoshihisa Numata, Tetsuya Abe, Eiji Higaki, Takahiro Hosoi, Hironori Fujieda, Takuya Nagao, Nobuhiro Hanai, Hidenori Suzuki, Daisuke Nishikawa, Keitaro Matsuo, Tsutomu Fujii, Yasuhiro Shimizu
Summary: Metastases to supraclavicular lymph nodes have a significant impact on the prognosis of patients with cervical esophageal cancer. These lymph nodes may be considered extra-regional in this patient population.
ANNALS OF SURGICAL ONCOLOGY
(2021)
Article
Gastroenterology & Hepatology
Yugo Suzuki, Daisuke Kikuchi, Shu Hoteya, Takayuki Okamura, Yorinari Ochiai, Junnosuke Hayasaka, Nobuhiro Dan, Yutaka Mitsunaga, Masami Tanaka, Hiroyuki Odagiri, Kosuke Nomura, Satoshi Yamashita, Akira Matsui, Toshiro Iizuka
Summary: CRT may be effective in preventing metachronous ESCC.
Article
Oncology
Wenming Yang, Zhaolun Cai, Pan Nie, Tao Yuan, Hang Zhou, Qiang Du, Siyuan Qiu, Jianhao Zhang, Lie Yang
Summary: This case report presents a rare solitary metachronous small bowel metastasis from RCC. The author highlights the importance of life-long follow-up for RCC patients and suggests that it has unpredictable behavior and the possibility of a long period of dormancy. Complete surgical resection remains the mainstay treatment for such patients.
FRONTIERS IN ONCOLOGY
(2022)
Article
Oncology
Zhencong Chen, Yiwei Huang, Zhengyang Hu, Mengnan Zhao, Yunyi Bian, Zongwei Chen, Yuansheng Zheng, Guoshu Bi, Yanrui Pang, Cheng Zhan, Zongwu Lin, Weigang Guo, Qun Wang, Lijie Tan
Summary: The study revealed that samples from NACT-ESCC patients exhibited characteristics of malignant cells and tumor microenvironment, unlike samples from SA-ESCC patients. The immune activation microenvironment in NACT-ESCC patients may affect treatment efficacy.
Review
Oncology
Xiaotao Geng, Jie Liu, Huimin Sun, Zhenguo Song, Shaoyong Qin, Yang Li, Yanan Zhang, Furong Hao, Yuanyuan Cai
Summary: This case report presents a rare case of metastatic esophageal squamous cell carcinoma, highlighting the diagnosis and treatment process. The authors hope to provide insights for clinical practice through their experience.
FRONTIERS IN ONCOLOGY
(2022)
Article
Surgery
Taro Mashiko, Akira Nakano, Yoshihito Masuoka, Seiichiro Yamamoto, Soji Ozawa, Toshio Nakagohri
Summary: This retrospective study evaluated the outcome of patients with pulmonary metastases from PDAC, showing that patients who underwent pulmonary resection had a significantly better prognosis. The findings suggest that pulmonary resection may improve the prognosis in selected patients with pulmonary metastases from PDAC.
Article
Medicine, General & Internal
Hou-Ying Cheng, Kai-Wen Huang, Jin-Tung Liang, Been-Ren Lin, John Huang, Ji-Shiang Hung, Chi-Ling Chen
Summary: Multi-RFA and hepatectomy provide similar survival benefits for resectable colorectal cancer liver metastases patients, while systemic treatment has inferior outcomes.
JOURNAL OF CLINICAL MEDICINE
(2021)
Review
Oncology
Jun Jia, Wei Sun, Dongmei Lin, Xiaodong Zhang
Summary: Metastasis of esophageal squamous cell carcinoma to the renal parenchyma can be rare but significant, with disease history and biopsy playing important roles in diagnosis. PET-CT scans are shown to be more sensitive in identifying unusual metastasis of ESCC compared to traditional CT scans.
TRANSLATIONAL CANCER RESEARCH
(2021)
Letter
Oncology
Jianing Chen, Hainan Yang, Chao Zhao, Tao Lin, Da Liu, Weiping Hong, Changguo Shan, Cheng Zhou, Ling Bao, Caicun Zhou, Linbo Cai, Chunxia Su, Zhaoming Zhou, Lei Wen
Summary: Brain metastasis is a major cause of cancer-related death. Some patients are diagnosed with brain metastases at their first visit without prior treatment, while others develop brain metastases during systemic therapies. The genomic differences between these two groups are unclear. In this study, we analyzed the genomic features of synchronous and metachronous brain metastases in lung adenocarcinoma patients using panel-targeted gene sequencing of cerebrospinal fluid and plasma samples. CSF liquid biopsies were found to be superior in detecting gene alterations. EGFR and TP53 were the most frequently altered genes in both groups, but with different exon point mutations. The RTK-RAS and TP53 pathways were identified as the most affected pathways.
EXPERIMENTAL HEMATOLOGY & ONCOLOGY
(2023)
Article
Medicine, General & Internal
Takeshi Sakai, Hiroshi Ichikawa, Takaaki Hanyu, Kenji Usui, Yosuke Kano, Yusuke Muneoka, Takashi Ishikawa, Yoshifumi Shimada, Jun Sakata, Toshifumi Wakai
Summary: The accuracy of preoperative endoscopic evaluations of EIL in EGJ adenocarcinoma is around 53.3%, with underestimation being common. Factors like undifferentiated histologic type and pN1-3 play a role in this underestimation, while EIL measurements of 2-3 cm and >3 cm are independent predictors of metastasis or recurrence in MLNs.
ANNALS OF MEDICINE AND SURGERY
(2021)
Article
Biochemistry & Molecular Biology
Mayuko Ikarashi, Junko Tsuchida, Masayuki Nagahashi, Shiho Takeuchi, Kazuki Moro, Chie Toshikawa, Shun Abe, Hiroshi Ichikawa, Yoshifumi Shimada, Jun Sakata, Yu Koyama, Nobuaki Sato, Nitai C. Hait, Yiwei Ling, Shujiro Okuda, Kazuaki Takabe, Toshifumi Wakai
Summary: Elevated plasma levels of S1P are associated with larger tumor size, lymph node metastasis, and advanced cancer stage in ER-positive breast cancer patients, indicating a role in cancer progression. Treatment with FTY720, a functional antagonist of S1P receptors, showed promising results in suppressing viability of hormone therapy-resistant cells, suggesting a potential new therapeutic strategy for ER-positive breast cancer.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Gastroenterology & Hepatology
Satoru Hashimoto, Hiroki Sato, Ken-ichi Mizuno, Kazuya Takahashi, Masafumi Takatsuna, Junji Yokoyama, Hiroshi Ichikawa, Manabu Takeuchi, Masaaki Kobayashi, Shuji Terai
Summary: The incidence of gastric tube carcinoma (GTC) after esophagectomy for esophageal carcinoma has increased in recent years. Surgical removal of the reconstructed gastric tube is associated with high mortality, and endoscopic submucosal dissection (ESD) is a promising alternative. This study investigated the efficacy and safety of ESD in GTC. Overall, 31 patients with 45 GTC lesions underwent ESD. The complete resection and curative resection rates were 80.6% and 48.4%, respectively. The 3-year and 5-year overall survival rates were 67.6% and 47.7%, respectively. The 3-year and 5-year disease-specific survival rates were 100% and 92.9%, respectively. ESD was safe and provided good long-term outcomes in patients with GTC.
CANADIAN JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY
(2022)
Meeting Abstract
Oncology
Junko Tsuchida, Rongrong Wu, Maiko Endo, Kazuki Moro, Chie Toshikawa, Yu Koyama, Hiroshi Ichikawa, Takaaki Hanyu, Yamato Takabe, Kazuyasu Takizawa, Yoshifumi Shimada, Takashi Kobayashi, Takashi Ishikawa, Jun Sakata, Toshifumi Wakai, Kazuaki Takabe
Article
Multidisciplinary Sciences
Shujiro Okuda, Yuki Hirose, Hayato Takihara, Akiko Okuda, Yiwei Ling, Yosuke Tajima, Yoshifumi Shimada, Hiroshi Ichikawa, Kazuyasu Takizawa, Jun Sakata, Toshifumi Wakai
Summary: With the discovery of bacterial symbiosis in tumor tissues, the study of the tumor microbiome is gaining attention. This research analyzed microbiome data in tumor-associated tissues and body fluids of pancreatic or biliary tract cancer patients. The results showed a similar bacterial composition in tumor-associated tissues, while body fluids displayed different bacterial compositions. Additionally, unidentified bacteria were found in deep inner body tissues and fluids, suggesting potential targets for precision therapy.
SCIENTIFIC REPORTS
(2022)
Article
Oncology
Yoshifumi Shimada, Mae Nakano, Ken-Ichi Mizuno, Junji Yokoyama, Akio Matsumoto, Kana Tanaka, Hidehito Oyanagi, Masato Nakano, Yuki Hirose, Hiroshi Ichikawa, Jun Sakata, Hitoshi Kameyama, Yasumasa Takii, Mika Sugai, Yiwei Ling, Shiho Takeuchi, Shujiro Okuda, Shuji Terai, Yoichi Ajioka, Toshifumi Wakai
Summary: Gene panel testing can detect important genetic alterations in UCAN, which can be useful for diagnosis and treatment, and provide clinicians with important information for tailored treatment strategies.
Article
Gastroenterology & Hepatology
Daisuke Motegi, Hiroshi Ichikawa, Takeo Bamba, Yusuke Muneoka, Yosuke Kano, Kenji Usui, Takaaki Hanyu, Takashi Ishikawa, Yuki Hirose, Kohei Miura, Yosuke Tajima, Yoshifumi Shimada, Jun Sakata, Satoru Nakagawa, Shin-ichi Kosugi, Toshifumi Wakai
Summary: This study aimed to identify risk factors for anastomotic leakage (AL) after esophagectomy for esophageal cancer. The results showed that peptic or endoscopic submucosal dissection (ESD) ulcer scars were independently associated with AL, in addition to diabetes mellitus. The scars in the anterior/posterior gastric wall were more frequent in patients with AL, and the gastric conduit with scars had significantly lower flow velocity evaluated by indocyanine green (ICG) fluorescence imaging. Therefore, preventive interventions and careful postoperative management should be provided to minimize the risk and severity of AL in patients with these risk factors.
JOURNAL OF GASTROINTESTINAL SURGERY
(2023)
Article
Surgery
Yosuke Kano, Hiroshi Ichikawa, Takaaki Hanyu, Yusuke Muneoka, Takashi Ishikawa, Masaki Aizawa, Atsushi Matsuki, Hiroshi Yabusaki, Takeo Bamba, Satoru Nakagawa, Kazuaki Kobayashi, Shirou Kuwabara, Shigeto Makino, Yasuyuki Kawachi, Tetsuya Naito, Tatsuo Tani, Hiroshi Hirukawa, Tetsuya Tada, Yoshifumi Shimada, Jun Sakata, Toshifumi Wakai
Summary: This study evaluated the long-term outcomes of patients with stage IV gastric cancer who underwent conversion surgery (CS) and identified prognostic factors. The results showed that CS provided a survival benefit for patients with initially resectable disease and achieving R0 resection.
Article
Oncology
Kazuki Moro, Masayuki Nagahashi, Haruka Uchida, Maiko Oji, Junko Tsuchida, Kumiko Yamaura, Chie Toshikawa, Mae Nakano, Mayuko Ikarashi, Yusuke Muneoka, Yosuke Tajima, Hiroshi Ichikawa, Yoshifumi Shimada, Jun Sakata, Yu Koyama, Kazuaki Takabe, Toshifumi Wakai
Summary: This study demonstrates that prophylactic use of pegfilgrastim can significantly reduce the incidence of severe neutropenia in patients undergoing neoadjuvant chemotherapy for breast cancer. Advanced stage breast cancer is a risk factor for severe neutropenia.
WORLD JOURNAL OF ONCOLOGY
(2022)
Editorial Material
Oncology
Jun Sakata, Kazuyasu Takizawa, Kohei Miura, Yuki Hirose, Yusuke Muneoka, Yosuke Tajima, Hiroshi Ichikawa, Yoshifumi Shimada, Takashi Kobayashi, Toshifumi Wakai
ANNALS OF SURGICAL ONCOLOGY
(2023)
Article
Oncology
Jun Sakata, Kazuyasu Takizawa, Kohei Miura, Yuki Hirose, Yusuke Muneoka, Yosuke Tajima, Hiroshi Ichikawa, Yoshifumi Shimada, Takashi Kobayashi, Toshifumi Wakai
Summary: The rational extent of regional lymphadenectomy for perihilar cholangiocarcinoma was clarified in this study. The number-based regional nodal classification was found to allow prognostic stratification of patients with this disease. No. 8 and no. 13a node groups should be considered regional nodes in addition to no. 12 node groups and should be dissected.
ANNALS OF SURGICAL ONCOLOGY
(2023)
Editorial Material
Oncology
Jun Sakata, Kazuyasu Takizawa, Kohei Miura, Yuki Hirose, Yusuke Muneoka, Yosuke Tajima, Hiroshi Ichikawa, Yoshifumi Shimada, Takashi Kobayashi, Toshifumi Wakai
ANNALS OF SURGICAL ONCOLOGY
(2023)
Article
Oncology
Masayuki Nagahashi, YiWei Ling, Chie Toshikawa, Tetsu Hayashida, Yuko Kitagawa, Manabu Futamura, Takashi Kuwayama, Seigo Nakamura, Hideko Yamauchi, Teruo Yamauchi, Koji Kaneko, Chizuko Kanbayashi, Nobuaki Sato, Junko Tsuchida, Kazuki Moro, Masato Nakajima, Yoshifumi Shimada, Hiroshi Ichikawa, Stephen Lyle, Yasuo Miyoshi, Kazuaki Takabe, Shujiro Okuda, Toshifumi Wakai
Summary: This study aimed to clarify the clinical significance of genomic profiling data, including copy number alterations (CNA) and tumor mutation burden (TMB), in TNBC patients. The results showed that CNA, but not TMB, was significantly associated with DFS and OS in TNBC patients. Additionally, the combination of CNA-high and TP53 alterations was identified as a promising biomarker for identifying a subgroup of TNBC patients with significantly worse prognosis.
Article
Oncology
Hiroki Nagaro, Hiroshi Ichikawa, Kazuyasu Takizawa, Masayuki Nagahashi, Shun Abe, Yuki Hirose, Kazuki Moro, Kohei Miura, Masato Nakano, Yoshifumi Shimada, Jun Sakata, Toshifumi Wakai
Summary: This study evaluated the expression of phosphorylated SphK1 in patients with pancreatic ductal adenocarcinoma (PDAC) and found that high pSphK1 expression is independently associated with lymphatic invasion and unfavorable prognosis.
ANTICANCER RESEARCH
(2023)
Article
Oncology
Shun Abe, Jun Sakata, Yuki Hirose, Tatsuya Nomura, Kabuto Takano, Chie Kitami, Naoyuki Yokoyama, Takashi Aono, Masahiro Minagawa, Akihiro Tsukahara, Taku Ohashi, Kazuyasu Takizawa, Kohei Miura, Hiroshi Ichikawa, Yoshifumi Shimada, Takashi Kobayashi, Toshifumi Wakai
Summary: This study aimed to evaluate the extent of lymphadenectomy and the impact of nodal classification on survival in patients with non-ampullary duodenal adenocarcinoma. The results showed that specific lymph nodes should be considered as regional nodes for accurate staging, and number-based nodal classification allows for good prognostic stratification.
