Article
Infectious Diseases
Alex R. Schuurman, Robert F. J. Kullberg, Willem Joost Wiersinga
Summary: There has been significant progress in understanding the gut microbiome in health and disease over the past decade. The gut microbiome interacts with the immune system and plays a crucial role in defending the host against pathogens. However, disturbances in the gut microbiome due to disease or interventions like antibiotic treatment can have negative consequences. This review focuses on the potential role of probiotics in the ICU, summarizes evidence from randomized clinical trials, and discusses challenges and future prospects.
Article
Immunology
Yong Du, Zhanjun Lu, Jing Jin, Tianyun Shi, Yi Ding, Ling Qian, Wei He, Qihui Huang, Jingjing Feng, Rong Jiang, Xuru Chen, Handong Jiang, Zhijun Jie
Summary: The study revealed that 2019-nCoV pneumonia should be considered a systemic disease. Lymphocyte percentage, blood urea nitrogen, calcium, myohemoglobin, and IL-6 levels are closely associated with patient prognosis. The survival rate of patients in the severe group was higher than that of patients in the critical group.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Article
Medicine, General & Internal
Junpei Haruna, Yoshiki Masuda, Hiroomi Tatsumi, Tomoko Sonoda
Summary: This study evaluated the accuracy of predicting unplanned ICU readmission using the Nursing Activities Score (NAS) at ICU discharge and compared it to the Accuracy of the prediction made using the Stability and Workload Index for Transfer (SWIFT) score. The study found that NAS was superior to SWIFT in predicting unplanned ICU readmission. Therefore, NAS may be an effective tool for predicting unplanned ICU readmission.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Public, Environmental & Occupational Health
Meijin Li, Jing Wang, Zhongwei Yao, Hailing Liao, Shufen Su, Xuying Yang, Mingzhou Xie, Yinan Zheng
Summary: This study used mNGS and conventional tests to detect 80 pathogens in 262 children with suspected pulmonary infections. RSV, Staphylococcus aureus, and rhinovirus were the most frequently detected pathogens. Co-infection was common, with bacterial-viral agents most commonly detected together. The study highlights the importance of using advanced diagnostic techniques like mNGS to improve our understanding of the microbial epidemiology of severe pneumonia in pediatric patients.
FRONTIERS IN PUBLIC HEALTH
(2023)
Article
Health Care Sciences & Services
Hiroyuki Ohbe, Yusuke Sasabuchi, Hayato Yamana, Hiroki Matsui, Hideo Yasunaga
Summary: For mechanically ventilated patients with pneumonia, critical care in the ICU was associated with a 7.2% decrease in 30-day in-hospital mortality compared to care in the HDU. The study utilized propensity score matching analysis, multivariable regression, overlap weighting, and instrumental variable analyses to evaluate the robustness of the findings.
LANCET REGIONAL HEALTH-WESTERN PACIFIC
(2021)
Article
Infectious Diseases
Ignacio Martin-Loeches, Adrian Ceccato, Marco Carbonara, Gianluigi li Bassi, Pierluigi di Natale, Stefano Nogas, Otavio Ranzani, Carla Speziale, Tarek Senussi, Francesco Idone, Anna Motos, Miquel Ferrer, Antoni Torres
Summary: This study revealed that persistent cardiovascular failure significantly impacts the outcomes of patients with ICU-acquired pneumonia (ICUAP), resulting in higher mortality rates. Persistent CVF may lead to treatment failures and bacterial superinfections, highlighting the importance of timely recognition to optimize patient management.
Article
Critical Care Medicine
Guillaume Eberst, Frederic Claude, Lucie Laurent, Aurelia Meurisse, Pauline Roux-Claude, Cindy Barnig, Dewi Vernerey, Sophie Paget-Bailly, Kevin Bouiller, Catherine Chirouze, Julien Behr, Franck Grillet, Ophelie Ritter, Sinan Karaer, Sebastien Pili-Floury, Hadrien Winiszewski, Emmanuel Samain, Pierre Decavel, Gilles Capellier, Virginie Westeel
Summary: This study aimed to evaluate the long-term pulmonary and extrapulmonary function of SARS-CoV-2 pneumonia survivors who stayed in the ICU for 12 months. The results showed that most patients had an improvement in DLCO at each timepoint.
ANNALS OF INTENSIVE CARE
(2022)
Article
Biology
Yan Wang, Xiaohui Liang, Yuqian Jiang, Danjiang Dong, Cong Zhang, Tianqiang Song, Ming Chen, Yong You, Han Liu, Min Ge, Haibin Dai, Fengchan Xi, Wanqing Zhou, Jian-Qun Chen, Qiang Wang, Qihan Chen, Wenkui Yu
Summary: The newly developed Species-Specific Bacterial Detector (SSBD) is a sensitive liquid biopsy system for detecting pathogenic bacteria in pneumonia patients. It has shown high accuracy in identifying specific bacteria strains and has great clinical value based on the comparison with traditional cultivation methods and controlled clinical trials.
Article
Immunology
Thomas A. Carmo, Isabella B. Ferreira, Rodrigo C. Menezes, Gabriel P. Telles, Matheus L. Otero, Maria B. Arriaga, Kiyoshi F. Fukutani, Licurgo P. Neto, Sydney Agareno, Nivaldo M. Filgueiras Filho, Bruno B. Andrade, Kevan M. Akrami
Summary: This study aimed to evaluate the performance of ICU severity scores in predicting mortality in pneumonia patients. The findings showed that commonly used severity scores such as SAPS 3, CURB-65, CRB-65, and qSOFA had poor predictive ability in this context. A novel pneumonia-specific ICU severity score (Shock score) was developed and found to outperform existing scores in identifying patients at highest risk of ICU death.
CLINICAL INFECTIOUS DISEASES
(2021)
Article
Pharmacology & Pharmacy
Bailiang Chen, Jiabin Xuan, Feng Wu, Nengxian Shi, Jianwei Dai, Shumin Cai, Shengli An, Qiaobing Huang, Xiaoling Huang, Zhongqing Chen, Zhenhua Zeng
Summary: This study investigates the association of rhTPO and platelet counts in ICU patients with pneumonia and thrombocytopenia. Results show that rhTPO administration leads to increased platelet counts, alleviated bleeding, and reduced blood transfusion requirements.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Multidisciplinary Sciences
Seung Min Baik, Na Rae Yang, Tae Yoon Kim, Kyung Sook Hong
Summary: This study aimed to compare the experience of open surgical ICU (OSICU) and closed surgical ICU (CSICU) systems in order to propose a better ICU system for critically ill patients. The results showed that a closed surgical ICU system is more beneficial for critically ill patients.
Review
Anesthesiology
Michael Mazzeffi, Samuel Galvagno, Clare Rock
Summary: Healthcare-associated infections are a major concern for intensive care unit patients, and understanding evidence-based prevention strategies is crucial for optimizing patient outcomes.
Article
Physiology
Li-Na Wang, Dai-Kun He, Yi-Ru Shao, Jiang Lv, Peng-Fei Wang, Ying Ge, Wei Yan
Summary: This study investigates the risk factors and prognostic indicators for severe aspiration pneumonia (SAP) in ICU patients. The results suggest that a low platelet count is an independent risk factor affecting the prognosis of death. Therefore, platelet level at admission may serve as a readily available marker for assessing the prognosis of patients with SAP.
FRONTIERS IN PHYSIOLOGY
(2023)
Article
Infectious Diseases
Sifen Lu, Wengeng Zhang, Xiaojin Li, Jinghong Xian, Ya Hu, Yongzhao Zhou
Summary: In this study, the skin microbiota of ICU patients with severe pneumonia was analyzed using 16S ribosomal ribonucleic acid sequencing. The results showed a significant decrease in the diversity of skin bacteria in the ICU patient group compared to the healthy control group, and differential abundance of certain bacterial species. These findings suggest a strong association between the skin microbiota and healthcare-associated infections in ICU patients with severe pneumonia, highlighting the importance of prevention and control of skin bacterial pathogens.
INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES
(2022)
Article
Cardiac & Cardiovascular Systems
Andrew F. Shorr, James Simmons, Nicolas Hampton, Scott T. Micek, Marin H. Kollef
Summary: Although macrolide resistance is common in Streptococcus pneumoniae ICU CAP, the addition of azithromycin to the antibiotic regimen is significantly associated with reduced in-hospital mortality, independent of multiple factors.
RESPIRATORY MEDICINE
(2021)