Article
Multidisciplinary Sciences
Sook-Kyoung Heo, Eui-Kyu Noh, Hye Jin Seo, Yoo Jin Lee, SuJin Koh, Young Joo Min, Yunsuk Choi, Jae-Cheol Jo
Summary: Radotinib has been shown to induce apoptosis and inhibit cell proliferation in multiple myeloma cells by suppressing the activity and expression of STAT3 and JAK2 proteins. It also inhibits the growth of MM cells and related signaling proteins, making it a potential candidate for MM treatment.
Article
Biochemistry & Molecular Biology
Shiori Mori, Rina Fujiwara-Tani, Momoko Gyoten, Shota Nukaga, Rika Sasaki, Ayaka Ikemoto, Ruiko Ogata, Shingo Kishi, Kiyomu Fujii, Hiroki Kuniyasu
Summary: Berberine (BBR) inhibits the proliferation, invasion, and drug resistance of gastrointestinal cancer cells, and induces cell death by inhibiting mitochondrial complex I and enhancing complex II activities. These effects are associated with autophagy and reactive oxidative species production. BBR shows significant anti-tumor and anti-stemness effects, making it a potential new cell death-inducing agent for the treatment of gastrointestinal cancer.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Oncology
Dong-Liang Lin, Li-Li Wang, Peng Zhao, Wen-Wen Ran, Wei Wang, Long-Xiao Zhang, Ming Han, Hua Bao, Kaihua Liu, Xue Wu, Yang Shao, Xiao-Ming Xing
Summary: The number of extra-appendiceal GCA in Chinese patients was underestimated. GCA can be seen as a distinct morphological, immunohistochemical, transcriptomic, and immunological entity. The classic low-grade component of GCA and the immunoreactivity for neuroendocrine markers are key points to diagnosing GCA.
FRONTIERS IN ONCOLOGY
(2021)
Article
Biotechnology & Applied Microbiology
Xuelian Gong, Ling Jiang, Wei Li, Qingbin Liang, Zhen Li
Summary: The study showed that curcumin effectively inhibited cell viability of renal cell carcinoma, induced apoptosis and autophagy by suppressing the AKT/mTOR pathway. Using curcumin to target the AKT/mTOR pathway could be a promising alternative treatment for RCC.
Article
Hematology
Venkatesh Kundumani-Sridharan, Jaganathan Subramani, Cade Owens, Kumuda C. Das
Summary: The study identified Nrg1 beta as a RIPC factor that interacts with endothelial ErbB2 to prevent degradation and decrease myocardial apoptosis through other molecular pathways. This finding is crucial for understanding the protective mechanism of RIPC.
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Dang Wei, Bian Rui, Fan Qingquan, Cai Chen, Hu Yun Ping, Song Xiaoling, Weng Hao, Gu Jun
Summary: Proliferation is a significant hallmark of gallbladder cancer, a relatively rare but fatal malignancy. This study identified KIF11 as a major upregulated regulator of proliferation in gallbladder cancer, potentially promoting GBC cell proliferation through the ERBB2/PI3K/AKT signaling pathway. The findings provide insights into the mechanisms underlying GBC cancer development and may contribute to the development of novel diagnostic and therapeutic targets.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2021)
Article
Cell Biology
Atsushi Saito, Yasunao Kamikawa, Taichi Ito, Koji Matsuhisa, Masayuki Kaneko, Takumi Okamoto, Tetsuro Yoshimaru, Yosuke Matsushita, Toyomasa Katagiri, Kazunori Imaizumi
Summary: The CREB/ATF transcription factor OASIS/CREB3L1 is upregulated in long-term-cultured astrocytes undergoing cell-cycle arrest due to loss of DNA integrity by repeated replication. OASIS arrests the cell cycle at G2/M phase after DNA damage via direct induction of p21. OASIS may act as a tumor suppressor by inhibiting cell-cycle and its low expression due to promoter hypermethylation is observed in some glioma patients.
Article
Cell Biology
Dan Wang, Jianfei Chen, Bohan Li, Qingling Jiang, Ling Liu, Ziyi Xia, Qiusheng Zheng, Minjing Li, Defang Li
Summary: Emerging evidence suggests that lncRNA-Gm31932 is significantly decreased in ATRA and PB-4-induced mouse melanoma B16 cells. Silencing lncRNA-Gm31932 inhibits cell proliferation, induces cell cycle arrest and differentiation, and affects the expression of cell cycle-related proteins through the miR-344d-3-5p/Prc1 (and Nuf2) axis.
CELL DEATH & DISEASE
(2022)
Article
Cell Biology
Yanli Bi, Longyuan Gong, Pengyuan Liu, Xiufang Xiong, Yongchao Zhao
Summary: This study reveals a novel mechanism in which nuclear ErbB2 represses the transcription of DEPTOR, leading to activation of the PI3K/AKT/mTOR pathway to inhibit autophagy.
CELL DEATH & DISEASE
(2021)
Article
Medicine, Research & Experimental
Fuhai Li, Jingfeng Wang, Yu Song, Dongli Shen, Yongchao Zhao, Chaofu Li, Mingqiang Fu, Yanyan Wang, Baozheng Qi, Xueting Han, Aijun Sun, Jingmin Zhou, Junbo Ge
Summary: The study demonstrated that Qiliqiangxin exerts protective effects against high-concentration angiotensin II-induced cardiac microvascular endothelial cell apoptosis by inhibiting autophagy, with ErbB2 phosphorylation playing a key role in downregulating autophagy through the AKT-FoxO3a axis.
Article
Oncology
Tuo Deng, Zihao He, Xiaolu Duan, Di Gu, Chao Cai, Wenqi Wu, Yongda Liu, Guohua Zeng
Summary: STAM1 expression is lower in ccRCC compared with normal renal tissues, and is associated with shorter overall survival in patients. In vitro experiments show that STAM1 inhibits cell viability, invasion, and migration in ccRCC cell lines. Further research is needed to understand the mechanisms of STAM1 in modulating ccRCC.
FRONTIERS IN ONCOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Shiqi Ma, Lu Zhang, Yuan Ren, Wei Dai, Tingqing Chen, Liping Luo, Juan Zeng, Kun Mi, Jinyi Lang, Bangrong Cao
Summary: This study revealed the impact of EREG on EGFR-TKI sensitivity and its mechanisms in NSCLC, suggesting macrophage-produced EREG as a potential novel regulator and biomarker for EGFR-TKI therapy in NSCLC.
Article
Medicine, Research & Experimental
Piman Pocasap, Apiyada Nonpunya, Natthida Weerapreeyakul
Summary: The extract of Pinus kesiya (PK) exhibited high selective cytotoxicity against HepG2 cells and induced apoptosis. FTIR microspectroscopy revealed molecular changes induced by PK in HepG2 cells, indicating a distinct anticancer mechanism compared to a positive control.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Article
Chemistry, Multidisciplinary
Uyanga Batbold, Jun-Jen Liu
Summary: In this study, the ethanol extract of Artemisia santolinifolia (ASE) demonstrated potential antitumor effects against non-small cell lung cancer (NSCLC) cells. The mechanisms of action involved caspase-dependent apoptosis and ferroptosis pathways. In addition, ASE inhibited cell proliferation by downregulating prosurvival protein expressions and inhibiting the STAT3 pathway.
APPLIED SCIENCES-BASEL
(2022)
Article
Cell Biology
Yuqing Duan, Yunlong Jia, Jiali Wang, Tianxu Liu, Zishuo Cheng, Meixiang Sang, Wei Lv, Jing Qin, Lihua Liu
Summary: The study reveals that upregulated lncRNA DGCR5 promotes proliferation, migration, and invasion of ESCC cells while inhibiting apoptosis. DGCR5 directly binds to SRSF1, increasing its stability and initiating important isoform switch of Mcl-1. Cell-derived xenograft model confirms DGCR5's role in facilitating ESCC tumorigenesis.
CELL DEATH & DISEASE
(2021)
Article
Gastroenterology & Hepatology
Mohammad Hamidi, Jacqueline Dauch, Raj Watson, Catherine O'Grady, Paul Hsu, Amanda Arrington, Taylor S. Riall, Mohammad Khreiss
Summary: In this study, no significant difference was found in short-term postoperative outcomes between preoperative biliary stenting (PBS) and no PBS in patients with obstructive jaundice undergoing pancreaticoduodenectomy. Contrary to previous studies, PBS did not increase the risk of complications after surgery, and patients who underwent PBS had a shorter hospital length of stay.
JOURNAL OF GASTROINTESTINAL SURGERY
(2021)
Article
Surgery
Amanda K. Arrington, Chiu-Hsieh Hsu, Kenzie L. Schaefer, Catherine L. O'Grady, Mohammad Khreiss, Taylor S. Riall
Summary: The study compared the outcomes of R1/R2 resection with neoadjuvant chemotherapy to chemotherapy alone in Stage II pancreatic cancer patients, finding that neoadjuvant patients had the best overall survival. Even with R2 resection, survival was better in surgical patients compared to those who underwent chemotherapy only.
JOURNAL OF THE AMERICAN COLLEGE OF SURGEONS
(2021)
Article
Medicine, General & Internal
Thao Wolbert, Rahman Barry, Todd Gress, Amanda Arrington, Errington Thompson
Summary: This study explores potential barriers to colorectal cancer (CRC) screening in the West Virginia Appalachian area. Through a cross-sectional survey, patient-reported barriers were identified using the health belief model to evaluate attitudes and behaviors. The discrepancies between the screened and unscreened groups mainly stem from perceptions of discomfort from screening tests, psychological and behavior deterrents in CRC screening and diagnosis, and limited resources for accessing care, especially transportation.
SOUTHERN MEDICAL JOURNAL
(2021)
Editorial Material
Oncology
Christopher J. LaRocca, Amanda O. Salzwedel, Mizuho Sato-Dahlman, Margarita V. Romanenko, Rafael Andrade, Julia Davydova, Masato Yamamoto
ANNALS OF SURGICAL ONCOLOGY
(2021)
Article
Gastroenterology & Hepatology
Jacqueline Dauch, Mohammad Hamidi, Amanda K. Arrington, Catherine L. O'Grady, Chiu-Hsieh Hsu, Bellal Joseph, Taylor S. Riall, Mohammad Khreiss
Summary: This study aimed to assess the impact of frailty on short-term outcomes after hepatectomy for colorectal liver metastasis (CRLM). Using the Modified Frailty Index (mFI), patients were divided into categories. The study found that frailty is associated with increased post-operative complications.
JOURNAL OF GASTROINTESTINAL SURGERY
(2022)
Article
Gastroenterology & Hepatology
Mohammad Hamidi, Catherine L. O'Grady, Sacha D. Brown, Amanda K. Arrington, Lilah Morris-Wiseman, Taylor S. Riall, Mohammad Khreiss
Summary: Lower preoperative eGFR levels (<60 mL/min/1.73m(2)) in patients undergoing pancreatectomy are associated with adverse outcomes, including prolonged length of stay, adverse discharge disposition, higher complication rates, and increased mortality risk.
JOURNAL OF GASTROINTESTINAL SURGERY
(2022)
Review
Pharmacology & Pharmacy
Margarita Romanenko, Ivan Osipov, Sergey V. Netesov, Julia Davydova
Summary: Adenovirus type 6 (HAdV-C6) shows promise in gene therapy, especially in vaccine and anticancer drug development. Compared to HAdV-C5, HAdV-C6 differs structurally and immunogenically, enabling evasion of specific immune cells uptake and influencing overall distribution after systemic administration.
Meeting Abstract
Biotechnology & Applied Microbiology
Sacha Robert, Kari Jacobsen, Margarita Romanenko, Kazuho Inoko, Stacey Wilber, Christopher LaRocca, Julia Davydova
Meeting Abstract
Biotechnology & Applied Microbiology
Margarita V. Romanenko, Jill Schappa Faustich, Sacha Robert, Kazuho Inoko, Kari Jacobsen, Richard W. Bianco, Julia Davydova
Meeting Abstract
Biotechnology & Applied Microbiology
Shuhei Shinoda, Naohiko Nakamura, Kazuho Inoko, Mizuho Sato-Dahlman, Julia Davydova, Masato Yamamoto
Meeting Abstract
Oncology
Fernando A. Angarita, Adriana Ordonez, Amanda K. Arrington, Helmi S. Khadra, Kelvin C. Allenson, Nestor F. Esnaola
ANNALS OF SURGICAL ONCOLOGY
(2022)
Letter
Surgery
Amanda K. Arrington, Taylor S. Riall
Meeting Abstract
Biotechnology & Applied Microbiology
Kazuho Inoko, Margarita Romanenko, Sacha Robert, Shuhei Shinoda, Kari Jacobsen, Christopher J. LaRocca, Takuro Noguchi, Masato Yamamoto, Julia Davydova
Meeting Abstract
Biotechnology & Applied Microbiology
Sacha Robert, Kari Jacobsen, Margarita Romanenko, Kazuho Inoko, Julia Davydova
Meeting Abstract
Biotechnology & Applied Microbiology
Margarita Romanenko, Ivan Osipov, Sergei Kutseikin, Mariia Sizova, Anastasiya Paramonik, Antonina Grazhdantseva, Galina Kochneva, Julia Davydova, Sergey Netesov