Article
Cell Biology
Fei Han, Qipeng Sun, Zhengyu Huang, Heng Li, Maolin Ma, Tao Liao, Zihuang Luo, Lingling Zheng, Nana Zhang, Nan Chen, Liangqing Hong, Ning Na, Qiquan Sun
Summary: The study reveals that donor plasma mitochondrial DNA (dmtDNA) levels are correlated with the occurrence of antibody-mediated rejection (ABMR) in renal allograft recipients. Higher dmtDNA levels are associated with acute rejection and ABMR, presenting dmtDNA as a potential predictive marker for ABMR in organ evaluation.
Article
Immunology
Bin Yang, Nicolas Sylvius, Jinli Luo, Cheng Yang, Zhanyun Da, Charlottelrm Crotty, Michael L. Nicholson
Summary: Gene expression changes may lead to different outcomes in kidney transplantation, potentially serving as biomarkers. These genes include differentially expressed genes at different time points and in different types of donors, which may contribute to different outcomes in recipients.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Cardiac & Cardiovascular Systems
Jose Luis Campo-Canaveral De La Cruz, Ben Dunne, Philippe Lemaitre, Mindaugas Rackauskas, Jiri Pozniak, Yui Watanabe, Andrea Mariscal, Jonathan Yeung, Kazuhiro Yasufuku, Andrew Pierre, Marc de Perrot, Thomas K. Waddell, Marcelo Cypel, Shaf Keshavjee, Laura Donahoe
Summary: LLTx from deceased donors is used to address donor-recipient size mismatch for small recipients. While LLTx patients often have longer ICU stays and higher mortality rates than LTx patients, recent advancements have led to comparable survival rates between the two procedures.
JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY
(2021)
Article
Surgery
Erzsi Tegzess, Antonio W. Gomes Neto, Robert A. Pol, Silke E. de Boer, Hessel Peters-Sengers, Jan-Stephan F. Sanders, Stefan P. Berger
Summary: In elderly kidney transplant recipients, living donor kidneys have significantly better nondeath-censored graft survival compared to regularly allocated and Eurotransplant Senior Program kidneys. However, there is decreased death-censored graft loss for living donor kidney recipients, while graft survival in regularly allocated and ESP kidneys remains satisfactory. Patient survival after 5 years does not show significant differences among the three types of donor kidneys.
TRANSPLANT INTERNATIONAL
(2021)
Article
Urology & Nephrology
Isaac E. Hall, Peter Philip Reese, Sherry G. Mansour, Sumit Mohan, Yaqi Jia, Heather R. Thiessen-Philbrook, Daniel C. Brennan, Mona D. Doshi, Thangamani Muthukumar, Enver Akalin, Meera Nair Harhay, Bernd Schroeppel, Pooja Singh, Francis L. Weng, Jonathan S. Bromberg, Chirag R. Parikh
Summary: A study on kidney transplant recipients found that deceased-donor AKI was independently associated with lower risk for BKV infection, contrary to the initial hypothesis. Data from the OPTN database also showed that donor AKI was linked to lower risk for graft failure attributed to BKV.
CLINICAL JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
(2021)
Article
Medicine, General & Internal
Rita Achermann, Michael Koller, Sabina De Geest, Karine Hadaya, Thomas F. Mueller, Uyen Huynh-Do, Manuel Pascual, Jurg Steiger, Alexander Kiss, Isabelle Binet
Summary: The study in Switzerland found that older age, lower education, lower working capacity, and not being in a committed relationship were associated with lower access to living kidney donation. Regional differences may also play a role in living donation opportunities.
SWISS MEDICAL WEEKLY
(2021)
Article
Immunology
Zhiliang Guo, Daqiang Zhao, Rula Sa, Lu Wang, Songxia Li, Guangyuan Zhao, Lan Zhu, Gang Chen
Summary: A modified IVIG-based perioperative regimen can achieve excellent intermediate-term graft and recipient survival outcomes in presensitized patients who received deceased donor kidney transplantation without prior desensitization.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Pathology
Ibrahim Batal, Geo Serban, Sumit Mohan, Syed A. Husain, Elena-Rodica Vasilescu, Russel J. Crew, Geoffrey Dube, P. Rodrigo Sandoval, Shana M. Coley, Dominick Santoriello, Michael B. Stokes, Vivette D. D'Agati, David J. Cohen, Glen Markowitz, Mark A. Hardy, Lloyd E. Ratner
Summary: The study revealed that deceased donor kidney allografts with baseline chronic histologic changes have increased immunogenicity, leading to a higher risk of severe acute rejection episodes and decreased allograft survival. Enhancing immunosuppression in recipients of deceased donor kidneys with baseline chronic histologic changes may be necessary to minimize acute rejection and prolong allograft survival.
Article
Medicine, General & Internal
You Luo, Jing Liang, Xiao Hu, Zuofu Tang, Jinhua Zhang, Lanqing Han, Zhanwen Dong, Weiming Deng, Bin Miao, Yong Ren, Ning Na
Summary: Deep learning models combined with clinical characteristics can improve the prediction performance of posttransplant renal function for kidney transplant recipients.
FRONTIERS IN MEDICINE
(2022)
Article
Medicine, General & Internal
Agnieszka Furmanczyk-Zawiska, Barbara Bullo-Piontecka, Michal Komorniczak, Alicja Debska-Slizien, Hanna Augustyniak-Bartosik, Magdalena Durlik
Summary: Antiphospholipid syndrome (APS) is a devastating autoimmune disease that can lead to allograft thrombosis or other extra-renal manifestations in renal transplant recipients. The impact of APS on renal allograft function and survival is still unknown, especially in recipients without APS nephropathy.
JOURNAL OF CLINICAL MEDICINE
(2023)
Review
Immunology
Priyanka Jethwani, Arundati Rao, Laurine Bow, Madhav C. Menon
Summary: Although there have been significant improvements in the rates of acute allograft rejection, kidney allograft longevity has not seen proportional improvements. Recent research suggests that anti-donor immune mechanisms play a role in cases of allograft loss, even without overt evidence of acute rejection. In addition to evaluating highly polymorphic HLA genes, specific variants in donor and recipient genes outside of the HLA loci have been shown to impact transplant outcomes.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Surgery
Katharina A. Mayer, Konstantin Doberer, Amanda Tillgren, Thierry Viard, Susanne Haindl, Sebastian Krivanec, Roman Reindl-Schwaighofer, Michael Eder, Farsad Eskandary, Silvia Casas, Markus Wahrmann, Heinz Regele, Georg A. Boehmig
Summary: Circulating donor-specific antibodies do not always lead to antibody-mediated rejection. Monitoring donor-derived cell-free DNA levels can help improve diagnostic accuracy for ABMR in kidney transplant recipients with DSA.
TRANSPLANT INTERNATIONAL
(2021)
Article
Medicine, General & Internal
Uwe Scheuermann, Sebastian Rademacher, Tristan Wagner, Andri Lederer, Hans-Michael Hau, Daniel Seehofer, Robert Sucher
Summary: The study suggests that multiple-donor renal arteries should not be considered a contraindication to deceased kidney transplantation, as morbidity rates and long-term outcomes appear to be comparable to grafts with single arteries and less complex anastomoses.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Multidisciplinary Sciences
Hanbi Lee, Yohan Park, Tae Hyun Ban, Sang Heon Song, Seung Hwan Song, Jaeseok Yang, Curie Ahn, Chul Woo Yang, Byung Ha Chung
Summary: This study aimed to investigate the synergistic adverse effects of delayed graft function (DGF) and pre-transplant sensitization on allograft outcome after deceased donor kidney transplantation (DDKT). The results showed that pre-sensitization combined with DGF significantly increased the risk of acute antibody-mediated rejection (ABMR) after DDKT. However, this combination did not have a significant impact on allograft function, and allograft or patient survival.
SCIENTIFIC REPORTS
(2021)
Article
Urology & Nephrology
Peter P. Reese, Mona D. Doshi, Isaac E. Hall, Behdad Besharatian, Jonathan S. Bromberg, Heather Thiessen-Philbrook, Yaqi Jia, Malek Kamoun, Sherry G. Mansour, Enver Akalin, Meera N. Harhay, Sumit Mohan, Thangamani Muthukumar, Bernd Schroppel, Pooja Singh, Francis L. Weng, Chirag R. Parikh
Summary: Urinary biomarkers associated with donor acute kidney injury (AKI) are not significantly associated with post-transplant acute rejection and allograft failure. These findings provide reassurance that deceased-donor kidneys with AKI can be successfully used for transplantation and immunological complications can be managed effectively.
AMERICAN JOURNAL OF KIDNEY DISEASES
(2023)