Journal
SURGERY
Volume 143, Issue 5, Pages 577-581Publisher
MOSBY-ELSEVIER
DOI: 10.1016/j.surg.2007.10.015
Keywords
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Categories
Funding
- NHLBI NIH HHS [R01HL085595, R01 HL085595, F32 HL085982, R01 HL085595-01A1, F32HL085982, HL0876077, R01 HL085595-02] Funding Source: Medline
- NIGMS NIH HHS [R01 GM070628-05, R01 GM070628-02, R01 GM070628-01, R01GM070628, R01 GM070628-04, R01 GM070628-03, R01 GM070628] Funding Source: Medline
- NIMHD NIH HHS [L32 MD000881-02, L32 MD000881] Funding Source: Medline
- PHS HHS [K99/R00] Funding Source: Medline
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STEM CELLs are undifferentiated, self-renewing, and multipotent (able to differentiate into multiple cell types). Unlike traditional treatment modalities, these unique characteristics may enable stem cells to undo irreversible cellular damage and rebuild injured or diseased tissue. Recent evidence suggests that stem cells may influence positively the recovery from injury via paracrine factors that promote tissue repair. Insights into paracrine mechanisms of stem cells may help the surgeon scientist devise more effective therapies and earlier widespread application. This review 1) unravels the pathways for stem cell-mediated paracrine protection; 2) highlights the growth factors and cytokines expressed; and 3) explores the potential of using stem cells clinically.
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