Article
Emergency Medicine
Nasim Ahmed, Yen-Hong Kuo
Summary: The study aimed to evaluate the outcomes of partial colectomy in cases of Fulminant Clostridium Difficile Colitis (FCDC). The results showed that there were no significant differences in demographics, comorbidities, mortality, length of hospital stay, and discharge disposition between the group that underwent partial colectomy and the group that underwent total abdominal colectomy (TAC).
WORLD JOURNAL OF EMERGENCY SURGERY
(2022)
Article
Pediatrics
Ryan M. Hanson, Amy J. Wagner
Summary: Severe, complicated Clostridium difficile colitis is rare in pediatric patients and little is known about its medical and surgical management in this population. A case report of a 15-year-old female patient with severe, complicated C difficile colitis successfully treated with diverting loop ileostomy and colonic lavage is presented. This approach, instead of subtotal colectomy and end ileostomy, should be considered as an alternative for pediatric patients with severe, complicated C difficile colitis.
Article
Gastroenterology & Hepatology
Helene Hermand, Jeremie H. Lefevre, Conor Shields, Najim Chafai, Clotilde Debove, Laurent Beaugerie, Magali Svrcek, Yann Parc
Summary: The study found that a small proportion of patients undergoing subtotal colectomy may have their diagnosis changed from ulcerative colitis to Crohn's disease postoperatively, with patients with a disease duration of less than 10 years and an initial diagnosis of IBDU being at higher risk for this diagnostic change.
INTERNATIONAL JOURNAL OF COLORECTAL DISEASE
(2021)
Article
Gastroenterology & Hepatology
Michael C. Plietz, Marine Coste, Jeremy Miller, Maia Kayal, Kathryn Ely Pierce Chuquin, Anam Rizvi, Venu Gopal Bangla, Marla C. C. Dubinsky, Sergey Khaitov, Patricia A. A. Sylla, Alexander J. J. Greenstein
Summary: The study aimed to compare rates of postoperative complications between emergent and non-emergent first-stage subtotal colectomies in three-stage IPAA patients. It found that patients who underwent emergent STC were more likely to experience postoperative anastomotic leaks and require additional procedures. However, there was no significant difference in other complications such as obstruction or wound infection.
JOURNAL OF GASTROINTESTINAL SURGERY
(2023)
Article
Medicine, General & Internal
Kazutaka Fukushima, Ryota Inokuchi, Ichiro Hirayama, Takahiro Hiruma, Kent Doi
Summary: Early diagnosis and conservative antibiotic therapy are crucial for saving fulminant CDI patients who are not eligible for surgery due to severe complicating conditions.
CLINICAL CASE REPORTS
(2021)
Article
Emergency Medicine
Nasim Ahmed, Yen-Hong Kuo, Robyn K. Guinto, Jordan Purewal
Summary: The study aimed to identify risk factors and develop a risk scoring system for mortality in patients undergoing colectomy for Clostridium difficile colitis. A logistic regression model was developed, revealing older age, ventilator dependency, septic shock, and history of steroid use as significant factors for 30-day mortality. The risk scoring system showed a strong correlation between scores and predicted mortality rates.
EUROPEAN JOURNAL OF TRAUMA AND EMERGENCY SURGERY
(2022)
Article
Pharmacology & Pharmacy
Giuseppe Esposito, Chiara Corpetti, Marcella Pesce, Luisa Seguella, Giuseppe Annunziata, Alessandro Del Re, Martina Vincenzi, Roberta Lattanzi, Jie Lu, Walter Sanseverino, Giovanni Sarnelli
Summary: The newly designed PEA-producing probiotic showed therapeutic potential in inhibiting colonic inflammation and restoring tight junction protein expression in a mouse model of CDI.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Infectious Diseases
Jeremy Grossman, Jun Fan, Felicia Allard, Jane Moon, Luis A. Marcos
Summary: This article reports a fatal case of S. stercoralis hyperinfection in an immigrant from rural Ecuador and emphasizes the importance of screening for this parasite in the appropriate clinical scenarios. Various diagnostic methods are introduced to make the diagnosis of S. stercoralis more accessible to practitioners.
INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES
(2022)
Article
Multidisciplinary Sciences
Mao Hagihara, Tadashi Ariyoshi, Yasutoshi Kuroki, Shuhei Eguchi, Seiya Higashi, Takeshi Mori, Tsunemasa Nonogaki, Kenta Iwasaki, Makoto Yamashita, Nobuhiro Asai, Yusuke Koizumi, Kentaro Oka, Motomichi Takahashi, Yuka Yamagishi, Hiroshige Mikamo
Summary: CBM 588 enhances the antibacterial activity against C. difficile, reduces colon epithelial damage, and improves immunity through upregulating pathogen specific immunoglobulin A and enhancing gut epithelial barrier function to protect colon tissue from CDI.
SCIENTIFIC REPORTS
(2021)
Review
Medicine, General & Internal
Gowthami Sai Kogilathota Jagirdhar, Salim Surani
Summary: Pseudomembranous colitis is a severe inflammation of the colon caused by various factors, with Clostridium difficile being the most common cause. Symptoms include abdominal pain, diarrhea, fever, and dehydration. Other than C. difficile, other pathogens, medications, and diseases should be considered as differential diagnoses. Complications can be serious, and early diagnosis and treatment are crucial.
WORLD JOURNAL OF CLINICAL CASES
(2023)
Article
Medicine, General & Internal
Preston S. Kerr, Nga T. Nguyen, Andrew Martinez, Aditya Srinivasan, Christopher D. Kosarek, Joseph Nicholas Sreshta
Summary: Robotic-assisted surgeries have become increasingly common, but data on postoperative complications are limited. This article presents a rare case of fulminant C. difficile colitis following a robotic-assisted pyelolithotomy. The importance of active prevention, early detection, and optimized management is emphasized.
JOURNAL OF MEDICAL CASE REPORTS
(2022)
Article
Gastroenterology & Hepatology
Edward V. Loftus, Daniel C. Baumgart, Krisztina Gecse, Jami A. Kinnucan, Susan B. Connelly, Leonardo Salese, Chinyu Su, Kenneth K. Kwok, John C. Woolcott, Alessandro Armuzzi
Summary: CDIs in patients with UC receiving tofacitinib were infrequent, with mild-moderate severity, and most cases resolved with treatment.
INFLAMMATORY BOWEL DISEASES
(2023)
Review
Public, Environmental & Occupational Health
Peng An Khun, Thomas V. Riley
Summary: This review provides an overview of Clostridium difficile infection (CDI) in southeast Asia, including its prevalence, detection methods, antimicrobial susceptibility profiles, and the potential significance of a One Health approach. CDI is a common cause of hospital-acquired gastroenteritis worldwide, with higher rates observed in high-income countries. Lack of knowledge and awareness about CDI, along with antimicrobial abuse and inadequate education on appropriate usage, contribute to its evolution. Underreporting of CDI rates and misuse of antimicrobial agents pose a significant threat in regions like Indochina, while C. difficile RT 017 strain is endemic in southeast Asia.
AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE
(2022)
Article
Gastroenterology & Hepatology
Tyler McKechnie, Jigish Khamar, Yung Lee, Lea Tessier, Edward Passos, Aristithes Doumouras, Dennis Hong, Cagla Eskicioglu
Summary: This study compared the outcomes and healthcare resource utilization between total abdominal colectomy (TAC) and diverting loop ileostomy (DLI) with antegrade colonic lavage for fulminant Clostridioides difficile infection (CDI) using the National Inpatient Sample (NIS) data from 2016 to 2019. The results showed that there were minimal differences in postoperative morbidity and mortality between the two surgical approaches, but significantly improved healthcare resource utilization in terms of total admission cost and postoperative length of stay (LOS) in TAC patients.
JOURNAL OF GASTROINTESTINAL SURGERY
(2023)
Article
Gastroenterology & Hepatology
Danial Haris Shaikh, Harish Patel, Rezwan Munshi, Haozhe Sun, Shehriyar Mehershahi, Ahmed Baiomi, Ahmed Alemam, Usman Pirzada, Iqra Nawaz, Kamrun Naher, Siddarth Hanumanthu, Suresh Nayudu
Summary: This study retrospectively reviewed data of 1580 patients with CDI and found that prior appendectomy may affect the severity of CDI, development of toxic megacolon, and the eventual need for colectomy.
WORLD JOURNAL OF GASTROINTESTINAL SURGERY
(2021)