Article
Cardiac & Cardiovascular Systems
Hideaki Ota, Hiroyuki Omori, Masanori Kawasaki, Akihiro Hirakawa, Hitoshi Matsuo
Summary: This study found that the proprotein convertase subtilisin-kexin type 9 inhibitor (PCSK9i) significantly decreased the lipid component of coronary plaques. The combination of statins and PCSK9i in the treatment of coronary artery disease patients may contribute to the stabilization and regression of residual vulnerable plaques.
EUROPEAN HEART JOURNAL-CARDIOVASCULAR IMAGING
(2022)
Article
Cardiac & Cardiovascular Systems
Gabriele Bambagioni, Carlo Di Mario, Rebecca Torguson, Pierluigi Demola, Ziad Ali, Varinder Singh, William Skinner, Andre Artis, Tim ten Cate, Cheng Zhang, Hector M. Garcia-Garcia, Gheorghe Doros, Gary S. Mintz, Ron Waksman
Summary: The presence of lipid-rich plaques, regardless of patient age, was strongly associated with predicting non-culprit major adverse cardiovascular events over a two-year period, with no significant difference in the association between patient age and high-risk plaques.
Article
Cardiac & Cardiovascular Systems
Hideaki Ota, Hitoshi Matsuo, Shunsuke Imai, Yuki Nakashima, Yoshiaki Kawase, Munenori Okubo, Hiroshi Takahashi, Hideki Kawai, Yoshihiro Sobue, Masanori Kawasaki, Takeshi Kondo, Takashi Muramatsu, Hideo Izawa
Summary: This study compared the efficacy of CCTA and NIRS-IVUS in predicting periprocedural myocardial injury during PCI in patients with significant coronary stenosis. The results showed that NIRS-IVUS was more competent in predicting the risk of periprocedural myocardial injury.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2023)
Article
Cardiac & Cardiovascular Systems
Satoshi Kitahara, Yu Kataoka, Hiroyuki Miura, Tatsuya Nishii, Kunihiro Nishimura, Kota Murai, Takamasa Iwai, Hayato Nakamura, Hayato Hosoda, Hideo Matama, Takahito Doi, Takahiro Nakashima, Satoshi Honda, Masashi Fujino, Kazuhiro Nakao, Shuichi Yoneda, Kensaku Nishihira, Tomoaki Kanaya, Fumiyuki Otsuka, Yasuhide Asaumi, Kenichi Tsujita, Teruo Noguchi, Satoshi Yasuda
Summary: The study revealed significant associations between CT density and remodeling index with lipid-rich plaque as measured by near-infrared spectroscopy in patients with coronary artery disease. CT density <32.9 HU and RI > 1.08 were identified as optimal cut-off values for predicting lipid-core burden index > 400. The synergistic value of CT density and positive remodeling in detecting lipid-rich plaque by CCTA was highlighted.
Article
Cardiac & Cardiovascular Systems
Rebecca Torguson, Evan Shlofmitz, Gary S. Mintz, Carlo Di Mario, Tim Ten Cate, Ziad A. Ali, Varinder Singh, William Skinner, Cheng Zhang, Corey Shea, Hector M. Garcia-Garcia, Ron Waksman
Summary: The study found that the lipidic content of nonculprit vessels and the rate of MACE occurrence were similar in patients with stable angina pectoris or silent ischemia compared to those with acute coronary syndrome.
AMERICAN JOURNAL OF CARDIOLOGY
(2021)
Article
Medicine, General & Internal
Soon Sang Park, Jisung Jung, Gary S. S. Mintz, Uram Jin, Jin-Sun Park, Bumhee Park, Han-Bit Shin, Kyoung-Woo Seo, Hyoung-Mo Yang, Hong-Seok Lim, Byoung-Joo Choi, Myeong-Ho Yoon, Joon-Han Shin, Seung-Jea Tahk, So-Yeon Choi
Summary: The study found a positive correlation between epicardial adipose tissue thickness and lipid core burden in patients with coronary artery disease, suggesting that epicardial fat may influence the stability of coronary artery plaques.
Editorial Material
Clinical Neurology
Ichiro Nakagawa, Shohei Yokoyama, Masashi Kotsugi
Summary: A patient in their 70s presented with acute basilar artery occlusion leading to weakness of the left limb and aphasia. After mechanical thrombectomy, dual antiplatelet therapy was initiated to prevent further complications. Despite experiencing a minor stroke due to restenosis of the artery, the patient recovered well after balloon angioplasty and stenting.
WORLD NEUROSURGERY
(2021)
Article
Cardiac & Cardiovascular Systems
Rebecca Torguson, Gary S. Mintz, Brian C. Case, Carlo Di Mario, Cheng Zhang, Corey Shea, Hector M. Garcia-Garcia, Ron Waksman
Summary: This study assessed the correlation between lipidic content and arterial plaque burden, finding that coronary segments with high lipid content but no measurable plaque burden are still associated with adverse coronary events.
INTERNATIONAL JOURNAL OF CARDIOLOGY
(2022)
Article
Clinical Neurology
Ichiro Nakagawa, Masashi Kotsugi, HunSoo Park, Shohei Yokoyama, Takanori Furuta, Kenta Nakase, Ai Okamoto, Kaoru Myouchin, Syuichi Yamada, Hiroyuki Nakase
Summary: The study found that the assessment of high LCPs by catheter-based NIRS correlates with the signal intensity ratio of MR imaging in symptomatic patients with unstable carotid plaques.
CEREBROVASCULAR DISEASES
(2021)
Article
Cardiac & Cardiovascular Systems
Mie Kunio, Joseph A. Gardecki, Kohei Watanabe, Kensuke Nishimiya, Sarika Verma, Farouc A. Jaffer, Guillermo J. Tearney
Summary: This study investigates the histopathological origins of near infrared auto-fluorescence (NIRAF) in human cadaver coronary arteries. The results show that NIRAF is associated with high-risk morphological features and can provide additional information for identifying high-risk coronary plaques.
Article
Cardiac & Cardiovascular Systems
Eisuke Usui, Taishi Yonetsu, Mari Ohmori, Yoshinori Kanno, Masahiko Nakao, Takayuki Niida, Yuji Matsuda, Junji Matsuda, Tomoyuki Umemoto, Toru Misawa, Masahiro Hada, Masahiro Hoshino, Yoshihisa Kanaji, Tomoyo Sugiyama, Tsunekazu Kakuta, Tetsuo Sasano
Summary: In patients with ACS culprit lesions, thin-cap fibroatheroma and cholesterol crystals detected by OCT are closely associated with a higher lipid-core burden, while plaque rupture and thrombi are not significantly related.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Peripheral Vascular Disease
Takashi Omatsu, Yohei Sotomi, Tomoaki Kobayashi, Yuma Hamanaka, Akio Hirata, Atsushi Hirayama, Yasunori Ueda, Yasushi Sakata, Yoshiharu Higuchi
Summary: This observational study aimed to validate subjective and qualitative angioscopic findings using objective and quantitative near-infrared spectroscopic (NIRS) assessment. The study found a positive correlation between angioscopic yellow color grade and LCBI (4), and determined the best cutoff value of LCBI (4) to predict the presence of yellow plaque.
JOURNAL OF ATHEROSCLEROSIS AND THROMBOSIS
(2022)
Article
Cardiac & Cardiovascular Systems
Inge J. van den Hoogen, Alexander R. van Rosendael, Fay Y. Lin, Umberto Gianni, Daniele Andreini, Mouaz H. Al-Mallah, Matthew J. Budoff, Filippo Cademartiri, Kavitha Chinnaiyan, Jung Hyun Choi, Edoardo Conte, Hugo Marques, Pedro de Araujo Goncalves, Ilan Gottlieb, Martin Hadamitzky, Jonathon Leipsic, Erica Maffei, Gianluca Pontone, Sanghoon Shin, Yong-Jin Kim, Byoung Kwon Lee, Eun Ju Chun, Ji Min Sung, Sang-Eun Lee, Daniel S. Berman, Renu Virmani, Habib Samady, Peter H. Stone, Jagat Narula, Hyuk-Jae Chang, James K. Min, Leslee J. Shaw, Jeroen J. Bax
Summary: This study investigated changes in coronary arterial remodelling and luminal narrowing over time using 3D metrics from serial CCTA scans. The results showed that for each increase in plaque volume, there was an increase in vessel volume and a decrease in lumen volume. Interestingly, these changes were similar regardless of baseline plaque volume, location within the coronary artery tree, or type of arterial segment.
EUROPEAN HEART JOURNAL-CARDIOVASCULAR IMAGING
(2022)
Article
Cardiac & Cardiovascular Systems
Hiroyuki Omori, Hitoshi Matsuo, Shinichiro Fujimoto, Yoshihiro Sobue, Yui Nozaki, Gaku Nakazawa, Kuniaki Takahashi, Kazuhiro Osawa, Ryo Okubo, Umihiko Kaneko, Hideyuki Sato, Takashi Kajiya, Toru Miyoshi, Keishi Ichikawa, Mitsunori Abe, Toshiro Kitagawa, Hiroki Ikenaga, Mike Saji, Nobuo Iguchi, Takeshi Ijichi, Hiroshi Mikamo, Akira Kurata, Masao Moroi, Raisuke Iijima, Shant Malkasian, Tami Crabtree, James K. Min, James P. Earls, Rine Nakanishi
Summary: AI-QCT showed excellent diagnostic performance in detecting significant LD-NCP using NIRS-IVUS as the reference standard. The measurements derived from AI-QCT strongly correlated with respective measurements from IVUS.
Article
Cardiac & Cardiovascular Systems
Teruo Sekimoto, Hiroyoshi Mori, Shinji Koba, Taito Arai, Naoki Matsukawa, Rikuo Sakai, Yuya Yokota, Shunya Sato, Hideaki Tanaka, Ryota Masaki, Yosuke Oishi, Kunihiro Ogura, Ken Arai, Kosuke Nomura, Koshiro Sakai, Hiroaki Tsujita, Seita Kondo, Shigeto Tsukamoto, Hiroshi Suzuki, Toshiro Shinke
Summary: This study compared the clinical features and lipid profiles of fibrous plaque and lipid-rich plaque in causing acute coronary syndrome (ACS). The study found significant differences in the characteristics and lipid profiles between fibrous plaque and lipid-rich plaque, while there were some similarities between lipid-rich plaque and plaque rupture.