Article
Biochemical Research Methods
Kelly Dimovska Nilsson, Anthi Karagianni, Ibrahim Kaya, Marcus Henricsson, John S. Fletcher
Summary: This work evaluates the potential of new water cluster-based ion beams for improving the capabilities of secondary ion mass spectrometry for in situ lipidomics. It found that using water clusters with carbon dioxide can lead to a more substantial signal increase in positive ion mode. Additionally, the use of water primary ion beam allowed ToF-SIMS results to approach those from MALDI, enabling the imaging of LPC lipids and other lipids that have been difficult to detect during SIMS analyses.
ANALYTICAL AND BIOANALYTICAL CHEMISTRY
(2021)
Article
Construction & Building Technology
Xiaohu Lu, Peter Sjovall, Hilde Soenen, Johan Blom, Martin Andersson
Summary: Microstructures of bitumen surfaces were imaged by AFM and chemically characterised by TOF-SIMS. Air-cooled bitumen surfaces showed bee structures with chemical explanation by wax crystallisation, while fractured surfaces generally lacked clear structure patterns. TOF-SIMS analysis revealed small chemical differences between structured and unstructured areas, suggesting a mechanism involving electron-induced heating in the formation of ESEM structures.
ROAD MATERIALS AND PAVEMENT DESIGN
(2021)
Article
Chemistry, Analytical
Satoka Aoyagi, Yukio Fujiwara, Akio Takano, Jean-Luc Vorng, Ian S. Gilmore, Yung-Chen Wang, Elke Tallarek, Birgit Hagenhoff, Shin-Ichi Iida, Andreas Luch, Harald Jungnickel, Yusheng Lang, Hyun Kyong Shon, Tae Geol Lee, Zhanping Li, Kazuhiro Matsuda, Ichiro Mihara, Ako Miisho, Yohei Murayama, Takaharu Nagatomi, Reiko Ikeda, Masayuki Okamoto, Kunio Saiga, Toshihiko Tsuchiya, Shigeaki Uemura
Summary: This study conducted an interlaboratory research on the identification of peptide sample TOF-SIMS spectra using machine learning. The results showed that Random Forest prediction can effectively determine the amino acids in unknown peptides, and achieve high prediction accuracy for trained peptides.
ANALYTICAL CHEMISTRY
(2021)
Article
Chemistry, Analytical
Andreas Dannhorn, Stephanie Ling, Steven Powell, Eileen McCall, Gareth Maglennon, Gemma N. Jones, Andrew J. Pierce, Nicole Strittmatter, Gregory Hamm, Simon T. Barry, Josephine Bunch, Richard J. A. Goodwin, Zoltan Takats
Summary: A decontamination approach using UV-C light was presented in this study to inactivate clinically relevant pathogens without causing damage to the tissue metabolome and xenobiotics, allowing for the study of the biodistribution of endogenous metabolites. Additionally, spatially integrated abundances of ATR inhibitor ceralasertib from decontaminated human biopsies were determined using DESI-MSI.
ANALYTICAL CHEMISTRY
(2021)
Article
Materials Science, Multidisciplinary
A. Franquet, V. Spampinato, S. Kayser, W. Vandervorst, P. van der Heide
Summary: Shrinking semiconductor device dimensions require new methods and technologies for materials characterization. SF-SIMS and OrbitrapTM-SIMS methods have been demonstrated to accurately quantify impurities in small structures.
Article
Biology
Jennifer Eng, Elmar Bucher, Zhi Hu, Ting Zheng, Summer L. Gibbs, Koei Chin, Joe W. Gray
Summary: The researchers developed a Python software called mplexable, which is used for image processing in multiplex imaging, and shared their optimization of signal removal, antibody specificity, background correction, and batch normalization through Jupyter notebooks. This work improves the CyCIF methodology and provides a framework for easily sharing and reproducing multiplexed image analytics.
COMMUNICATIONS BIOLOGY
(2022)
Article
Chemistry, Physical
Mikolaj Golunski, Sviatoslav Hrabar, Zbigniew Postawa
Summary: Through molecular dynamics simulations, the mechanism of molecular ejection from a monolayer of phenylalanine molecules on two-layer graphene due to projectile bombardment is investigated. The angle of incidence is found to have a significant impact on the efficiency of molecular emission.
APPLIED SURFACE SCIENCE
(2021)
Article
Chemistry, Inorganic & Nuclear
Hanhan Chen, Kangting Zheng, Jingru Wang, Bingxue Niu, Jingping Wang, Pengtao Ma, Jingyang Niu
Summary: Two novel arsenotungstate species, [As4W48O168]36- (1a) and [As2W21O77(H2O)3]22- (2a), have been successfully isolated under a one-pot synthetic method. 1a is the second largest arsenotungstate cluster constructed from four {AsW12} clusters combined together. 2a can be described as lacunary sites of {As2W19} filled by {W2O8} units. Compounds 1 and 2 exhibit proton conductivity properties, and the conductivity value of 1 is 5.0 x 10-3 S cm-1 at 98% relative humidity and 75 degrees C. This work proves the participation of lattice water molecules and polyoxoanions in hydrogen bond formation as an effective pathway for intermolecular proton conduction.
INORGANIC CHEMISTRY
(2023)
Article
Materials Science, Multidisciplinary
Olga S. Ovchinnikova, Nikolay Borodinov, Artem A. Trofimov, Steven T. King, Matthias Lorenz, William Lamberti, David Abmayr, Anton Ievlev
Summary: Chemical imaging of polymers and polymer blends has traditionally been done using ToF-SIMS with limited spatial resolution, but recent work has focused on using HIM-SIMS for higher resolution. By utilizing HIM-SIMS, differentiation between PE and PP as well as imaging of phase-separated domains within PE has been achieved, demonstrating its potential for analyzing complex polymeric systems.
ACS APPLIED POLYMER MATERIALS
(2021)
Article
Chemistry, Analytical
Yu Wang, Bing Xia, Shunyan Deng, Ye Ye, Yan Zhou
Summary: The study introduces a new mass spectrometry imaging method that involves imprinting chemicals on a two-dimensional string plane for large sample analysis, demonstrating the ability to reconstruct 2D MSI images through data processing.
ANALYTICAL CHEMISTRY
(2022)
Article
Materials Science, Multidisciplinary
Anna Dobkowska, Millicent Dayle H. Castillo, Joseph P. Turnbull, Sridhar Ramamurthy, Dmitrij Zagidulin, Desmond E. Moser, Mehran Behazin, Peter G. Keech, David W. Shoesmith, James J. Noel
Summary: The study focused on the corrosion behavior of coarse- and fine-grained copper materials in an aerated aqueous nitric acid solution. Crystallographic orientations greatly influenced the corrosion rate in coarse-grained materials, while grain boundary etching and grain boundary pores played a significant role in fine-grained materials.
Article
Instruments & Instrumentation
Klaus-Ulrich Miltenberger, Max Doebeli, Christof Vockenhuber, Hans-Arno Synal
Summary: The redesigned CHIMP probe at ETH Zurich allows simultaneous analysis of positive and negative secondary ions, studying correlations between different polarities and identifying a cluster effect in the ion yields. Measurements with small primary Cn cluster ions show the influence of cluster size on secondary ion emission multiplicity.
NUCLEAR INSTRUMENTS & METHODS IN PHYSICS RESEARCH SECTION B-BEAM INTERACTIONS WITH MATERIALS AND ATOMS
(2021)
Article
Chemistry, Physical
Maximilian G. Muenst, Milan Oncak, Martin K. Beyer, Christian van der Linde
Summary: This study investigates the structure and chemical properties of hydrated molecular anions in the atmosphere, revealing their microsolvation characteristics through spectroscopic measurements. The experimental results show that the interaction of hydrogen atoms with the central ion affects the infrared spectra, while the high fluxionality of water molecules contributes to spectral broadening.
JOURNAL OF CHEMICAL PHYSICS
(2021)
Article
Nanoscience & Nanotechnology
Mohamed M. Shehata, Daniel H. Macdonald, Lachlan E. Black
Summary: This study demonstrates that the passivation performance of amorphous thin-film TiOx prepared via atomic layer deposition strongly depends on the accumulation of chlorine at the silicon surface. It shows that ALD TiOx can be used as a capping layer to reduce silicon surface recombination and emphasizes the importance of residual chlorine in enhancing interface passivation.
ACS APPLIED MATERIALS & INTERFACES
(2023)
Article
Nanoscience & Nanotechnology
Mohamed M. Shehata, Daniel H. Macdonald, Lachlan E. Black
Summary: The key part of the high level of surface passivation of ALD TiOx layers is due to the accumulation of chlorine (Cl) at the Si surface. This passivation mechanism can be classified as an effective passivation element, similar to the role of hydrogen in passivating Si dangling bonds. The presence of residual chlorine emphasizes the importance of enhancing the passivation of buried interfaces and motivates the use of metal chloride precursors for silicon surface passivation applications.
ACS APPLIED MATERIALS & INTERFACES
(2023)
Article
Chemistry, Analytical
C. Hughes, A. Henderson, M. Kansiz, K. M. Dorling, M. Jimenez-Hernandez, M. D. Brown, N. W. Clarke, P. Gardner
Article
Biochemical Research Methods
Irma Berrueta Razo, Sadia Sheraz (Nee Rabbani), Alex Henderson, Nicholas P. Lockyer, John C. Vickerman
RAPID COMMUNICATIONS IN MASS SPECTROMETRY
(2015)
Article
Biophysics
Shusuke Nakano, Yuta Yokoyama, Satoka Aoyagi, Naoyuki Himi, John S. Fletcher, Nicholas P. Lockyer, Alex Henderson, John C. Vickerman
Article
Chemistry, Physical
Michael J. Pilling, Alex Henderson, Benjamin Bird, Mick D. Brown, Noel W. Clarke, Peter Gardner
FARADAY DISCUSSIONS
(2016)
Article
Biophysics
Shusuke Nakano, Yuta Yokoyama, Satoka Aoyagi, Naoyuki Himi, John S. Fletcher, Nicholas P. Lockyer, Alex Henderson, John C. Vickerman
Article
Chemistry, Physical
Michael J. Pilling, Alex Henderson, Benjamin Bird, Mick D. Brown, Noel W. Clarke, Peter Gardner
FARADAY DISCUSSIONS
(2016)
Correction
Chemistry, Analytical
Matthew J. Baker, Hugh J. Byrne, John Chalmers, Peter Gardner, Royston Goodacre, Alex Henderson, Sergei G. Kazarian, Francis L. Martin, Julian Moger, Nick Stone, Josep Sule-Suso
Review
Chemistry, Analytical
Matthew J. Baker, Hugh J. Byrne, John Chalmers, Peter Gardner, Royston Goodacre, Alex Henderson, Sergei G. Kazarian, Francis L. Martin, Julian Moger, Nick Stone, Josep Sule-Suso
Article
Biochemistry & Molecular Biology
Hua Tian, John S. Fletcher, Raphael Thuret, Alex Henderson, Nancy Papalopulu, John C. Vickerman, Nicholas P. Lockyer
JOURNAL OF LIPID RESEARCH
(2014)
Article
Chemistry, Analytical
Dougal Ferguson, Alex Henderson, Elizabeth F. McInnes, Rob Lind, Jan Wildenhain, Peter Gardner
Summary: This article reviews the potential of using infrared microscopy techniques, such as FTIR and QCL, for the detection and classification of cancerous tissues. It also suggests using the F1-Score as a quantitative metric to compare model performances. Furthermore, the article provides suggestions for data handling techniques and reporting standards for future studies.
Article
Chemistry, Analytical
Jiayi Tang, Alex Henderson, Peter Gardner
Summary: The use of infrared spectroscopy in histopathology shows promise for diagnosing various diseases. Comparing the performance of AdaBoost and Random Forests algorithms on non-uniform data sets, it was found that both algorithms demonstrated excellent classification accuracy on breast cancer tissue samples, with AdaBoost showing more robustness in handling imbalanced datasets. This study provides insights into the choice of machine learning approach for building models in histopathology.
Article
Chemistry, Analytical
Michael J. Pilling, Alex Henderson, Peter Gardner
ANALYTICAL CHEMISTRY
(2017)
Article
Chemistry, Analytical
Michael J. Pilling, Alex Henderson, Jonathan H. Shanks, Michael D. Brown, Noel W. Clarke, Peter Gardner
Article
Chemistry, Analytical
Artur Dawid Surowka, Michael Pilling, Alex Henderson, Herve Boutin, Lidan Christie, Magdalena Szczerbowska-Boruchowska, Peter Gardner
