Journal
SURFACE AND INTERFACE ANALYSIS
Volume 43, Issue 1-2, Pages 269-271Publisher
WILEY-BLACKWELL
DOI: 10.1002/sia.3529
Keywords
lipid profile; C-60(+); MALDI; yandem MS; aplysia neuron; trimethylamine; mass spectrometry imaging (MSI)
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Funding
- Lipid MAPS Consortium [GM 069338-07]
- National Institutes of Health [2R01 EB002016-16]
- National Science Foundation [CHE-0908226]
- Division Of Chemistry
- Direct For Mathematical & Physical Scien [0908226] Funding Source: National Science Foundation
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The dual functionality of a C-60(+)-Q-Star hybrid instrument allows for the examination of complex lipid profiles with both MALDI and SIMS methodologies.([1]) The difficulties associated with characterizing lipids in situ - isobaric interference and salt contamination - are discussed. The inherent advantages of both methodologies were used to deconvolute complex lipid spectra and establish characteristic fragmentation pathways. The high lateral resolution of SIMS allows for single cell images of aplysia californica neurons, while the established protocols were utilized to identify a major lipid component. Copyright (C) 2010 John Wiley & Sons, Ltd.
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