Article
Chemistry, Analytical
Yusheng Lang, Lilin Zhou, Yutaka Imamura
Summary: Time-of-flight secondary ion mass spectrometry (ToF-SIMS) is an important analysis technique for gathering information from surfaces. This study proposed a new approach that treats ToF-SIMS spectra as images and uses convolutional neural network (CNN) for analysis, avoiding the challenges of descriptor generation.
ANALYTICAL CHEMISTRY
(2022)
Article
Engineering, Environmental
Yiren Li, Jian Liu, Yiheng Wang, Xianjin Tang, Jianming Xu, Xingmei Liu
Summary: Cadmium (Cd) and lead (Pb) are common elements in contaminated sites and their behavior in the soil can be influenced by competition for adsorption sites. This study used adsorption experiments, multi-surface models, and advanced spectroscopy technology to explain the adsorption mechanisms of Cd and Pb and determine the contribution of each component in the competitive system. The results showed that pH is a key factor influencing the adsorption contribution of soil components, with soil organic matter being the dominant adsorbent for both Cd and Pb. Clay minerals play a role at low pH, while Fe/Al oxides primarily adsorb metals at high pH. Additionally, the competitive effect of Pb on Cd was mainly observed on soil organic matter rather than clay minerals, emphasizing the importance of considering this competition in soils with high organic matter content.
JOURNAL OF HAZARDOUS MATERIALS
(2023)
Article
Chemistry, Multidisciplinary
Yuchen Zhang, Andrew Plymale, Jiyoung Son, Qiaoyun Huang, Wenli Chen, Xiao-Ying Yu
Summary: The interactions between soil microorganisms and soil minerals are crucial for mineral formation, evolution, and soil stability. However, our understanding of the functions of bacterial biofilms in soil minerals at the microscale is limited. This study used a soil mineral-bacterial biofilm system as a model and analyzed it using time-of-flight secondary ion mass spectrometry (ToF-SIMS) to obtain molecular level information. The results showed that a dynamic flow-cell culture of biofilms in microfluidics provided better observation of characteristic molecules compared to static culture in multi-wells. These findings suggest that using flow-cell culture and advanced mass spectral imaging techniques like ToF-SIMS can enhance the study of the interaction mechanism between biofilms and soil minerals at the molecular level.
FRONTIERS IN CHEMISTRY
(2023)
Article
Chemistry, Medicinal
Tahereh G. Avval, Behnam Moeini, Victoria Carver, Neal Fairley, Emily F. Smith, Jonas Baltrusaitis, Vincent Fernandez, Bonnie J. Tyler, Neal Gallagher, Matthew R. Linford
Summary: Unsupervised exploratory data analysis (EDA) is crucial in understanding complex data sets. This paper compares the performance of various summary statistics in EDA, highlighting the superiority of pattern recognition entropy (PRE). The introduction of divided spectrum-PRE (DS-PRE) enhances the discrimination power of PRE and can be used in conjunction with the k-nearest neighbor (kNN) algorithm, making PRE and DS-PRE effective tools for unsupervised EDA.
JOURNAL OF CHEMICAL INFORMATION AND MODELING
(2021)
Review
Physics, Applied
Albina Jetybayeva, Nikolay Borodinov, Anton V. Ievlev, Md Inzamam Ul Haque, Jacob Hinkle, William A. Lamberti, J. Carson Meredith, David Abmayr, Olga S. Ovchinnikova
Summary: Imaging mass spectrometry (IMS) is a powerful analytical technique used in various fields that provides qualitative compositional analysis and spatial mapping. The combination of mass spectra with spatial information produces large high-dimensional datasets, making automated computational methods crucial for exploratory analysis.
JOURNAL OF APPLIED PHYSICS
(2023)
Article
Chemistry, Physical
Malgorzata Trzyna-Sowa, Nicolas Berchenko, Piotr Dziawa, Jozef Cebulski
Summary: The study utilized Time of Flight Secondary Ion Mass Spectrometry to analyze the molecular speciation of oxidized bismuth, lead, tin, and tellurium. It revealed that different oxidation states possess different chemical compositions of high-mass clusters, and semi-quantitative molecular speciation was performed using the Plog's model.
APPLIED SURFACE SCIENCE
(2022)
Article
Chemistry, Analytical
P. Hirchenhahn, A. Al Sayyad, J. Bardon, P. Plapper, L. Houssiau
Summary: The biomedical industry increasingly uses polymer/metal hybrid assemblies, and laser welding is an excellent option for assembling them due to its quick process and advantages for biomedical applications. However, studying the molecular-level information of the deeply buried interface between the materials is a challenging analytical task.
Article
Construction & Building Technology
Stepanka Kuckova, Gabriela Rambouskova, Petra Junkova, Jiri Santrucek, Pavel Cejnar, Tatiana Anatolievna Smirnova, Ondrej Novotny, Radovan Hynek
Summary: The enrichment of mortar mixtures with natural organic materials has a long history, with protein additives proven to enhance mortar durability and strength. This study aimed to identify and quantify proteins in model mortars with various protein additives using mass spectrometry techniques. The results confirmed the possibility of identifying protein additives in century-old mortars, shedding light on traditional recipes.
CONSTRUCTION AND BUILDING MATERIALS
(2021)
Article
Materials Science, Multidisciplinary
A. Franquet, V. Spampinato, S. Kayser, W. Vandervorst, P. van der Heide
Summary: Shrinking semiconductor device dimensions require new methods and technologies for materials characterization. SF-SIMS and OrbitrapTM-SIMS methods have been demonstrated to accurately quantify impurities in small structures.
Article
Multidisciplinary Sciences
Yafei Wang, Long Chen, Jiating Yu, Xudong Guo, Shuangqing Wang, Guoqiang Yang
Summary: The negative-tone molecular glass photoresist shows good contrast, resolution, and sensitivity in electron beam lithography, making it a promising candidate for use in this field.
ROYAL SOCIETY OPEN SCIENCE
(2021)
Article
Engineering, Chemical
Hao Lai, Jiushuai Deng, Quanjun Liu, Shuming Wen, Qiang Song
Summary: This study investigated the surface chemistry differences between minerals in lead concentrate and tailings in complex flotation circuits of lead-zinc sulfide ores. The results showed that the adsorption of lead ions onto specific mineral surfaces was an important reason for the failed separation of minerals from galena. The surface chemical evidence provided by this study helps to better understand the selective separation mechanism of lead-zinc sulfide ores.
SEPARATION AND PURIFICATION TECHNOLOGY
(2021)
Article
Physics, Applied
A. A. Murthy, J. Lee, C. Kopas, M. J. Reagor, A. P. McFadden, D. P. Pappas, M. Checchin, A. Grassellino, A. Romanenko
Summary: This study investigates the impacts of fabrication procedures on the dissipation mechanisms in superconducting qubits using time-of-flight secondary ion mass spectrometry. The results show that the formation of oxide and silicide regions and the incorporation of impurity species, such as niobium hydrides and carbides, affect the superconducting properties of the Nb thin film. It also reveals the presence of halogen species in the patterned thin films. Understanding the source of these impurities can contribute to intelligent fabrication of superconducting qubits and prolong coherence times.
APPLIED PHYSICS LETTERS
(2022)
Article
Biochemical Research Methods
Kuangnan Fang, Rui Ren, Qingzhao Zhang, Shuangge Ma
Summary: Dimension reduction techniques like PCA, PLS, and CCA are extensively used in the analysis of high-dimensional omics data. Integrative analysis, which outperforms meta-analysis and individual-data analysis, has been developed for multiple datasets with compatible designs. We developed the R package iSFun to facilitate integrative dimension reduction analysis, offering comprehensive analysis options under different models and penalties.
Article
Environmental Sciences
Antoine Aynard, Cecile Courreges, Javier Jimenez-Lamana, Anassya Raad, Christelle Miqueu, Bruno Grassl, Stephanie Reynaud
Summary: The mass and volume concentration of nanoplastics are low, but their surface area is high, which can increase their toxicity by adsorbing chemical co-pollutants such as trace metals. This study investigated the interactions between carboxylated nanoplastics and copper, and confirmed that nanoplastics can act as carriers for metal pollutants through both adsorption and absorption processes.
ENVIRONMENTAL POLLUTION
(2023)
Article
Engineering, Electrical & Electronic
Luiz Paulo O. Sousa, Katia L. Fukushima, Vanessa P. Scagion, Murilo H. M. Facure, Daniel S. Correa, Juliano E. Oliveira, Danton D. Ferreira
Summary: Electronic tongues are sensors inspired by biological recognition systems, used to determine flavors or substances in samples. The sensor arrays are generally non-specific, requiring data processing techniques for specific information. Principal curves can be a promising technique for analyzing electronic tongues data.
IEEE SENSORS JOURNAL
(2021)
Article
Cell & Tissue Engineering
Jeremie D. Oliver, Shihai Jia, Leslie R. Halpern, Emily M. Graham, Emma C. Turner, John S. Colombo, David W. Grainger, Rena N. D'Souza
Summary: Clefts of the lip and/or palate are common orofacial birth defects, with challenges in correcting severe cleft defects through surgery alone. Advances in tissue engineering offer new avenues to stimulate bone formation at the site of surgical correction for palatal clefts, potentially improving treatment outcomes.
TISSUE ENGINEERING PART B-REVIEWS
(2021)
Article
Obstetrics & Gynecology
Goro Kuramoto, Ibrahim A. Hammad, Brett D. Einerson, Amanda A. Allshouse, Michelle Debbink, David W. Grainger, Robert M. Silver, Teruo Okano
Summary: This study demonstrates the feasibility of transplanting human umbilical cord mesenchymal stem cell sheets in a rat model and highlights the potential benefits of reducing uterine fibrosis and scarring. The use of stem cell sheets significantly reduces fibroblast infiltration and uterine scar tissue formation during healing.
AMERICAN JOURNAL OF PERINATOLOGY
(2022)
Article
Chemistry, Multidisciplinary
Kyungsook Kim, Sophia Bou-Ghannam, Sumako Kameishi, Masatoshi Oka, David W. Grainger, Teruo Okano
Summary: The evolution of drug discovery in the early 20th century saw a shift from focusing on symptom control to pursuing radical cures, with cell therapy emerging as a promising new treatment targeting specific tissues and dynamic signaling environments. Cell delivery methods play a crucial role in realizing the therapeutic potential of cell therapy, especially in the context of mesenchymal stem cell (MSC) engraftment and bioactive function. Cell sheet technology is presented as a breakthrough in cell therapy, showcasing therapeutic success in tissue regeneration and discussing its anticipated clinical impacts.
JOURNAL OF CONTROLLED RELEASE
(2021)
Article
Chemistry, Multidisciplinary
James M. Anderson, David W. Grainger
Summary: Sung Wan Kim's initial efforts as an independent investigator were focused on improving the understanding of early events in blood/material interactions, leading to the development of blood compatible materials. His studies were supported by NIH grants for over 40 years and contributed to the fields of biomaterials and non-thrombogenic biomaterial research.
JOURNAL OF CONTROLLED RELEASE
(2021)
Editorial Material
Chemistry, Multidisciplinary
David W. Grainger, Wim Hennink, Raymond Schiffelers, You Han Bae
JOURNAL OF CONTROLLED RELEASE
(2021)
Article
Computer Science, Information Systems
Alan H. Morris, Brian Stagg, Michael Lanspa, James Orme, Terry P. Clemmer, Lindell K. Weaver, Frank Thomas, Colin K. Grissom, Ellie Hirshberg, Thomas D. East, Carrie Jane Wallace, Michael P. Young, Dean F. Sittig, Antonio Pesenti, Michela Bombino, Eduardo Beck, Katherine A. Sward, Charlene Weir, Shobha S. Phansalkar, Gordon R. Bernard, B. Taylor Thompson, Roy Brower, Jonathon D. Truwit, Jay Steingrub, R. Duncan Hite, Douglas F. Willson, Jerry J. Zimmerman, Vinay M. Nadkarni, Adrienne Randolph, Martha A. Q. Curley, Christopher J. L. Newth, Jacques Lacroix, Michael S. D. Agus, Kang H. Lee, Bennett P. DeBoisblanc, R. Scott Evans, Dean K. Sorenson, Anthony Wong, Michael Boland, David W. Grainger, Willard H. Dere, Alan S. Crandall, Julio C. Facelli, Stanley M. Huff, Peter J. Haug, Ulrike Pielmeier, Stephen E. Rees, Dan S. Karbing, Steen Andreassen, Eddy Fan, Roberta M. Goldring, Kenneth Berger, Beno W. Oppenheimer, E. Wesley Ely, Ognjen Gajic, Brian Pickering, David A. Schoenfeld, Irena Tocino, Russell S. Gonnering, Peter J. Pronovost, Lucy A. Savitz, Didier Dreyfuss, Arthur S. Slutsky, James D. Crapo, Derek Angus, Michael R. Pinsky, Brent James, Donald Berwick
Summary: Clinical decision-making relies on knowledge, expertise, and authority, but unaided clinicians are often affected by cognitive limitations and biases. Electronic health records have the potential to improve healthcare quality by reducing unwarranted clinician decision variation. Providing replicable decision-support tools can personalize patient care, enhance clinical care and research quality, and potentially create a learning healthcare system.
JOURNAL OF THE AMERICAN MEDICAL INFORMATICS ASSOCIATION
(2021)
Article
Multidisciplinary Sciences
Tuan Ngoc Nguyen, Andre Rangel, David W. Grainger, Veronique Migonney
Summary: PET fibers and fabrics are commonly used in medical devices, and efforts to enhance their biocompatibility have included functionalizing them with anionic polymers. However, long-term storage of PET fabrics without proper cleaning processes can lead to degradation of spin finish oil, impacting surface cleaning and causing surface degradation. Understanding the effects of storage conditions on these fabrics is important for maintaining their surface functionalization and preventing degradation.
SCIENTIFIC REPORTS
(2021)
Review
Pharmacology & Pharmacy
Ulrich Dirnagl, Georg N. Duda, David W. Grainger, Petra Reinke, Ronenn Roubenoff
Summary: Biomedical research accuracy and relevance are costly problems, with issues in data quality, reporting, methodology, and reproducibility. Preclinical models and clinical data are deficient, leading to inefficient translation from basic research to clinical solutions, resulting in wasted resources and limited new clinical solutions for diseases.
ADVANCED DRUG DELIVERY REVIEWS
(2022)
Article
Computer Science, Information Systems
Alan H. Morris, Christopher Horvat, Brian Stagg, David W. Grainger, Michael Lanspa, James Orme, Terry P. Clemmer, Lindell K. Weaver, Frank O. Thomas, Colin K. Grissom, Ellie Hirshberg, Thomas D. East, Carrie Jane Wallace, Michael P. Young, Dean F. Sittig, Mary Suchyta, James E. Pearl, Antinio Pesenti, Michela Bombino, Eduardo Beck, Katherine A. Sward, Charlene Weir, Shobha Phansalkar, Gordon R. Bernard, B. Taylor Thompson, Roy Brower, Jonathon Truwit, Jay Steingrub, R. Duncan Hiten, Douglas F. Willson, Jerry J. Zimmerman, Vinay Nadkarni, Adrienne G. Randolph, Martha A. Q. Curley, Christopher J. L. Newth, Jacques Lacroix, Michael S. D. Agus, Kang Hoe Lee, Bennett P. DeBoisblanc, Frederick Alan Moore, R. Scott Evans, Dean K. Sorenson, Anthony Wong, Michael Boland, Willard H. Dere, Alan Crandall, Julio Facelli, Stanley M. Huff, Peter J. Haug, Ulrike Pielmeier, Stephen E. Rees, Dan S. Karbing, Steen Andreassen, Eddy Fan, Roberta M. Goldring, Kenneth Berger, Beno W. Oppenheimer, E. Wesley Ely, Brian W. Pickering, David A. Schoenfeld, Irena Tocino, Russell S. Gonnering, Peter J. Pronovost, Lucy A. Savitz, Didier Dreyfuss, Arthur S. Slutsky, James D. Crapo, Michael R. Pinsky, Brent James, Donald M. Berwick
Summary: Delivering the best care in various clinical settings is a challenging problem. Evidence-based guidelines currently address only a fraction of the care provided by clinicians, especially in underserved areas. The use of validated clinical decision support systems (eActions) could help overcome cognitive limitations in advanced healthcare environments.
JOURNAL OF THE AMERICAN MEDICAL INFORMATICS ASSOCIATION
(2022)
Article
Cell Biology
Sophia Bou-Ghannam, Kyungsook Kim, Makoto Kondo, David W. Grainger, Teruo Okano
Summary: Cell sheet technology is a scaffold-free 3D cell delivery platform that can sustain cell engraftment, survival, and reparative function. Recent evidence shows that cell sheets stimulate mesenchymal stem cells (MSC) to produce paracrine factors. This study introduces a centrifugation strategy to enhance MSC paracrine factor production by stacking and centrifuging cell sheets, resulting in a 3D MSC-delivery platform with boosted therapeutic factor production capacity.
Article
Cell & Tissue Engineering
Masatoshi Oka, Sumako Kameishi, Yun-Kyoung Cho, Sun U. U. Song, David W. W. Grainger, Teruo Okano
Summary: Chronic kidney disease (CKD) is the irreversible loss of nephron function, leading to toxins build-up, inflammation, and fibrosis. Mesenchymal stem/stromal cell (MSC) transplantation is a promising strategy to treat CKD, but concerns remain about kidney decapsulation. In this study, clinically relevant human clonal BMSC (cBMSC) sheets were transplanted onto intact renal capsule, effectively suppressing tubular epithelial cell injury and renal fibrosis in a rat model of ischemia-reperfusion injury (IRI).
TISSUE ENGINEERING PART C-METHODS
(2023)
Article
Cell Biology
Celia M. Dunn, Sumako Kameishi, Yun-Kyoung Cho, Sun U. Song, David W. Grainger, Teruo Okano
Summary: Mesenchymal stromal cells (MSCs) have diverse immunomodulatory functions and hold promise as a treatment for immune-related diseases. In this study, IFN-γ priming and thermoresponsive cultureware were combined to produce transplantable scaffold-free immunosuppressive cell sheets. The use of human clinical-grade single-cell-derived clonal bone marrow-derived MSCs further enhances the clinical relevance of this approach. The results show that MSC sheets produced with IFN-γ priming upregulate expression of immunosuppressive factors and exhibit increased ability to inhibit T-cell proliferation.
Article
Biophysics
Lara J. Gamble, David Radford, David W. Grainger, David G. Castner
Summary: This study characterized the properties of self-assembled monolayers (SAMs) of perfluoroalkanethiols on gold surfaces using XPS, NEXAFS, and ToF-SIMS techniques. It was found that SAMs with longer carbon chains exhibited higher ordering on gold surfaces, while SAMs with shorter carbon chains showed lower ordering.
Editorial Material
Cell Biology
Georg N. Duda, David W. Grainger, Robert E. Guldberg, Gady Goldsobel, Glenn D. Prestwich, Brenna Rauw, Hans-Dieter Volk
Summary: Translational impact assessment is crucial in determining the potential of biomedical research discoveries to be transformed into practical, beneficial products for human health. However, measuring translational success is challenging as it goes beyond commercial achievements and may vary from case to case. Prioritizing societal impact is essential in a globalized society.
SCIENCE TRANSLATIONAL MEDICINE
(2023)
Article
Biotechnology & Applied Microbiology
Pranothi Mulinti, Dorina Diekjurgen, Kristen Kurtzeborn, Narayanaganesh Balasubramanian, Shane J. Stafslien, David W. Grainger, Amanda E. Brooks
Summary: In this study, a small basic peptide known for its antimicrobial properties was genetically linked to a mechanically robust silk-like peptide. The fusion protein showed both heparin-binding and antimicrobial capabilities, creating a designer silk-like protein with improved hemocompatibility and antimicrobial properties.
BIOENGINEERING-BASEL
(2022)