Review
Medicine, General & Internal
Mayur D. Mody, James W. Rocco, Sue S. Yom, Robert Haddad, Nabil F. Saba
Summary: Head and neck cancer is the seventh most common type of cancer worldwide, with the predominant risk factors being tobacco use, alcohol abuse, and oncogenic viruses. Treatment typically involves a multidisciplinary approach with surgery, radiotherapy, and systemic therapy, and is challenging due to site-specific and histology-specific variations.
Review
Dentistry, Oral Surgery & Medicine
Y. Ye, D. D. Jensen, C. T. Viet, H. L. Pan, W. M. Campana, M. Amit, M. D. Boada
Summary: Head and neck cancer not only has a high mortality rate, but also causes severe pain that affects patients' quality of life. The pathophysiology of HNC pain involves anatomical, histopathological, and molecular differences between cancers. The tumor microenvironment and peripheral nerves play a crucial role in HNC pain, and there is evidence of a functional loop of cross-activation between them. Understanding the mechanisms underlying pain and cancer progression in HNC can help develop targeted treatments for both conditions.
JOURNAL OF DENTAL RESEARCH
(2022)
Review
Medicine, General & Internal
Maria Kouri, Martina Rekatsina, Athina Vadalouca, Ioanna Siafaka, Emmanouil Vardas, Erofili Papadopoulou, Antonella Paladini, Giustino Varrassi
Summary: This review analyzed studies on systematically administered medication for neuropathic pain (NP) management in head and neck cancer (HNC) patients undergoing radiotherapy. The results showed that treatments including pregabalin, methadone, ketamine, and gabapentin provided pain relief against HNC NP. However, there is limited research on pharmacological management of therapy-related NP in HNC patients, highlighting the need for more studies to develop specific treatment algorithms.
JOURNAL OF CLINICAL MEDICINE
(2022)
Review
Biochemistry & Molecular Biology
Juliana Runnels, Julie R. Bloom, Kristin Hsieh, Daniel R. Dickstein, Yuhao Shi, Brianna M. Jones, Eric J. Lehrer, Richard L. Bakst
Summary: Head and neck squamous cell carcinoma (HNSCC) is a prevalent and deadly disease worldwide. Immunotherapy has shown promise as a treatment option for HNSCC, and combining it with radiation therapy (RT) may enhance effectiveness. This review highlights the advantages of combining RT and immunotherapy, such as improved tumor response rates, increased survival, and reduced toxicity, while also discussing the challenges in redefining the standard of care and the need for further research.
Article
Otorhinolaryngology
Holly McMillan, Carly E. A. Barbon, Richard Cardoso, Abigail Sedory, Sheila Buoy, Christine Porsche, Kiara Savage, Lauren Mayo, Katherine A. Hutcheson
Summary: This retrospective case series study demonstrates that manual therapy can effectively increase oral opening in patients with radiation-associated trismus. The largest improvement in oral opening was observed after the initial treatment, but further gains could still be achieved with serial treatment.
JAMA OTOLARYNGOLOGY-HEAD & NECK SURGERY
(2022)
Article
Otorhinolaryngology
Raniv D. Rojo, Jenny L. Ren, Demis N. Lipe, Hoda Badr, Sanjay Shete, Ehab Y. Hanna, Cielito C. Reyes-Gibby
Summary: This study assessed the prevalence and associated risk factors of neuropathic pain (NP) among head and neck cancer (HNC) survivors through a cross-sectional survey. The results showed that NP remained prevalent in HNC survivors, and severe pain was more common among those with NP. Age, surgery, depression, and comorbidities were identified as risk factors for NP.
HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK
(2022)
Review
Oncology
Margherita Gobbo, Praveen R. Arany, Elisabetta Merigo, Rene-Jean Bensadoun, Alan Roger Santos-Silva, Luiz Alcino Gueiros, Giulia Ottaviani
Summary: The role of photobiomodulation (PBM) in head and neck cancer (HNC) treatment was investigated. PBM showed beneficial effects in improving quality of life (QoL), nutritional status, reducing pain and functional impairment. It may also reduce interruptions in radiotherapy (RT) and improve cancer treatment outcomes. However, it does not directly impact cancer survival/recurrences. PBM should be included in supportive cancer care for HNC patients due to its efficacy, safety, feasibility, and tolerability.
SUPPORTIVE CARE IN CANCER
(2023)
Article
Oncology
Heleen Bollen, Julie van der Veen, Annouschka Laenen, Sandra Nuyts
Summary: IMRT and VMAT have become standard of care in treating head and neck cancer. By analyzing treatment failure patterns, this study indirectly investigated the quality of target volume delineation and treatment delivery, which were performed accurately with few recurrences outside high-dose regions and no marginal failures observed.
FRONTIERS IN ONCOLOGY
(2021)
Article
Oncology
Indu S. Voruganti, Ian Poon, Zain A. Husain, Andrew Bayley, Elizabeth A. Barnes, Liying Zhang, Lee Chin, Darby Erler, Kevin Higgins, Danny Enepekides, Antoine Eskander, Irene Karam
Summary: This study reported the outcomes of SBRT for head and neck skin cancer patients, including local control, overall survival, and late toxicity. The results showed that SBRT provides durable disease control with acceptable toxicity for high-risk patients unable to undergo standard treatment approaches.
RADIOTHERAPY AND ONCOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Martina Raudenska, Jan Balvan, Klara Hanelova, Maria Bugajova, Michal Masarik
Summary: Cancer-associated fibroblasts (CAFs) play crucial roles in the pathogenesis of head and neck squamous cell carcinoma (HNSCC), including extracellular matrix structure formation, angiogenesis, immune and metabolic reprogramming in the tumor microenvironment, which contribute to metastasis and resistance to radiotherapy and chemotherapy. The heterogeneity and plasticity of CAFs result in context-dependent effects on carcinogenesis. Targeting specific molecules in CAFs may hold promise for future HNSCC therapy. This review article focuses on the role of CAFs in the HNSCC tumor microenvironment and discusses clinically relevant agents and signaling pathways that can be targeted for therapy.
BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER
(2023)
Review
Oncology
Francesca De Felice, Carlo Guglielmo Cattaneo, Pierfrancesco Franco
Summary: This review explores the current radio(chemo)therapy strategy for head and neck squamous cell carcinoma (HNSCC) in order to improve understanding of the disease and potentially enhance patient care. The best practice for managing HNSCC should involve discussion within a multidisciplinary team. Currently, radiation therapy (RT) with or without chemotherapy is the standard treatment for locally advanced disease, and intensity-modulated photon therapy (IMRT) is the recommended RT technique.
Article
Otorhinolaryngology
Punam A. Patel, Lavanya Nagappan, Daohai Yu, Xiaoning Liu, Cecelia E. Schmalbach
Summary: The study revealed that female patients, younger individuals, smokers, and those requiring higher doses of opioids during hospital stay are more likely to experience inadequate pain control postoperatively. These patients could benefit from additional education, earlier follow-up visits, and a comprehensive nonopioid pain management regimen.
OTOLARYNGOLOGY-HEAD AND NECK SURGERY
(2021)
Review
Biochemistry & Molecular Biology
Sankar Jagadeeshan, Ofra Z. Novoplansky, Oded Cohen, Ina Kurth, Jochen Hess, Ari J. Rosenberg, Jennifer R. Grandis, Moshe Elkabets
Summary: This article reviews the alterations and pathway activations of RAS genes in head and neck cancer (HNC), highlighting their role in HNC initiation, progression, and metastasis. The intrinsic role of mutated-RAS in tumor cell signaling and its extrinsic role in determining tumor microenvironment (TME) heterogeneity are discussed. Furthermore, the article summarizes the impact of RAS alterations on therapy resistance and explores the potential of targeting RAS as a single agent or in combination with other therapeutic agents for HNC patients with RAS-activated tumors.
BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER
(2023)
Article
Oncology
Ashley Hinther, Steven C. Nakoneshny, Shamir P. Chandarana, T. Wayne Matthews, Robert Hart, Christiaan Schrag, Jennifer Matthews, C. David McKenzie, Gordon H. Fick, Joseph C. Dort
Summary: Chronic opioid use is a global health issue, often first introduced through surgery. Multimodal analgesia (MMA) aims to reduce opioid use in surgical patients, but its impact on major head and neck surgery has not been studied. This research found that MMA is effective in pain control and reducing opioids in patients undergoing head and neck surgery with free flap reconstruction, improving early postoperative pain management.
Review
Biochemistry & Molecular Biology
Yair Sharav, Yaron Haviv, Rafael Benoliel
Summary: The purpose of this study is to explore the potential differences between orofacial migraine (OFM) and neurovascular orofacial pain (NVOP). Facial presentations of primary headache resemble primary headache disorders, but they occur in specific locations associated with the trigeminal nerve. The International Classification of Orofacial Pain, 1st edition (ICOP) classifies these conditions as orofacial pains resembling primary headaches, including OFM and NVOP. The subtle differences and similar response to therapy suggest a possible overlap between NVOP and OFM, and further investigations are needed to separate them into distinct entities.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Toxicology
S. M. Lim, A. U. J. Yap, C. S. L. Loo, J. Ng, C. Y. Goh, C. H. L. Hong, W. S. Toh
HUMAN & EXPERIMENTAL TOXICOLOGY
(2017)
Article
Dentistry, Oral Surgery & Medicine
Catherine Hong, Kok Siew Tang, Mariflor Villegas, Poh Lin Tan
ORAL SURGERY ORAL MEDICINE ORAL PATHOLOGY ORAL RADIOLOGY
(2016)
Article
Dentistry, Oral Surgery & Medicine
Songping Nicholas Lim, Leroy Kiang, Ranjan Manohara, Hub Jinn Tong, Rahul Nair, Catherine Hong, Shijia Hu
INTERNATIONAL JOURNAL OF PAEDIATRIC DENTISTRY
(2017)
Review
Oncology
Catherine H. L. Hong, Shijia Hu, Thijs Haverman, Monique Stokman, Joel J. Napenas, Jacolien Bos-den Braber, Erich Gerber, Margot Geuke, Emmanouil Vardas, Tuomas Waltimo, Siri Beier Jensen, Deborah P. Saunders
SUPPORTIVE CARE IN CANCER
(2018)
Article
Dentistry, Oral Surgery & Medicine
C. H. L. Hong, M. M. Aung, K. Kanagasabai, C. A. Lim, S. Liang, K. S. Tan
INTERNATIONAL JOURNAL OF DENTAL HYGIENE
(2018)
Article
Dentistry, Oral Surgery & Medicine
Jing Jing Ng, Oy Chu Eu, Rahul Nair, Catherine Hsu Ling Hong
INTERNATIONAL JOURNAL OF PAEDIATRIC DENTISTRY
(2015)
Review
Oncology
Sharon Elad, Judith E. Raber-Durlacher, Michael T. Brennan, Deborah P. Saunders, Arno P. Mank, Yehuda Zadik, Barry Quinn, Joel B. Epstein, Nicole M. A. Blijlevens, Tuomas Waltimo, Jakob R. Passweg, M. Elvira P. Correa, Goran Dahllof, Karin U. E. Garming-Legert, Richard M. Logan, Carin M. J. Potting, Michael Y. Shapira, Yoshihiko Soga, Jacqui Stringer, Monique A. Stokman, Samuel Vokurka, Elisabeth Wallhult, Noam Yarom, Siri Beier Jensen
SUPPORTIVE CARE IN CANCER
(2015)
Article
Dentistry, Oral Surgery & Medicine
N. Gupta, S. Y. Quah, J. F. Yeo, J. Ferreira, K. S. Tan, C. H. L. Hong
ARCHIVES OF ORAL BIOLOGY
(2019)
Article
Dentistry, Oral Surgery & Medicine
Catherine H. L. Hong, David R. Dean, Katrusha Hull, Shi Jia Hu, Yu Fan Sim, Christine Nadeau, Sandra Goncalves, Giovanni Lodi, Tim A. Hodgson
Review
Oncology
Catherine H. L. Hong, Luiz Alcino Gueiros, Janet S. Fulton, Karis Kin Fong Cheng, Abhishek Kandwal, Dimitra Galiti, Jane M. Fall-Dickson, Jorgen Johansen, Suzanne Ameringer, Tomoko Kataoka, Dianna Weikel, June Eilers, Vinasha Ranna, Anusha Vaddi, Rajesh V. Lalla, Paolo Bossi, Sharon Elad
SUPPORTIVE CARE IN CANCER
(2019)
Article
Multidisciplinary Sciences
Nitasha Gupta, Joao Ferreira, Catherine Hsu Ling Hong, Kai Soo Tan
SCIENTIFIC REPORTS
(2020)
Article
Oncology
Wanessa Miranda-Silva, Wagner Gomes-Silva, Yehuda Zadik, Noam Yarom, Abdul Rahman Al-Azri, Catherine H. L. Hong, Anura Ariyawardana, Deborah P. Saunders, M. Elvira Correa, Praveen R. Arany, Joanne Bowen, Karis Kin Fong Cheng, Wim J. E. Tissing, Paolo Bossi, Sharon Elad
Summary: The analysis highlights limited or conflicting evidence on interventions for managing oral mucositis in pediatric cancer patients, with chewing gum being ineffective. It is suggested to extrapolate data from adult studies for pediatric patient management and consider implementing a basic oral care protocol due to lack of high level evidence. Honey and photobiomodulation therapy show promising potential in this patient population.
SUPPORTIVE CARE IN CANCER
(2021)
Article
Dentistry, Oral Surgery & Medicine
S. J. Quek, Y. F. Sim, B. Lai, W. Lim, C. H. Hong
Summary: The study found that authoritative parents were more likely to pay attention to their children's dietary habits and oral hygiene practices, while permissive parents were more likely to neglect these aspects. However, parenting styles did not have a significant impact on the dmft and PI indices of the children.
EUROPEAN ARCHIVES OF PAEDIATRIC DENTISTRY
(2021)
Review
Dentistry, Oral Surgery & Medicine
S. F. Tan, H. J. Tong, X. Y. Lin, B. Mok, C. H. Hong
EUROPEAN ARCHIVES OF PAEDIATRIC DENTISTRY
(2016)
Article
Dentistry, Oral Surgery & Medicine
Qiyue Naomi Yang, Vinicius Rosa, Catherine Hsu Ling Hong, Hui Xian Melissa Tan, Shijia Hu
PEDIATRIC DENTISTRY
(2020)