Review
Geriatrics & Gerontology
D. Robert Paval, Rebekah Patton, James McDonald, Richard J. E. Skipworth, Iain J. Gallagher, Barry J. Laird
Summary: Cancer cachexia is a clinical need that affects more than 50% of cancer patients. This systematic review examines the relationship between cytokines and cachexia syndrome in patients with incurable cancer. The findings suggest that cytokines, particularly IL-6, TNF-α, and IL-8, are associated with the development of cachexia.
JOURNAL OF CACHEXIA SARCOPENIA AND MUSCLE
(2022)
Review
Oncology
Aline Emanuel, Julia Krampitz, Friederike Rosenberger, Sabine Kind, Ingeborg Roetzer
Summary: This systematic review investigates the impact of nutritional interventions on cachexia, malnutrition, and weight loss in patients with pancreatic cancer. The results suggest that enteral nutrition and dietary supplements enriched with omega-3 fatty acids have positive effects on the treatment of pancreatic cancer patients.
Review
Nutrition & Dietetics
Irina Mihaela Abdulan, Gabriela Popescu, Alexandra Mastaleru, Andra Oancea, Alexandru Dan Costache, Doina-Clementina Cojocaru, Carmen-Marinela Cumpat, Bogdan Mihnea Ciuntu, Bogdan Rusu, Maria Magdalena Leon
Summary: This article examines the impact of diet during winter holidays on weight. The study found that most participants experienced significant weight fluctuations during holiday periods, and the weight gained during these times tended to be maintained even after the end of the studies. A supervised exercise program and controlled diet at work during Christmas were effective strategies for preventing weight gain and its negative effects in individuals with metabolic syndrome or weight problems. Additionally, attention should be paid to the psycho-social factors during holidays to avoid excessive calorie intake.
Article
Nutrition & Dietetics
Takeshi Kikutani, Yoko Ichikawa, Eri Kitazume, Arato Mizukoshi, Takashi Tohara, Noriaki Takahashi, Fumiyo Tamura, Manami Matsutani, Junko Onishi, Eiichiro Makino
Summary: The study found that more than 10% weight loss during COVID-19 infection treatment was significantly associated with decreased eating function and transitioning to parenteral feeding. However, chlorpromazine equivalents, comorbidities, and hospitalization days showed no significant associations with decreased eating function.
Review
Health Care Sciences & Services
Olivia Patsalos, Johanna Keeler, Ulrike Schmidt, Brenda W. J. H. Penninx, Allan H. Young, Hubertus Himmerich
Summary: This systematic review found that calorie-restricted diets can reduce depressive symptoms in obese patients, with effect sizes ranging from approximately 0.2 to 0.6. However, the effects of dietary supplements on depression were less clear.
JOURNAL OF PERSONALIZED MEDICINE
(2021)
Review
Nutrition & Dietetics
Jessica Cheng, Hai -Wei Liang, Mary Lou Klem, Tina Costacou, Lora E. Burke
Summary: This article aims to systematically review the evidence from randomized controlled trials on the effect of behavioral interventions on diet quality among adults with overweight and obesity. The study found that the efficacy of behavioral weight loss interventions for improving diet quality is limited, but some studies indicated improvements in diet quality as measured by the Healthy Eating Index (HEI) scores.
JOURNAL OF THE ACADEMY OF NUTRITION AND DIETETICS
(2023)
Review
Geriatrics & Gerontology
Lucile Simon, Christine Baldwin, Anastasia Z. Kalea, Adrian Slee
Summary: CAC is a wasting syndrome characterized by involuntary weight loss and anorexia, with a lack of clear definition and diagnostic criteria making it difficult to estimate prevalence and interpret research. Although some studies support the use of cannabinoids for cachexia in other chronic diseases, evidence specifically in cancer populations is limited.
JOURNAL OF CACHEXIA SARCOPENIA AND MUSCLE
(2022)
Article
Nutrition & Dietetics
Giovanna Flore, Antonio Preti, Mauro Giovanni Carta, Andrea Deledda, Michele Fosci, Antonio Egidio Nardi, Andrea Loviselli, Fernanda Velluzzi
Summary: Only 25% of patients succeed in maintaining the result of weight loss for a long time after a low-calorie diet. This systematic review and meta-analysis find that intensive intervention during the maintenance phase may contribute to greater preservation of weight loss achieved during the previous slimming phase, although the difference from the control group is not statistically significant.
Review
Nutrition & Dietetics
Jessica Cheng, Hai-Wei Liang, Mary Lou Klem, Tina Costacou, Lora E. Burke
Summary: This study systematically reviewed the evidence from randomized controlled trials on the effect of behavioral interventions on diet quality among adults with overweight and obesity. The findings suggest that the efficacy of these interventions in improving diet quality is limited, but modest improvements were observed in some studies.
JOURNAL OF THE ACADEMY OF NUTRITION AND DIETETICS
(2023)
Article
Nutrition & Dietetics
Sunil K. Saini, Arashdeep Singh, Manisha Saini, Marta Gonzalez-Freire, Christiaan Leeuwenburgh, Stephen D. Anton
Summary: Time-restricted eating (TRE), a form of intermittent fasting, has been shown to provide health benefits by influencing the expression of circulatory miRNAs. This study aimed to examine the effects of a 4-week TRE regimen on global circulatory miRNA in older overweight participants. The results demonstrated that TRE downregulated miRNA, which could inhibit cell growth pathways and activate cell survival pathways, potentially promoting healthy aging.
Review
Pharmacology & Pharmacy
Kenichi Nishie, Tomomi Nishie, Seiichi Sato, Masayuki Hanaoka
Summary: Cancer cachexia is a complex syndrome involving functional impairment and body composition changes that cannot be reversed by nutritional support. It decreases skeletal muscle mass, increases lipolysis, and reduces food intake. As no effective interventions are currently available, it remains an unmet need in cancer treatment. However, recent discoveries and treatments, along with published guidelines, provide hope for developing effective strategies to diagnose and treat cancer cachexia, which could lead to breakthroughs in cancer treatment.
DRUG DISCOVERY TODAY
(2023)
Article
Endocrinology & Metabolism
Lili Liu, Wei Chen, Dan Wu, Fang Hu
Summary: This meta-analysis and systematic review suggests that time-restricted eating may be an effective approach to improving the metabolic state of nonobese individuals, particularly overweight individuals.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2022)
Review
Nutrition & Dietetics
Jolyn Johal, Chad Yixian Han, Ria Joseph, Zachary Munn, Oluwaseyifunmi Andi Agbejule, Fiona Crawford-Williams, Matthew P. Wallen, Raymond J. Chan, Nicolas H. Hart
Summary: This scoping review examines the role of dietary supplements in managing malnutrition-related conditions in patients with metastatic cancers. The review finds that while these supplements show potential, there is a lack of research in this area, particularly in randomized controlled trials.
Review
Biochemistry & Molecular Biology
Hiroki Nishikawa, Masahiro Goto, Shinya Fukunishi, Akira Asai, Shuhei Nishiguchi, Kazuhide Higuchi
Summary: Cachexia is a malnutrition associated with chronic diseases, characterized by decreased skeletal muscle mass and weight loss. Current standard treatments are lacking due to the complexity of its pathogenesis, which involves multiple etiologies.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Biochemistry & Molecular Biology
Iain Phillips, Mark Stares, Lindsay Allan, Judith Sayers, Richard Skipworth, Barry Laird
Summary: Lung cancer is the most common malignancy worldwide and the leading cause of cancer death. However, many patients with advanced lung cancer are too unwell for treatment, leading to poor outcomes. Cancer cachexia, which is common in patients with Non-Small Cell Lung Cancer, is one of the reasons patients are not fit for treatment. There is emerging data suggesting that multi-modal intervention may have a role in treating cachexia.
FRONTIERS IN BIOSCIENCE-LANDMARK
(2022)
Review
Oncology
Koji Amano, Vickie E. Baracos, Jane B. Hopkinson
CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY
(2019)
Article
Nursing
Sarah L. Fry, Daniel Kelly, Jane Hopkinson
JOURNAL OF ADVANCED NURSING
(2020)
Article
Oncology
Jane Hopkinson, Amanda King, Nicholas Courtier, Rebecca Milton, Jayne Elias
EUROPEAN JOURNAL OF ONCOLOGY NURSING
(2020)
Article
Oncology
Nick Courtier, Jo Armes, Andrew Smith, Lesley Radley, Jane B. Hopkinson
Summary: The ACTIVE intervention targets a behavioural fatigue self-management programme for women undergoing radiotherapy for early breast cancer, using a novel fatigue propensity tool. Feasibility and outcomes of the intervention were assessed, indicating lower fatigue levels in the intervention group during and after treatment, with all secondary measures favoring the intervention group.
SUPPORTIVE CARE IN CANCER
(2022)
Article
Gastroenterology & Hepatology
Rose Maunsell, Samantha Sodergren, Jane Hopkinson, Clare Shaw, Claire Foster, Sally Wheelwright
Summary: Nutritional issues such as poor appetite, weight loss, and unmet needs are common among patients with CRC. However, the availability of CRC dietetic resources in the UK is limited, highlighting the need to improve nutritional care for CRC patients.
COLORECTAL DISEASE
(2021)
Review
Endocrinology & Metabolism
Koji Amano, Jane Hopkinson, Vickie Baracos
Summary: This review examines the impact of cachexia on the physical and psychological symptoms in cancer patients and the emotional distress experienced by patients and their families. The research highlights the role of the central nervous system in amplifying tumor-induced systemic inflammation, resulting in a cluster of psychological symptoms and emotional distress. There is a growing recognition of the need for holistic multimodal interventions to address the psychological symptoms and emotional distress in both patients and families.
CURRENT OPINION IN CLINICAL NUTRITION AND METABOLIC CARE
(2022)
Article
Oncology
Sarah Louise Fry, Jane Hopkinson, Daniel Kelly
Summary: This study aims to understand the social knowledge of prostate cancer risk among different cultural groups. The findings suggest that there are differences in the way men from different cultural backgrounds construct their understanding of prostate cancer risk, and this socially-derived knowledge may influence their perception and acceptance of the risk. The results of this research can help healthcare providers and third sector organizations develop targeted health information and offer tailored and culturally appropriate support for men.
EUROPEAN JOURNAL OF ONCOLOGY NURSING
(2022)
Article
Geriatrics & Gerontology
Charlie C. Hall, Richard J. E. Skipworth, Honor Blackwood, Duncan Brown, Jane Cook, Katharina Diernberger, Elizabeth Dixon, Valerie Gibson, Catriona Graham, Peter Hall, Erna Haraldsdottir, Jane Hopkinson, Anna Lloyd, Matthew Maddocks, Lucy Norris, Sharon Tuck, Marie T. Fallon, Barry J. A. Laird
Summary: Despite limited evidence supporting rehabilitation for people with incurable cancer, this trial showed that an exercise and nutrition based rehabilitation programme is feasible and may have potential benefits for this population. Further larger trials are warranted to test the efficacy of this approach.
JOURNAL OF CACHEXIA SARCOPENIA AND MUSCLE
(2021)
Article
Oncology
Koji Amano, Sayaka Arakawa, Jane B. Hopkinson, Vickie E. Baracos, Shunsuke Oyamada, Saori Koshimoto, Naoharu Mori, Hiroto Ishiki, Tatsuya Morita, Takashi Takeuchi, Eriko Satomi
Summary: This study examined factors associated with practicing multimodal care for cancer cachexia among physicians and nurses. The results showed that factors such as gender, specialization in palliative care versus oncology, number of clinical guidelines used, training for cancer cachexia, knowledge on cancer cachexia, and confidence in cancer cachexia management were associated with the practice of multimodal care.
JCO ONCOLOGY PRACTICE
(2023)
Article
Nursing
Nichola Gale, Una Jones, Tracy Rees, Alexandra Hicks, Janet Davies, Samantha Holliday, Jane Hopkinson
Summary: The study used a mixed-methods codesign approach to develop the CAN-PAL tool, aiming to assist cancer care workers in supporting cancer patients to incorporate physical activity into their lifestyles. Through focus groups and interviews, suitable physical activities and resources were identified, and a prototype and user guide were designed based on the themes identified. Healthcare professionals' survey responses indicated good usability of the CAN-PAL tool.
JOURNAL OF CLINICAL NURSING
(2023)
Review
Nursing
Jane B. Hopkinson
Summary: Supportive care for cancer cachexia patients is continuously evolving, with the incorporation of psychosocial support into multimodal interventions being a key focus. Research has shown that psychosocial support can help patients adhere to treatment, cope with emotional challenges, and manage comorbid anxiety and depression. Recognizing the different functions of psychosocial support is crucial for providing holistic care in cancer nursing.
ASIA-PACIFIC JOURNAL OF ONCOLOGY NURSING
(2021)
Article
Public, Environmental & Occupational Health
Jane Hopkinson, Amanda King, Lucy Young, Kirsten McEwan, Fiona Elliott, Kate Hydon, Sabarigirivasan Muthukrishnan, Rosie Tope, Anne-Marie Veitch, Cristie Howells, Mathew Hoskins
Summary: The study focused on identifying critical factors for crisis resolution for people with dementia living at home, finding that the Home Treatment Crisis Team was able to successfully resolve crises and avoid hospital admissions in over 80% of cases through immediate action to reduce harm, expertise in dementia care, communication skills, shared decision-making, and other key factors.
HEALTH & SOCIAL CARE IN THE COMMUNITY
(2021)
Review
Gerontology
Jane B. Hopkinson, Amanda King, Jane Mullins, Lucy Young, Sugandha Kumar, Kate Hydon, Sabarigirivasan Muthukrishnan, Fiona Elliott, Martin Hopkinson
Summary: Crisis is a process for individuals with dementia that may lead to harm and require resolution. In managing crisis at home, medical treatment, community resources, psychosocial support, as well as knowledge and skills of carers and professionals play crucial roles.
DEMENTIA-INTERNATIONAL JOURNAL OF SOCIAL RESEARCH AND PRACTICE
(2021)
Article
Oncology
Jane B. Hopkinson, Catherine Kazmi, Jayne Elias, Sally Wheelwright, Rhiannon Williams, Ann Russell, Clare Shaw
Review
Nursing
Jane Hopkinson
ASIA-PACIFIC JOURNAL OF ONCOLOGY NURSING
(2018)