Article
Clinical Neurology
Ling Gao, Jiedi Liu, Jiping Yang, Xingchao Wang
Summary: The study revealed bidirectional relationships between cyber victimization and depressive symptoms among adolescents, with peer pressure playing a mediating role. The relationship was stronger for males than females. Family socioeconomic status and economic stress did not moderate the relationships.
JOURNAL OF AFFECTIVE DISORDERS
(2021)
Article
Clinical Neurology
Francesca Felicia Operto, Grazia Maria Giovanna Pastorino, Federica Pippa, Chiara Padovano, Valentina Vivenzio, Chiara Scuoppo, Ilaria Pistola, Giangennaro Coppola
Summary: The study identified a high presence of emotional and behavioral symptoms in children and adolescents with epilepsy, along with elevated levels of parental stress. Parental stress was significantly linked to emotional and behavioral problems in their children.
FRONTIERS IN NEUROLOGY
(2021)
Article
Clinical Neurology
Yanyun Yang, Xianchen Liu, Zhen-Zhen Liu, Jenn-Yun Tein, Cun-Xian Jia
Summary: This longitudinal study explored the associations between life stress, insomnia, and anxiety/depressive symptoms (ADS) in a large sample of adolescents. The results showed that the prevalence and persistence rates of insomnia and ADS significantly increased with elevated life stress score. Cross-lagged panel analysis revealed bidirectional relationships between life stress, insomnia, and ADS over time, with insomnia partially mediating the relationship between life stress and ADS, and vice versa. These findings highlight the importance of assessing and intervening in sleep and mental health among adolescents following life stress.
JOURNAL OF AFFECTIVE DISORDERS
(2023)
Article
Psychology, Developmental
Xingchao Wang, Yuran Qiao
Summary: Parental phubbing, when parents are distracted by smartphones when interacting with their children, has been found to have an impact on adolescents' self-esteem and suicidal ideation. This study found bidirectional relationships between parental phubbing, self-esteem, and suicidal ideation, with self-esteem mediating the association between parental phubbing and suicidal ideation. Extraversion was found to moderate the link between parental phubbing and suicidal ideation, as well as the link between self-esteem and suicidal ideation, during the first year.
JOURNAL OF YOUTH AND ADOLESCENCE
(2022)
Article
Environmental Sciences
Ziqin Liang, Claudia Mazzeschi, Elisa Delvecchio
Summary: The challenges and consequences of COVID-19 have led to significant changes in adolescents' daily routines, impacting their mental health. Parental stress has been found to affect adolescents' anxiety and depression symptoms, with expressive suppression mediating the association between parental stress and internalizing symptoms in adolescents.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2021)
Article
Clinical Neurology
Xianchen Liu, Yanyun Yang, Zhen-Zhen Liu, Cun-Xian Jia
Summary: This large-scale longitudinal study on adolescents found associations between life stress, insomnia, depression, and suicidality. The study revealed that life stress predicts suicidality 1-2 years later, with insomnia and depression mediating this association for suicidal ideation and depression mediating for suicide attempt.
Article
Pediatrics
Maryam Pyar Ali Lakhdir, Ghazal Peerwani, Salman Muhammad Soomar, Apsara Ali Nathwani, Salima Farooq, Naureen Akber Ali, Asif Khaliq, Muhammad Masood Kadir, Syed Iqbal Azam
Summary: The study found that frequent parent-to-child maltreatment is significantly associated with an increased risk of developing GAD symptoms among adolescents in Pakistani settings, with parental education playing a crucial role in this association.
CHILD AND ADOLESCENT PSYCHIATRY AND MENTAL HEALTH
(2021)
Article
Psychiatry
Rianca Kroon, Nicole Bothma, Sharna Mathieu, Leonardo F. Fontenelle, Lara J. Farrell
Summary: To meet the needs of children and families during and after the COVID-19 pandemic, a specific response strategy is necessary. This study investigates the impact of COVID-19 on the mental health symptoms of Australian parents and children, particularly OCD symptoms, as well as the stability of this relationship over time and the need for mental health support.
JOURNAL OF PSYCHIATRIC RESEARCH
(2022)
Article
Clinical Neurology
Shu-Juan Liu, Zhen-Zhen Liu, Ze-Ying Wang, Bao-Peng Liu, Shuo Cheng, Xianchen Liu, Cun-Xian Jia
Summary: The study found that symptoms of sleep disordered breathing (SDB) are an independent and significant predictor of depressive symptoms in adolescents. 4.5% of adolescents had persistent depressive symptoms, and the incidence rate of depressive symptoms at 1-year follow-up was 6.5%. Elevated frequency of any SDB symptoms was significantly associated with incident depressive symptoms after adjusting for potential confounders.
JOURNAL OF AFFECTIVE DISORDERS
(2021)
Article
Psychology, Developmental
David Pagliaccio, Poornima Kumar, Rahil A. Kamath, Diego A. Pizzagalli, Randy P. Auerbach
Summary: This study found that neural responses to peer feedback may be core risk factors predicting changes in the severity of adolescent depression symptoms. The sensitivity of the brain to peer feedback interacts with peer interpersonal stressors.
JOURNAL OF CHILD PSYCHOLOGY AND PSYCHIATRY
(2023)
Article
Psychology, Developmental
Olalla Cutrin, Lorena Maneiro, Yasmynn Chowdhury, Stephen S. Kulis, Flavio F. Marsiglia, Jose Antonio Gomez Fraguela
Summary: This study identified the longitudinal effects of parental support and parental knowledge on adolescent adjustment, highlighting the direct predictive role of parental knowledge in antisocial behavior and emotional problems, and the indirect impact of parental support through parental knowledge. Increasing parental knowledge is suggested as a target for educational-prevention programs based on the findings.
JOURNAL OF YOUTH AND ADOLESCENCE
(2022)
Article
Psychology, Developmental
Melanie J. Zimmer-Gembeck, Ellen A. Skinner, Riley A. Scott, Katherine M. Ryan, Tanya Hawes, Alex A. Gardner, Amanda L. Duffy
Summary: The aim of this study was to examine the influence of parental support and negative interactions on adolescents' academic coping. The results showed that parental support was positively related to positive coping, while negative interactions were positively related to negative coping. Furthermore, parental support predicted positive changes in coping strategies over time, while negative interactions predicted an increase in negative coping.
JOURNAL OF YOUTH AND ADOLESCENCE
(2023)
Article
Family Studies
Chris Hoeboer, Carlijn de Roos, Gabrielle E. van Son, Philip Spinhoven, Bernet Elzinga
Summary: Parental emotional abuse is associated with more severe PTSD symptoms in children and adolescents, regardless of whether it is reported as the index traumatic event. Additionally, emotional abuse is linked to more severe PTSD symptoms over the course of treatment.
CHILD ABUSE & NEGLECT
(2021)
Article
Public, Environmental & Occupational Health
Xiaoyu Jia, Jun Wang, Yuchi Zhang
Summary: This study examined the influence of social and parental factors on bullying behaviors among Chinese adolescents. The results showed that social and parental support had different effects on adolescents' active defending and passive bystanding behaviors. These findings emphasize the importance of considering family and cultural values in research on bullying bystanders.
FRONTIERS IN PUBLIC HEALTH
(2023)
Article
Clinical Neurology
Lei Hu, Zhen-Zhen Liu, Zi-Yang Wang, Cun-Xian Jia, Xianchen Liu
Summary: In Chinese adolescents, there is a significant association between headache, stomachache, and other nonspecific pain with depressive symptoms. Increased pain frequencies are significantly linked to higher prevalence and incidence rates of depressive symptoms.
JOURNAL OF AFFECTIVE DISORDERS
(2022)
Article
Oncology
Anne-Sophie E. Darlington, Claire E. Wakefield, Loes M. E. van Erp, Winette T. A. van der Graaf, Richard J. Cohn, Martha A. Grootenhuis
Summary: Survivors of childhood cancer and survivors of cancer in adolescence or young adulthood may experience similar and different psychosocial issues, and it is necessary to have a clearer delineation for these two groups.
Article
Oncology
Silvia Stacchiotti, Winette T. A. Van der Graaf, Roberta G. Sanfilippo, Sandrine Marreaud, Winan J. Van Houdt, Ian R. Judson, Alessandro Gronchi, Hans Gelderblom, Saskia Litiere, Bernd Kasper
Summary: This retrospective analysis of first-line chemotherapy in intra-abdominal liposarcoma found that anthracycline-based chemotherapy had limited efficacy, while regimens containing ifosfamide showed higher activity, although not statistically significant in a small number of cases. The study provides a benchmark for future trials on new drugs in well-differentiated/dedifferentiated liposarcoma.
Review
Oncology
Deborah van de Wal, Mai Elie, Axel Le Cesne, Elena Fumagalli, Dide den Hollander, Robin L. Jones, Gloria Marquina, Neeltje Steeghs, Winette T. A. van der Graaf, Olga Husson
Summary: This study systematically reviews the HRQoL issues and side effects of different TKIs registered for the treatment of GIST. The results show that most patients maintained stable HRQoL during TKI therapy, but patients treated with sunitinib reported a decrease in HRQoL. Severe fatigue and fear of recurrence or progression negatively impacted overall HRQoL.
Review
Oncology
Simone A. van Maren, Max M. van Noesel, Olga Husson, Winette T. A. van der Graaf
Summary: Desmoid-type fibromatosis (DTF) is a rare and locally aggressive tumor, with an increasing incidence as age grows. For most patients, DTF is a chronic and symptomatic disease that impacts their quality of life. The treatment approaches for DTF patients differ between pediatric oncologists and medical oncologists, mainly due to the accessibility of certain drugs in pediatric oncology. Additionally, there is a lack of research on patient-reported outcomes, which is crucial for patients with chronic diseases like DTF.
PEDIATRIC BLOOD & CANCER
(2022)
Article
Oncology
Danielle L. van de Graaf, Carla Vlooswijk, Nadine Bol, Emiel J. Krahmer, Rhode Bijlsma, Suzanne Kaal, Sophia H. E. Sleeman, Winette T. A. van der Graaf, Olga Husson, Mies C. van Eenbergen
Summary: Adolescents and young adults diagnosed with cancer often rely on the Internet for cancer-related information, but healthcare professionals' perceptions of their needs may not align with their actual needs. A survey found discrepancies between AYAs' online information and eHealth needs and HCPs' perceptions, highlighting the potential for insufficient guidance.
Article
Oncology
Anne-Rose W. Schut, Emma Lidington, Milea J. M. Timbergen, Eugenie Younger, Winette T. A. van der Graaf, Winan J. van Houdt, Johannes J. Bonenkamp, Robin L. Jones, Dirk J. Grunhagen, Stefan Sleijfer, Cornelis Verhoef, Spyridon Gennatas, Olga Husson
Summary: Desmoid-type fibromatosis (DTF) is a rare soft tissue tumor that significantly impacts the health-related quality of life (HRQoL) of patients. This study evaluated HRQoL among different groups of DTF patients and identified factors such as age, sex, presence of comorbidities, and treatment type that were associated with DTF-specific HRQoL.
Article
Oncology
Sophie J. M. Reijers, Nicolo Gennaro, Annemarie Bruining, Hester van Boven, Petur Snaebjornsson, Elise M. M. Bekers, Frits van Coevorden, Astrid N. N. Scholten, Yvonne Schrage, Winette T. A. van der Graaf, Rick L. M. Haas, Winan J. J. van Houdt
Summary: This study aimed to assess the association between radiological and histopathological response after neoadjuvant radiotherapy in soft tissue sarcoma, and the prognostic value of different response evaluation methods. The results showed that radiological response was not significantly associated with survival rates, while only necrosis in histopathological parameters was associated with overall survival.
Editorial Material
Oncology
Winette Van der Graaf, Denis Lacombe
EUROPEAN JOURNAL OF CANCER
(2023)
Article
Oncology
Cas Drabbe, Elena S. Coenraadts, Winan J. van Houdt, Michiel A. J. van de Sande, Johannes J. Bonenkamp, Jacco J. de Haan, Johanna W. M. Nin, Cornelis Verhoef, Winette T. A. van der Graaf, Olga Husson
Summary: This study aims to identify AYA sarcoma survivors with impaired social functioning (ISF) and determine the clinical and psychosocial factors associated with ISF. The study found that more than one-quarter of AYA sarcoma survivors experience ISF long after diagnosis. Unemployment and having to make lifestyle changes due to financial problems caused by physical conditions or medical treatment were associated with ISF, while better social support was associated with non-ISF. These results emphasize the importance of follow-up care that focuses not only on the disease but also on the psychological and social domains.
Article
Oncology
Deborah van de Wal, Shreenila Venkatesan, Charlotte Benson, Winette T. A. van der Graaf, Colin D. Johnson, Olga Husson, Samantha C. Sodergren
Summary: The aim of this study was to explore the side effects of tyrosine kinase inhibitors on gastrointestinal stromal tumor patients from the patient's perspective, and compare it with the perspective of healthcare professionals. Semi-structured interviews were conducted with 19 advanced or metastatic gastrointestinal stromal tumor patients, and a focus group was held with five patients and six healthcare professionals. Thematic analysis revealed that most participants reported gastrointestinal symptoms, tiredness, edema, muscle cramps, skin problems, eye problems, and trouble sleeping. Patients, but not healthcare professionals, reported cognitive problems or symptoms of depression. These findings highlight the importance of including the patient's perspective in symptom reporting.
Article
Oncology
Ties M. Siebinga, Silvie H. M. Janssen, Anke W. Boumans, Mies C. Van Eenbergen, Bettina Siflinger, Winette T. A. Van der Graaf, Olga Husson
Summary: This study explored the long-term income patterns and determinants among adolescent and young adult (AYA) cancer survivors, and compared them with their peers. It was found that, on average, AYA cancer survivors experience an 8.5% decrease in annual earnings compared to the control group. Younger age, marriage, female gender, diagnosis of stage IV disease, and central nervous system cancer were associated with the largest decline in income.
JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE
(2023)
Article
Oncology
Anne-Rose W. Schut, Leanne E. de Bruin, Belle H. de Rooij, Emma Lidington, Milea J. M. Timbergen, Winette T. A. van Der Graaf, Winan J. van Houdt, Johannes J. Bonenkamp, Robin L. Jones, Dirk. J. Gruenhagen, Stefan Sleijfer, Spyridon Gennatas, Cornelis Verhoef, Olga Husson
Summary: By studying the level of symptom burden, DTF patients can be categorized into four subgroups, with patients in the high symptom burden subgroup having poorer health-related quality of life and higher healthcare utilization. Understanding the symptom burden of DTF patients can help identify high-risk patients and tailor supportive care to individual needs.
Review
Oncology
Milou J. P. Reuvers, Asiye Gedik, Kirsty M. Way, Sanne M. van de Stadt, Winette T. A. van der Graaf, Olga Husson
Summary: This review provides an overview of the impact of being a caregiver for an AYA cancer patient on different domains of their lives and reports the unmet needs they identify. By being more attentive to the caregivers and intervening accordingly, caregivers' quality of life can increase, resulting in better caregiving capabilities. This not only benefits the patient but also decreases caregiver burden.
Letter
Medicine, General & Internal
Winette T. A. van der Graaf, Olga Husson, Winan J. van Houdt
Article
Oncology
Kim Westerdijk, Neeltje Steeghs, Casper S. J. Tacke, Winette T. A. van der Graaf, Nielka P. van Erp, Gerard van Oortmerssen, Rosella P. M. G. Hermens, Ingrid M. E. Desar, DPOG
Summary: Personalized dosing based on drug level measurement and adjustment can improve efficacy and reduce toxicity in oncological treatment. However, the use of therapeutic drug monitoring (TDM)-guided dosing for imatinib, sunitinib, and pazopanib is not widely adopted, despite evidence supporting individualized dosing.