Article
Medicine, Research & Experimental
Ya-Na Niu, Yan Zeng, Fang-Fang Zhong, Si-Li Long, Dan-Wei Ren, Xiang Qin, Wen-Jun Liu
Summary: The study found that SAL could overcome DEX resistance in CEM-C1 cells by inhibiting cell proliferation, inducing apoptosis, and promoting autophagy, possibly through downregulation of c-Myc.
EXPERIMENTAL AND THERAPEUTIC MEDICINE
(2021)
Article
Cell Biology
Mayumi Sugita, Takahiro Yamazaki, Mohammad Alhomoud, Jeremie Martinet, Jean-Baptiste Latouche, Encouse Golden, Olivier Boyer, Koen Van Besien, Silvia C. Formenti, Lorenzo Galluzzi, Monica L. Guzman
Summary: Autologous T cells engineered with CAR specific for CD19 have been approved for treating CD19(+) hematological malignancies. However, relapse often occurs when neoplastic cells lose CD19 expression. Preclinical models have shown that radiation therapy (RT) can overcome CD19 loss by inducing death receptor expression in cancer cells. Using a human model of CD19(+) acute lymphoblastic leukemia (ALL), it was found that low-dose total body irradiation (LD-TBI) administered before CAR T cell infusion significantly improved overall survival and CAR T cell expansion. These findings support the initiation of clinical trials combining LD-TBI with CAR T cells.
CELL DEATH & DISEASE
(2023)
Article
Endocrinology & Metabolism
Annelienke M. van Hulst, Emma J. Verwaaijen, Sjoerd A. A. van den Berg, Raphaele R. L. van Litsenburg, Martha A. Grootenhuis, Marta Fiocco, Sebastian J. C. M. M. Neggers, Marry M. van den Heuvel-Eibrink, Erica L. T. van den Akker
Summary: The study found that children with acute lymphoblastic leukemia (ALL) experienced significant changes in leptin, fat mass, hunger scores, and sleep after five days of dexamethasone treatment, while BMI remained unchanged. Elevated leptin was associated with older age, higher fat mass, and earlier maintenance treatment week.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2023)
Review
Oncology
Francesco Tamiro, Andrew P. Weng, Vincenzo Giambra
Summary: Leukemia-initiating cells (LIC) are unique cells in different types of leukemia that have self-renewing capabilities and produce tumors, which are functionally distinct from bulk leukemia cells. Current conventional treatments are not effective in eliminating LICs, hence innovative therapeutics targeting LICs hold promise for developing an effective cure for ALL.
Article
Oncology
Emma J. Verwaaijen, Annelienke M. van Hulst, Annelies Hartman, Rob Pieters, Marta Fiocco, Saskia M. F. Pluijm, Raphaele R. L. van Litsenburg, Martha A. Grootenhuis, Erica L. T. van den Akker, Marry M. van den Heuvel-Eibrink
Summary: Dexamethasone treatment for pediatric acute lymphoblastic leukemia (ALL) can lead to muscle atrophy and increase the risk of physical frailty. This study found that the proportion of patients with frailty significantly increased after a 5-day dexamethasone course, while the proportions of sarcopenia and prefrailty remained similar. Lower appendicular skeletal muscle mass, weaker muscle strength, and less physical activity minutes per day increased the risk of frailty, while slower walking performance also increased the risk.
Article
Oncology
Emanuele Murgo, Elisabetta De Santis, Francesca Sansico, Valentina Melocchi, Tommaso Colangelo, Costanzo Padovano, Mattia Colucci, Annalucia Carbone, Beatrice Totti, Alireza Basti, Lisa Gottschlich, Angela Relogio, Nazzareno Capitanio, Fabrizio Bianchi, Gianluigi Mazzoccoli, Vincenzo Giambra
Summary: This study investigates the role of the biological clock in the regulation of cellular dynamics in T-ALL. The disruption of the circadian clock negatively affects LIC activity and JAK/STAT signaling in T-ALL cells. Targeting circadian components could be a potential therapeutic strategy for T-ALL treatment.
JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
(2023)
Article
Oncology
Aman Wadhwa, Yanjun Chen, Lindsey Hageman, Anna L. Hoppmann, Anne Angiolillo, David S. Dickens, Glen Lew, Joseph P. Neglia, Yaddanapudi Ravindranath, A. Kim Ritchey, Amanda Termuhlen, F. Lennie Wong, Wendy Landier, Smita Bhatia
Summary: This study found that extreme obesity during maintenance therapy is associated with a greater hazard of relapse in children with acute lymphoblastic leukemia (ALL). The levels of erythrocyte thioguanine nucleotides were lower in obese children, but this difference did not explain the increased risk of relapse. Further investigation is needed to understand the underlying mechanisms of this association.
Article
Biochemistry & Molecular Biology
Shamil Urazbakhtin, Anastasia Smirnova, Anastasiya Volakhava, Elena Zerkalenkova, Maria Salyutina, Michael Doubek, Hana Jelinkova, Nelly Khudainazarova, Egor Volchkov, Laima Belyaeva, Ekaterina Komech, Sarka Pavlova, Yuri Lebedev, Karla Plevova, Yulia Olshanskaya, Alexander Komkov, Ilgar Mamedov
Summary: Retroelements have been proposed to play a role in cancerogenesis and different cancer types are characterized by varying levels of tumor-specific RE insertions. Recent study found that acute lymphoblastic leukemia and childhood acute leukemias have low levels of RE insertional activity, and no new tumor-specific RE insertions were identified in the acute leukemia samples tested. Additionally, increased transcription levels of active L1 copies were found, but this was not sufficient for a significant elevation of L1 retrotranspositional activity in leukemia.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Geriatrics & Gerontology
Jong Eun Park, Seulgi Lee, Kirang Kim
Summary: This study investigated the effects of nutritional and physical activity factors on different categories of individuals based on the presence or absence of sarcopenia and central obesity. The findings suggest that adequate energy intake and meeting recommended physical activity levels can lower the likelihood of sarcopenia and sarcopenic obesity. However, prioritizing physical activity guidelines may be more important in the case of sarcopenic obesity.
Article
Hematology
Aman Wadhwa, Yanjun Chen, Lindsey Hageman, Anna Hoppmann, Anne Angiolillo, David S. Dickens, Joseph P. Neglia, Yaddanapudi Ravindranath, A. Kim Ritchey, Amanda Termuhlen, F. Lennie Wong, Wendy Landier, Smita Bhatia
Summary: The association between individual-level poverty and relapse in children receiving maintenance treatment for acute lymphoblastic leukemia (ALL) was investigated in this study. The analysis showed that living in extreme poverty was associated with a higher risk of relapse among patients. Although nonadherence to medication partially explained the association, further research is needed to understand the underlying mechanisms.
Article
Oncology
Debbie Piktel, Javohn C. Moore, Sloan Nesbit, Samuel A. Sprowls, Michael D. Craig, Stephanie L. Rellick, Rajesh R. Nair, Ethan Meadows, John M. Hollander, Werner J. Geldenhuys, Karen H. Martin, Laura F. Gibson
Summary: This study investigates the effects of pitavastatin in chemo-resistant ALL cells and provides evidence for the repurposing of this drug as a potential treatment for eliminating chemoresistant tumor cells. The results demonstrate that pitavastatin inhibits the proliferation of chemo-resistant ALL cells and induces apoptosis, highlighting its potential as a therapeutic agent in the treatment of chemo-resistant ALL.
Article
Multidisciplinary Sciences
Tomas Vyhlidal, Jan Dygryn, Jaroslava Hruba, Frantisek Chmelik
Summary: The main purpose of this study is to characterize device-measured physical activity and sedentary behavior among adult survivors of childhood acute lymphoblastic leukemia (ASALL), and compare their movement behavior with a healthy control group (CG). The results showed no significant differences in movement behavior or compliance with physical activity recommendations between ASALL and the CG.
SCIENTIFIC REPORTS
(2023)
Article
Cell Biology
Aleksandra Georgievski, Anais Michel, Charles Thomas, Zandile Mlamla, Jean-Paul Pais de Barros, Stephanie Lemaire-Ewing, Carmen Garrido, Ronan Quere
Summary: This study demonstrates that extracellular vesicles (EVs) produced by proliferative acute lymphoblastic leukemia (ALL) cells can specifically target hematopoietic stem and progenitor cells (HSPC), influencing their quiescence and maintenance. The researchers discovered that ALL EVs are enriched in cholesterol and other metabolites that promote mitochondrial function in targeted HSPC. These findings provide insights into a new oncogenic mechanism and its impact on a healthy hematopoiesis system during leukemia development.
CELL DEATH & DISEASE
(2022)
Article
Oncology
Emily R. Finch, Laura J. Janke, Lie Li, Monique A. Payton, David A. Jenkins, Kristine R. Crews, Mary Relling, Seth E. Karol
Summary: Based on the results of our preclinical murine studies, we conclude that dasatinib is unlikely to increase the osteonecrotic effects of dexamethasone in ALL regimens.
PEDIATRIC BLOOD & CANCER
(2022)
Article
Oncology
Mayuko Iijima, Wei Liu, John C. Panetta, Melissa M. Hudson, Ching-Hon Pui, Deo Kumar Srivastava, Kevin R. Krull, Hiroto Inaba
Summary: This study found a significant association between overweight/obesity and neurocognitive impairment in survivors of childhood acute lymphoblastic leukemia (ALL). Early overweight/obesity status was associated with worse cognitive flexibility and slower motor speed.
Article
Cardiac & Cardiovascular Systems
Yutong Cai, Anna L. Hansell, Marta Blangiardo, Paul R. Burton, Kees de Hoogh, Dany Doiron, Isabel Fortier, John Gulliver, Kristian Hveem, Stephane Mbatchou, DavidW. Morley, Ronald P. Stolk, Wilma L. Zijlema, Paul Elliott, Susan Hodgson
EUROPEAN HEART JOURNAL
(2017)
Article
Biochemistry & Molecular Biology
Ilja M. Nolte, Peter J. van der Most, Behrooz Z. Alizadeh, Paul I. W. de Bakker, H. Marike Boezen, Marcel Bruinenberg, Lude Franke, Pim van der Harst, Gerjan Navis, Dirkje S. Postma, Marianne G. Rots, Ronald P. Stolk, Morris A. Swertz, Bruce H. R. Wolffenbuttel, Cisca Wijmenga, Harold Snieder
EUROPEAN JOURNAL OF HUMAN GENETICS
(2017)
Article
Environmental Sciences
Ana Julia de F. C. Lichtenfels, Diana A. van der plaat, Kim de Jong, Cleo C. van diemen, Dirkje S. Postma, Ivana Nedeljkovic, Cornelia M. van Duijn, Najaf Amin, Sacha la Bastide-van Gemert, Maaike de Vries, Cavin K. Ward-Caviness, Kathrin Wolf, Melanie Waldenberger, Annette Peters, Ronald P. Stolk, Bert Brunekreef, H. Marike Boezen, Judith M. Vonk
ENVIRONMENTAL HEALTH PERSPECTIVES
(2018)
Correction
Endocrinology & Metabolism
A. Abbasi, E. Corpeleijn, E. Meijer, D. Postmus, R. T. Gansevoort, R. O. B. Gans, J. Struck, H. L. Hillege, R. P. Stolk, G. Navis, S. J. L. Bakker
Article
Environmental Sciences
Judith Aris-Meijer, Claudi Bockting, Ronald Stolk, Tjitte Verbeek, Chantal Beijers, Marielle van Pampus, Huibert Burger
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2019)
Article
Pediatrics
Silvia I. Brouwer, Ronald P. Stolk, Eva Corpeleijn
Article
Ethics
Reinder Broekstra, Judith Aris-Meijer, Els Maeckelberghe, Ronald Stolk, Sabine Otten
JOURNAL OF EMPIRICAL RESEARCH ON HUMAN RESEARCH ETHICS
(2020)
Article
Environmental Sciences
Silvia I. Brouwer, Ronald P. Stolk, Meike Bartels, Toos C. E. M. van Beijsterveld, Dorret I. Boomsma, Eva Corpeleijn
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2020)
Article
Ethics
R. Broekstra, E. L. M. Maeckelberghe, J. L. Aris-Meijer, R. P. Stolk, S. Otten
BMC MEDICAL ETHICS
(2020)
Article
Biochemistry & Molecular Biology
Reinder Broekstra, Judith Aris-Meijer, Els Maeckelberghe, Ronald Stolk, Sabine Otten
Summary: Health-related values play a crucial role in participation decisions in genetic research. There is no significant difference in general prosociality between participants and refusers, emphasizing the importance of addressing communication and trust issues in recruitment strategies. Future research should explore how prosocial intrapersonal characteristics drive participation decisions and relate to contextual attributes.
EUROPEAN JOURNAL OF HUMAN GENETICS
(2021)
Article
Multidisciplinary Sciences
Shifteh Abedian, Ali Abbasi, Anthonius de Boer, Bruno H. Stricker, Stephan J. L. Bakker, Pim van der Harst, Sanaz Sedaghat, Maryam Darvishian, M. Arfan Ikram, Gerjan Navis, Abbas Dehghan, Ido Pen, Ronald P. Stolk, Harold Snieder, Olaf H. Klungel, Patrick Souverein, Behrooz Z. Alizadeh
Summary: Genetic determinants play a role in the development of co-morbid diseases in T2D patients, with certain SNPs identified to be associated with them. The study found that CVD was most common, followed by chronic eye disease, with potential involvement of specific SNPs like rs1870849 and rs8051326 in chronic eye disease incidence in T2D patients. Further research is needed to validate these associations.
SCIENTIFIC REPORTS
(2021)
Article
Biochemistry & Molecular Biology
Reinder Broekstra, Judith L. Aris-Meijer, Els L. M. Maeckelberghe, Ronald P. Stolk, Sabine Otten
Summary: The study found that individuals' motives for participation or withdrawal from data donation in biobanks were mainly based on perceptions of benefits or harm to society and themselves. General values and trust played crucial roles in participation, withdrawal, and willingness to permit data linkage, but were associated differently with motives. The findings highlighted the complexity and uniqueness of decision-making processes related to participation or withdrawal from biobanking, suggesting new directions for recruitment, retention, and safeguarding strategies.
EUROPEAN JOURNAL OF HUMAN GENETICS
(2022)
Meeting Abstract
Biochemistry & Molecular Biology
Reinder Broekstra, Judith L. Aris-Meijer, Els L. M. Maeckelberghe, Ronald P. Stolk, Sabine Otten
EUROPEAN JOURNAL OF HUMAN GENETICS
(2022)
Correction
Medicine, General & Internal
Hiltje Oude Luttikhuis, Louise Baur, Hanneke Jansen, Vanessa A. Shrewsbury, Claire O'Malley, Ronald P. Stolk, Carolyn D. Summerbell
COCHRANE DATABASE OF SYSTEMATIC REVIEWS
(2019)
Article
Public, Environmental & Occupational Health
Marloes Oldenkamp, Ute Bultmann, Rafael P. M. Wittek, Ronald P. Stolk, Mariet Hagedoorn, Nynke Smidt
HEALTH & SOCIAL CARE IN THE COMMUNITY
(2018)