Review
Microbiology
Sara Shakir, Muhammad Mubin, Nazia Nahid, Saad Serfraz, Muhammad Amir Qureshi, Taek-Kyun Lee, Iram Liaqat, Sukchan Lee, Muhammad Shah Nawaz-ul-Rehman
Summary: Rep, the replication-associated protein of circular single-stranded DNA viruses of the family Geminiviridae, plays multiple roles in virus DNA replication, transcription of virus genes, and suppression of host defense responses. Recent studies have revealed the complex structure and functions of Geminivirus Rep, which is believed to have evolved from plasmids containing a signature domain for single-stranded DNA binding with nuclease activity.
FRONTIERS IN MICROBIOLOGY
(2023)
Review
Plant Sciences
Muhammad Amir Qureshi, Aamir Lal, Muhammad Shah Nawaz-ul-Rehman, Thuy Thi Bich Vo, Gusti Ngurah Prabu Wira Sanjaya, Phuong Thi Ho, Bupi Nattanong, Eui-Joon Kil, Shah Mohammad Hemayet Jahan, Kyeong-Yeoll Lee, Chi-Wei Tsai, Hang Thi Dao, Trinh Xuan Hoat, Tin-Tin Aye, Nang Kyu Win, Jangha Lee, Sang-Mok Kim, Sukchan Lee
Summary: Plant viruses are responsible for devastating plant diseases worldwide, particularly in tropical and subtropical regions. The emergence of new begomoviruses, a genus of plant viruses transmitted by insects, has become a major concern due to their increasing host range and geographical expansion. Four highly destructive begomoviruses from Asia have been identified, causing massive economic losses in Europe. Understanding the characteristics of these emerging viruses is crucial for implementing preventive measures.
FRONTIERS IN PLANT SCIENCE
(2022)
Article
Public, Environmental & Occupational Health
Ronaldo da Silva Francisco Junior, Luiz G. P. de Almeida, Alessandra P. Lamarca, Liliane Cavalcante, Yasmmin Martins, Alexandra L. Gerber, Ana Paula de C. Guimaraes, Ricardo Barbosa Salviano, Fernanda Leitao dos Santos, Thiago Henrique de Oliveira, Isabelle Vasconcellos de Souza, Erika Martins de Carvalho, Mario Sergio Ribeiro, Silvia Carvalho, Flavio Dias da Silva, Marcio Henrique de Oliveira Garcia, Leandro Magalhaes de Souza, Cristiane Gomes da Silva, Caio Luiz Pereira Ribeiro, Andrea Cony Cavalcanti, Claudia Maria Braga de Mello, Amilcar Tanuri, Ana Tereza R. Vasconcelos
Summary: This study reports the first case of intra-host SARS-CoV-2 recombination between the variants of concern AY.33 (Delta) and P.1 (Gamma) during coinfection. By analyzing sequencing reads that contain lineage-defining mutations from both variants, the researchers identified six recombinant regions in the SARS-CoV-2 genome within a sample, four in the spike gene and two in the nucleocapsid gene. This represents a potential threat to public health management during the COVID-19 pandemic due to the emergence of viruses with recombinant phenotypes.
FRONTIERS IN PUBLIC HEALTH
(2022)
Article
Biochemistry & Molecular Biology
Tianpeng Wang, Yaqiong Guo, Dawn M. Roellig, Na Li, Monica Santin, Jason Lombard, Martin Kvac, Doaa Naguib, Ziding Zhang, Yaoyu Feng, Lihua Xiao
Summary: Genetic recombination between sympatric ancestral populations leads to the emergence of divergent subpopulations of the zoonotic parasite Cryptosporidium parvum with modified host ranges. This study reveals the ancestral origins of C. parvum and suggests that pathogen import through modern animal farming promotes the emergence of subpopulations with modified host preference.
MOLECULAR BIOLOGY AND EVOLUTION
(2022)
Review
Virology
Maryam Shafaati, Milad Zandi
Summary: This article focuses on the current state of human monkeypox infection outbreak, research & development of immune responses, and clinical interventions to prevent and treat human monkeypox virus and other human poxviruses.
JOURNAL OF MEDICAL VIROLOGY
(2023)
Article
Genetics & Heredity
Lindsey L. Bohr, Madison A. Youngblom, Vegard Eldholm, Caitlin S. Pepperell
Summary: Mycobacterium abscessus is a rapid growing bacterium that causes lung infections in humans. Recently emerged dominant circulating clones in M. abscessus subspecies massiliense and abscessus are globally distributed and provide insights into the mechanisms of pathogen emergence and host adaptation. Differences in lateral gene transfer patterns, genome reorganization, and selection pressures were observed between environmental and host-adapted bacteria, suggesting major changes in genome evolution during host adaptation.
MICROBIAL GENOMICS
(2021)
Article
Virology
Alexandre Hassanin, Opale Rambaud
Summary: A new method called coloured genomic bootstrap (CGB) barcodes is proposed to study the origins of coronaviruses and understand their host and geographic origins. The study reveals that SARS-CoV and SARS-CoV-2 contain genomic regions of mixed ancestry from horseshoe bat viruses. Different regions of the viruses share exclusive ancestry with various Rhinolophus viruses from different regions of China and Southeast Asia, supporting their emergence in these bat species. However, further research is needed to investigate the diversity of coronaviruses in bats from other Southeast Asian countries.
Article
Veterinary Sciences
Lei Tan, Jun Yao, Lei Lei, Kaiwen Xu, Fan Liao, Shibiao Yang, Lincheng Yang, Xianghua Shu, Deyong Duan, Aibing Wang
Summary: In this study, a novel recombinant PRV strain called HN-2019 was isolated from a sick piglet and its genetic features and pathogenicity were investigated. The results suggested a natural recombination event might have occurred in the genome of the HN-2019 strain between the PRV classical strain and the HB-98 vaccine strain, providing useful guidelines for future PRV vaccine design.
FRONTIERS IN VETERINARY SCIENCE
(2022)
Article
Biology
Clara L. Shaw, David A. Kennedy
Summary: This article introduces a promising experimental system: Caenorhabditis hosts and Orsay virus. The study found variations in susceptibility and transmission of Orsay virus among Caenorhabditis strains, suggesting the system could be valuable for studying spillover and emergence.
PROCEEDINGS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES
(2022)
Article
Virology
Frank Vandenbussche, Elisabeth Mathijs, Wannes Philips, Meruyert Saduakassova, Ilse De Leeuw, Akhmetzhan Sultanov, Andy Haegeman, Kris De Clercq
Summary: Several vaccine-like recombinant strains of lumpy skin disease virus (LSDV) were discovered in Kazakhstan and neighboring regions. The analysis suggests that these strains emerged as a result of a spillover from animals vaccinated with the Lumpivax vaccine, which was found to be a complex mixture of multiple viruses.
Article
Microbiology
Megha Mishra, Rakesh Kumar Verma, Vineeta Pandey, Aarshi Srivastava, Pradeep Sharma, Rajarshi Gaur, Akhtar Ali
Summary: This study highlights the factors responsible for genetic diversity, recombination, and evolution of Chilli leaf curl virus (ChiLCV) and associated satellites. The research findings suggest that ChiLCV has the potential for rapid evolution and adaptation to different geographic conditions, and can infect a wide range of crops, including diverse chilli cultivars.
Article
Infectious Diseases
Zongyi Bo, Yurun Miao, Rui Xi, Xiaoyu Gao, Denian Miao, Huan Chen, Yong-Sam Jung, Yingjuan Qian, Jianjun Dai
Summary: Two PRV variants, named JSY7 and JSY13 strains, were isolated from a Bartha-K61-vaccinated swine farm. These variants showed different cytopathic effects and plaque sizes, but had the same Aspartate insertions in the gE protein. Genomic analysis clustered JSY7 and JSY13 strains in the same clade with other PRV isolates in China. The study also revealed evidence of genomic recombination between the JSY13 strain and the Bartha and JSY7 strains, highlighting the importance of this process in PRV evolution and virulence.
TRANSBOUNDARY AND EMERGING DISEASES
(2021)
Article
Biochemistry & Molecular Biology
Yange Lang, Fangfang Li, Qiang Liu, Zhiqiang Xia, Zhenglin Ji, Juan Hu, Yuting Cheng, Minjun Gao, Fang Sun, Bingzheng Shen, Chang Xie, Wei Yi, Yingliang Wu, Jing Yao, Zhijian Cao
Summary: The functional Kv1.3 ion channel restricts the entry of HCV, DENV, and ZIKV by inhibiting endosome acidification-mediated viral membrane fusion, with no effect on SeV. The Kv1.3 antagonist PAP-1 accelerates animal death in ZIKV-infected Ifnar1(-/-) mice, and deletion of Kv1.3 promotes weight loss and reduces survival rate in ZIKV-infected Kv1.3(-/-) mice. Overall, the Kv1.3 ion channel acts as a host factor that limits viral entry and expands understanding of ion channel biology.
Article
Microbiology
Jing Chen, Mengru Liu, Yixuan Li, Liu Yang, Yunhan Tang, Ruitong Dan, Muhan Xie, Rendong Fang, Nengzhang Li, Chao Ye, Yuanyi Peng
Summary: In this study, recent outbreaks of bovine ephemeral fever (BEF) in Southwest China were reported, and the complete genome of one BEFV isolate (BEFV/CQ1/2022) was sequenced. Comparative genomic analysis revealed significant divergence between BEFV/CQ1/2022 and other available isolates. Phylogenetic analysis showed that global BEFV isolates could be classified into 4 distinct lineages, with the East Asia lineage being the most diverse and further divided into 4 sublineages. Notably, BEFV/CQ1/2022 and other recent isolates from Mainland China were clustered in sublineage 2. Additionally, evidence of recombination among East Asian BEFV isolates was found for the first time.
FRONTIERS IN MICROBIOLOGY
(2023)
Review
Neurosciences
Peter L. Strick, Richard P. Dum, Jean-Alban Rathelot
Summary: The enhancement of manual dexterity in primates relies on generating complex muscle activity patterns and coordinating muscle activity spatiotemporally, which require extensive practice to acquire and refine. The improved motor capabilities in primates are partly attributed to major organizational changes in the primary motor cortex and the proliferation of output pathways from other areas of the cerebral cortex.
ANNUAL REVIEW OF NEUROSCIENCE, VOL 44, 2021
(2021)
Article
Plant Sciences
Francisco Monci, Susana Garcia-Andres, Sonia Sanchez-Campos, Rafael Fernandez-Munoz, Juan Antonio Diaz-Pendon, Enrique Moriones
Article
Virology
Juan A. Diaz-Pendon, Sonia Sanchez-Campos, Isabel Maria Fortes, Enrique Moriones
Article
Agriculture, Multidisciplinary
Natalia M. Barboza, Paul Esker, Alice K. Inoue-Nagata, Enrique Moriones
ANNALS OF APPLIED BIOLOGY
(2019)
Review
Microbiology
Pierre Lefeuvre, Darren P. Martin, Santiago F. Elena, Dionne N. Shepherd, Philippe Roumagnac, Arvind Varsani
NATURE REVIEWS MICROBIOLOGY
(2019)
Article
Plant Sciences
Veronica Perez-Padilla, Isabel M. Fortes, Beatriz Romero-Rodriguez, Manuel Arroyo-Mateos, Araceli G. Castillo, Cristina Moyano, Leandro De Leon, Enrique Moriones
Article
Multidisciplinary Sciences
Sohini Claverie, Alassane Ouattara, Murielle Hoareau, Denis Filloux, Arvind Varsani, Philippe Roumagnac, Darren P. Martin, Jean-Michel Lett, Pierre Lefeuvre
SCIENTIFIC REPORTS
(2019)
Article
Plant Sciences
Isabel M. Fortes, Rafael Fernandez-Munoz, Enrique Moriones
FRONTIERS IN PLANT SCIENCE
(2020)
Article
Entomology
Maria J. Rodriguez-Lopez, Enrique Moriones, Rafael Fernandez-Munoz
Article
Biochemistry & Molecular Biology
Damien Richard, Olivier Pruvost, Francois Balloux, Claudine Boyer, Adrien Rieux, Pierre Lefeuvre
Summary: Horizontal gene transfer plays a key role in the evolution by redistributing phenotypically important genes among lineages. Studies on a bacterial plant pathogen lineage demonstrated extensive gene content variation among lineages even at small phylogenetic and geographic scales. Accessory genes are preferentially located on plasmids, while chromosomal regions also play a role in hosting ecologically important genes.
Article
Virology
Rafaela S. Fontenele, Amulya Bhaskara, Ilaria N. Cobb, Lucas C. Majure, Andrew M. Salywon, Jesus A. Avalos-Calleros, Gerardo R. Arguello-Astorga, Kara Schmidlin, Philippe Roumagnac, Simone G. Ribeiro, Simona Kraberger, Darren P. Martin, Pierre Lefeuvre, Arvind Varsani
Summary: The study identified Squash leaf curl virus (SLCV) and watermelon chlorotic stunt virus (WCSV) in samples from Cactaceae, Solanaceae, Cucurbitaceae, and Lamiaceae plants. The detection of these viruses in cactus plants suggests possible spillover events from agricultural areas into native vegetation. The study also highlights the need for more surveillance of WCSV in the USA as it poses a serious threat to watermelon cultivation.
Article
Microbiology
Selim Ben Chehida, Denis Filloux, Emmanuel Fernandez, Oumaima Moubset, Murielle Hoareau, Charlotte Julian, Laurence Blondin, Jean-Michel Lett, Philippe Roumagnac, Pierre Lefeuvre
Summary: Next-generation sequencing (NGS) has led to the discovery of numerous new viruses, but the current metagenomic protocols are still laborious and costly. In the study of CRESS DNA viruses, alternative long-read NGS protocols showed promise in detecting and characterizing viral genomes, although there are accuracy issues with homopolymeric tracks that need to be addressed. The use of bench-top sequencers could offer new possibilities for CRESS DNA virus research.
Article
Plant Sciences
Isabel M. Fortes, Veronica Perez-Padilla, Beatriz Romero-Rodriguez, Rafael Fernandez-Munoz, Cristina Moyano, Araceli G. G. Castillo, Leandro De Leon, Enrique Moriones
Summary: This study found that the Tomato leaf curl New Delhi virus (ToLCNDV) was seedborne in melon plants, with the virus detectable in the floral parts and mature seeds. The virus could be reduced on the seed coat by chemical disinfection, but low levels of the virus were still present in the internal portion of the seed. However, grow-out studies showed that ToLCNDV was not transmitted from seeds to offspring.
Article
Plant Sciences
Chaymaa Riahi, Alberto Urbaneja, Rafael Fernandez-Munoz, Isabel M. Fortes, Enrique Moriones, Meritxell Perez-Hedo
Summary: This study demonstrates the potential of using zoophytophagous predators to enhance the constitutive resistance of tomato plants against whiteflies and whitefly-transmitted viruses. Feeding-punctured by the predator N. tenuis significantly increases the density of type IV trichomes and acylsugar production. This induces the expression of defensive genes and provides early protection. Preplant release of N. tenuis in tomato nurseries could be an effective strategy for controlling these pests and transmitted viruses.
Article
Virology
Sohini Claverie, Murielle Hoareau, Selim Ben Chehida, Denis Filloux, Arvind Varsani, Philippe Roumagnac, Darren P. Martin, Jean-Michel Lett, Pierre Lefeuvre
Summary: As highly pervasive parasites, viruses are likely major components of all natural ecosystems. We focused on understanding the ecological roles of viruses by studying Mastrevirus genus, which infects uncultivated grasses throughout tropical and sub-tropical regions. Our findings reveal the host preferences and diverse distribution of Mastrevirus, suggesting the importance of perennial plant species in generating viral recombinants.
Article
Biology
Natalia Barboza, Eduardo Hernandez, Alice K. Inoue-Nagata, Enrique Moriones, Luko Hilje
REVISTA DE BIOLOGIA TROPICAL
(2019)
