4.1 Article

Are Sexes Affected Differently by Ketamine? An Exploratory Study in Ketamine Users

Journal

SUBSTANCE USE & MISUSE
Volume 49, Issue 4, Pages 395-404

Publisher

TAYLOR & FRANCIS INC
DOI: 10.3109/10826084.2013.841248

Keywords

ketamine; substance abuse; sex; cognitive functions; memory; executive function

Funding

  1. Beat Drugs Fund in Hong Kong [BDF 090066]
  2. Narcotics Division of Hong Kong

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One hundred primary ketamine users and 100 controls were recruited in Hong Kong between December 2009 and December 2011. Cognitive assessment included general intelligence, working, verbal, and visual memory, and executive functions. A Univariate General Linear Model was used to compare cognitive performance between the male and female ketamine users and controls. The female users appeared to have a higher risk of visual memory impairment than their male counterparts. Further studies are warranted to clarify the mechanism of the sex-specific effect of ketamine on cognitive functions.

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