Journal
CELL REPORTS
Volume 13, Issue 10, Pages 2135-2146Publisher
CELL PRESS
DOI: 10.1016/j.celrep.2015.10.078
Keywords
-
Categories
Funding
- National Cancer Institute of the NIH [R01CA154356, F31CA195887]
- Med into Grad'' initiative of the Howard Hughes Medical Institute
- Cleveland Clinic Research Program Committee
Ask authors/readers for more resources
A critical need in understanding the biology of prostate cancer is characterizing the molecular differences between indolent and aggressive cases. Because DNA methylation can capture the regulatory state of tumors, we analyzed differential methylation patterns genome-wide among benign prostatic tissue and low-grade and high-grade prostate cancer and found extensive, focal hypermethylation regions unique to high-grade disease. These hypermethylation regions occurred not only in the promoters of genes but also in gene bodies and at intergenic regions that are enriched for DNA-protein binding sites. Integration with existing RNA-sequencing (RNA-seq) and survival data revealed regions where DNA methylation correlates with reduced gene expression associated with poor outcome. Regions specific to aggressive disease are proximal to genes with distinct functions from regions shared by indolent and aggressive disease. Our compendium of methylation changes reveals crucial molecular distinctions between indolent and aggressive prostate cancer.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available